<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/nport" xmlns:com="http://www.sec.gov/edgar/common" xmlns:ncom="http://www.sec.gov/edgar/nportcommon" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
    <submissionType>NPORT-P</submissionType>
    <isConfidential>false</isConfidential>
    <filerInfo>
      
      <filer>
        <issuerCredentials>
          <cik>0000729528</cik>
          <ccc>XXXXXXXX</ccc>
        </issuerCredentials>
      </filer>
      
      
      <seriesClassInfo>
        <seriesId>S000040666</seriesId>
        <classId>C000126056</classId>
        <classId>C000126057</classId>
      </seriesClassInfo>
      
      
    </filerInfo>
  </headerData>
  <formData>
    <genInfo>
      <regName>AMERICAN FUNDS INSURANCE SERIES</regName>
      <regFileNumber>811-03857</regFileNumber>
      <regCik>0000729528</regCik>
      <regLei>5493006ZFTN01BKM5294</regLei>
      <regStreet1>333 South Hope Street</regStreet1>
      <regStreet2>55th Floor</regStreet2>
      <regCity>Los Angeles</regCity>
      <regStateConditional regCountry="US" regState="US-CA"/>
      <regZipOrPostalCode>90071</regZipOrPostalCode>
      <regPhone>9499755000</regPhone>
      <seriesName>Managed Risk EUPAC Fund</seriesName>
      <seriesId>S000040666</seriesId>
      <seriesLei>549300EQNHSXPJ8N9K49</seriesLei>
      <repPdEnd>2026-12-31</repPdEnd>
      <repPdDate>2026-06-30</repPdDate>
      <isFinalFiling>N</isFinalFiling>
    </genInfo>
    <fundInfo>
      <totAssets>112057912.000000000000</totAssets>
      <totLiabs>403566.210000000000</totLiabs>
      <netAssets>111654345.790000000000</netAssets>
      <assetsAttrMiscSec>0.000000000000</assetsAttrMiscSec>
      <assetsInvested>0.000000000000</assetsInvested>
      <amtPayOneYrBanksBorr>0.000000000000</amtPayOneYrBanksBorr>
      <amtPayOneYrCtrldComp>0.000000000000</amtPayOneYrCtrldComp>
      <amtPayOneYrOthAffil>0.000000000000</amtPayOneYrOthAffil>
      <amtPayOneYrOther>0.000000000000</amtPayOneYrOther>
      <amtPayAftOneYrBanksBorr>0.000000000000</amtPayAftOneYrBanksBorr>
      <amtPayAftOneYrCtrldComp>0.000000000000</amtPayAftOneYrCtrldComp>
      <amtPayAftOneYrOthAffil>0.000000000000</amtPayAftOneYrOthAffil>
      <amtPayAftOneYrOther>0.000000000000</amtPayAftOneYrOther>
      <delayDeliv>0.000000000000</delayDeliv>
      <standByCommit>0.000000000000</standByCommit>
      <liquidPref>0.000000000000</liquidPref>
      <cshNotRptdInCorD>0.070000000000</cshNotRptdInCorD>
      <isNonCashCollateral>N</isNonCashCollateral>
      <returnInfo>
        <monthlyTotReturns>
          <monthlyTotReturn classId="C000126056" rtn1="7.3119459900000000" rtn2="5.1097999900000000" rtn3="-0.1158160000000000"/>
          <monthlyTotReturn classId="C000126057" rtn1="7.3592000000000000" rtn2="5.0398520000000000" rtn3="-0.1071839900000000"/>
        </monthlyTotReturns>
        <monthlyReturnCats>
          <equityContracts>
            <mon1 netRealizedGain="-4460.38" netUnrealizedAppr="-928907.08"/>
            <mon2 netRealizedGain="-76225.09" netUnrealizedAppr="73291.6900000001"/>
            <mon3 netRealizedGain="138914" netUnrealizedAppr="-143819.39"/>
            <futureCategory>
              <instrMon1 netRealizedGain="-4460.38" netUnrealizedAppr="-198969.58"/>
              <instrMon2 netRealizedGain="95967.32" netUnrealizedAppr="82567.68"/>
              <instrMon3 netRealizedGain="138914" netUnrealizedAppr="-81957.4"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="N/A" netUnrealizedAppr="-729937.5"/>
              <instrMon2 netRealizedGain="-172192.41" netUnrealizedAppr="-9275.98999999993"/>
              <instrMon3 netRealizedGain="N/A" netUnrealizedAppr="-61861.99"/>
            </optionCategory>
          </equityContracts>
        </monthlyReturnCats>
        <othMon1 netRealizedGain="1388702.61" netUnrealizedAppr="6455694.83"/>
        <othMon2 netRealizedGain="443396.45" netUnrealizedAppr="5031650.65"/>
        <othMon3 netRealizedGain="1214561.97" netUnrealizedAppr="-10260423.68"/>
      </returnInfo>
      <mon1Flow redemption="2044150.0300" reinvestment="0.0000" sales="5234.2100"/>
      <mon2Flow redemption="834196.2900" reinvestment="0.0000" sales="265157.8400"/>
      <mon3Flow redemption="3317569.6800" reinvestment="1429298.6500" sales="20820.7300"/>
      <varInfo>
        
