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  <xsd:import namespace="http://xbrl.sec.gov/dei/2026" schemaLocation="https://xbrl.sec.gov/dei/2026/dei-2026.xsd" />
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  <xsd:element id="ibio_ContractLiabilitiesPolicyTextBlock" name="ContractLiabilitiesPolicyTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
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  <xsd:element id="ibio_LoansReceivableFixedRatesOfInterest" name="LoansReceivableFixedRatesOfInterest" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="ibio_CollaborationAndLicenseAgreementAgreementTerm" name="CollaborationAndLicenseAgreementAgreementTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="ibio_LesseeOperatingLeaseAnnualPercentageIncreaseInBaseRent" name="LesseeOperatingLeaseAnnualPercentageIncreaseInBaseRent" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="ibio_LetterOfCreditSanDiegoLeaseMember" name="LetterOfCreditSanDiegoLeaseMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
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  <xsd:element name="PercentageOfCollateralRequired" id="ibio_PercentageOfCollateralRequired" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="CompanyPurchasingCardMember" id="ibio_CompanyPurchasingCardMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ImpairmentOfPrepaidExpensesCurrent" id="ibio_ImpairmentOfPrepaidExpensesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
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  <xsd:element name="PreFundedWarrantsMember" id="ibio_PreFundedWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RepresentativeWarrantsMember" id="ibio_RepresentativeWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NumberOfEquipmentLeases" id="ibio_NumberOfEquipmentLeases" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="RubrycTherapeuticsIncMember" id="ibio_RubrycTherapeuticsIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeriesCWarrantsMember" id="ibio_SeriesCWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeriesDWarrantsMember" id="ibio_SeriesDWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeriesEWarrantsMember" id="ibio_SeriesEWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ReducedPlacementAgentFeesPaidAsPercentageOfAggregateGrossProceeds" id="ibio_ReducedPlacementAgentFeesPaidAsPercentageOfAggregateGrossProceeds" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="WoodforestNationalBankMember" id="ibio_WoodforestNationalBankMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WarrantAgreementWithBryanCapitalMember" id="ibio_WarrantAgreementWithBryanCapitalMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="BryanCapitalMember" id="ibio_BryanCapitalMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NotesReceivablePaymentsForInterest" id="ibio_NotesReceivablePaymentsForInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NotesReceivablePaymentsOnPrincipalBalance" id="ibio_NotesReceivablePaymentsOnPrincipalBalance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="PrepaymentFeePercentageOfPrincipalAmountRepaidWhenPrepaymentOccursPriorToOneYearFromIssuance" id="ibio_PrepaymentFeePercentageOfPrincipalAmountRepaidWhenPrepaymentOccursPriorToOneYearFromIssuance" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="PrepaymentFeePercentageOfPrincipalAmountRepaidWhenPrepaymentOccursAfterOneYearButPriorToTwoYearsFromIssuance" id="ibio_PrepaymentFeePercentageOfPrincipalAmountRepaidWhenPrepaymentOccursAfterOneYearButPriorToTwoYearsFromIssuance" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="CreditAndSecurityAgreementEventOfDefaultMember" id="ibio_CreditAndSecurityAgreementEventOfDefaultMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AggregateOfferingPriceInStockSalesAgreement" id="ibio_AggregateOfferingPriceInStockSalesAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="UnderwritingDiscountFeePercentage" id="ibio_UnderwritingDiscountFeePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="UnderwritersPurchaseOptionPeriod" id="ibio_UnderwritersPurchaseOptionPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PercentageOfTotalCommonSharesInOfferingWarrantsAvailableForUnderwriters" id="ibio_PercentageOfTotalCommonSharesInOfferingWarrantsAvailableForUnderwriters" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="StockIssuanceCostsLegalExpenseReimbursement" id="ibio_StockIssuanceCostsLegalExpenseReimbursement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="NonAccountableExpenseAllowanceGrantedToSalesAgent" id="ibio_NonAccountableExpenseAllowanceGrantedToSalesAgent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AccruedStockIssuanceCosts" id="ibio_AccruedStockIssuanceCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="OwnershipThresholdPercentage" id="ibio_OwnershipThresholdPