<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019f3528-a815-776f-a610-561736282a52,g:f5997094-fb22-490b-bfc9-f2f473510580-->
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:meso="http://www.mesoblast.com/20260630" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:dtr-types1="http://www.xbrl.org/dtr/type/2022-03-31" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.mesoblast.com/20260630">
  <xs:import namespace="http://fasb.org/srt/2025" schemaLocation="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2022-03-31" schemaLocation="https://www.xbrl.org/dtr/type/2022-03-31/types.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd"/>
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/country/2025" schemaLocation="https://xbrl.sec.gov/country/2025/country-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/currency/2025" schemaLocation="https://xbrl.sec.gov/currency/2025/currency-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/cyd-af-sub/2025" schemaLocation="https://xbrl.sec.gov/cyd/2025/cyd-af-sub-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2025" schemaLocation="https://xbrl.sec.gov/dei/2025/dei-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd-sub/2025" schemaLocation="https://xbrl.sec.gov/ecd/2025/ecd-sub-2025.xsd"/>
  <xs:import namespace="https://xbrl.ifrs.org/taxonomy/2025-03-27/ifrs-full" schemaLocation="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd"/>
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="meso-20260630_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="meso-20260630_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="meso-20260630_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="meso-20260630_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/>
      <link:roleType id="CoverPage" roleURI="http://www.mesoblast.com/role/CoverPage">
        <link:definition>0000001 - Document - Cover Page</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AuditInformation" roleURI="http://www.mesoblast.com/role/AuditInformation">
        <link:definition>0000002 - Document - Audit Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedIncomeStatement" roleURI="http://www.mesoblast.com/role/ConsolidatedIncomeStatement">
        <link:definition>9952151 - Statement - Consolidated Income Statement</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedIncomeStatementParenthetical" roleURI="http://www.mesoblast.com/role/ConsolidatedIncomeStatementParenthetical">
        <link:definition>9952152 - Statement - Consolidated Income Statement (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedStatementofComprehensiveIncome" roleURI="http://www.mesoblast.com/role/ConsolidatedStatementofComprehensiveIncome">
        <link:definition>9952153 - Statement - Consolidated Statement of Comprehensive Income</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedStatementofChangesinEquity" roleURI="http://www.mesoblast.com/role/ConsolidatedStatementofChangesinEquity">
        <link:definition>9952154 - Statement - Consolidated Statement of Changes in Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedBalanceSheet" roleURI="http://www.mesoblast.com/role/ConsolidatedBalanceSheet">
        <link:definition>9952155 - Statement - Consolidated Balance Sheet</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedStatementofCashFlows" roleURI="http://www.mesoblast.com/role/ConsolidatedStatementofCashFlows">
        <link:definition>9952156 - Statement - Consolidated Statement of Cash Flows</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Basisofpreparation" roleURI="http://www.mesoblast.com/role/Basisofpreparation">
        <link:definition>9952157 - Disclosure - Basis of preparation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Significantchangesinthecurrentreportingperiod" roleURI="http://www.mesoblast.com/role/Significantchangesinthecurrentreportingperiod">
        <link:definition>9952158 - Disclosure - Significant changes in the current reporting period</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Lossbeforeincometax" roleURI="http://www.mesoblast.com/role/Lossbeforeincometax">
        <link:definition>9952159 - Disclosure - Loss before income tax</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Incometaxbenefitexpense" roleURI="http://www.mesoblast.com/role/Incometaxbenefitexpense">
        <link:definition>9952160 - Disclosure - Income tax benefit/(expense)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Financialassetsandliabilities" roleURI="http://www.mesoblast.com/role/Financialassetsandliabilities">
        <link:definition>9952161 - Disclosure - Financial assets and liabilities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Nonfinancialassetsandliabilities" roleURI="http://www.mesoblast.com/role/Nonfinancialassetsandliabilities">
        <link:definition>9952162 - Disclosure - Non-financial assets and liabilities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Equity" roleURI="http://www.mesoblast.com/role/Equity">
        <link:definition>9952163 - Disclosure - Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Cashflowinformation" roleURI="http://www.mesoblast.com/role/Cashflowinformation">
        <link:definition>9952164 - Disclosure - Cash flow information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Significantestimatesjudgmentsanderrors" roleURI="http://www.mesoblast.com/role/Significantestimatesjudgmentsanderrors">