        <fundsDesignatedInfo>
          <nameDesignatedIndex>S&amp;P 500 INDEX</nameDesignatedIndex>
          <indexIdentifier>SPX Index</indexIdentifier>
          
        </fundsDesignatedInfo>
        
      </varInfo>
    </fundInfo>
    <invstOrSecs>
      <invstOrSec>
        <name>MSCI EAFE SEP26</name>
        <lei>N/A</lei>
        <title>MSCI EAFE SEP26</title>
        <cusip>N/A</cusip>
        <identifiers>
          <ticker value="MFSU6"/>
          <other otherDesc="CG Symbol" value="MFSU6 INDEX"/>
        </identifiers>
        <balance>23</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>12117.6</valUSD>
        <pctVal>0.0108527795</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        
        <isRestrictedSec>N</isRestrictedSec>
        
        <fairValLevel>1</fairValLevel>
        <derivativeInfo>
          <futrDeriv derivCat="FUT">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <payOffProf>Long</payOffProf>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>MSCI EAFE SEP26</issuerName>
                <issueTitle>MSCI EAFE SEP26_MFSU6 INDEX</issueTitle>
                <identifiers>
                  <other otherDesc="CG Symbol" value="MFSU6 INDEX"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <expDate>2026-09-18</expDate>
            <notionalAmt>3617095</notionalAmt>
            <curCd>USD</curCd>
            <unrealizedAppr>12117.6</unrealizedAppr>
          </futrDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EFA US 12/18/26 P80</name>
        <lei>N/A</lei>
        <title>EFA US 12/18/26 P80</title>
        <cusip>N/A</cusip>
        <identifiers>
          <ticker value="EFA 12 P80"/>
          <other otherDesc="CG Symbol" value="EFA US 12/18/26 P80"/>
        </identifiers>
        <balance>1200</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>183600</valUSD>
        <pctVal>0.1644360537</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        
        <isRestrictedSec>N</isRestrictedSec>
        
        <fairValLevel>1</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="OPT">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Put</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <indexBasketInfo>
                <indexName>ISHARES MSCI EAFE ETF</indexName>
                <indexIdentifier>EFA</indexIdentifier>
              </indexBasketInfo>
            </descRefInstrmnt>
            <shareNo>1200</shareNo>
            <exercisePrice>80.000000000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2026-12-18</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>53342.46</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EFA US 12/18/26 P85</name>
        <lei>N/A</lei>
        <title>EFA US 12/18/26 P85</title>
        <cusip>N/A</cusip>
        <identifiers>
          <ticker value="EFA 12 P85"/>
          <other otherDesc="CG Symbol" value="EFA US 12/18/26 P85"/>
        </identifiers>
        <balance>250</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>27125</valUSD>
        <pctVal>0.0242937253</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        
        <isRestrictedSec>N</isRestrictedSec>
        
        <fairValLevel>1</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="OPT">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Put</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <indexBasketInfo>
                <indexName>ISHARES MSCI EAFE ETF</indexName>
                <indexIdentifier>EFA</indexIdentifier>
              </indexBasketInfo>
            </descRefInstrmnt>
            <shareNo>250</shareNo>
            <exercisePrice>85.000000000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2026-12-18</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>1738.01</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EFA US 09/18/26 P70</name>
        <lei>N/A</lei>
        <title>EFA US 09/18/26 P70</title>
        <cusip>N/A</cusip>
        <identifiers>
          <ticker value="EFA 9 P70"/>
          <other otherDesc="CG Symbol" value="EFA US 09/18/26 P70"/>
        </identifiers>
        <balance>675</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>25987.5</valUSD>
        <pctVal>0.0232749561</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        
        <isRestrictedSec>N</isRestrictedSec>
        
