|
|
Shares or
Principal
Amount
|
Value
|
|
|
Convertible Preferred Stocks(a),(b),(c)—7.5%
|
|||
|
Biotechnology—2.3%
|
|||
|
Abcuro, Inc. Series B
|
|
601,124
|
$1,221,003
|
|
Abcuro, Inc. Series C1
|
|
133,045
|
803,419
|
|
Atalanta Therapeutics, Inc. Series B
|
|
1,944,444
|
1,905,555
|
|
Atalanta Therapeutics, Inc. Series B2
|
|
2,692,308
|
1,750,000
|
|
Glycomine, Inc. Series C, 8.00%
|
|
7,417,198
|
4,450,319
|
|
Seismic Therapeutics, Inc. Series B
|
|
730,764
|
3,299,984
|
|
Third Arc Bio, Inc. Series A, 8.00%
|
|
2,718,372
|
5,719,998
|
|
|
|
|
19,150,278
|
|
Health Care Equipment & Supplies—0.0%
|
|||
|
IO Light Holdings, Inc. Series A2
|
|
189,858
|
19
|
|
Pharmaceuticals—5.2%
|
|||
|
Crystalys Therapeutics, Inc. Series A
|
|
4,180,265
|
4,187,999
|
|
Endeavor Biomedicine, Inc. Series B, 8.00%
|
|
742,138
|
3,499,997
|
|
Endeavor Biomedicine, Inc. Series C, 8.00%
|
|
137,039
|
894,125
|
|
Engrail Therapeutics, Inc. Series B, 8.00%
|
|
1,652,502
|
791,548
|
|
VeraDermics, Inc. Series C
|
|
273,261
|
33,594,707
|
|
|
|
|
42,968,376
|
|
Total Convertible Preferred Stocks
|
62,118,673
|
||
|
Non-Convertible Notes—12.0%
|
|
|
|
|
Biotechnology—0.3%
|
|||
|
AbbVie, Inc., 4.45%, 05/14/46
|
|
$3,080,000
|
2,645,473
|
|
Health Care Equipment & Supplies—2.5%
|
|||
|
Abbott Laboratories, 4.75%, 11/30/36
|
|
10,498,000
|
10,245,539
|
|
DH Europe Finance II SARL, 3.25%, 11/15/39
|
|
1,760,000
|
1,413,315
|
|
Stryker Corp., 3.65%, 03/07/28
|
|
3,500,000
|
3,450,966
|
|
Zimmer Biomet Holdings, Inc., 4.25%,
08/15/35
|
|
6,000,000
|
5,508,757
|
|
|
|
|
20,618,577
|
|
Health Care Providers & Services—5.0%
|
|||
|
Cigna Group, 4.38%, 10/15/28
|
|
1,504,000
|
1,497,770
|
|
Cigna Group, 2.38%, 03/15/31
|
|
5,800,000
|
5,221,339
|
|
Cigna Group, 6.13%, 11/15/41
|
|
8,250,000
|
8,658,099
|
|
CVS Health Corp., 4.78%, 03/25/38
|
|
2,100,000
|
1,968,875
|
|
CVS Health Corp., 5.05%, 03/25/48
|
|
3,700,000
|
3,268,114
|
|
Elevance Health, Inc., 4.10%, 03/01/28
|
|
2,975,000
|
2,954,354
|
|
Elevance Health, Inc., 2.55%, 03/15/31
|
|
5,800,000
|
5,260,878
|
|
Elevance Health, Inc., 4.65%, 08/15/44
|
|
2,325,000
|
2,022,492
|
|
UnitedHealth Group, Inc., 4.20%, 05/15/32
|
|
4,916,000
|
4,779,438
|
|
UnitedHealth Group, Inc., 4.50%, 04/15/33
|
|
5,800,000
|
5,673,042
|
|
|
|
|
41,304,401
|
|
Life Sciences Tools & Services—0.8%
|
|||
|
Thermo Fisher Scientific, Inc., 5.40%,
08/10/43
|
|
6,500,000
|
6,425,844
|
|
Pharmaceuticals—3.4%
|
|||
|
AstraZeneca PLC, 6.45%, 09/15/37(d)
|
|
4,750,000
|
5,274,607
|
|
Johnson & Johnson, 3.70%, 03/01/46
|
|
10,130,000
|
8,090,851
|
|
Merck & Co., Inc., 3.40%, 03/07/29
|
|
4,000,000
|
3,901,163
|
|
Pfizer, Inc., 3.45%, 03/15/29
|
|
8,100,000
|
7,911,454
|
|
Pfizer, Inc., 4.00%, 12/15/36
|
|
3,200,000
|
2,935,275
|
|
|
|
|
28,113,350
|
|
Total Non-Convertible Notes
|
99,107,645
|
||
|
|
Shares or
Principal
Amount
|
Value
|
|
|
Common Stocks—106.3%
|
|
|
|
|
Biotechnology—24.7%
|
|||
|
AbbVie, Inc.
