|
|
Shares or
Principal
Amount
|
Value
|
|
|
NON-CONVERTIBLE NOTES—8.5%
|
|
|
|
|
UNITED KINGDOM—0.2%
|
|
|
|
|
GlaxoSmithKline Capital PLC, 3.38%,
06/01/2029
|
|
$1,000,000
|
$973,722
|
|
UNITED STATES—8.3%
|
|
|
|
|
Abbott Laboratories, 4.75%, 11/30/2036
|
|
5,652,000
|
5,516,078
|
|
AbbVie, Inc., 4.45%, 05/14/2046
|
|
1,705,000
|
1,464,458
|
|
AbbVie, Inc., 4.50%, 05/14/2035
|
|
3,200,000
|
3,083,168
|
|
Cigna Group, 2.38%, 03/15/2031
|
|
3,200,000
|
2,880,739
|
|
CVS Health Corp., 1.88%, 02/28/2031
|
|
2,448,000
|
2,147,153
|
|
DH Europe Finance II SARL, 3.25%,
11/15/2039
|
|
985,000
|
790,975
|
|
Elevance Health, Inc., 2.55%, 03/15/2031
|
|
3,200,000
|
2,902,553
|
|
Johnson & Johnson, 3.70%, 03/01/2046
|
|
5,470,000
|
4,368,900
|
|
Mallinckrodt CB LLC, 10.00%,
06/15/2029(a),(b)
|
|
997,897
|
–
|
|
Medtronic, Inc., 4.38%, 03/15/2035
|
|
1,675,000
|
1,609,488
|
|
Pfizer, Inc., 3.45%, 03/15/2029
|
|
5,300,000
|
5,176,631
|
|
Roche Holdings, Inc., 2.08%, 12/13/2031(a)
|
|
3,600,000
|
3,171,712
|
|
Shire Acquisitions Investments Ireland DAC,
3.20%, 09/23/2026
|
|
35,000
|
34,913
|
|
Thermo Fisher Scientific, Inc., 5.40%,
08/10/2043
|
|
3,500,000
|
3,460,070
|
|
UnitedHealth Group, Inc., 4.20%,
05/15/2032
|
|
6,060,000
|
5,891,659
|
|
Zimmer Biomet Holdings, Inc., 4.25%,
08/15/2035
|
|
5,000,000
|
4,590,630
|
|
|
|
47,089,127
|
|
|
Total Non-Convertible Notes
|
48,062,849
|
||
|
CONVERTIBLE PREFERRED STOCKS(b),(c),(d)—6.2%
|
|||
|
IRELAND—0.0%
|
|
|
|
|
Priothera Co. Ltd. Series A, 6.00%
|
|
194,134
|
22
|
|
UNITED STATES—6.2%
|
|
|
|
|
Alpha-9 Oncology, Inc. Series C
|
|
2,871,748
|
5,000,001
|
|
Atalanta Therapeutics, Inc. Series B
|
|
1,055,555
|
1,034,444
|
|
Atalanta Therapeutics, Inc. Series B2
|
|
1,461,537
|
949,999
|
|
Crystalys Therapeutics, Inc. Series A
|
|
2,215,900
|
2,219,999
|
|
Endeavor Biomedicine, Inc. Series B, 8.00%
|
|
424,079
|
1,999,999
|
|
Endeavor Biomedicine, Inc. Series C, 8.00%
|
|
78,308
|
510,928
|
|
Engrail Therapeutics, Inc. Series B, 8.00%
|
|
897,073
|
429,698
|
|
IO Light Holdings, Inc. Series A2
|
|
101,839
|
10
|
|
Radiant Biotherapeutics, Inc. (e)
|
|
1,147,236
|
4,999,999
|
|
VeraDermics, Inc. Series C
|
|
148,342
|
18,237,166
|
|
|
|
|
35,382,243
|
|
Total Convertible Preferred Stocks
|
|
|
35,382,265
|
|
|
|
Shares
|
Value
|
|
COMMON STOCKS—102.0%
|
|
|
|
|
BELGIUM—0.7%
|
|
||
|
