<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:01a0a158-578c-7903-a439-052bb34899eb,g:17cc98ec-4489-48b0-98e4-bf06be0d003f-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.repligencorp.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="rgen-20260910.xsd#DocumentandEntityInformation"/>
  <link:presentationLink xlink:role="http://www.repligencorp.com/role/DocumentandEntityInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_01a0a158-578c-7d38-a364-24c411c662b3" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_DocumentType_01a0a158-578c-7d38-a364-24c411c662b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_01a0a158-578c-7182-ba16-35fc219b339e" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_DocumentPeriodEndDate_01a0a158-578c-7182-ba16-35fc219b339e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_01a0a158-578c-7e1a-a663-2f4607119fd7" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_EntityRegistrantName_01a0a158-578c-7e1a-a663-2f4607119fd7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_01a0a158-578c-71cb-83e0-6868b1435d12" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_EntityIncorporationStateCountryCode_01a0a158-578c-71cb-83e0-6868b1435d12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_01a0a158-578c-7383-a090-b0ed32dca960" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_EntityFileNumber_01a0a158-578c-7383-a090-b0ed32dca960" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_01a0a158-578c-77f4-8288-3ed093fb4c89" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_EntityTaxIdentificationNumber_01a0a158-578c-77f4-8288-3ed093fb4c89" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_01a0a158-578c-7d6b-a3eb-1c1d7a442bdc" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_EntityAddressAddressLine1_01a0a158-578c-7d6b-a3eb-1c1d7a442bdc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_01a0a158-578c-70ef-880f-fc84e38edcd2" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_EntityAddressCityOrTown_01a0a158-578c-70ef-880f-fc84e38edcd2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_01a0a158-578c-7444-9551-f891378b3280" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_EntityAddressStateOrProvince_01a0a158-578c-7444-9551-f891378b3280" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_01a0a158-578c-7714-a353-8437fce1353f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_EntityAddressPostalZipCode_01a0a158-578c-7714-a353-8437fce1353f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_01a0a158-578c-7a61-acee-12be0ff38367" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_CityAreaCode_01a0a158-578c-7a61-acee-12be0ff38367" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_01a0a158-578c-7e90-bee3-c572707b21eb" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_LocalPhoneNumber_01a0a158-578c-7e90-bee3-c572707b21eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_01a0a158-578c-7442-a4e3-988fd942ca8c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_WrittenCommunications_01a0a158-578c-7442-a4e3-988fd942ca8c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_01a0a158-578c-7a8a-9f6b-04375f37cd39" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_SolicitingMaterial_01a0a158-578c-7a8a-9f6b-04375f37cd39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_01a0a158-578c-7a87-b3b4-5282ad5dee00" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_PreCommencementTenderOffer_01a0a158-578c-7a87-b3b4-5282ad5dee00" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_01a0a158-578c-7075-9252-1c5c45142015" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_01a0a158-578c-7075-9252-1c5c45142015" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_01a0a158-578c-7e23-9f22-c70111ab3db8" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_Security12bTitle_01a0a158-578c-7e23-9f22-c70111ab3db8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_01a0a158-578c-759c-9bf1-1c9d37d2fb8f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_TradingSymbol_01a0a158-578c-759c-9bf1-1c9d37d2fb8f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_01a0a158-578c-789e-87e8-641e8d77e367" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_SecurityExchangeName_01a0a158-578c-789e-87e8-641e8d77e367" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_01a0a158-578c-76fe-a7dc-0db37b317f3b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_EntityEmergingGrowthCompany_01a0a158-578c-76fe-a7dc-0db37b317f3b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_01a0a158-578c-786b-9cf7-e22084387495" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_EntityCentralIndexKey_01a0a158-578c-786b-9cf7-e22084387495" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_01a0a158-578c-7bbe-a052-2f4ddfdf1e98" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a0a158-578c-7781-ac75-3a3e141b30a5" xlink:to="loc_dei_AmendmentFlag_01a0a158-578c-7bbe-a052-2f4ddfdf1e98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
