<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019fcf09-3376-701f-bc51-a2f9216237e6,g:f16119ea-2672-4a66-a12f-072bc6d4fb53-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.medtronic.com/role/ConsolidatedStatementsofIncomeUnaudited" xlink:type="simple" xlink:href="mdt-20260731.xsd#ConsolidatedStatementsofIncomeUnaudited"/>
  <link:calculationLink xlink:role="http://www.medtronic.com/role/ConsolidatedStatementsofIncomeUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019fcf09-3628-7dfc-a938-5b559f532f74" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fcf09-3628-7e43-890f-c44d045ad313" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_019fcf09-3628-7dfc-a938-5b559f532f74" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fcf09-3628-7e43-890f-c44d045ad313" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019fcf09-3628-7f78-98b8-b48ee9247b59" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_019fcf09-3628-7dfc-a938-5b559f532f74" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019fcf09-3628-7f78-98b8-b48ee9247b59" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fcf09-3628-7338-9c6a-695290191022" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019fcf09-3628-78b1-868e-e060d81210b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fcf09-3628-7338-9c6a-695290191022" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019fcf09-3628-78b1-868e-e060d81210b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019fcf09-3628-74ae-b78a-4baef55a20a6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fcf09-3628-7338-9c6a-695290191022" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019fcf09-3628-74ae-b78a-4baef55a20a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019fcf09-3628-7484-89aa-7950cf41d4d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fcf09-3628-7338-9c6a-695290191022" xlink:to="loc_us-gaap_OperatingIncomeLoss_019fcf09-3628-7484-89aa-7950cf41d4d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019fcf09-3628-71be-9d6c-fa2288e93e31" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019fcf09-3628-7fad-9287-5a7eb6c4b5e1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019fcf09-3628-71be-9d6c-fa2288e93e31" xlink:to="loc_us-gaap_ProfitLoss_019fcf09-3628-7fad-9287-5a7eb6c4b5e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_019fcf09-3628-7219-9639-3e60aec9c487" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019fcf09-3628-71be-9d6c-fa2288e93e31" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_019fcf09-3628-7219-9639-3e60aec9c487" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019fcf09-3628-7855-9119-c0d22b336e0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019fcf09-3628-709b-a98e-12c09fb89057" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fcf09-3628-7855-9119-c0d22b336e0b" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019fcf09-3628-709b-a98e-12c09fb89057" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019fcf09-3628-7897-b538-b1bca00dd3c2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fcf09-3628-7855-9119-c0d22b336e0b" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019fcf09-3628-7897-b538-b1bca00dd3c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019fcf09-3628-7e18-912a-1016e9a28a22" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fcf09-3628-7855-9119-c0d22b336e0b" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019fcf09-3628-7e18-912a-1016e9a28a22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fcf09-3628-7d3e-9c34-582820ab8517" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fcf09-3628-7855-9119-c0d22b336e0b" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fcf09-3628-7d3e-9c34-582820ab8517" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019fcf09-3628-7d9c-b959-a518f9a4ea74" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fcf09-3628-7855-9119-c0d22b336e0b" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019fcf09-3628-7d9c-b959-a518f9a4ea74" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_mdt_RestructuringChargesNetOfRestructuringReversalsIncludingCostOfProductSoldImpact_019fcf09-3628-7993-8c79-a3d3c1f9adf2" xlink:href="mdt-20260731.xsd#mdt_RestructuringChargesNetOfRestructuringReversalsIncludingCostOfProductSoldImpact"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fcf09-3628-7855-9119-c0d22b336e0b" xlink:to="loc_mdt_RestructuringChargesNetOfRestructuringReversalsIncludingCostOfProductSoldImpact_019fcf09-3628-7993-8c79-a3d3c1f9adf2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyLossInPeriod_019fcf09-3628-7ecd-9870-b07cd2df5db7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingencyLossInPeriod"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fcf09-3628-7855-9119-c0d22b336e0b" xlink:to="loc_us-gaap_LossContingencyLossInPeriod_019fcf09-3628-7ecd-9870-b07cd2df5db7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingIncomeExpenseNet_019fcf09-3628-7275-8e2c-44890c24c854" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherOperatingIncomeExpenseNet"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fcf09-3628-7855-9119-c0d22b336e0b" xlink:to="loc_us-gaap_OtherOperatingIncomeExpenseNet_019fcf09-3628-7275-8e2c-44890c24c854" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medtronic.com/role/CondensedConsolidatedStatementsofComprehensiveIncomeUnaudited" xlink:type="simple" xlink:href="mdt-20260731.xsd#CondensedConsolidatedStatementsofComprehensiveIncomeUnaudited"/>
  <link:calculationLink xlink:role="http://www.medtronic.com/role/CondensedConsolidatedStatementsofComprehensiveIncomeUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019fcf09-3628-7a06-82a7-537a4f7ba21e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019fcf09-3628-72c3-8e93-88428589d94c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019fcf09-3628-7a06-82a7-537a4f7ba21e" xlink:to="loc_us-gaap_ProfitLoss_019fcf09-3628-72c3-8e93-88428589d94c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019fcf09-3628-790e-85d4-b79fce87a938" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019fcf09-3628-7a06-82a7-537a4f7ba21e" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019fcf09-3628-790e-85d4-b79fce87a938" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019fcf09-3628-7d7a-a0d2-a6faddc55d49" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_019fcf09-3628-7287-91eb-e154f6b10568" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019fcf09-3628-7d7a-a0d2-a6faddc55d49" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_019fcf09-3628-7287-91eb-e154f6b10568" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_019fcf09-3628-7622-9f35-0f1ac71bdea7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019fcf09-3628-7d7a-a0d2-a6faddc55d49" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_019fcf09-3628-7622-9f35-0f1ac71bdea7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_mdt_OtherComprehensiveIncomeLossUnrealizedGainLossOnDerivativesArisingDuringPeriodNetInvestmentHedgeNetOfTax_019fcf09-3628-7081-94f0-57eeed60154c" xlink:href="mdt-20260731.xsd#mdt_OtherComprehensiveIncomeLossUnrealizedGainLossOnDerivativesArisingDuringPeriodNetInvestmentHedgeNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019fcf09-3628-7d7a-a0d2-a6faddc55d49" xlink:to="loc_mdt_OtherComprehensiveIncomeLossUnrealizedGainLossOnDerivativesArisingDuringPeriodNetInvestmentHedgeNetOfTax_019fcf09-3628-7081-94f0-57eeed60154c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_019fcf09-3628-7079-9897-4065d90707fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019fcf09-3628-7d7a-a0d2-a6faddc55d49" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_019fcf09-3628-7079-9897-4065d90707fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019fcf09-3628-7451-8cf3-14e9e98d8fa1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019fcf09-3628-7d7a-a0d2-a6faddc55d49" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_019fcf09-3628-7451-8cf3-14e9e98d8fa1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019fcf09-3628-7d0f-b6ac-7ae2fc44ca5b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019fcf09-3628-7140-a779-67ce818ed63b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019fcf09-3628-7d0f-b6ac-7ae2fc44ca5b" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_019fcf09-3628-7140-a779-67ce818ed63b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_019fcf09-3628-72c9-89d7-1679988df6a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019fcf09-3628-7d0f-b6ac-7ae2fc44ca5b" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_019fcf09-3628-72c9-89d7-1679988df6a2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medtronic.com/role/CondensedConsolidatedBalanceSheetsUnaudited" xlink:type="simple" xlink:href="mdt-20260731.xsd#CondensedConsolidatedBalanceSheetsUnaudited"/>