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="OwnershipThresholdPercentageElectionOfHolder" id="ibio_OwnershipThresholdPercentageElectionOfHolder" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="WarrantExercisesOwnershipLimitationTermOfWrittenNotice" id="ibio_WarrantExercisesOwnershipLimitationTermOfWrittenNotice" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DaysToFileRegistrationStatement" id="ibio_DaysToFileRegistrationStatement" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DaysToFileRegistrationStatementSecReview" id="ibio_DaysToFileRegistrationStatementSecReview" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DurationOfSecuritiesPurchasingAgreement" id="ibio_DurationOfSecuritiesPurchasingAgreement" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DaysToSuspendSecuritiesPurchasingAgreement" id="ibio_DaysToSuspendSecuritiesPurchasingAgreement" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="OmnibusEquityIncentivePlan2023Member" id="ibio_OmnibusEquityIncentivePlan2023Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="OmnibusEquityIncentivePlan2020Member" id="ibio_OmnibusEquityIncentivePlan2020Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NonEmployeeCompensationMaximumAnnualDistribution" id="ibio_NonEmployeeCompensationMaximumAnnualDistribution" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NonEmployeeDirectorCompensationMaximumAnnualDistributionInitialAppointment" id="ibio_NonEmployeeDirectorCompensationMaximumAnnualDistributionInitialAppointment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NonEmployeeDirectorCompensationMaximumAnnualDistributionInitialChairAppointment" id="ibio_NonEmployeeDirectorCompensationMaximumAnnualDistributionInitialChairAppointment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AssetsOperatedUnderFinancingLeaseMember" id="ibio_AssetsOperatedUnderFinancingLeaseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AssetsOperatedUnderOperatingLeaseMember" id="ibio_AssetsOperatedUnderOperatingLeaseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NumberOfSignificantCustomersContributingToOperatingRevenues" id="ibio_NumberOfSignificantCustomersContributingToOperatingRevenues" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PotentialContingentPaymentsRelatedToSaleOfIntellectualProperty" id="ibio_PotentialContingentPaymentsRelatedToSaleOfIntellectualProperty" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="StockOptionIssuances2023PlanMember" id="ibio_StockOptionIssuances2023PlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="StockOptionIssuanceEmploymentInducementGrantMember" id="ibio_StockOptionIssuanceEmploymentInducementGrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="StockOptionIssuanceProfessionalServiceFeeGrantMember" id="ibio_StockOptionIssuanceProfessionalServiceFeeGrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="OperatingLeaseRouAssetsTextBlock" id="ibio_OperatingLeaseRouAssetsTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="SecuritiesPurchaseAgreement2025Member" id="ibio_SecuritiesPurchaseAgreement2025Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PotentialContingentPaymentsRelatedToLicensingAgreement" id="ibio_PotentialContingentPaymentsRelatedToLicensingAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CeilingOnStockOwnershipPercentage" id="ibio_CeilingOnStockOwnershipPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="InterestCostsIncludedInBalloonPaymentLiability" id="ibio_InterestCostsIncludedInBalloonPaymentLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="NonCashActivityIntangibleAssetAddition" id="ibio_NonCashActivityIntangibleAssetAddition" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NonCashActivitySharesIssuedForLicenseFee" id="ibio_NonCashActivitySharesIssuedForLicenseFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="NonCashActivitySubscriptionReceivable" id="ibio_NonCashActivitySubscriptionReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NonCashActivityCostsToRaiseCapital" id="ibio_NonCashActivityCostsToRaiseCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NonCashActivityCostsToRaiseCapitalInAccruedExpenses" id="ibio_NonCashActivityCostsToRaiseCapitalInAccruedExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NonCashActivityReservesForTermPromissoryNote" id="ibio_NonCashActivityReservesForTermPromissoryNote" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ConsiderationPerShareOfInducementWarrants" id="ibio_ConsiderationPerShareOfInducementWarrants" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="LeasesRightOfUseAssetsPolicyTextBlock" id="ibio_LeasesRightOfUseAssetsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NonCashActivityCreditProvidedByAstralbio" id="ibio_NonCashActivityCreditProvidedByAstralbio" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="InducementWarrantsConversionPercentageToCommonStock" id="ibio_InducementWarrantsConversionPercentageToCommonStock" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ExclusiveLicenseAgreementWithAstralbioForActivinEMember" id="ibio_ExclusiveLicenseAgreementWithAstralbioForActivinEMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExclusiveLicenseAgreementWithAstralbioForMyostatinMember" id="ibio_ExclusiveLicenseAgreementWithAstralbioForMyostatinMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeriesGWarrantsMember" id="ibio_SeriesGWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeriesHWarrantsMember" id="ibio_SeriesHWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PreFundedWarrantsAndSeriesGWarrantsMember" id="ibio_PreFundedWarrantsAndSeriesGWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PreFundedSeriesHWarrantsMember" id="ibio_PreFundedSeriesHWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeriesGAndSeriesHWarrantsMember" id="ibio_SeriesGAndSeriesHWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CommonStockSharesIssuedFromExerciseOfWarrants" id="ibio_CommonStockSharesIssuedFromExerciseOfWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="SharesNoLongerAvailableForFutureIssuance" id="ibio_SharesNoLongerAvailableForFutureIssuance" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="NonCashActivityUnpaidFixedAssetsInAccountsPayable" id="ibio_NonCashActivityUnpaidFixedAssetsInAccountsPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ValueOfCommonStockPerShareAtSettlementDate" id="ibio_ValueOfCommonStockPerShareAtSettlementDate" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="SummaryOfSignificantAccountingPoliciesTable" id="ibio_SummaryOfSignificantAccountingPoliciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SummaryOfSignificantAccountingPoliciesLineItems" id="ibio_SummaryOfSignificantAccountingPoliciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TotalCashAndCashEquivalentsAndInvestmentsInDebtSecurities" id="ibio_TotalCashAndCashEquivalentsAndInvestmentsInDebtSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="FinanceLeaseRouAssetsTextBlock" id="ibio_FinanceLeaseRouAssetsTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="IncreaseDecreaseInPrepaidExpenseAndOtherCurrentAssets" id="ibio_IncreaseDecreaseInPrepaidExpenseAndOtherCurrentAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="IncreaseDecreaseInPrepaidExpenseNoncurrent" id="ibio_IncreaseDecreaseInPrepaidExpenseNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ProceedsFromIssuanceOfCommonStockSubscriptionReceivable" id="ibio_ProceedsFromIssuanceOfCommonStockSubscriptionReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NatureOfBusinessAbstract" id="ibio_NatureOfBusinessAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeRevenuesMember" id="ibio_CollaborativeRevenuesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PromissoryNoteReceivableFirstOneYearExtensionMember" id="ibio_PromissoryNoteReceivableFirstOneYearExtensionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PromissoryNoteReceivableSecondOneYearExtensionMember" id="ibio_PromissoryNoteReceivableSecondOneYearExtensionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FinanceLeaseRightOfUseAssetsTableTextBlock" id="ibio_FinanceLeaseRightOfUseAssetsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NumberOfFinanceLeaseRightOfUseAssetsReturned" id="ibio_NumberOfFinanceLeaseRightOfUseAssetsReturned" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NumberOfFinanceLeaseRightOfUseAssetsPurchased" id="ibio_NumberOfFinanceLeaseRightOfUseAssetsPurchased" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="FinanceLeaseMonthlyPaymentAmount" id="ibio_FinanceLeaseMonthlyPaymentAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="TenantImprovementAllowance" id="ibio_TenantImprovementAllowance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ClassOfWarrantOrRightNumberWarrantsExercised" id="ibio_ClassOfWarrantOrRightNumberWarrantsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PreFundedWarrants2025Member" id="ibio_PreFundedWarrants2025Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SaleOfStockPricePerWarrant" id="ibio_SaleOfStockPricePerWarrant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="TermLoan2024Member" id="ibio_TermLoan2024Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PaymentsOfTermLoanAppraisalCosts" id="ibio_PaymentsOfTermLoanAppraisalCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PaymentsOfTermLoanBankWireFees" id="ibio_PaymentsOfTermLoanBankWireFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DisclosureOfSignificantTransactionsAbstract" id="ibio_DisclosureOfSignificantTransactionsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DisclosureOfSignificantTransactionsTextBlock" id="ibio_DisclosureOfSignificantTransactionsTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="OtsukaPd1PurchaseAgreementMember" id="ibio_OtsukaPd1PurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DisclosureOfSignificantTransactionsTable" id="ibio_DisclosureOfSignificantTransactionsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DisclosureOfSignificantTransactionsLineItems" id="ibio_DisclosureOfSignificantTransactionsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollegeStationPurchaseAndSaleAgreementMember" id="ibio_CollegeStationPurchaseAndSaleAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WoodforestCreditAgreementMember" id="ibio_WoodforestCreditAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsRepresentingFinalPaymentOfSublease" id="ibio_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsRepresentingFinalPaymentOfSublease" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ValueOfWarrantsOutstandingRepresentingFinalPaymentOfRentDueUnderSublease" id="ibio_ValueOfWarrantsOutstandingRepresentingFinalPaymentOfRentDueUnderSublease" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RubrycCollaborationOptionAndLicenseAgreementMember" id="ibio_RubrycCollaborationOptionAndLicenseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="EquitySecuritiesNumberOfSharesAcquired" id="ibio_EquitySecuritiesNumberOfSharesAcquired" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="RubrycStockPurchaseAgreementMember" id="ibio_RubrycStockPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FixedAssetsMember" id="ibio_FixedAssetsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AssetAcquisitionConsiderationTransferredEquityInterestSharesIssuedNumberOfShares" id="ibio_AssetAcquisitionConsiderationTransferredEquityInterestSharesIssuedNumberOfShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="AssetAcquisitionConsiderationTransferredEquityInterestIssuedAndIssuableFairValue" id="ibio_AssetAcquisitionConsiderationTransferredEquityInterestIssuedAndIssuableFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AssetAcquisitionAdvancePayment" id="ibio_AssetAcquisitionAdvancePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="InducementWarrantsMember" id="ibio_InducementWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PublicOfferingMember" id="ibio_PublicOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="IndefiniteLivedIntellectualPropertyMember" id="ibio_IndefiniteLivedIntellectualPropertyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NoncashEffectOfUnrealizedLossOnAvailableForSaleDebtSecurities" id="ibio_NoncashEffectOfUnrealizedLossOnAvailableForSaleDebtSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ExercisePrice1.00Member" id="ibio_ExercisePrice1.00Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExercisePrice0.893Member" id="ibio_ExercisePrice0.893Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExercisePrice2.23Member" id="ibio_ExercisePrice2.23Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WarrantsExercisesInPeriodForCommonStock" id="ibio_WarrantsExercisesInPeriodForCommonStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="WarrantsExercisesInPeriodForPreFundedWarrants" id="ibio_WarrantsExercisesInPeriodForPreFundedWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="SecuritiesPurchaseAgreement2023Member" id="ibio_SecuritiesPurchaseAgreement2023Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SecuritiesPurchaseAgreement2024Member" id="ibio_SecuritiesPurchaseAgreement2024Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AtMarketAgreementMember" id="ibio_AtMarketAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AstralbioMyostatinLicenseAgreementMember" id="ibio_AstralbioMyostatinLicenseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="InducementOfExistingWarrantsMember" id="ibio_InducementOfExistingWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SecuritiesPurchaseAgreement2026Member" id="ibio_SecuritiesPurchaseAgreement2026Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AtMarketAgreement2026Member" id="ibio_AtMarketAgreement2026Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ClassOfWarrantOrRightIssued" id="ibio_ClassOfWarrantOrRightIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="EquityOffering2022Member" id="ibio_EquityOffering2022Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PreFundedWarrants2022Member" id="ibio_PreFundedWarrants2022Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeriesaCommonStockPurchaseWarrantsMember" id="ibio_SeriesaCommonStockPurchaseWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="UnderwriterOptionNumberOfCommonSharesWhichMayBePurchased" id="ibio_UnderwriterOptionNumberOfCommonSharesWhichMayBePurchased" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="EquityOffering2022UnderwriterOptionMember" id="ibio_EquityOffering2022UnderwriterOptionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeriesaAndBWarrantsMember" id="ibio_SeriesaAndBWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="UnderwriterOptionNumberOfCommonSharesWhichMayBePurchasedUponExerciseOfWarrants" id="ibio_UnderwriterOptionNumberOfCommonSharesWhichMayBePurchasedUponExerciseOfWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="PreFundedWarrants2023Member" id="ibio_PreFundedWarrants2023Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeriesCAndDWarrantsMember" id="ibio_SeriesCAndDWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SaleOfStockPricePerUnitCommonShareAndCommonShareWarrants" id="ibio_SaleOfStockPricePerUnitCommonShareAndCommonShareWarrants" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="SaleOfStockPricePerUnitPreFundedWarrantsAndCommonShareWarrants" id="ibio_SaleOfStockPricePerUnitPreFundedWarrantsAndCommonShareWarrants" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="PreFundedWarrants2024Member" id="ibio_PreFundedWarrants2024Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExistingWarrantsMember" id="ibio_ExistingWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LeerinkUnderwritingAgreement2025Member" id="ibio_LeerinkUnderwritingAgreement2025Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PreFundedSeriesGWarrantsMember" id="ibio_PreFundedSeriesGWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PreFundedWarrants2026Member" id="ibio_PreFundedWarrants2026Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LegalFeesForFilingOfAnnualReport" id="ibio_LegalFeesForFilingOfAnnualReport" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LegalFeesForFilingOfQuarterlyReport" id="ibio_LegalFeesForFilingOfQuarterlyReport" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AdditionalGrossProceedsAvailableUponExerciseOfWarrants" id="ibio_AdditionalGrossProceedsAvailableUponExerciseOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="Lynx1MasterFundLpMember" id="ibio_Lynx1MasterFundLpMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtInstrumentNumberOfExtensions" id="ibio_DebtInstrumentNumberOfExtensions" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentTermOfEachExtension" id="ibio_DebtInstrumentTermOfEachExtension" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PrepaidExpensesMember" id="ibio_PrepaidExpensesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PromissoryNoteReceivableIncludingAccruedInterestCurrent" id="ibio_PromissoryNoteReceivableIncludingAccruedInterestCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="PromissoryNoteReceivableIncludingAccruedInterestNoncurrent" id="ibio_PromissoryNoteReceivableIncludingAccruedInterestNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="StockIssuedDuringPeriodValueWarrantInducement" id="ibio_StockIssuedDuringPeriodValueWarrantInducement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="StockIssuedDuringPeriodSharesWarrantInducement" id="ibio_StockIssuedDuringPeriodSharesWarrantInducement" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ProceedsFromExerciseOfWarrantsForCommonStock" id="ibio_ProceedsFromExerciseOfWarrantsForCommonStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ProceedsFromExerciseOfWarrantsForPreFundedWarrants" id="ibio_ProceedsFromExerciseOfWarrantsForPreFundedWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ProceedsFromWarrantInducementTransaction" id="ibio_ProceedsFromWarrantInducementTransaction" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateYearTwo" id="ibio_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateYearTwo" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateYearThree" id="ibio_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateYearThree" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ResearchAndDevelopmentMilestoneLiabilityCurrent" id="ibio_ResearchAndDevelopmentMilestoneLiabilityCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CostsToRaiseCapitalCurrent" id="ibio_CostsToRaiseCapitalCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ShareBasedPaymentArrangementVestingAfterOneYearMember" id="ibio_ShareBasedPaymentArrangementVestingAfterOneYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedPaymentArrangementVestingInEqualInstallmentsMember" id="ibio_ShareBasedPaymentArrangementVestingInEqualInstallmentsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AssetAcquisitionContingentConsiderationNumberOfMilestonesAchieved" id="ibio_AssetAcquisitionContingentConsiderationNumberOfMilestonesAchieved" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="AssetAcquisitionMaximumContingentConsideration" id="ibio_AssetAcquisitionMaximumContingentConsideration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DeferredTaxAssetsLiabilitiesGoodwillAndIntangibleAssets" id="ibio_DeferredTaxAssetsLiabilitiesGoodwillAndIntangibleAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="BioPharmaInc.Member" id="ibio_BioPharmaInc.