|
|
80,912
|
$20,360,696
|
|
Abivax SA, ADR(b)
|
|
141,841
|
18,901,732
|
|
Alkermes PLC(b)
|
|
54,000
|
2,829,330
|
|
Arcus Biosciences, Inc.(b)
|
|
207,838
|
6,407,646
|
|
ARS Pharmaceuticals, Inc.(b)
|
|
1,805,535
|
14,462,335
|
|
BioCryst Pharmaceuticals, Inc.(b)
|
|
2,088,571
|
20,885,710
|
|
CareDx, Inc.(b)
|
|
128,795
|
3,670,657
|
|
Disc Medicine, Inc.(b)
|
|
100,151
|
7,325,044
|
|
Hemab Therapeutics Holdings, Inc.(b)
|
|
15,270
|
560,867
|
|
Kailera Therapeutics, Inc.(b)
|
|
40,727
|
897,216
|
|
Mineralys Therapeutics, Inc.(b)
|
|
221,516
|
5,976,502
|
|
Myriad Genetics, Inc.(b)
|
|
1,308,933
|
7,474,007
|
|
Odyssey Therapeutics, Inc.(b)
|
|
48,400
|
905,564
|
|
Oruka Therapeutics, Inc.(b)
|
|
250,767
|
23,865,495
|
|
Praxis Precision Medicines, Inc.(b)
|
|
43,765
|
14,652,084
|
|
Revolution Medicines, Inc.(b)
|
|
8,754
|
1,639,449
|
|
Sarepta Therapeutics, Inc.(b)
|
|
921,334
|
16,556,372
|
|
Sera Prognostics, Inc., Class A(b)
|
|
1,367,407
|
2,488,681
|
|
uniQure NV(b)
|
|
460,834
|
21,226,014
|
|
Vericel Corp.(b)
|
|
294,506
|
13,102,572
|
|
|
|
|
204,187,973
|
|
Financial Services—0.5%
|
|||
|
Perceptive Capital Solutions Corp.(b)
|
|
355,447
|
3,867,263
|
|
Health Care Equipment & Supplies—21.8%
|
|||
|
Abbott Laboratories
|
|
433,683
|
39,352,395
|
|
Becton Dickinson & Co.
|
|
39,575
|
5,988,885
|
|
Boston Scientific Corp.(b)
|
|
465,063
|
19,848,889
|
|
Dexcom, Inc.(b)
|
|
42,503
|
2,862,577
|
|
GE HealthCare Technologies, Inc.
|
|
121,807
|
7,796,866
|
|
Inspire Medical Systems, Inc.(b)
|
|
140,853
|
6,283,452
|
|
InspireMD, Inc.(b)
|
|
1,259,385
|
881,695
|
|
Insulet Corp.(b)
|
|
101,696
|
15,483,216
|
|
Intuitive Surgical, Inc.(b)
|
|
70,415
|
28,002,637
|
|
Lucid Diagnostics, Inc.(b)
|
|
3,822,997
|
4,090,607
|
|
Medtronic PLC
|
|
449,937
|
35,198,572
|
|
Mobia Medical, Inc.(b)
|
|
199,584
|
2,674,426
|
|
Stryker Corp.
|
|
27,571
|
8,680,454
|
|
Tandem Diabetes Care, Inc.(b)
|
|
192,312
|
2,901,988
|
|
|
|
|
180,046,659
|
|
Health Care Providers & Services—24.5%
|
|||
|
Acadia Healthcare Co., Inc.(b)
|
|
353,243
|
10,431,266
|
|
Alignment Healthcare, Inc.(b)
|
|
577,052
|
13,739,608
|
|
Biodesix, Inc.(b)
|
|
388,639
|
8,763,809
|
|
CVS Health Corp.
|
|
263,513
|
27,260,420
|
|
Elevance Health, Inc.
|
|
54,645
|
21,132,861
|
|
GeneDx Holdings Corp.(b),(e)
|
|
165,138
|
11,336,724
|
|
Humana, Inc.
|
|
57,188
|
22,716,217
|
|
McKesson Corp.
|
|
9,893
|
7,475,151
|
|
Molina Healthcare, Inc.(b)
|
|
52,318
|
11,965,127
|
|
NeoGenomics, Inc.(b)
|
|
1,069,634
|
15,605,960
|
|
Tenet Healthcare Corp.(b)
|
|
10,692
|
2,000,259
|
|
UnitedHealth Group, Inc.