        <link:definition>9952165 - Disclosure - Significant estimates, judgments and errors</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Financialriskmanagement" roleURI="http://www.mesoblast.com/role/Financialriskmanagement">
        <link:definition>9952166 - Disclosure - Financial risk management</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Capitalmanagement" roleURI="http://www.mesoblast.com/role/Capitalmanagement">
        <link:definition>9952167 - Disclosure - Capital management</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Interestsinotherentities" roleURI="http://www.mesoblast.com/role/Interestsinotherentities">
        <link:definition>9952168 - Disclosure - Interests in other entities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Contingentassetsandliabilities" roleURI="http://www.mesoblast.com/role/Contingentassetsandliabilities">
        <link:definition>9952169 - Disclosure - Contingent assets and liabilities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Commitments" roleURI="http://www.mesoblast.com/role/Commitments">
        <link:definition>9952170 - Disclosure - Commitments</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Eventsoccurringafterthereportingperiod" roleURI="http://www.mesoblast.com/role/Eventsoccurringafterthereportingperiod">
        <link:definition>9952171 - Disclosure - Events occurring after the reporting period</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Relatedpartytransactions" roleURI="http://www.mesoblast.com/role/Relatedpartytransactions">
        <link:definition>9952172 - Disclosure - Related party transactions</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Sharebasedpayments" roleURI="http://www.mesoblast.com/role/Sharebasedpayments">
        <link:definition>9952173 - Disclosure - Share-based payments</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Remunerationofauditors" roleURI="http://www.mesoblast.com/role/Remunerationofauditors">
        <link:definition>9952174 - Disclosure - Remuneration of auditors</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Lossespershare" roleURI="http://www.mesoblast.com/role/Lossespershare">
        <link:definition>9952175 - Disclosure - Losses per share</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Parententityfinancialinformation" roleURI="http://www.mesoblast.com/role/Parententityfinancialinformation">
        <link:definition>9952176 - Disclosure - Parent entity financial information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Segmentinformation" roleURI="http://www.mesoblast.com/role/Segmentinformation">
        <link:definition>9952177 - Disclosure - Segment information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Summaryofmaterialaccountingpolicies" roleURI="http://www.mesoblast.com/role/Summaryofmaterialaccountingpolicies">
        <link:definition>9952178 - Disclosure - Summary of material accounting policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SummaryofmaterialaccountingpoliciesPolicies" roleURI="http://www.mesoblast.com/role/SummaryofmaterialaccountingpoliciesPolicies">
        <link:definition>9955511 - Disclosure - Summary of material accounting policies (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LossbeforeincometaxTables" roleURI="http://www.mesoblast.com/role/LossbeforeincometaxTables">
        <link:definition>9955512 - Disclosure - Loss before income tax (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncometaxbenefitexpenseTables" roleURI="http://www.mesoblast.com/role/IncometaxbenefitexpenseTables">
        <link:definition>9955513 - Disclosure - Income tax benefit/(expense) (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesTables" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesTables">
        <link:definition>9955514 - Disclosure - Financial assets and liabilities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesTables" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesTables">
        <link:definition>9955515 - Disclosure - Non-financial assets and liabilities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EquityTables" roleURI="http://www.mesoblast.com/role/EquityTables">
        <link:definition>9955516 - Disclosure - Equity (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CashflowinformationTables" roleURI="http://www.mesoblast.com/role/CashflowinformationTables">
        <link:definition>9955517 - Disclosure - Cash flow information (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialriskmanagementTables" roleURI="http://www.mesoblast.com/role/FinancialriskmanagementTables">
        <link:definition>9955518 - Disclosure - Financial risk management (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="InterestsinotherentitiesTables" roleURI="http://www.mesoblast.com/role/InterestsinotherentitiesTables">
        <link:definition>9955519 - Disclosure - Interests in other entities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RelatedpartytransactionsTables" roleURI="http://www.mesoblast.com/role/RelatedpartytransactionsTables">
        <link:definition>9955520 - Disclosure - Related party transactions (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SharebasedpaymentsTables" roleURI="http://www.mesoblast.com/role/SharebasedpaymentsTables">
        <link:definition>9955521 - Disclosure - Share-based payments (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RemunerationofauditorsTables" roleURI="http://www.mesoblast.com/role/RemunerationofauditorsTables">