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationShareBasedPaymentArrangementExpirationsAndForfeituresAmount" id="ibio_EffectiveIncomeTaxRateReconciliationShareBasedPaymentArrangementExpirationsAndForfeituresAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationShareBasedPaymentArrangementExpirationsAndForfeituresPercent" id="ibio_EffectiveIncomeTaxRateReconciliationShareBasedPaymentArrangementExpirationsAndForfeituresPercent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="InducementWarrantsSeriesaMember" id="ibio_InducementWarrantsSeriesaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="InducementWarrantsSeriesCMember" id="ibio_InducementWarrantsSeriesCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="InducementWarrantsSeriesDMember" id="ibio_InducementWarrantsSeriesDMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ClassOfWarrantOrRightReducedExercisePriceOfWarrantsOrRights" id="ibio_ClassOfWarrantOrRightReducedExercisePriceOfWarrantsOrRights" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="InducementWarrantsSeriesCAndSeriesDMember" id="ibio_InducementWarrantsSeriesCAndSeriesDMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="InducementWarrantsSeriesEMember" id="ibio_InducementWarrantsSeriesEMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="UnderwritingArrangementWarrantExerciseRelatedFeeTerm" id="ibio_UnderwritingArrangementWarrantExerciseRelatedFeeTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PlacementAgentFeeQuarterlyPaymentDuePeriod" id="ibio_PlacementAgentFeeQuarterlyPaymentDuePeriod" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NonEmployeeDirectorMember" id="ibio_NonEmployeeDirectorMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AggregateNumberOfSharesIssuedUnderPlan" id="ibio_AggregateNumberOfSharesIssuedUnderPlan" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ShareBasedPaymentArrangementVesting25PercentInFirstYearAndQuarterlyThereafterMember" id="ibio_ShareBasedPaymentArrangementVesting25PercentInFirstYearAndQuarterlyThereafterMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedPaymentArrangementVestingMonthlyOverOneYearMember" id="ibio_ShareBasedPaymentArrangementVestingMonthlyOverOneYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedPaymentArrangementVestingMonthlyOverThreeYearsMember" id="ibio_ShareBasedPaymentArrangementVestingMonthlyOverThreeYearsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedPaymentArrangementVestingFullyVestedUponGrantMember" id="ibio_ShareBasedPaymentArrangementVestingFullyVestedUponGrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedPaymentArrangementVestingMonthlyBetween12And36MonthsMember" id="ibio_ShareBasedPaymentArrangementVestingMonthlyBetween12And36MonthsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedPaymentArrangementVestingQuarterlyOverFirstYearMember" id="ibio_ShareBasedPaymentArrangementVestingQuarterlyOverFirstYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExercisePrice1.82To2.15Member" id="ibio_ExercisePrice1.82To2.15Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExercisePrice1.42Member" id="ibio_ExercisePrice1.42Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExercisePrice1.92To3.91Member" id="ibio_ExercisePrice1.92To3.91Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExercisePrice2.45Member" id="ibio_ExercisePrice2.45Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExercisePrice3.48Member" id="ibio_ExercisePrice3.48Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExercisePrice1.81Member" id="ibio_ExercisePrice1.81Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExercisePrice1.83Member" id="ibio_ExercisePrice1.83Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExercisePrice1.72To2.58Member" id="ibio_ExercisePrice1.72To2.58Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExercisePrice2.80To4.20Member" id="ibio_ExercisePrice2.80To4.20Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExercisePrice0.893To1.42Member" id="ibio_ExercisePrice0.893To1.42Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExercisePrice7.00To10.50Member" id="ibio_ExercisePrice7.00To10.50Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExercisePrice140.00To210.00Member" id="ibio_ExercisePrice140.00To210.00Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExercisePrice347.00To520.50Member" id="ibio_ExercisePrice347.00To520.50Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExercisePrice530.00To795.00Member" id="ibio_ExercisePrice530.00To795.00Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExercisePrice1025.00To1537.50Member" id="ibio_ExercisePrice1025.00To1537.50Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AstralBioAmylinLicenseAgreementMember" id="ibio_AstralBioAmylinLicenseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
</xsd:schema>