|
|
120,631
|
50,137,863
|
|
|
|
|
202,565,265
|
|
Health Care REITs—8.0%
|
|||
|
Diversified Healthcare Trust, REIT
|
|
293,879
|
2,733,075
|
|
|
Shares or
Principal
Amount
|
Value
|
|
|
Common Stocks (continued)
|
|
|
|
|
Health Care REITs (continued)
|
|||
|
Healthcare Realty Trust, Inc., REIT
|
|
77,778
|
$1,568,782
|
|
Healthpeak Properties, Inc., REIT
|
|
485,067
|
10,380,434
|
|
LTC Properties, Inc., REIT
|
|
139,352
|
5,358,084
|
|
National Health Investors, Inc., REIT
|
|
5,596
|
426,751
|
|
Omega Healthcare Investors, Inc., REIT
|
|
278,033
|
13,256,614
|
|
Sabra Health Care REIT, Inc.
|
|
482,214
|
9,407,995
|
|
Ventas, Inc., REIT
|
|
110,408
|
9,804,230
|
|
Welltower, Inc., REIT
|
|
57,915
|
13,144,968
|
|
|
|
|
66,080,933
|
|
Life Sciences Tools & Services—12.3%
|
|||
|
Charles River Laboratories International,
Inc.(b)
|
|
44,454
|
10,081,722
|
|
Danaher Corp.
|
|
139,737
|
26,617,104
|
|
ICON PLC(b)
|
|
49,689
|
8,631,476
|
|
IQVIA Holdings, Inc.(b)
|
|
36,599
|
7,071,659
|
|
Repligen Corp.(b)
|
|
48,404
|
6,604,242
|
|
Thermo Fisher Scientific, Inc.
|
|
68,956
|
34,571,780
|
|
Waters Corp.(b)
|
|
20,517
|
7,694,696
|
|
|
|
|
101,272,679
|
|
Pharmaceuticals—14.5%
|
|||
|
Avalyn Pharma, Inc.(b)
|
|
19,705
|
648,689
|
|
Bristol-Myers Squibb Co.
|
|
221,600
|
12,768,592
|
|
Eli Lilly & Co.
|
|
2,195
|
2,632,749
|
|
Fusion Pharmaceuticals, Inc. CVR(a),(b)
|
|
7,160
|
9,881
|
|
Merck & Co., Inc.
|
|
283,202
|
36,391,457
|
|
Oculis Holding AG(b),(d)
|
|
688,627
|
9,551,256
|
|
Oculis Holding AG(b),(d)
|
|
22,433
|
311,146
|
|
Seaport Therapeutics, Inc.(b)
|
|
88,659
|
1,925,673
|
|
|
Shares or
Principal
Amount
|
Value
|
|
|
|
|
|
|
|
|
|||
|
SpyGlass Pharma, Inc.(b)
|
|
129,589
|
$2,884,651
|
|
VeraDermics, Inc.(b)
|
|
353,716
|
43,485,845
|
|
Zoetis, Inc.
|
|
131,249
|
9,431,553
|
|
|
|
|
120,041,492
|
|
Total Common Stocks
|
878,062,264
|
||
|
Short-Term Investment—1.9%
|
|||
|
State Street Institutional U.S. Government
Money Market Fund, Premier Class,
3.58%(f)
|
|
15,337,270
|
15,337,270
|
|
Total Short-Term Investment
|
15,337,270
|
||
|
Total Investments (Cost $871,441,877)—127.7%
|
1,054,625,852
|
||
|
Long Term Debt Securities—(27.2%)
|
(225,000,000
)
|
||
|
Liabilities in Excess of Other Assets—(0.4%)
|
(3,561,544
)
|
||
|
Net Assets—100.0%
|
$826,064,308
|
||
|
(a)
|
Level 3 security. See Note 1(a) of the accompanying Notes to Portfolio of
Investments.
|
|
(b)
|
Non-income producing security.
|
|
(c)
|
Restricted security.
|
|
(d)
|
Foreign security.
|
|
(e)
|
A portion of security is pledged as collateral for call options written.
|
|
(f)
|
Registered investment company advised by State Street Investment
Management. The rate shown is the 7 day yield as of June 30, 2026.
|
|
ADR
|
American Depositary Receipt
|
|
CVR
|
Contingent Value Right
|
|
PLC
|
Public Limited Company
|
|
REIT
|
Real Estate Investment Trust
|
|
|
Number of Contracts
(100 shares each)
|
Notional Amount ($)
|
Value ($)
|
|
Option Contracts Written—0.0%
|
|||
|
Call Options Written—0.0%
|
|||
|
GENEDX HOLDINGS Corp. SEP26 75 CALL
|
200
|
(1,500,000)
|
(171,000)
|
|
Total Call Options Written
(Premiums received $(26,826))
|
(171,000)
|
||
|
|
3
|
|
4
|
|