        <fairValLevel>1</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="OPT">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Put</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <indexBasketInfo>
                <indexName>ISHARES MSCI EAFE ETF</indexName>
                <indexIdentifier>EFA</indexIdentifier>
              </indexBasketInfo>
            </descRefInstrmnt>
            <shareNo>675</shareNo>
            <exercisePrice>70.000000000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2026-09-18</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>-7857.92</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EFA US 09/18/26 P75</name>
        <lei>N/A</lei>
        <title>EFA US 09/18/26 P75</title>
        <cusip>N/A</cusip>
        <identifiers>
          <ticker value="EFA 9 P75"/>
          <other otherDesc="CG Symbol" value="EFA US 09/18/26 P75"/>
        </identifiers>
        <balance>8975</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>197450</valUSD>
        <pctVal>0.1768404074</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        
        <isRestrictedSec>N</isRestrictedSec>
        
        <fairValLevel>1</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="OPT">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Put</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <indexBasketInfo>
                <indexName>ISHARES MSCI EAFE ETF</indexName>
                <indexIdentifier>EFA</indexIdentifier>
              </indexBasketInfo>
            </descRefInstrmnt>
            <shareNo>8975</shareNo>
            <exercisePrice>75.000000000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2026-09-18</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>-383925.04</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EFA US 09/18/26 P81</name>
        <lei>N/A</lei>
        <title>EFA US 09/18/26 P81</title>
        <cusip>N/A</cusip>
        <identifiers>
          <ticker value="EFA 9 P81"/>
          <other otherDesc="CG Symbol" value="EFA US 09/18/26 P81"/>
        </identifiers>
        <balance>75</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>2887.5</valUSD>
        <pctVal>0.0025861062</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        
        <isRestrictedSec>N</isRestrictedSec>
        
        <fairValLevel>1</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="OPT">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Put</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <indexBasketInfo>
                <indexName>ISHARES MSCI EAFE ETF</indexName>
                <indexIdentifier>EFA</indexIdentifier>
              </indexBasketInfo>
            </descRefInstrmnt>
            <shareNo>75</shareNo>
            <exercisePrice>81.000000000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2026-09-18</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>-2853.66</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>State Street Institutional U.S. Government Money Market Fund - Premier Class</name>
        <lei>N/A</lei>
        <title>State Street Institutional U.S. Government Money Market Fund - Premier Class</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="CG Symbol" value="070126CAP"/>
        </identifiers>
        <balance>3218106.92</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>3218106.92</valUSD>
        <pctVal>2.8822048056</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        
        <isRestrictedSec>N</isRestrictedSec>
        
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMERICAN FUNDS INSURANCE SERIES - THE BOND FUND OF AMERICA</name>
        <lei>F2Q0NH642XF1RP5YCC95</lei>
        <title>AMERICAN FUNDS INSURANCE SERIES - THE BOND FUND OF AMERICA</title>
        <cusip>030372809</cusip>
        <identifiers>
          <ticker value="VABND1V"/>
          <other otherDesc="CG Symbol" value="030372809"/>
        </identifiers>
        <balance>1387405.074</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13180348.2</valUSD>
        <pctVal>11.8045993703</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        
        <isRestrictedSec>N</isRestrictedSec>
        
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>American Funds Insurance Series - EUPAC World Fund</name>
        <lei>N/A</lei>
        <title>American Funds Insurance Series - EUPAC World Fund</title>
        <cusip>030372700</cusip>
        <identifiers>
          <ticker value="VAINT1V"/>
          <other otherDesc="CG Symbol" value="030372700"/>
        </identifiers>
        <balance>4051885.15</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>94773593.66</valUSD>
        <pctVal>84.8812403937</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        
        <isRestrictedSec>N</isRestrictedSec>
        
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2026-08-27</ncom:dateSigned>
      <ncom:nameOfApplicant>AMERICAN FUNDS INSURANCE SERIES</ncom:nameOfApplicant>
      <ncom:signature>Scott Lewis</ncom:signature>
      <ncom:signerName>Scott Lewis</ncom:signerName>
      <ncom:title>Compliance Specialist Senior</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