        <link:definition>9955522 - Disclosure - Remuneration of auditors (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LossespershareTables" roleURI="http://www.mesoblast.com/role/LossespershareTables">
        <link:definition>9955523 - Disclosure - Losses per share (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ParententityfinancialinformationTables" roleURI="http://www.mesoblast.com/role/ParententityfinancialinformationTables">
        <link:definition>9955524 - Disclosure - Parent entity financial information (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofpreparationDetails" roleURI="http://www.mesoblast.com/role/BasisofpreparationDetails">
        <link:definition>9955525 - Disclosure - Basis of preparation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SignificantchangesinthecurrentreportingperiodDetails" roleURI="http://www.mesoblast.com/role/SignificantchangesinthecurrentreportingperiodDetails">
        <link:definition>9955526 - Disclosure - Significant changes in the current reporting period (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LossbeforeincometaxSummaryofLossBeforeIncomeTaxDetails" roleURI="http://www.mesoblast.com/role/LossbeforeincometaxSummaryofLossBeforeIncomeTaxDetails">
        <link:definition>9955527 - Disclosure - Loss before income tax - Summary of Loss Before Income Tax (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LossbeforeincometaxSummaryofProductSalesNetDetails" roleURI="http://www.mesoblast.com/role/LossbeforeincometaxSummaryofProductSalesNetDetails">
        <link:definition>9955528 - Disclosure - Loss before income tax - Summary of Product Sales Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LossBeforeIncomeTaxAdditionalInformationDetails" roleURI="http://www.mesoblast.com/role/LossBeforeIncomeTaxAdditionalInformationDetails">
        <link:definition>9955529 - Disclosure - Loss Before Income Tax - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LossbeforeincometaxSummaryofGrossProductSalestoNetProductSalesDetails" roleURI="http://www.mesoblast.com/role/LossbeforeincometaxSummaryofGrossProductSalestoNetProductSalesDetails">
        <link:definition>9955530 - Disclosure - Loss before income tax - Summary of Gross Product Sales to Net Product Sales (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LossbeforeincometaxSummaryofProvisionsandCreditPaymentsforSalesRelatedDeductionsDetails" roleURI="http://www.mesoblast.com/role/LossbeforeincometaxSummaryofProvisionsandCreditPaymentsforSalesRelatedDeductionsDetails">
        <link:definition>9955531 - Disclosure - Loss before income tax - Summary of Provisions, and Credit Payments, for Sales-Related Deductions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LossbeforeincometaxEquitySettledShareBasedPaymentsDetails" roleURI="http://www.mesoblast.com/role/LossbeforeincometaxEquitySettledShareBasedPaymentsDetails">
        <link:definition>9955532 - Disclosure - Loss before income tax - Equity Settled Share Based Payments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncometaxbenefitexpenseSummaryofReconciliationofIncomeTaxtoPrimaFacieTaxPayableDetails" roleURI="http://www.mesoblast.com/role/IncometaxbenefitexpenseSummaryofReconciliationofIncomeTaxtoPrimaFacieTaxPayableDetails">
        <link:definition>9955533 - Disclosure - Income tax benefit/(expense) - Summary of Reconciliation of Income Tax to Prima Facie Tax Payable (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncometaxbenefitexpenseSummaryofIncomeTaxExpenseBenefitDetails" roleURI="http://www.mesoblast.com/role/IncometaxbenefitexpenseSummaryofIncomeTaxExpenseBenefitDetails">
        <link:definition>9955534 - Disclosure - Income tax benefit/(expense) - Summary of Income Tax Expense/(Benefit) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncometaxbenefitexpenseSummaryofAmountsThatWouldBeRecognizedDirectlyinEquityifBroughttoAccountDetails" roleURI="http://www.mesoblast.com/role/IncometaxbenefitexpenseSummaryofAmountsThatWouldBeRecognizedDirectlyinEquityifBroughttoAccountDetails">
        <link:definition>9955535 - Disclosure - Income tax benefit/(expense) - Summary of Amounts That Would Be Recognized Directly in Equity if Brought to Account (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncometaxbenefitexpenseSummaryofAmountsThatWouldBeRecognizedDirectlyinEquityDetails" roleURI="http://www.mesoblast.com/role/IncometaxbenefitexpenseSummaryofAmountsThatWouldBeRecognizedDirectlyinEquityDetails">
        <link:definition>9955536 - Disclosure - Income tax benefit/(expense) - Summary of Amounts That Would Be Recognized Directly in Equity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncometaxbenefitexpenseSummaryofDeferredTaxAssetsNotBroughttoAccountDetails" roleURI="http://www.mesoblast.com/role/IncometaxbenefitexpenseSummaryofDeferredTaxAssetsNotBroughttoAccountDetails">
        <link:definition>9955537 - Disclosure - Income tax benefit/(expense) - Summary of Deferred Tax Assets Not Brought to Account (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncometaxbenefitexpenseAdditionalInformationDetails" roleURI="http://www.mesoblast.com/role/IncometaxbenefitexpenseAdditionalInformationDetails">
        <link:definition>9955538 - Disclosure - Income tax benefit/(expense) - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofFinancialInstrumentsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofFinancialInstrumentsDetails">
        <link:definition>9955539 - Disclosure - Financial assets and liabilities - Summary of Financial Instruments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofCashandCashEquivalentsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofCashandCashEquivalentsDetails">
        <link:definition>9955540 - Disclosure - Financial assets and liabilities - Summary of Cash and Cash Equivalents (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofTradeandOtherReceivablesDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofTradeandOtherReceivablesDetails">
        <link:definition>9955541 - Disclosure - Financial assets and liabilities - Summary of Trade and Other Receivables (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofPrepaymentsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofPrepaymentsDetails">
        <link:definition>9955542 - Disclosure - Financial assets and liabilities - Summary of Prepayments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesAdditionalInformationTradeandOtherReceivablesDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesAdditionalInformationTradeandOtherReceivablesDetails">
        <link:definition>9955543 - Disclosure - Financial assets and liabilities - Additional Information Trade and Other Receivables (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofOtherNoncurrentAssetsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofOtherNoncurrentAssetsDetails">
        <link:definition>9955544 - Disclosure - Financial assets and liabilities - Summary of Other Non-current Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofTradeandOtherPayablesDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofTradeandOtherPayablesDetails">
        <link:definition>9955545 - Disclosure - Financial assets and liabilities - Summary of Trade and Other Payables (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofBorrowingsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofBorrowingsDetails">
        <link:definition>9955546 - Disclosure - Financial assets and liabilities - Summary of Borrowings (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesAdditionalInformationBorrowingsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesAdditionalInformationBorrowingsDetails">
        <link:definition>9955547 - Disclosure - Financial assets and liabilities - Additional Information Borrowings (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofNetDebtDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofNetDebtDetails">
        <link:definition>9955548 - Disclosure - Financial assets and liabilities - Summary of Net Debt (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofNetDebtReconciliationDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofNetDebtReconciliationDetails">
        <link:definition>9955549 - Disclosure - Financial assets and liabilities - Summary of Net Debt Reconciliation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofFinancialAssetsandLiabilitiesMeasuredandRecognizedatFairValueDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofFinancialAssetsandLiabilitiesMeasuredandRecognizedatFairValueDetails">
        <link:definition>9955550 - Disclosure - Financial assets and liabilities - Summary of Financial Assets and Liabilities Measured and Recognized at Fair Value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesAdditionalInformationFairvaluemeasurementsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesAdditionalInformationFairvaluemeasurementsDetails">
        <link:definition>9955551 - Disclosure - Financial assets and liabilities - Additional Information, Fair value measurements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofChangesintheContingentConsiderationFairValueofLevel3InstrumentsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofChangesintheContingentConsiderationFairValueofLevel3InstrumentsDetails">
        <link:definition>9955552 - Disclosure - Financial assets and liabilities - Summary of Changes in the Contingent Consideration Fair Value of Level 3 Instruments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofQuantitativeInformationAbouttheSignificantUnobservableInputsUsedinLevel3FairValueMeasurementsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofQuantitativeInformationAbouttheSignificantUnobservableInputsUsedinLevel3FairValueMeasurementsDetails">
        <link:definition>9955553 - Disclosure - Financial assets and liabilities - Summary of Quantitative Information About the Significant Unobservable Inputs Used in Level 3 Fair Value Measurements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesAdditionalInformationValuationProcessedofContingentConsiderationDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesAdditionalInformationValuationProcessedofContingentConsiderationDetails">
        <link:definition>9955554 - Disclosure - Financial assets and liabilities - Additional Information, Valuation Processed of Contingent Consideration (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofContingentConsiderationInputsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofContingentConsiderationInputsDetails">
        <link:definition>9955555 - Disclosure - Financial assets and liabilities - Summary of Contingent Consideration Inputs (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofValuationProcessesofContingentConsiderationatFairValueDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofValuationProcessesofContingentConsiderationatFairValueDetails">