  <link:calculationLink xlink:role="http://www.medtronic.com/role/CondensedConsolidatedBalanceSheetsUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019fcf09-3628-7f3f-9bd3-624dc07028cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019fcf09-3628-75d6-95b1-adfee3dca64d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fcf09-3628-7f3f-9bd3-624dc07028cc" xlink:to="loc_us-gaap_AssetsCurrent_019fcf09-3628-75d6-95b1-adfee3dca64d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019fcf09-3628-76b8-b4b3-1cd6deb1ffbe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fcf09-3628-7f3f-9bd3-624dc07028cc" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019fcf09-3628-76b8-b4b3-1cd6deb1ffbe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019fcf09-3628-71f8-9848-3961c10e6acb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fcf09-3628-7f3f-9bd3-624dc07028cc" xlink:to="loc_us-gaap_Goodwill_019fcf09-3628-71f8-9848-3961c10e6acb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fcf09-3628-7c9d-b813-bb2951068149" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fcf09-3628-7f3f-9bd3-624dc07028cc" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019fcf09-3628-7c9d-b813-bb2951068149" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_019fcf09-3628-729d-b68b-e25350c18d2e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fcf09-3628-7f3f-9bd3-624dc07028cc" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_019fcf09-3628-729d-b68b-e25350c18d2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019fcf09-3628-7973-a47d-4b5383936fd6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fcf09-3628-7f3f-9bd3-624dc07028cc" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019fcf09-3628-7973-a47d-4b5383936fd6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019fcf09-3628-7c59-ae81-5f03ac8f1290" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019fcf09-3628-75ab-8861-24b59cd73874" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019fcf09-3628-7c59-ae81-5f03ac8f1290" xlink:to="loc_us-gaap_StockholdersEquity_019fcf09-3628-75ab-8861-24b59cd73874" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterest_019fcf09-3628-7a67-b8ae-506880f51349" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MinorityInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019fcf09-3628-7c59-ae81-5f03ac8f1290" xlink:to="loc_us-gaap_MinorityInterest_019fcf09-3628-7a67-b8ae-506880f51349" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019fcf09-3628-72e1-b7b5-3163e6a8cc91" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019fcf09-3628-7b52-a978-5a4555caff36" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fcf09-3628-72e1-b7b5-3163e6a8cc91" xlink:to="loc_us-gaap_LiabilitiesCurrent_019fcf09-3628-7b52-a978-5a4555caff36" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_019fcf09-3628-7626-b8e3-8bbd3910556d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fcf09-3628-72e1-b7b5-3163e6a8cc91" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_019fcf09-3628-7626-b8e3-8bbd3910556d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_019fcf09-3628-7b6a-8297-78ac52845576" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fcf09-3628-72e1-b7b5-3163e6a8cc91" xlink:to="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_019fcf09-3628-7b6a-8297-78ac52845576" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesNoncurrent_019fcf09-3628-7aba-834e-4397930727a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedIncomeTaxesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fcf09-3628-72e1-b7b5-3163e6a8cc91" xlink:to="loc_us-gaap_AccruedIncomeTaxesNoncurrent_019fcf09-3628-7aba-834e-4397930727a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019fcf09-3628-7863-973b-b08a9727da46" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fcf09-3628-72e1-b7b5-3163e6a8cc91" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019fcf09-3628-7863-973b-b08a9727da46" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019fcf09-3628-710f-89e8-62f4037828d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fcf09-3628-72e1-b7b5-3163e6a8cc91" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019fcf09-3628-710f-89e8-62f4037828d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019fcf09-3628-78ac-b77f-d9f4e4e2d5c4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019fcf09-3628-7587-8c04-9889f8f59fd4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fcf09-3628-78ac-b77f-d9f4e4e2d5c4" xlink:to="loc_us-gaap_CommonStockValue_019fcf09-3628-7587-8c04-9889f8f59fd4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_019fcf09-3628-78db-8ec6-3308ce6cd6bd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fcf09-3628-78ac-b77f-d9f4e4e2d5c4" xlink:to="loc_us-gaap_AdditionalPaidInCapital_019fcf09-3628-78db-8ec6-3308ce6cd6bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019fcf09-3628-7107-915b-72ebac105b98" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fcf09-3628-78ac-b77f-d9f4e4e2d5c4" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019fcf09-3628-7107-915b-72ebac105b98" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019fcf09-3628-7006-b4cf-0cf7b41b6a49" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fcf09-3628-78ac-b77f-d9f4e4e2d5c4" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019fcf09-3628-7006-b4cf-0cf7b41b6a49" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fcf09-3628-7434-b656-6129d4f3b2be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019fcf09-3628-7934-8d24-1157fa3b8cad" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fcf09-3628-7434-b656-6129d4f3b2be" xlink:to="loc_us-gaap_Liabilities_019fcf09-3628-7934-8d24-1157fa3b8cad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019fcf09-3628-746d-a92b-f4699ccf79db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fcf09-3628-7434-b656-6129d4f3b2be" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019fcf09-3628-746d-a92b-f4699ccf79db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019fcf09-3628-7f0f-a621-d24dd4c195be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fcf09-3628-7434-b656-6129d4f3b2be" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019fcf09-3628-7f0f-a621-d24dd4c195be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019fcf09-3628-701a-9f1e-eba4e3e3201f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019fcf09-3628-701b-a508-d1c608ce94be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fcf09-3628-701a-9f1e-eba4e3e3201f" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019fcf09-3628-701b-a508-d1c608ce94be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_019fcf09-3628-7743-9667-a4b28ccfffdf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fcf09-3628-701a-9f1e-eba4e3e3