AgomAb Therapeutics NV, ADR(c)
|
|
312,731
|
$4,059,248
|
|
CANADA—0.0%
|
|
||
|
Fusion Pharmaceuticals, Inc. CVR(b),(c),(d)
|
|
3,689
|
5,091
|
|
CHINA—2.2%
|
|
||
|
Hangzhou Tigermed Consulting Co. Ltd., H
Shares (a)
|
|
411,500
|
1,827,392
|
|
|
|
Shares
|
Value
|
|
|
|
|
|
|
|
|
||
|
WuXi XDC Cayman, Inc.(c)
|
|
601,000
|
$4,398,247
|
|
Zai Lab Ltd., ADR(c)
|
|
311,294
|
5,914,586
|
|
|
|
|
12,140,225
|
|
DENMARK—3.5%
|
|
||
|
Ascendis Pharma AS(c)
|
|
8,031
|
2,142,028
|
|
Novo Nordisk AS, ADR
|
|
367,740
|
17,629,456
|
|
|
|
|
19,771,484
|
|
FINLAND—0.6%
|
|
||
|
Orion OYJ, Class B
|
|
43,708
|
3,590,503
|
|
FRANCE(c)—6.3%
|
|
||
|
Abivax SA
|
|
37,000
|
4,879,927
|
|
Abivax SA, ADR
|
|
189,508
|
25,253,836
|
|
Inventiva SACA, ADR
|
|
1,214,281
|
4,589,982
|
|
OSE Immuno
|
|
275,416
|
981,881
|
|
|
|
|
35,705,626
|
|
GERMANY—2.0%
|
|
||
|
Bayer AG
|
|
121,869
|
6,740,352
|
|
Immatics NV(c)
|
|
466,940
|
4,730,102
|
|
|
|
|
11,470,454
|
|
ISRAEL(c)—0.5%
|
|
||
|
InspireMD, Inc.
|
|
695,460
|
486,892
|
|
Quoin Pharmaceuticals Ltd., ADR
|
|
40,400
|
195,536
|
|
Teva Pharmaceutical Industries Ltd., ADR
|
|
62,726
|
2,125,157
|
|
|
|
|
2,807,585
|
|
NETHERLANDS(c)—13.3%
|
|
||
|
Argenx SE, ADR
|
|
19,265
|
17,873,489
|
|
Newamsterdam Pharma Co. NV
|
|
382,193
|
12,952,521
|
|
ProQR Therapeutics NV
|
|
6,307,646
|
11,732,221
|
|
uniQure NV
|
|
714,265
|
32,899,046
|
|
|
|
|
75,457,277
|
|
SWITZERLAND—2.9%
|
|
||
|
Lonza Group AG
|
|
14,055
|
9,481,560
|
|
Oculis Holding AG(c)
|
|
417,823
|
5,795,205
|
|
Oculis Holding AG(c)
|
|
11,538
|
160,032
|
|
Sandoz Group AG, ADR
|
|
7,614
|
688,991
|
|
|
|
|
16,125,788
|
|
UNITED KINGDOM—8.5%
|
|
||
|
AstraZeneca PLC
|
|
145,278
|
27,547,614
|
|
Diaceutics PLC(c)
|
|
1,845,064
|
3,573,182
|
|
OXB(c)
|
|
1,478,680
|
12,239,105
|
|
Oxford Nanopore Technologies PLC(c)
|
|
2,891,768
|
4,760,210
|
|
|
|
|
48,120,111
|
|
UNITED STATES—61.5%
|
|
||
|
Abbott Laboratories
|
|
182,305
|
16,542,356
|
|
Alcon AG
|
|
81,177
|
5,473,758
|
|
Alcon AG
|
|
121,688
|
8,165,265
|
|
Alkermes PLC(c)
|
|
35,087
|
1,838,383
|
|
Avalyn Pharma, Inc.(c)
|
|
12,390
|
407,879
|
|
Becton Dickinson & Co.
|
|
11,731
|
1,775,252
|
|
Boston Scientific Corp.(c)
|
|
270,298
|
11,536,319
|
|
CareDx, Inc.(c)
|
|
96,034
|
2,736,969
|
|
Charles River Laboratories International,
Inc.(c)
|
|
30,525
|
6,922,765
|
|
CVS Health Corp.