        <link:definition>9955556 - Disclosure - Financial assets and liabilities - Summary of Valuation Processes of Contingent Consideration at Fair Value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofWarrantLiabilityDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofWarrantLiabilityDetails">
        <link:definition>9955557 - Disclosure - Financial assets and liabilities - Summary of Warrant Liability (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesAdditionalInformationWarrantsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesAdditionalInformationWarrantsDetails">
        <link:definition>9955558 - Disclosure - Financial assets and liabilities - Additional Information Warrants (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofFairValueofWarrantsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofFairValueofWarrantsDetails">
        <link:definition>9955559 - Disclosure - Financial assets and liabilities - Summary of Fair Value of Warrants (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesSummaryofPropertyPlantandEquipmentDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesSummaryofPropertyPlantandEquipmentDetails">
        <link:definition>9955560 - Disclosure - Non-financial assets and liabilities - Summary of Property, Plant and Equipment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesAdditionalInformationpropertyplantandequipmentDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesAdditionalInformationpropertyplantandequipmentDetails">
        <link:definition>9955561 - Disclosure - Non-financial assets and liabilities - Additional Information, property plant and equipment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesScheduleofRightofUseAssetsDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesScheduleofRightofUseAssetsDetails">
        <link:definition>9955562 - Disclosure - Non-financial assets and liabilities - Schedule of Right-of-Use Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesScheduleofLeaseLiabilitiesDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesScheduleofLeaseLiabilitiesDetails">
        <link:definition>9955563 - Disclosure - Non-financial assets and liabilities - Schedule of Lease Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesAdditionalinformationLeaseLiabilitiesDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesAdditionalinformationLeaseLiabilitiesDetails">
        <link:definition>9955564 - Disclosure - Non-financial assets and liabilities - Additional information, Lease Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesSummaryofIntangibleAssetsDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesSummaryofIntangibleAssetsDetails">
        <link:definition>9955565 - Disclosure - Non-financial assets and liabilities - Summary of Intangible Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesSummaryofCarryingValueofInProcessResearchandDevelopmentAcquiredbyProductDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesSummaryofCarryingValueofInProcessResearchandDevelopmentAcquiredbyProductDetails">
        <link:definition>9955566 - Disclosure - Non-financial assets and liabilities - Summary of Carrying Value of In Process Research and Development Acquired by Product (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesAdditionalInformationIntangiblesDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesAdditionalInformationIntangiblesDetails">
        <link:definition>9955567 - Disclosure - Non-financial assets and liabilities - Additional Information, Intangibles (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesSummaryofProvisionsDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesSummaryofProvisionsDetails">
        <link:definition>9955568 - Disclosure - Non-financial assets and liabilities - Summary of Provisions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesAdditionalinformationprovisionsDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesAdditionalinformationprovisionsDetails">
        <link:definition>9955569 - Disclosure - Non-financial assets and liabilities - Additional information, provisions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesSummaryofDeferredTaxBalancesDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesSummaryofDeferredTaxBalancesDetails">
        <link:definition>9955570 - Disclosure - Non-financial assets and liabilities - Summary of Deferred Tax Balances (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesScheduleofMovementsRelatedtoDeferredTaxAssetsandLiabilitiesDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesScheduleofMovementsRelatedtoDeferredTaxAssetsandLiabilitiesDetails">
        <link:definition>9955571 - Disclosure - Non-financial assets and liabilities - Schedule of Movements Related to Deferred Tax Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesScheduleofDeferredConsiderationDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesScheduleofDeferredConsiderationDetails">
        <link:definition>9955572 - Disclosure - Non-financial assets and liabilities - Schedule of Deferred Consideration (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesInventoryDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesInventoryDetails">
        <link:definition>9955573 - Disclosure - Non-financial assets and liabilities - Inventory (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesAdditionalinformationInventoriesandothercurrentassetsDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesAdditionalinformationInventoriesandothercurrentassetsDetails">