201f" xlink:to="loc_us-gaap_ShortTermInvestments_019fcf09-3628-7743-9667-a4b28ccfffdf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019fcf09-3628-700c-b82a-9a0e71b4f8e3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fcf09-3628-701a-9f1e-eba4e3e3201f" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019fcf09-3628-700c-b82a-9a0e71b4f8e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019fcf09-3628-7380-b9fe-0781f28484c8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fcf09-3628-701a-9f1e-eba4e3e3201f" xlink:to="loc_us-gaap_InventoryNet_019fcf09-3628-7380-b9fe-0781f28484c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_019fcf09-3628-72ee-8cbf-771942bf1818" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fcf09-3628-701a-9f1e-eba4e3e3201f" xlink:to="loc_us-gaap_OtherAssetsCurrent_019fcf09-3628-72ee-8cbf-771942bf1818" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019fcf09-3628-702f-9539-100eaec5f4e6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtCurrent_019fcf09-3628-78c8-9010-83e5b2b19f28" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fcf09-3628-702f-9539-100eaec5f4e6" xlink:to="loc_us-gaap_DebtCurrent_019fcf09-3628-78c8-9010-83e5b2b19f28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019fcf09-3628-77bb-8fd3-ce32078409cf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fcf09-3628-702f-9539-100eaec5f4e6" xlink:to="loc_us-gaap_AccountsPayableCurrent_019fcf09-3628-77bb-8fd3-ce32078409cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredCompensationLiabilityCurrent_019fcf09-3628-7889-a8cb-8e755a0d9a5c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredCompensationLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fcf09-3628-702f-9539-100eaec5f4e6" xlink:to="loc_us-gaap_DeferredCompensationLiabilityCurrent_019fcf09-3628-7889-a8cb-8e755a0d9a5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_019fcf09-3628-770c-8e56-3aacf547d91e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fcf09-3628-702f-9539-100eaec5f4e6" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_019fcf09-3628-770c-8e56-3aacf547d91e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019fcf09-3628-78d8-99bd-059b167faee7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fcf09-3628-702f-9539-100eaec5f4e6" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_019fcf09-3628-78d8-99bd-059b167faee7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medtronic.com/role/CondensedConsolidatedStatementsofCashFlowsUnaudited" xlink:type="simple" xlink:href="mdt-20260731.xsd#CondensedConsolidatedStatementsofCashFlowsUnaudited"/>
  <link:calculationLink xlink:role="http://www.medtronic.com/role/CondensedConsolidatedStatementsofCashFlowsUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fcf09-3628-78b4-970c-cd41acf72e52" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebtMaturingInThreeMonthsOrLess_019fcf09-3628-74fd-bb15-9bb42135fc6f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromRepaymentsOfShortTermDebtMaturingInThreeMonthsOrLess"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fcf09-3628-78b4-970c-cd41acf72e52" xlink:to="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebtMaturingInThreeMonthsOrLess_019fcf09-3628-74fd-bb15-9bb42135fc6f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_019fcf09-3628-7fe6-9c44-7b98ad3fa9b6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fcf09-3628-78b4-970c-cd41acf72e52" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_019fcf09-3628-7fe6-9c44-7b98ad3fa9b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividendsCommonStock_019fcf09-3629-7a96-8b13-1383a939d9be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsOfDividendsCommonStock"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fcf09-3628-78b4-970c-cd41acf72e52" xlink:to="loc_us-gaap_PaymentsOfDividendsCommonStock_019fcf09-3629-7a96-8b13-1383a939d9be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019fcf09-3629-7575-887a-a4bcc86892cf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fcf09-3628-78b4-970c-cd41acf72e52" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019fcf09-3629-7575-887a-a4bcc86892cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_019fcf09-3629-7ebf-8f50-de18848ab552" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fcf09-3628-78b4-970c-cd41acf72e52" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_019fcf09-3629-7ebf-8f50-de18848ab552" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019fd6bc-7661-7a80-b5a6-00a107d67d8b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fcf09-3628-78b4-970c-cd41acf72e52" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019fd6bc-7661-7a80-b5a6-00a107d67d8b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fcf09-3629-7102-99ad-0cef264cb5f0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fcf09-3629-7fe5-ac67-039d4de5055d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fcf09-3629-7102-99ad-0cef264cb5f0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fcf09-3629-7fe5-ac67-039d4de5055d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fcf09-3629-7a31-bb9d-4d91da80c045" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fcf09-3629-7102-99ad-0cef264cb5f0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fcf09-3629-7a31-bb9d-4d91da80c045" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fcf09-3629-7f1d-8459-d04f95891d13" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fcf09-3629-7102-99ad-0cef264cb5f0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fcf09-3629-7f1d-8459-d04f95891d13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019fcf09-3629-7aab-978f-f69fa61162b4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019fcf09-3629-7102-99ad-0cef264cb5f0" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019fcf09-3629-7aab-978f-f69fa61162b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fcf09-3629-752a-8c0d-b7a84c32a39b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019fcf09-3629-76a4-bc6d-103faa0c035b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fcf09-3629-752a-8c0d-b7a84c32a39b" xlink:to="loc_us-gaap_ProfitLoss_019fcf09-3629-76a4-bc6d-103faa0c035b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019fcf09-3629-73fa-97e7-9b7b8c45ce9f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fcf09-3629-752a-8c0d-b7a84c32a39b" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019fcf09-3629-73fa-97e7-9b7b8c45ce9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_019fcf09-3629-73be-a796-5c4290a2f01e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProvisionForDoubtfulAccounts"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fcf09-3629-752a-8c0d-b7a84c32a39b" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_019fcf09-3629-73be-a796-5c4290a2f01e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_019fcf09-3629-7274-9d8a-d35dc41a8b98" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxesAndTaxCredits"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fcf09-3629-752a-8c0d-b7a84c32a39b" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_019fcf09-3629-7274-9d8a-d35dc41a8b98" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019fcf09-3629-75ec-a8b5-a631056647f4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fcf09-3629-752a-8c0d-b7a84c32a39b" xlink:to="loc_us-gaap_ShareBasedCompensation_019fcf09-3629-75ec-a8b5-a631056647f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_019fcf09-3629-705d-a8a2-a660cd505f2e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fcf09-3629-752a-8c0d-b7a84c32a39b" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_019fcf09-3629-705d-a8a2-a660cd505f2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsAndNotesReceivable_019fcf09-3629-7803-a7ab-6ddc07c3469b