|
|
83,357
|
8,623,282
|
|
Danaher Corp.
|
|
74,859
|
14,259,142
|
|
Dexcom, Inc.(c)
|
|
42,251
|
2,845,605
|
|
|
|
Shares
|
Value
|
|
COMMON STOCKS (continued)
|
|
|
|
|
United States (continued)
|
|
||
|
Disc Medicine, Inc.(c)
|
|
71,985
|
$5,264,983
|
|
Elevance Health, Inc.
|
|
11,744
|
4,541,757
|
|
GeneDx Holdings Corp.(c),(f)
|
|
69,306
|
4,757,857
|
|
Healthcare Realty Trust, Inc., REIT
|
|
152,505
|
3,076,026
|
|
Healthpeak Properties, Inc., REIT
|
|
241,545
|
5,169,063
|
|
Hemab Therapeutics Holdings, Inc.(c)
|
|
9,642
|
354,151
|
|
Humana, Inc.
|
|
21,487
|
8,535,066
|
|
ICON PLC(c)
|
|
30,658
|
5,325,601
|
|
Immunic, Inc.(c)
|
|
47,625
|
731,996
|
|
Inspire Medical Systems, Inc.(c)
|
|
70,089
|
3,126,670
|
|
Insulet Corp.(c)
|
|
40,331
|
6,140,395
|
|
Intuitive Surgical, Inc.(c)
|
|
30,687
|
12,203,606
|
|
IQVIA Holdings, Inc.(c)
|
|
28,419
|
5,491,119
|
|
Jazz Pharmaceuticals PLC(c)
|
|
11,844
|
2,854,049
|
|
Kailera Therapeutics, Inc.(c)
|
|
25,455
|
560,774
|
|
LivaNova PLC(c)
|
|
7,817
|
642,792
|
|
Maze Therapeutics, Inc.(c)
|
|
84,992
|
2,536,161
|
|
McKesson Corp.
|
|
4,102
|
3,099,471
|
|
Medtronic PLC
|
|
190,766
|
14,923,624
|
|
Merck & Co., Inc.
|
|
93,962
|
12,074,117
|
|
Mobia Medical, Inc.(c)
|
|
141,126
|
1,891,088
|
|
Molina Healthcare, Inc.(c)
|
|
14,253
|
3,259,661
|
|
Odyssey Therapeutics, Inc.(c)
|
|
30,525
|
571,123
|
|
Omega Healthcare Investors, Inc., REIT
|
|
71,075
|
3,388,856
|
|
Perceptive Capital Solutions Corp.(c)
|
|
223,118
|
2,427,524
|
|
Praxis Precision Medicines, Inc.(c)
|
|
32,827
|
10,990,151
|
|
Precision BioSciences, Inc.(c)
|
|
1,144,208
|
8,993,475
|
|
Renalytix PLC(a),(c),(d)
|
|
17,802,728
|
543,132
|
|
Revolution Medicines, Inc.(c)
|
|
5,721
|
1,071,429
|
|
Roche Holding AG, ADR
|
|
279,410
|
14,347,703
|
|
Sabra Health Care REIT, Inc.
|
|
136,559
|
2,664,266
|
|
Sanofi SA, ADR
|
|
471,254
|
20,103,696
|
|
Seaport Therapeutics, Inc.(c)
|
|
56,795
|
1,233,587
|
|
SpyGlass Pharma, Inc.(c)
|
|
108,188
|
2,408,265
|
|
Structure Therapeutics, Inc., ADR(c)
|
|
176,459
|
9,470,555
|
|
Stryker Corp.
|
|
8,490
|
2,672,992
|
|
Thermo Fisher Scientific, Inc.
|
|
28,268
|
14,172,444
|
|
UnitedHealth Group, Inc.
|
|
38,128
|
15,847,141
|
|
Ventas, Inc., REIT
|
|
113,939
|
10,117,783
|
|
VeraDermics, Inc.(c)
|
|
193,541
|
23,793,931
|
|
Waters Corp.(c)
|
|
10,752
|
4,032,430
|
|
Welltower, Inc., REIT
|
|
40,285
|
9,143,486
|
|
Zoetis, Inc.
