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            <startDate>2026-09-09</startDate>
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        <measure>pure</measure>
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    <ffd:OfferingNote contextRef="c-1" id="f-13">&lt;div style="margin-bottom:12pt"&gt;&lt;span style="color:#000000;font-family:'Times New Roman',serif;font-size:11pt;font-weight:400;line-height:100%"&gt;In accordance with Rule 416 under the Securities Act of 1933, as amended (the &#x201c;Securities Act&#x201d;), this registration statement shall be deemed to cover any additional securities that may from time to time be offered or issued to prevent dilution resulting from stock splits, stock dividends or similar transactions.&lt;/span&gt;&lt;/div&gt;&lt;div style="padding-right:-2.63pt"&gt;&lt;span style="color:#000000;font-family:'Times New Roman',serif;font-size:11pt;font-weight:400;line-height:120%"&gt;Consists of shares issuable under an inducement stock option award pursuant to an inducement stock option agreement entered into by the Registrant with Daniel S. Ory, the Registrant&#x2019;s Chief Medical Officer, which was granted on September 8, 2026, in accordance with Nasdaq Listing Rule 5635(c)(4).&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:12pt"&gt;&lt;span style="color:#000000;font-family:'Times New Roman',serif;font-size:11pt;font-weight:400;line-height:100%"&gt;Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act, based on the exercise price per share of the 950,000 shares issuable under the inducement stock option award for Dr. Ory.&lt;/span&gt;&lt;/div&gt;</ffd:OfferingNote>
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