        <link:definition>9955574 - Disclosure - Non-financial assets and liabilities - Additional information, Inventories and other current assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EquitySummaryofShareCapitalDetails" roleURI="http://www.mesoblast.com/role/EquitySummaryofShareCapitalDetails">
        <link:definition>9955575 - Disclosure - Equity - Summary of Share Capital (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EquitySummaryofMovementsinOrdinaryShareCapitalDetails" roleURI="http://www.mesoblast.com/role/EquitySummaryofMovementsinOrdinaryShareCapitalDetails">
        <link:definition>9955576 - Disclosure - Equity - Summary of Movements in Ordinary Share Capital (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EquitySummaryofMovementsinOrdinaryShareCapitalFootnoteNarrativeDetails" roleURI="http://www.mesoblast.com/role/EquitySummaryofMovementsinOrdinaryShareCapitalFootnoteNarrativeDetails">
        <link:definition>9955577 - Disclosure - Equity - Summary of Movements in Ordinary Share Capital Footnote Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EquitySummaryofMovementsofSharesinShareTrustDetails" roleURI="http://www.mesoblast.com/role/EquitySummaryofMovementsofSharesinShareTrustDetails">
        <link:definition>9955578 - Disclosure - Equity - Summary of Movements of Shares in Share Trust (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EquitySummaryofReservesDetails" roleURI="http://www.mesoblast.com/role/EquitySummaryofReservesDetails">
        <link:definition>9955579 - Disclosure - Equity - Summary of Reserves (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EquitySummaryofReconciliationofReservesDetails" roleURI="http://www.mesoblast.com/role/EquitySummaryofReconciliationofReservesDetails">
        <link:definition>9955580 - Disclosure - Equity - Summary of Reconciliation of Reserves (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EquityAdditionalInformationDetails" roleURI="http://www.mesoblast.com/role/EquityAdditionalInformationDetails">
        <link:definition>9955581 - Disclosure - Equity - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EquitySummaryofAssumptionsBasedonObservableMarketConditionsExistedatIssueDateDetails" roleURI="http://www.mesoblast.com/role/EquitySummaryofAssumptionsBasedonObservableMarketConditionsExistedatIssueDateDetails">
        <link:definition>9955582 - Disclosure - Equity - Summary of Assumptions Based on Observable Market Conditions Existed at Issue Date (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CashFlowInformationDetails" roleURI="http://www.mesoblast.com/role/CashFlowInformationDetails">
        <link:definition>9955583 - Disclosure - Cash Flow Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialriskmanagementAdditionalInformationDetails" roleURI="http://www.mesoblast.com/role/FinancialriskmanagementAdditionalInformationDetails">
        <link:definition>9955584 - Disclosure - Financial risk management - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialriskmanagementScheduleofBalancesHeldattheEndofYearwithanAnalysiswhichAssessesImpactonProfitandLossDuetoChangeinExchangeRateDetails" roleURI="http://www.mesoblast.com/role/FinancialriskmanagementScheduleofBalancesHeldattheEndofYearwithanAnalysiswhichAssessesImpactonProfitandLossDuetoChangeinExchangeRateDetails">
        <link:definition>9955585 - Disclosure - Financial risk management - Schedule of Balances Held at the End of Year with an Analysis which Assesses Impact on Profit and Loss Due to Change in Exchange Rate (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialriskmanagementScheduleofDepositsHeldwhichDeriveInterestRevenueTogetherwiththeMaximumandMinimumInterestRatesBeingEarnedDetails" roleURI="http://www.mesoblast.com/role/FinancialriskmanagementScheduleofDepositsHeldwhichDeriveInterestRevenueTogetherwiththeMaximumandMinimumInterestRatesBeingEarnedDetails">
        <link:definition>9955586 - Disclosure - Financial risk management - Schedule of Deposits Held which Derive Interest Revenue Together with the Maximum and Minimum Interest Rates Being Earned (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialriskmanagementSummaryofBorrowingtoPriceRateChangesDetails" roleURI="http://www.mesoblast.com/role/FinancialriskmanagementSummaryofBorrowingtoPriceRateChangesDetails">
        <link:definition>9955587 - Disclosure - Financial risk management - Summary of Borrowing to Price Rate Changes (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialriskmanagementScheduleofWarrantLiabilitiesIncreaseorDecreaseSharePriceOthervariablesDetails" roleURI="http://www.mesoblast.com/role/FinancialriskmanagementScheduleofWarrantLiabilitiesIncreaseorDecreaseSharePriceOthervariablesDetails">
        <link:definition>9955588 - Disclosure - Financial risk management - Schedule of Warrant Liabilities Increase or Decrease Share Price Other variables (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialriskmanagementSummaryofGroupsReceivablesDetails" roleURI="http://www.mesoblast.com/role/FinancialriskmanagementSummaryofGroupsReceivablesDetails">
        <link:definition>9955589 - Disclosure - Financial risk management - Summary of Group's Receivables (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialriskmanagementScheduleofMaturityProfileofAnticipatedFutureContractualCashFlowsCarryingValueDetails" roleURI="http://www.mesoblast.com/role/FinancialriskmanagementScheduleofMaturityProfileofAnticipatedFutureContractualCashFlowsCarryingValueDetails">