|
|
40,851
|
2,935,553
|
|
|
|
|
348,616,524
|
|
Total Common Stocks
|
|
|
577,869,916
|
|
|
|
Shares
|
Value
|
|
WARRANTS(c)—3.5%
|
|
||
|
UNITED STATES—3.5%
|
|||
|
Immunic, Inc.
|
|
310,893
|
$4,778,424
|
|
Immunic, Inc., Series B, (expiration date
6/30/2030, exercise price $0.75)(b)
|
|
310,893
|
3,679,449
|
|
Precision BioSciences, Inc., (expiration date
11/11/2030, exercise price $7.25)(b)
|
|
396,233
|
1,796,718
|
|
Immunic, Inc.
|
|
388,793
|
5,975,753
|
|
Immunic, Inc., Series C, (expiration date
1/31/2027, exercise price $0.87)(b)
|
|
388,793
|
3,571,766
|
|
Total United States
|
|
19,802,110
|
|
|
Total Warrants
|
|
19,802,110
|
|
|
SHORT-TERM INVESTMENT—0.8%
|
|
||
|
State Street Institutional U.S. Government
Money Market Fund, Premier Class,
3.58%(g)
|
|
4,792,264
|
4,792,264
|
|
Total Short-Term Investment
|
|
4,792,264
|
|
|
Total Investments Before Milestone Interests—121.0%
(Cost $549,247,864)
|
685,909,404
|
||
|
|
|
Interest
|
|
|
MILESTONE INTEREST 0.3%
|
|
||
|
Amolyt Milestone Interest(b),(c),(d)
|
|
1
|
$1,545,435
|
|
Total Milestone Interest
|
|
|
1,545,435
|
|
Total Investments 121.3%—(Cost $550,226,359)
|
687,454,839
|
||
|
Long Term Debt Securities—(21.2%)
|
(120,000,000
)
|
||
|
Liabilities in Excess of Other Assets—(0.1%)
|
|
|
(752,425
)
|
|
Net Assets—100.0%
|
|
|
$566,702,414
|
|
(a)
|
Denotes a security issued under Regulation S or Rule 144A.
|
|
(b)
|
Level 3 security. See Note 1(a) of the accompanying Notes to Portfolio of
Investments.
|
|
(c)
|
Non-income producing security.
|
|
(d)
|
Restricted security.
|
|
(e)
|
Affiliated issuers in which the Fund holds 5% or more of the voting securities .
|
|
(f)
|
A portion of security is pledged as collateral for call options written.
|
|
(g)
|
Registered investment company advised by State Street Investment
Management. The rate shown is the 7 day yield as of June 30, 2026.
|
|
ADR
|
American Depositary Receipt
|
|
CVR
|
Contingent Value Right
|
|
DAC
|
Designated Activity Company
|
|
PLC
|
Public Limited Company
|
|
REIT
|
Real Estate Investment Trust
|
|
As of June 30, 2026, the Fund held the following forward foreign currency contracts:
|
|
Purchase Contracts
Settlement Date
|
Counterparty
|
Currency
Purchased
|
Amount
Purchased
|
Currency
Sold
|
Amount
Sold
|
Fair Value
|
Unrealized
Appreciation/
(Depreciation)
|
|
|
British Pound/United States Dollar
|
|
|
|
|
|
|||
|
07/16/2026
|
Standard Chartered Bank
|
GBP
|
505,967
|
USD
|
679,122
|
$671,132
|
$(7,990
)
|
|
|
Danish Krone/United States Dollar
|
|
|
|
|
|
|||
|
07/16/2026
|
Royal Bank of Canada
|
DKK
|
6,536,539
|
USD
|
1,015,558
|
999,951
|
(15,607
)
|
|
|
Purchase Contracts
Settlement Date
|
Counterparty
|
Currency
Purchased
|
Amount
Purchased
|
Currency
Sold
|
Amount
Sold
|
Fair Value
|
Unrealized
Appreciation/
(Depreciation)
|
|
|
Euro/United States Dollar
|
|
|
|
|
|
|||
|
07/16/2026
|
Royal Bank of Canada
|
EUR
|
2,118,406
|
USD
|
2,403,752
|
$2,421,861
|
$18,109
|
|
|
Israeli Shekel/United States Dollar
|
|
|
|
|
|
|||
|
07/16/2026
|
Goldman Sachs & Co.