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsAndNotesReceivable"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fcf09-3629-752a-8c0d-b7a84c32a39b" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsAndNotesReceivable_019fcf09-3629-7803-a7ab-6ddc07c3469b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019fcf09-3629-78de-ae3e-7a7e3e53f93a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fcf09-3629-752a-8c0d-b7a84c32a39b" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019fcf09-3629-78de-ae3e-7a7e3e53f93a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_019fcf09-3629-7bf8-8592-7def975fb7ce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fcf09-3629-752a-8c0d-b7a84c32a39b" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_019fcf09-3629-7bf8-8592-7def975fb7ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_019fcf09-3629-7edf-9659-ccf80992faaa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fcf09-3629-752a-8c0d-b7a84c32a39b" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_019fcf09-3629-7edf-9659-ccf80992faaa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fcf09-3629-72fc-a80e-d5370b32c39e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019fcf09-3629-74d9-a2cc-949c7b019944" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fcf09-3629-72fc-a80e-d5370b32c39e" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019fcf09-3629-74d9-a2cc-949c7b019944" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019fcf09-3629-73af-8408-fed01cfe376d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fcf09-3629-72fc-a80e-d5370b32c39e" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019fcf09-3629-73af-8408-fed01cfe376d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInvestments_019fcf09-3629-7434-985d-979b90a07493" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireInvestments"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fcf09-3629-72fc-a80e-d5370b32c39e" xlink:to="loc_us-gaap_PaymentsToAcquireInvestments_019fcf09-3629-7434-985d-979b90a07493" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_019fcf09-3629-72b5-a1a6-e07c08757309" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fcf09-3629-72fc-a80e-d5370b32c39e" xlink:to="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_019fcf09-3629-72b5-a1a6-e07c08757309" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_019fcf09-3629-7e8e-98e7-12ca9568705f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fcf09-3629-72fc-a80e-d5370b32c39e" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_019fcf09-3629-7e8e-98e7-12ca9568705f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medtronic.com/role/AcquisitionsDispositionsandFundedResearchandDevelopmentArrangementsScheduleofAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="simple" xlink:href="mdt-20260731.xsd#AcquisitionsDispositionsandFundedResearchandDevelopmentArrangementsScheduleofAssetsAcquiredandLiabilitiesAssumedDetails"/>
  <link:calculationLink xlink:role="http://www.medtronic.com/role/AcquisitionsDispositionsandFundedResearchandDevelopmentArrangementsScheduleofAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_mdt_BusinessCombinationConsiderationTransferredIncludingAdjustments_01a03434-097c-7581-a844-c3223fa37d22" xlink:href="mdt-20260731.xsd#mdt_BusinessCombinationConsiderationTransferredIncludingAdjustments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_01a03434-097c-7319-8d00-9845e450d809" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_mdt_BusinessCombinationConsiderationTransferredIncludingAdjustments_01a03434-097c-7581-a844-c3223fa37d22" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_01a03434-097c-7319-8d00-9845e450d809" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_mdt_BusinessCombinationConsiderationTransferredSettlementOfDebtAndAccruedInterest_01a03434-097c-73af-a5e7-fa0ed574941f" xlink:href="mdt-20260731.xsd#mdt_BusinessCombinationConsiderationTransferredSettlementOfDebtAndAccruedInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_mdt_BusinessCombinationConsiderationTransferredIncludingAdjustments_01a03434-097c-7581-a844-c3223fa37d22" xlink:to="loc_mdt_BusinessCombinationConsiderationTransferredSettlementOfDebtAndAccruedInterest_01a03434-097c-73af-a5e7-fa0ed574941f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_019fd128-b5db-7211-9798-3f4879628167" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesOther_019fd128-b5db-7d25-a66b-414f07e6c757" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesOther"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_019fd128-b5db-7211-9798-3f4879628167" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesOther_019fd128-b5db-7d25-a66b-414f07e6c757" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_mdt_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAccruedIncomeTaxes_019fd128-b5db-7606-86da-f10e7fa8c654" xlink:href="mdt-20260731.xsd#mdt_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAccruedIncomeTaxes"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_019fd128-b5db-7211-9798-3f4879628167" xlink:to="loc_mdt_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAccruedIncomeTaxes_019fd128-b5db-7606-86da-f10e7fa8c654" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_01a020b7-1b8e-71da-8709-8de453538753" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_01a020b7-1b8e-7331-bfdc-7915ba7920af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_01a020b7-1b8e-71da-8709-8de453538753" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_01a020b7-1b8e-7331-bfdc-7915ba7920af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_01a020b7-1b8e-7a6d-986c-fb90dd23ecfc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_01a020b7-1b8e-71da-8709-8de453538753" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_01a020b7-1b8e-7a6d-986c-fb90dd23ecfc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019fd128-b5db-7bbe-a430-8029c6872498" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_019fd128-b5db-74ff-9b11-fd15b19ce602" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019fd128-b5db-7bbe-a430-8029c6872498" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_019fd128-b5db-74ff-9b11-fd15b19ce602" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_019fd128-b5db-7249-8a5d-e4cf12cd8776" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019fd128-b5db-7bbe-a430-8029c6872498" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_019fd128-b5db-7249-8a5d-e4cf12cd8776" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_019fd128-b5db-70e8-abca-15d69167c35c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019fd128-b5db-7bbe-a430-8029c6872498" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_019fd128-b5db-70e8-abca-15d69167c35c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredIncludingEquityInterestInAcquireeHeldPriorToCombination1_01a03174-d4d8-7d29-9f48-5f635ab10f41" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationConsiderationTransferredIncludingEquityInterestInAcquireeHeldPriorToCombination1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_01a03174-d4d8-7c8f-a04b-e913d1735719" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferredIncludingEquityInterestInAcquireeHeldPriorToCombination1_01a03174-d4d8-7d29-9f48-5f635ab10f41" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_01a03174-d4d8-7c8f-a04b-e913d1735719" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationStepAcquisitionEquityInterestInAcquireeFairValue1_01a03174-d4d8-76fa-827f-4df5bbb00310" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationStepAcquisitionEquityInterestInAcquireeFairValue1"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferredIncludingEquityInterestInAcquireeHeldPriorToCombination1_01a03174-d4d8-7d29-9f48-5f635ab10