v3.26.1
Accounting Principles - Additional Information (Detail)
$ / shares in Units, $ in Thousands
 3 Months Ended 4 Months Ended 6 Months Ended
May 03, 2024
USD ($)
$ / shares
shares
Nov. 14, 2023
USD ($)
Nov. 06, 2023
USD ($)
$ / shares
shares
Nov. 01, 2023
USD ($)
Jun. 30, 2026
USD ($)
shares
Jun. 30, 2025
USD ($)
shares
May 03, 2024
USD ($)
$ / shares
shares
Jun. 30, 2026
USD ($)
SegmentUnit
shares
Jun. 30, 2025
USD ($)
shares
Dec. 31, 2025
USD ($)
shares
Nov. 17, 2025
USD ($)
Dec. 31, 2024
USD ($)
shares
Dec. 31, 2023
USD ($)
Disclosure of changes in accounting estimates [line items]                          
Number of operating and reportable segments | SegmentUnit               1          
Cash and cash equivalents         $ 35,590 $ 59,809   $ 35,590 $ 59,809 $ 61,533   $ 143,251  
Bank deposits         131,100     131,100          
Gain on change in fair value measurement recognized         $ 2,255 $ 0   $ 8,761 $ 1,766        
"Class A" Convertible Preferred Shares [Member]                          
Disclosure of changes in accounting estimates [line items]                          
Number of shares issued | shares 10,000,000           10,000,000            
Share issuance price | $ / shares $ 5           $ 5            
"Class B" Convertible Preferred Shares [Member]                          
Disclosure of changes in accounting estimates [line items]                          
Number of shares issued | shares 18,000,000           18,000,000            
Share issuance price | $ / shares $ 5           $ 5            
Ordinary shares [member]                          
Disclosure of changes in accounting estimates [line items]                          
Number of shares issued | shares         72,698,158 72,325,229   72,698,158 72,325,229 72,339,441   72,093,873  
Preference shares [member]                          
Disclosure of changes in accounting estimates [line items]                          
Number of shares issued | shares         28,000,000 28,000,000   28,000,000 28,000,000 28,000,000   28,000,000  
Conversion ratio description   Both classes of preferred shares benefit from a liquidation preference and are convertible into ordinary shares with the same rights as the outstanding ordinary shares on a one-for-one basis.                      
Conversion ratio   1                      
Astra Zeneca [Member]                          
Disclosure of changes in accounting estimates [line items]                          
Proceeds from sale of ordinary shares     $ 80,000                    
Share issuance price | $ / shares     $ 5                    
Proceeds from sale of preferred shares $ 140,000                        
Astra Zeneca [Member] | Ordinary shares [member]                          
Disclosure of changes in accounting estimates [line items]                          
Number of shares issued | shares     16,000,000                    
Joint Collaboration and Research Agreement [Member]                          
Disclosure of changes in accounting estimates [line items]                          
Collaboration agreement, upfront payment received       $ 25,000                  
Total upfront payments   $ 109,100                      
Joint Collaboration and Research Agreement [Member] | Astra Zeneca [Member]                          
Disclosure of changes in accounting estimates [line items]                          
Initial term for selection of candidate products       5 years                  
Subsequent Investment Agreement (SIA) [Member]                          
Disclosure of changes in accounting estimates [line items]                          
Initial fair value amount $ 57,000 48,400         $ 57,000           $ 42,700
Gain on change in fair value measurement recognized             $ 14,300            
Initial Investment Agreement [Member]                          
Disclosure of changes in accounting estimates [line items]                          
Fair value of ordinary shares       $ 44,300                  
Reallocated proceeds from sale of ordinary shares       35,700                  
AZ JRCA, IIA and SIA [Member]                          
Disclosure of changes in accounting estimates [line items]                          
Deferred revenue   $ 84,100                      
Top of Range [member] | Joint Collaboration and Research Agreement [Member]                          
Disclosure of changes in accounting estimates [line items]                          
Variable consideration amount       220,000             $ 253,000    
Bottom of Range [member] | Joint Collaboration and Research Agreement [Member]                          
Disclosure of changes in accounting estimates [line items]                          
Variable consideration amount       $ 70,000             $ 80,000