        <link:definition>9955590 - Disclosure - Financial risk management - Schedule of Maturity Profile of Anticipated Future Contractual Cash Flows Carrying Value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="InterestsinotherentitiesDetails" roleURI="http://www.mesoblast.com/role/InterestsinotherentitiesDetails">
        <link:definition>9955591 - Disclosure - Interests in other entities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ContingentAssetsandLiabilitiesDetails" roleURI="http://www.mesoblast.com/role/ContingentAssetsandLiabilitiesDetails">
        <link:definition>9955592 - Disclosure - Contingent Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsDetails" roleURI="http://www.mesoblast.com/role/CommitmentsDetails">
        <link:definition>9955593 - Disclosure - Commitments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RelatedpartytransactionsScheduleofKeyManagementPersonnelCompensationDetails" roleURI="http://www.mesoblast.com/role/RelatedpartytransactionsScheduleofKeyManagementPersonnelCompensationDetails">
        <link:definition>9955594 - Disclosure - Related party transactions - Schedule of Key Management Personnel Compensation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RelatedpartytransactionsAdditionalInformationDetails" roleURI="http://www.mesoblast.com/role/RelatedpartytransactionsAdditionalInformationDetails">
        <link:definition>9955595 - Disclosure - Related party transactions - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RelatedpartytransactionsTransactionswithotherrelatedpartiesDetails" roleURI="http://www.mesoblast.com/role/RelatedpartytransactionsTransactionswithotherrelatedpartiesDetails">
        <link:definition>9955596 - Disclosure - Related party transactions - Transactions with other related parties (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RelatedpartytransactionsLoanstofromrelatedpartiesDetails" roleURI="http://www.mesoblast.com/role/RelatedpartytransactionsLoanstofromrelatedpartiesDetails">
        <link:definition>9955597 - Disclosure - Related party transactions - Loans to/from related parties (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SharebasedpaymentsAdditionalInformationDetails" roleURI="http://www.mesoblast.com/role/SharebasedpaymentsAdditionalInformationDetails">
        <link:definition>9955598 - Disclosure - Share-based payments - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SharebasedpaymentsReconciliationofOutstandingShareBasedPaymentsDetails" roleURI="http://www.mesoblast.com/role/SharebasedpaymentsReconciliationofOutstandingShareBasedPaymentsDetails">
        <link:definition>9955599 - Disclosure - Share-based payments - Reconciliation of Outstanding Share Based Payments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SharebasedpaymentsGeneralTermsDetails" roleURI="http://www.mesoblast.com/role/SharebasedpaymentsGeneralTermsDetails">
        <link:definition>9955600 - Disclosure - Share-based payments - General Terms (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SharebasedpaymentsReconciliationofOutstandingShareBasedPaymentsModelinputsDetails" roleURI="http://www.mesoblast.com/role/SharebasedpaymentsReconciliationofOutstandingShareBasedPaymentsModelinputsDetails">
        <link:definition>9955601 - Disclosure - Share-based payments - Reconciliation of Outstanding Share Based Payments - Model inputs (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RemunerationofauditorsDetails" roleURI="http://www.mesoblast.com/role/RemunerationofauditorsDetails">
        <link:definition>9955602 - Disclosure - Remuneration of auditors (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LossespershareDetails" roleURI="http://www.mesoblast.com/role/LossespershareDetails">
        <link:definition>9955603 - Disclosure - Losses per share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ParentEntityFinancialInformationSummaryofParentEntityFinancialInformationDetails" roleURI="http://www.mesoblast.com/role/ParentEntityFinancialInformationSummaryofParentEntityFinancialInformationDetails">
        <link:definition>9955604 - Disclosure - Parent Entity Financial Information - Summary of Parent Entity Financial Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ParentEntityFinancialInformationAdditionalInformationDetails" roleURI="http://www.mesoblast.com/role/ParentEntityFinancialInformationAdditionalInformationDetails">
        <link:definition>9955605 - Disclosure - Parent Entity Financial Information - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentInformationDetails" roleURI="http://www.mesoblast.com/role/SegmentInformationDetails">
        <link:definition>9955606 - Disclosure - Segment Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SummaryofmaterialaccountingpoliciesSegmentReportingDetails" roleURI="http://www.mesoblast.com/role/SummaryofmaterialaccountingpoliciesSegmentReportingDetails">
        <link:definition>9955607 - Disclosure - Summary of material accounting policies - Segment Reporting (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SummaryofmaterialaccountingpoliciesRevenueDetails" roleURI="http://www.mesoblast.com/role/SummaryofmaterialaccountingpoliciesRevenueDetails">
        <link:definition>9955608 - Disclosure - Summary of material accounting policies - Revenue (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SummaryofmaterialaccountingpoliciesInventoriesDetails" roleURI="http://www.mesoblast.com/role/SummaryofmaterialaccountingpoliciesInventoriesDetails">
