0001808805 2026-09-11 2026-09-11 0001808805 1 2026-09-11 2026-09-11 0001808805 2 2026-09-11 2026-09-11 0001808805 3 2026-09-11 2026-09-11 0001808805 4 2026-09-11 2026-09-11 0001808805 5 2026-09-11 2026-09-11 0001808805 6 2026-09-11 2026-09-11 0001808805 7 2026-09-11 2026-09-11 0001808805 8 2026-09-11 2026-09-11 0001808805 9 2026-09-11 2026-09-11 iso4217:USD 0001808805 EX-FILING FEES N/A N/A S-3 S-3 Nautilus Biotechnology, Inc. Equity Common Stock, par value $0.0001 per share true S-3 333-277437 2024-03-06 0 Equity Preferred Stock, par value $0.0001 per share true S-3 333-277437 2024-03-06 0 Debt Debt Securities true S-3 333-277437 2024-03-06 0 Equity Depositary Shares true S-3 333-277437 2024-03-06 0 Equity Warrants true S-3 333-277437 2024-03-06 0 Other Subscription Rights true S-3 333-277437 2024-03-06 0 Other Purchase Contracts true S-3 333-277437 2024-03-06 0 Other Units true S-3 333-277437 2024-03-06 0 Other Unallocated (Universal) Shelf true 300000000 S-3 333-277437 2024-03-06 44280 300000000 0 0 0 0 <div style="margin-bottom:9pt;padding-right:10.8pt;text-align:justify"><span style="background-color:#ffffff;color:#000000;font-family:'Times New Roman',serif;font-size:8pt;font-weight:700;line-height:120%">Offering Note</span><span style="background-color:#ffffff;color:#000000;font-family:'Times New Roman',serif;font-size:8pt;font-weight:400;line-height:120%"> 1</span></div><div style="padding-left:36pt;text-indent:-18pt"><span style="background-color:#ffffff;color:#000000;font-family:'Times New Roman',serif;font-size:8pt;font-weight:400;line-height:120%">a.</span><span style="background-color:#ffffff;color:#000000;font-family:'Times New Roman',serif;font-size:8pt;font-weight:400;line-height:120%;padding-left:12.45pt">The securities registered hereunder include such indeterminate number of (a) shares of common stock, (b) shares of preferred stock, (c) debt securities, (d) depositary shares, (e) warrants to purchase common stock, preferred stock, debt securities or depositary shares of the registrant, (f) subscription rights to purchase common stock, preferred stock, debt securities, depositary shares, warrants or units consisting of some or all of these securities of the registrant, (g) purchase contracts and (h) units consisting of some or all of these securities, as may be sold from time to time by the registrant. The securities registered hereunder also include an indeterminate number of shares of common stock and preferred stock as shall be issuable upon conversion, exchange or exercise of any securities that provide for such issuance. </span></div><div style="padding-left:36pt"><span style="background-color:#ffffff;color:#000000;font-family:'Times New Roman',serif;font-size:8pt;font-weight:400;line-height:120%">Pursuant to Rule 416 under the Securities Act of 1933, as amended (the “Securities Act”), this registration statement also covers any additional shares of the registrant’s securities that become issuable by reason of any share splits, share dividends or similar transactions.</span></div><div style="padding-left:36pt;text-indent:-18pt"><span style="background-color:#ffffff;color:#000000;font-family:'Times New Roman',serif;font-size:8pt;font-weight:400;line-height:120%">b.</span><span style="background-color:#ffffff;color:#000000;font-family:'Times New Roman',serif;font-size:8pt;font-weight:400;line-height:120%;padding-left:12pt">The proposed maximum offering price per security and proposed maximum aggregate offering price per class of security will be determined from time to time by the registrant in connection with the issuance by the registrant of the securities registered hereunder and is not specified as to each class of security pursuant to Instruction 2.A(iii)(b) of Item 16(b) of Form S-3 under the Securities Act. Separate consideration may or may not be received for securities that are issuable on exercise, conversion or exchange of other securities, or that are issued in units.</span></div><div style="padding-left:36pt;text-indent:-18pt"><span style="background-color:#ffffff;color:#000000;font-family:'Times New Roman',serif;font-size:8pt;font-weight:400;line-height:120%">c.</span><span style="background-color:#ffffff;color:#000000;font-family:'Times New Roman',serif;font-size:8pt;font-weight:400;line-height:120%;padding-left:12.45pt">Pursuant to Rule 415(a)(6) under the Securities Act, securities with a maximum aggregate price of $300,000,000 registered hereunder are unsold securities (the “Unsold Securities”) previously covered by the registrant’s registration statement on Form S-3 (File No. 333-277437) which was initially filed with the Securities and Exchange Commission on February 28, 2024 and declared effective on March 6, 2024 (the “Prior Registration Statement”), and are included in this registration statement. In connection with the filing of the Prior Registration Statement, the registrant paid a filing fee of $44,280 with respect to an aggregate of $300,000,000 of securities (based on the filing fee rate in effect at the time of the filing of the Prior Registration Statement). The registrant may continue to offer and sell under the Prior Registration Statement the Unsold Securities being registered hereunder. To the extent that, after the filing date hereof and prior to the effectiveness of this Registration Statement, the registrant sells any Unsold Securities pursuant to the Prior Registration Statement, the registrant will identify in a pre-effective amendment to this Registration Statement the updated amount of Unsold Securities from the Prior Registration Statement to be included in this Registration Statement pursuant to Rule 415(a)(6) and the updated amount of new securities to be registered on this Registration Statement. Pursuant to Rule 415(a)(6) under the Securities Act, the offering of the Unsold Securities under the Prior Registration Statement will be deemed terminated as of the date of effectiveness of this Registration Statement.</span></div>