f41" xlink:to="loc_us-gaap_BusinessCombinationStepAcquisitionEquityInterestInAcquireeFairValue1_01a03174-d4d8-76fa-827f-4df5bbb00310" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_mdt_BusinessCombinationConsiderationTransferredSettlementOfDebtAndAccruedInterest_01a03174-d4d8-77f4-8516-acbc8cff685b" xlink:href="mdt-20260731.xsd#mdt_BusinessCombinationConsiderationTransferredSettlementOfDebtAndAccruedInterest"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferredIncludingEquityInterestInAcquireeHeldPriorToCombination1_01a03174-d4d8-7d29-9f48-5f635ab10f41" xlink:to="loc_mdt_BusinessCombinationConsiderationTransferredSettlementOfDebtAndAccruedInterest_01a03174-d4d8-77f4-8516-acbc8cff685b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_mdt_BusinessCombinationConsiderationTransferredSettlementOfPreExistingRelationships_01a03174-d4d8-76a9-b496-356b88aba349" xlink:href="mdt-20260731.xsd#mdt_BusinessCombinationConsiderationTransferredSettlementOfPreExistingRelationships"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferredIncludingEquityInterestInAcquireeHeldPriorToCombination1_01a03174-d4d8-7d29-9f48-5f635ab10f41" xlink:to="loc_mdt_BusinessCombinationConsiderationTransferredSettlementOfPreExistingRelationships_01a03174-d4d8-76a9-b496-356b88aba349" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_01a0369d-8601-7811-b7c7-c2ec81deb026" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_01a0369d-8601-7362-8665-97a08713f513" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_01a0369d-8601-7811-b7c7-c2ec81deb026" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_01a0369d-8601-7362-8665-97a08713f513" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_01a0369d-8601-77e6-b873-f175ce0efb9a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_01a0369d-8601-7811-b7c7-c2ec81deb026" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_01a0369d-8601-77e6-b873-f175ce0efb9a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019fd128-b5db-7965-808d-69d2715e6acd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_019fd128-b5db-7aab-a6c5-6e367b9812ab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019fd128-b5db-7965-808d-69d2715e6acd" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_019fd128-b5db-7aab-a6c5-6e367b9812ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_019fd128-b5db-76f4-a543-23ea6c522eed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019fd128-b5db-7965-808d-69d2715e6acd" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_019fd128-b5db-76f4-a543-23ea6c522eed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019fd128-b5db-72e8-9662-39b1ffe0f7b0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019fd128-b5db-7965-808d-69d2715e6acd" xlink:to="loc_us-gaap_Goodwill_019fd128-b5db-72e8-9662-39b1ffe0f7b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_019fd128-b5db-7a87-be3f-1d4fc63169d0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019fd128-b5db-7965-808d-69d2715e6acd" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_019fd128-b5db-7a87-be3f-1d4fc63169d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_019fd128-b5db-789a-82c5-4ba4714b87b6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019fd128-b5db-7965-808d-69d2715e6acd" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_019fd128-b5db-789a-82c5-4ba4714b87b6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medtronic.com/role/FinancialInstrumentsScheduleofInvestmentsinAvailableforSaleDebtSecuritiesbySignificantInvestmentCategoryandRelatedConsolidatedBalanceSheetClassificationDetails" xlink:type="simple" xlink:href="mdt-20260731.xsd#FinancialInstrumentsScheduleofInvestmentsinAvailableforSaleDebtSecuritiesbySignificantInvestmentCategoryandRelatedConsolidatedBalanceSheetClassificationDetails"/>
  <link:calculationLink xlink:role="http://www.medtronic.com/role/FinancialInstrumentsScheduleofInvestmentsinAvailableforSaleDebtSecuritiesbySignificantInvestmentCategoryandRelatedConsolidatedBalanceSheetClassificationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_019fcf09-36e5-7fde-b1f8-799a2f83f70b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019fcf09-36e5-7532-aeba-37f896a0a225" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_019fcf09-36e5-7fde-b1f8-799a2f83f70b" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019fcf09-36e5-7532-aeba-37f896a0a225" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019fcf09-36e5-7d98-9c0f-083346722bb4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_019fcf09-36e5-7fde-b1f8-799a2f83f70b" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019fcf09-36e5-7d98-9c0f-083346722bb4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019fcf09-36e5-794b-a6fb-787b7c156245" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_019fcf09-36e5-7fde-b1f8-799a2f83f70b" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019fcf09-36e5-794b-a6fb-787b7c156245" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medtronic.com/role/FinancialInstrumentsScheduleofAvailableforSaleDebtSecuritiesbyContractualMaturityDetails" xlink:type="simple" xlink:href="mdt-20260731.xsd#FinancialInstrumentsScheduleofAvailableforSaleDebtSecuritiesbyContractualMaturityDetails"/>
  <link:calculationLink xlink:role="http://www.medtronic.com/role/FinancialInstrumentsScheduleofAvailableforSaleDebtSecuritiesbyContractualMaturityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019fcf09-36e5-70a9-ab9b-8e509bdda0a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_019fcf09-36e5-75af-ab5f-9a01b8f9cf13" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019fcf09-36e5-70a9-ab9b-8e509bdda0a4" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_019fcf09-36e5-75af-ab5f-9a01b8f9cf13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_019fcf09-36e5-74d9-abff-abe233d6f503" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019fcf09-36e5-70a9-ab9b-8e509bdda0a4" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_019fcf09-36e5-74d9-abff-abe233d6f503" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_019fcf09-36e5-7925-af27-85f2325a18f3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019fcf09-36e5-70a9-ab9b-8e509bdda0a4" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_019fcf09-36e5-7925-af27-85f2325a18f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_019fcf09-36e5-7f30-ade7-c691e014f500" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019fcf09-36e5-70a9-ab9b-8e509bdda0a4" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_019fcf09-36e5-7f30-ade7-c691e014f500" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019fcf09-36e5-7045-b0c5-80dc810113d7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_019fcf09-36e5-7733-93d4-a72b186861ce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019fcf09-36e5-7045-b0c5-80dc810113d7" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_019fcf09-36e5-7733-93d4-a72b186861ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_019fcf09-36e5-7582-bc8b-c2342d6e32f4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019fcf09-36e5-7045-b0c5-80dc810113d7" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_019fcf09-36e5-7582-bc8b-c2342d6e32f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_019fcf09-36e5-7f6e-b698-ee8a0b2a58d2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019fcf09-36e5-7045-b0c5-80dc810113d7" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_019fcf09-36e5-7f6e-b698-ee8a0b2a58d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_019fcf09-36e5-796a-a9be-d7f5cca5f16f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestBeforeAllowanceForCreditLoss_019fcf09-36e5-7045-b0c5-80dc810113d7" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_019fcf09-36e5-796a-a9be-d7f5cca5f16f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medtronic.com/role/FinancialInstrumentsScheduleofEquityandOtherInvestmentsDetails" xlink:type="simple" xlink:href="mdt-20260731.xsd#FinancialInstrumentsScheduleofEquityandOtherInvestmentsDetails"/>
