<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:01a06872-7d9a-7a57-b4de-f5fade9d24b0,g:c7b08720-d24d-41f5-a0ad-388fd3f807db-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://wwwvallon-pharma.com/role/Cover" xlink:type="simple" xlink:href="val-20260908.xsd#Cover"/>
  <link:presentationLink xlink:role="http://wwwvallon-pharma.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_01a06872-7d9a-7235-97ab-087553028258" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_DocumentType_01a06872-7d9a-7235-97ab-087553028258" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_01a06872-7d9a-7797-ad92-ceddce184bae" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_DocumentPeriodEndDate_01a06872-7d9a-7797-ad92-ceddce184bae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_01a06872-7d9a-7463-a71b-7a8859a4b832" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_EntityRegistrantName_01a06872-7d9a-7463-a71b-7a8859a4b832" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_01a06872-7d9a-7737-8cc7-1d513115cb41" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_EntityIncorporationStateCountryCode_01a06872-7d9a-7737-8cc7-1d513115cb41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_01a06872-7d9a-7a5e-b05a-38b639145357" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_EntityFileNumber_01a06872-7d9a-7a5e-b05a-38b639145357" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_01a06872-7d9a-78d7-b569-5d8d41649b3e" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_EntityTaxIdentificationNumber_01a06872-7d9a-78d7-b569-5d8d41649b3e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_01a06872-7d9a-76d7-a83c-023e5b36b667" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_EntityAddressAddressLine1_01a06872-7d9a-76d7-a83c-023e5b36b667" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_01a06872-7d9a-7d75-aa55-06c5f948ed55" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_EntityAddressAddressLine2_01a06872-7d9a-7d75-aa55-06c5f948ed55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_01a06872-7d9a-7deb-aa75-7cddc093dfb3" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_EntityAddressCityOrTown_01a06872-7d9a-7deb-aa75-7cddc093dfb3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_01a06872-7d9a-7f8f-af65-5abf48bf2321" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_EntityAddressStateOrProvince_01a06872-7d9a-7f8f-af65-5abf48bf2321" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_01a06872-7d9a-709a-9c09-605c239166b1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_EntityAddressPostalZipCode_01a06872-7d9a-709a-9c09-605c239166b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_01a06872-7d9a-788b-9c7c-87d30f0391bc" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_CityAreaCode_01a06872-7d9a-788b-9c7c-87d30f0391bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_01a06872-7d9a-746f-8544-9f88957235fc" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_LocalPhoneNumber_01a06872-7d9a-746f-8544-9f88957235fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_01a06872-7d9a-7d35-be2b-b1a7786e2793" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_WrittenCommunications_01a06872-7d9a-7d35-be2b-b1a7786e2793" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_01a06872-7d9a-7665-ab58-8f5d0679e79a" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_SolicitingMaterial_01a06872-7d9a-7665-ab58-8f5d0679e79a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_01a06872-7d9a-70bc-9fd0-22b3fa9f96dc" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_PreCommencementTenderOffer_01a06872-7d9a-70bc-9fd0-22b3fa9f96dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_01a06872-7d9a-74b3-ba6b-6f941d5877a3" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_01a06872-7d9a-74b3-ba6b-6f941d5877a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_01a06872-7d9a-78e7-8d81-4f8fd2118d3f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_Security12bTitle_01a06872-7d9a-78e7-8d81-4f8fd2118d3f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_01a06872-7d9a-7d93-870d-905e488bfa52" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_TradingSymbol_01a06872-7d9a-7d93-870d-905e488bfa52" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_01a06872-7d9a-7b0a-b03c-e9918ebf3687" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_SecurityExchangeName_01a06872-7d9a-7b0a-b03c-e9918ebf3687" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_01a06872-7d9a-7431-b75c-1517b417511e" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_EntityEmergingGrowthCompany_01a06872-7d9a-7431-b75c-1517b417511e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_01a06872-7d9a-769d-ab5f-0a6695c95db9" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_EntityExTransitionPeriod_01a06872-7d9a-769d-ab5f-0a6695c95db9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_01a06872-7d9a-7b41-b52a-23b72ac5acb8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_EntityCentralIndexKey_01a06872-7d9a-7b41-b52a-23b72ac5acb8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_01a06872-7d9a-70fb-98bb-a34d8039cacf" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a06872-7d9a-78a8-83a5-d8ae7a50c105" xlink:to="loc_dei_AmendmentFlag_01a06872-7d9a-70fb-98bb-a34d8039cacf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