|
ILS
|
1,040,072
|
USD
|
357,040
|
349,630
|
(7,410
)
|
|
|
Total
|
$4,442,574
|
$(12,898
)
|
||||||
|
Sale Contracts
Settlement Date
|
Counterparty
|
Currency
Purchased
|
Amount
Purchased
|
Currency
Sold
|
Amount
Sold
|
Fair Value
|
Unrealized
Appreciation/
(Depreciation)
|
|
|
United States Dollar/British Pound
|
|
|
|
|
|
|||
|
07/16/2026
|
Citibank N.A.
|
USD
|
10,617,252
|
GBP
|
7,972,428
|
$10,574,905
|
$42,347
|
|
|
07/16/2026
|
Standard Chartered Bank
|
USD
|
632,699
|
GBP
|
478,649
|
634,897
|
(2,198
)
|
|
|
United States Dollar/Danish Krone
|
|
|
|
|
|
|||
|
07/16/2026
|
Morgan Stanley & Co.
|
USD
|
9,028,649
|
DKK
|
58,539,433
|
8,955,287
|
73,362
|
|
|
07/16/2026
|
Royal Bank of Canada
|
USD
|
798,710
|
DKK
|
5,257,174
|
804,236
|
(5,526
)
|
|
|
United States Dollar/Euro
|
|
|
|
|
|
|||
|
07/16/2026
|
Deutsche Bank AG
|
USD
|
38,086,180
|
EUR
|
33,073,860
|
37,811,592
|
274,588
|
|
|
07/16/2026
|
Deutsche Bank AG
|
USD
|
3,366,669
|
EUR
|
2,953,468
|
3,376,543
|
(9,874
)
|
|
|
United States Dollar/Hong Kong Dollar
|
|
|
|
|
|
|||
|
07/16/2026
|
Morgan Stanley & Co.
|
USD
|
483,477
|
HKD
|
3,789,616
|
483,431
|
46
|
|
|
07/16/2026
|
Standard Chartered Bank
|
USD
|
5,450,955
|
HKD
|
42,659,968
|
5,442,022
|
8,933
|
|
|
United States Dollar/Israeli Shekel
|
|
|
|
|
|
|||
|
07/16/2026
|
Goldman Sachs & Co.
|
USD
|
110,242
|
ILS
|
328,487
|
110,424
|
(182
)
|
|
|
07/16/2026
|
Morgan Stanley & Co.
|
USD
|
1,373,352
|
ILS
|
4,051,285
|
1,361,878
|
11,474
|
|
|
United States Dollar/Swiss Franc
|
|
|
|
|
|
|||
|
07/16/2026
|
Goldman Sachs & Co.
|
USD
|
13,745,610
|
CHF
|
10,930,660
|
13,548,746
|
196,864
|
|
|
07/16/2026
|
Morgan Stanley & Co.
|
USD
|
1,006,614
|
CHF
|
815,801
|
1,011,200
|
(4,586
)
|
|
|
Total
|
$84,115,161
|
$585,248
|
||||||
|
Unrealized appreciation on forward foreign currency exchange contracts
|
$625,723
|
|||||||
|
Unrealized depreciation on forward foreign currency exchange contracts
|
$(53,373
)
|
|||||||
|
|
Number of Contracts
(100 shares each)
|
Notional Amount ($)
|
Value ($)
|
|
Option Contracts Written—0.0%
|
|||
|
Call Options Written—0.0%
|
|||
|
GENEDX HOLDINGS Corp. SEP26 75 CALL
|
70
|
(525,000)
|
(59,850)
|
|
Total Call Options Written
(Premiums received $(9,389))
|
(59,850)
|
||
|
4
|
|
|
|
5
|