  <link:calculationLink xlink:role="http://www.medtronic.com/role/FinancialInstrumentsScheduleofEquityandOtherInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_mdt_EquitySecuritiesFVNIEquitySecuritiesWithoutReadilyDeterminableFairValueAndEquityMethodInvestments_019fcf09-36e5-7d13-9d4b-06fdff8fd504" xlink:href="mdt-20260731.xsd#mdt_EquitySecuritiesFVNIEquitySecuritiesWithoutReadilyDeterminableFairValueAndEquityMethodInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_019fcf09-36e5-7772-aece-08e95c498ccc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_mdt_EquitySecuritiesFVNIEquitySecuritiesWithoutReadilyDeterminableFairValueAndEquityMethodInvestments_019fcf09-36e5-7d13-9d4b-06fdff8fd504" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_019fcf09-36e5-7772-aece-08e95c498ccc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_019fcf09-36e5-73f7-8290-c9a5b6675162" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_mdt_EquitySecuritiesFVNIEquitySecuritiesWithoutReadilyDeterminableFairValueAndEquityMethodInvestments_019fcf09-36e5-7d13-9d4b-06fdff8fd504" xlink:to="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_019fcf09-36e5-73f7-8290-c9a5b6675162" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestments_019fcf09-36e5-75ed-b9fb-c4e7e44d9786" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityMethodInvestments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_mdt_EquitySecuritiesFVNIEquitySecuritiesWithoutReadilyDeterminableFairValueAndEquityMethodInvestments_019fcf09-36e5-7d13-9d4b-06fdff8fd504" xlink:to="loc_us-gaap_EquityMethodInvestments_019fcf09-36e5-75ed-b9fb-c4e7e44d9786" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medtronic.com/role/FinancingArrangementsScheduleofDebtObligationsDetails" xlink:type="simple" xlink:href="mdt-20260731.xsd#FinancingArrangementsScheduleofDebtObligationsDetails"/>
  <link:calculationLink xlink:role="http://www.medtronic.com/role/FinancingArrangementsScheduleofDebtObligationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_019fcf09-36e5-7f18-92cd-6d5ce62d614a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_01a01419-dcc2-7220-af15-f6d31ba49ddd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_019fcf09-36e5-7f18-92cd-6d5ce62d614a" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_01a01419-dcc2-7220-af15-f6d31ba49ddd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_019fcf09-36e5-7b9d-985b-68d1a80012ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_019fcf09-36e5-7f18-92cd-6d5ce62d614a" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_019fcf09-36e5-7b9d-985b-68d1a80012ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_01a020ce-65ce-788d-95a8-ed8e8c0f3848" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_019fcf09-36e5-7f18-92cd-6d5ce62d614a" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_01a020ce-65ce-788d-95a8-ed8e8c0f3848" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_01a020ce-65ce-74a2-8b79-395d57210001" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_019fcf09-36e5-7f18-92cd-6d5ce62d614a" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_01a020ce-65ce-74a2-8b79-395d57210001" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLongTermDebt_01a020ce-65ce-7605-80b3-190906af0e6e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLongTermDebt"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_019fcf09-36e5-7f18-92cd-6d5ce62d614a" xlink:to="loc_us-gaap_OtherLongTermDebt_01a020ce-65ce-7605-80b3-190906af0e6e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medtronic.com/role/DerivativesandCurrencyExchangeRiskManagementScheduleofGainsandLossesonHedgingInstrumentsDetails" xlink:type="simple" xlink:href="mdt-20260731.xsd#DerivativesandCurrencyExchangeRiskManagementScheduleofGainsandLossesonHedgingInstrumentsDetails"/>
  <link:calculationLink xlink:role="http://www.medtronic.com/role/DerivativesandCurrencyExchangeRiskManagementScheduleofGainsandLossesonHedgingInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax_019fcf09-36e6-7840-a559-d0812d38106b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossDerivativeExcludedComponentIncreaseDecreaseBeforeAdjustmentsAndTax_019fcf09-36e6-784a-ba26-a0424ea506fc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossDerivativeExcludedComponentIncreaseDecreaseBeforeAdjustmentsAndTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax_019fcf09-36e6-7840-a559-d0812d38106b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossDerivativeExcludedComponentIncreaseDecreaseBeforeAdjustmentsAndTax_019fcf09-36e6-784a-ba26-a0424ea506fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019fcf09-36e6-7942-871a-4a7b481e2cfc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax_019fcf09-36e6-7840-a559-d0812d38106b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019fcf09-36e6-7942-871a-4a7b481e2cfc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_019fcf09-36e6-7b2c-8a28-12de471d19f3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax_019fcf09-36e6-7840-a559-d0812d38106b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_019fcf09-36e6-7b2c-8a28-12de471d19f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax_019fcf09-36e6-73a6-af17-75e1e908c2c9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossDerivativeExcludedComponentIncreaseDecreaseAdjustmentsBeforeTax_019fcf09-36e6-716a-b809-34ce7b61cbd4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossDerivativeExcludedComponentIncreaseDecreaseAdjustmentsBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax_019fcf09-36e6-73a6-af17-75e1e908c2c9" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossDerivativeExcludedComponentIncreaseDecreaseAdjustmentsBeforeTax_019fcf09-36e6-716a-b809-34ce7b61cbd4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_019fcf09-36e6-72d2-bdd4-60e583f69af0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax_019fcf09-36e6-73a6-af17-75e1e908c2c9" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_019fcf09-36e6-72d2-bdd4-60e583f69af0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossReclassificationBeforeTax_019fcf09-36e6-77c9-a846-e54e684f20bd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossReclassificationBeforeTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax_019fcf09-36e6-73a6-af17-75e1e908c2c9" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossReclassificationBeforeTax_019fcf09-36e6-77c9-a846-e54e684f20bd" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medtronic.com/role/DerivativesandCurrencyExchangeRiskManagementScheduleofOffsettingAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="mdt-20260731.xsd#DerivativesandCurrencyExchangeRiskManagementScheduleofOffsettingAssetsandLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.medtronic.com/role/DerivativesandCurrencyExchangeRiskManagementScheduleofOffsettingAssetsandLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_mdt_DerivativeAssetsandLiabilitiesNetCollateralObligationtoReturnCash_019fcf09-36e6-7737-ab20-897760ac389a" xlink:href="mdt-20260731.xsd#mdt_DerivativeAssetsandLiabilitiesNetCollateralObligationtoReturnCash"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralObligationToReturnCash_019fcf09-36e6-7895-9efc-18b5610c6b8d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeCollateralObligationToReturnCash"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_mdt_DerivativeAssetsandLiabilitiesNetCollateralObligationtoReturnCash_019fcf09-36e6-7737-ab20-897760ac389a" xlink:to="loc_us-gaap_DerivativeCollateralObligationToReturnCash_019fcf09-36e6-7895-9efc-18b5610c6b8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralRightToReclaimCash_019fcf09-36e6-74f4-ba55-37c4c9d2034f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeCollateralRightToReclaimCash"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_mdt_DerivativeAssetsandLiabilitiesNetCollateralObligationtoReturnCash_019fcf09-36e6-7737-ab20-897760ac389a" xlink:to="loc_us-gaap_DerivativeCollateralRightToReclaimCash_019fcf09-36e6-74f4-ba55-37c4c9d2034f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_mdt_DerivativeAssetLiabilityFairValueGrossAssetLiability_019fcf09-36e6-7253-adc0-b3e667e8aa00" xlink:href="mdt-20260731.xsd#mdt_DerivativeAssetLiabilityFairValueGrossAssetLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_019fcf09-36e6-735f-b02f-387d011228ed" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_mdt_DerivativeAssetLiabilityFairValueGrossAssetLiability_019fcf09-36e6-7253-adc0-b3e667e8aa00" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_019fcf09-36e6-735f-b02f-387d011228ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_019fcf09-36e6-78c8-9bee-2acf6a069a24" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_mdt_DerivativeAssetLiabilityFairValueGrossAssetLiability_019fcf09-36e6-7253-adc0-b3e667e8aa00" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_019fcf09-36e6-78c8-9bee-2acf6a069a24" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_019fcf09-36e6-78f1-b584-c1d455762c5e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_019fcf09-36e6-75d2-bc13-4ddb5d465d60" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_019fcf09-36e6-78f1-b584-c1d455762c5e" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_019fcf09-36e6-75d2-bc13-4ddb5d465d60" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetNotOffsetPolicyElectionDeduction_019fcf09-36e6-782c-a309-ba3b6535e47e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssetNotOffsetPolicyElectionDeduction"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_019fcf09-36e6-78f1-b584-c1d455762c5e" xlink:to="loc_us-gaap_DerivativeAssetNotOffsetPolicyElectionDeduction_019fcf09-36e6-782c-a309-ba3b6535e47e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralObligationToReturnCash_019fcf09-36e6-70bb-b645-9648887b120d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeCollateralObligationToReturnCash"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_019fcf09-36e6-78f1-b584-c1d455762c5e" xlink:to="loc_us-gaap_DerivativeCollateralObligationToReturnCash_019fcf09-36e6-70bb-b645-9648887b120d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_019fcf09-36e6-71ca-a825-d650bac1b67b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_019fcf09-36e6-7f4e-a0b0-af316df6ba1d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_019fcf09-36e6-71ca-a825-d650bac1b67b" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_019fcf09-36e6-7f4e-a0b0-af316df6ba1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityNotOffsetPolicyElectionDeduction_019fcf09-36e6-7141-a6b9-732aef961c7c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilityNotOffsetPolicyElectionDeduction"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_019fcf09-36e6-71ca-a825-d650bac1b67b" xlink:to="loc_us-gaap_DerivativeLiabilityNotOffsetPolicyElectionDeduction_019fcf09-36e6-7141-a6b9-732aef961c7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralRightToReclaimCash_019fcf09-36e6-7c27-bf4c-0b62733dd5b7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeCollateralRightToReclaimCash"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_019fcf09-36e6-71ca-a825-d650bac1b67b" xlink:to="loc_us-gaap_DerivativeCollateralRightToReclaimCash_019fcf09-36e6-7c27-bf4c-0b62733dd5b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueAmountOffsetAgainstCollateralNet_019fcf09-36e6-71af-b2c2-66efeef308b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeFairValueAmountOffsetAgainstCollateralNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_019fcf09-36e6-7500-8812-840dc9749aae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueAmountOffsetAgainstCollateralNet_019fcf09-36e6-71af-b2c2-66efeef308b8" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_019fcf09-36e6-7500-8812-840dc9749aae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_019fcf09-36e6-7f52-9a27-c21806c90c18" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueAmountOffsetAgainstCollateralNet_019fcf09-36e6-71af-b2c2-66efeef308b8" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_019fcf09-36e6-7f52-9a27-c21806c90c18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_mdt_DerivativeAssetsandLiabilitiesNetNotOffsetPolicyElectionDeduction_019fcf09-36e6-7da7-9e37-505f018845dd" xlink:href="mdt-20260731.xsd#mdt_DerivativeAssetsandLiabilitiesNetNotOffsetPolicyElectionDeduction"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetNotOffsetPolicyElectionDeduction_019fcf09-36e6-79d1-86ad-c1e828d19681" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssetNotOffsetPolicyElectionDeduction"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_mdt_DerivativeAssetsandLiabilitiesNetNotOffsetPolicyElectionDeduction_019fcf09-36e6-7da7-9e37-505f018845dd" xlink:to="loc_us-gaap_DerivativeAssetNotOffsetPolicyElectionDeduction_019fcf09-36e6-79d1-86ad-c1e828d19681" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityNotOffsetPolicyElectionDeduction_019fcf09-36e6-7474-a73e-2b355c5f1702" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilityNotOffsetPolicyElectionDeduction"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_mdt_DerivativeAssetsandLiabilitiesNetNotOffsetPolicyElectionDeduction_019fcf09-36e6-7da7-9e37-505f018845dd" xlink:to="loc_us-gaap_DerivativeLiabilityNotOffsetPolicyElectionDeduction_019fcf09-36e6-7474-a73e-2b355c5f1702" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medtronic.com/role/DerivativesandCurrencyExchangeRiskManagementScheduleofOffsettingAssetsandLiabilitiesDetails_1" xlink:type="simple" xlink:href="mdt-20260731.xsd#DerivativesandCurrencyExchangeRiskManagementScheduleofOffsettingAssetsandLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.medtronic.com/role/DerivativesandCurrencyExchangeRiskManagementScheduleofOffsettingAssetsandLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueAmountOffsetAgainstCollateralNet_019fcf09-36e6-7055-92d8-0e2c128eb231" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeFairValueAmountOffsetAgainstCollateralNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_mdt_DerivativeAssetLiabilityFairValueGrossAssetLiability_019fcf09-36e6-711c-855d-3f3a0e1e34bd" xlink:href="mdt-20260731.xsd#mdt_DerivativeAssetLiabilityFairValueGrossAssetLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueAmountOffsetAgainstCollateralNet_019fcf09-36e6-7055-92d8-0e2c128eb231" xlink:to="loc_mdt_DerivativeAssetLiabilityFairValueGrossAssetLiability_019fcf09-36e6-711c-855d-3f3a0e1e34bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_mdt_DerivativeAssetsandLiabilitiesNetNotOffsetPolicyElectionDeduction_019fcf09-36e6-70c2-985d-cbb63c42c5bc" xlink:href="mdt-20260731.xsd#mdt_DerivativeAssetsandLiabilitiesNetNotOffsetPolicyElectionDeduction"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueAmountOffsetAgainstCollateralNet_019fcf09-36e6-7055-92d8-0e2c128eb231" xlink:to="loc_mdt_DerivativeAssetsandLiabilitiesNetNotOffsetPolicyElectionDeduction_019fcf09-36e6-70c2-985d-cbb63c42c5bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_mdt_DerivativeAssetsandLiabilitiesNetCollateralObligationtoReturnCash_019fcf09-36e6-730c-9455-ab689aa95a23" xlink:href="mdt-20260731.xsd#mdt_DerivativeAssetsandLiabilitiesNetCollateralObligationtoReturnCash"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueAmountOffsetAgainstCollateralNet_019fcf09-36e6-7055-92d8-0e2c128eb231" xlink:to="loc_mdt_DerivativeAssetsandLiabilitiesNetCollateralObligationtoReturnCash_019fcf09-36e6-730c-9455-ab689aa95a23" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medtronic.com/role/InventoriesDetails" xlink:type="simple" xlink:href="mdt-20260731.xsd#InventoriesDetails"/>
  <link:calculationLink xlink:role="http://www.medtronic.com/role/InventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019fcf09-36e6-7784-8874-603c532511b7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019fcf09-36e6-7fd1-8ed6-9adc9e5d3604" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019fcf09-36e6-7784-8874-603c532511b7" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019fcf09-36e6-7fd1-8ed6-9adc9e5d3604" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019fcf09-36e6-7f14-b6ea-9b1d5cf8160c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019fcf09-36e6-7784-8874-603c532511b7" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019fcf09-36e6-7f14-b6ea-9b1d5cf8160c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019fcf09-36e6-790c-b5d0-e27a7091eafa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019fcf09-36e6-7784-8874-603c532511b7" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019fcf09-36e6-790c-b5d0-e27a7091eafa" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medtronic.com/role/EarningsPerShareScheduleofComputationofBasicandDilutedEarningsPerShareDetails" xlink:type="simple" xlink:href="mdt-20260731.xsd#EarningsPerShareScheduleofComputationofBasicandDilutedEarningsPerShareDetails"/>
  <link:calculationLink xlink:role="http://www.medtronic.com/role/EarningsPerShareScheduleofComputationofBasicandDilutedEarningsPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019fcf09-36e6-7103-84b8-c7b285ce414a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019fcf09-36e6-7c22-8131-8778abf90168" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019fcf09-36e6-7103-84b8-c7b285ce414a" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019fcf09-36e6-7c22-8131-8778abf90168" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019fcf09-36e6-7a26-9acb-3b769ae23797" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019fcf09-36e6-7103-84b8-c7b285ce414a" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019fcf09-36e6-7a26-9acb-3b769ae23797" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToNonvestedSharesWithForfeitableDividends_019fcf09-36e6-761c-aaae-e94a2315f9f3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncrementalCommonSharesAttributableToNonvestedSharesWithForfeitableDividends"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019fcf09-36e6-7103-84b8-c7b285ce414a" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToNonvestedSharesWithForfeitableDividends_019fcf09-36e6-761c-aaae-e94a2315f9f3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medtronic.com/role/RetirementBenefitPlansDetails" xlink:type="simple" xlink:href="mdt-20260731.xsd#RetirementBenefitPlansDetails"/>
  <link:calculationLink xlink:role="http://www.medtronic.com/role/RetirementBenefitPlansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019fcf09-36e6-7639-9b42-6ed325bfc0fc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_019fcf09-36e6-7241-89d7-1320cc838071" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanServiceCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019fcf09-36e6-7639-9b42-6ed325bfc0fc" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_019fcf09-36e6-7241-89d7-1320cc838071" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_019fcf09-36e6-7cf3-926d-6e029f8777f0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019fcf09-36e6-7639-9b42-6ed325bfc0fc" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_019fcf09-36e6-7cf3-926d-6e029f8777f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_019fcf09-36e6-7f30-9b99-1d72d9789530" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019fcf09-36e6-7639-9b42-6ed325bfc0fc" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_019fcf09-36e6-7f30-9b99-1d72d9789530" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_019fcf09-36e6-757c-b6fe-976b5b9a8bf9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019fcf09-36e6-7639-9b42-6ed325bfc0fc" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_019fcf09-36e6-757c-b6fe-976b5b9a8bf9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_019fcf09-36e6-7a88-9925-0837e5b1bd7f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019fcf09-36e6-7639-9b42-6ed325bfc0fc" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_019fcf09-36e6-7a88-9925-0837e5b1bd7f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medtronic.com/role/AccumulatedOtherComprehensiveLossScheduleofChangesinAccumulatedOtherComprehensiveLossAOCLNetofTaxbyComponentDetails" xlink:type="simple" xlink:href="mdt-20260731.xsd#AccumulatedOtherComprehensiveLossScheduleofChangesinAccumulatedOtherComprehensiveLossAOCLNetofTaxbyComponentDetails"/>
  <link:calculationLink xlink:role="http://www.medtronic.com/role/AccumulatedOtherComprehensiveLossScheduleofChangesinAccumulatedOtherComprehensiveLossAOCLNetofTaxbyComponentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019fcf09-36e6-7dcb-812c-ef8ecb503a8b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_019fcf09-36e6-76bc-8fe6-24b644f6f1f4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019fcf09-36e6-7dcb-812c-ef8ecb503a8b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_019fcf09-36e6-76bc-8fe6-24b644f6f1f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_019fcf09-36e6-7a0a-b9f3-4876cd875def" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019fcf09-36e6-7dcb-812c-ef8ecb503a8b" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_019fcf09-36e6-7a0a-b9f3-4876cd875def" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medtronic.com/role/SegmentandGeographicInformationSegmentReportingDetails" xlink:type="simple" xlink:href="mdt-20260731.xsd#SegmentandGeographicInformationSegmentReportingDetails"/>
  <link:calculationLink xlink:role="http://www.medtronic.com/role/SegmentandGeographicInformationSegmentReportingDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fcf09-36e6-7d95-8e0d-00a7f3f767a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019fcf09-36e6-7093-acad-1502d60fb9b3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fcf09-36e6-7d95-8e0d-00a7f3f767a4" xlink:to="loc_us-gaap_OperatingIncomeLoss_019fcf09-36e6-7093-acad-1502d60fb9b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019fcf09-36e6-772d-a44a-ffb06a3c077c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fcf09-36e6-7d95-8e0d-00a7f3f767a4" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019fcf09-36e6-772d-a44a-ffb06a3c077c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019fcf09-36e6-726d-b820-7d55eca32ee6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fcf09-36e6-7d95-8e0d-00a7f3f767a4" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019fcf09-36e6-726d-b820-7d55eca32ee6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_019fcf09-36e6-7ddf-b03d-47c40a8c4b9a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCharges"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fcf09-36e6-7d95-8e0d-00a7f3f767a4" xlink:to="loc_us-gaap_RestructuringCharges_019fcf09-36e6-7ddf-b03d-47c40a8c4b9a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyLossInPeriod_019fcf09-36e6-70b6-bca7-9375949898b9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingencyLossInPeriod"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fcf09-36e6-7d95-8e0d-00a7f3f767a4" xlink:to="loc_us-gaap_LossContingencyLossInPeriod_019fcf09-36e6-70b6-bca7-9375949898b9" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