        <link:definition>9955609 - Disclosure - Summary of material accounting policies - Inventories (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SummaryofmaterialaccountingpoliciesTradeandOtherReceivablesDetails" roleURI="http://www.mesoblast.com/role/SummaryofmaterialaccountingpoliciesTradeandOtherReceivablesDetails">
        <link:definition>9955610 - Disclosure - Summary of material accounting policies - Trade and Other Receivables (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SummaryofmaterialaccountingpoliciesTradeandOtherPayablesDetails" roleURI="http://www.mesoblast.com/role/SummaryofmaterialaccountingpoliciesTradeandOtherPayablesDetails">
        <link:definition>9955611 - Disclosure - Summary of material accounting policies - Trade and Other Payables (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SummaryofmaterialaccountingpoliciesBorrowingsDetails" roleURI="http://www.mesoblast.com/role/SummaryofmaterialaccountingpoliciesBorrowingsDetails">
        <link:definition>9955612 - Disclosure - Summary of material accounting policies - Borrowings (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SummaryofmaterialaccountingpoliciesLeasesDetails" roleURI="http://www.mesoblast.com/role/SummaryofmaterialaccountingpoliciesLeasesDetails">
        <link:definition>9955613 - Disclosure - Summary of material accounting policies - Leases (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="meso_FairValueRemeasurementOfContingentConsideration" abstract="false" name="FairValueRemeasurementOfContingentConsideration" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_FairValueRemeasurementOfWarrantLiability" abstract="false" name="FairValueRemeasurementOfWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CurrentMarketedProductsMember" abstract="true" name="CurrentMarketedProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_InvestmentRevaluationReserveMember" abstract="true" name="InvestmentRevaluationReserveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_IncreaseThroughContributionsByOwnersForUnissuedOrdinarySharesEquity" abstract="false" name="IncreaseThroughContributionsByOwnersForUnissuedOrdinarySharesEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TaxCreditedOrDebitedToEquity" abstract="false" name="TaxCreditedOrDebitedToEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CurrentProvisionsAndOtherCurrentLiabilities" abstract="false" name="CurrentProvisionsAndOtherCurrentLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_NoncurrentProvisionsAndOtherNoncurrentLiabilities" abstract="false" name="NoncurrentProvisionsAndOtherNoncurrentLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredConsiderationNonCurrent" abstract="false" name="DeferredConsiderationNonCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_GovernmentGrantsAndTaxIncentivesReceived" abstract="false" name="GovernmentGrantsAndTaxIncentivesReceived" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_PaymentsToSuppliersAndEmployeesInclusiveOfGoodsAndServicesTax" abstract="false" name="PaymentsToSuppliersAndEmployeesInclusiveOfGoodsAndServicesTax" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_PaymentsForReceiptsFromInvestmentInSublease" abstract="false" name="PaymentsForReceiptsFromInvestmentInSublease" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ReceiptOfSecurityDeposits" abstract="false" name="ReceiptOfSecurityDeposits" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_PaymentsOfTransactionCostsFromBorrowings" abstract="false" name="PaymentsOfTransactionCostsFromBorrowings" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_InterestAndOtherCostsOfFinancePaidClassifiedAsFinancingActivities" abstract="false" name="InterestAndOtherCostsOfFinancePaidClassifiedAsFinancingActivities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ProceedsFromIssuingWarrants" abstract="false" name="ProceedsFromIssuingWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ProceedsFromSettlementOfLeaseLiabilitiesClassifiedAsFinancingActivities" abstract="false" name="ProceedsFromSettlementOfLeaseLiabilitiesClassifiedAsFinancingActivities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_BasisOfPreparationAbstract" abstract="true" name="BasisOfPreparationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfSignificantChangesInCurrentReportingPeriodAbstract" abstract="true" name="DisclosureOfSignificantChangesInCurrentReportingPeriodAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfSignificantChangesInCurrentReportingPeriodExplanatoryTextBlock" abstract="false" name="DisclosureOfSignificantChangesInCurrentReportingPeriodExplanatoryTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfLossBeforeIncomeTaxAbstract" abstract="true" name="DisclosureOfLossBeforeIncomeTaxAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfDetailedInformationAboutLossBeforeIncomeTaxExplanatoryTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutLossBeforeIncomeTaxExplanatoryTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfFinancialAssetsAndLiabilitiesAbstract" abstract="true" name="DisclosureOfFinancialAssetsAndLiabilitiesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfFinancialAssetsAndFinancialLiabilitiesExplanatoryTextBlock" abstract="false" name="DisclosureOfFinancialAssetsAndFinancialLiabilitiesExplanatoryTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfNonFinancialAssetsAndLiabilitiesAbstract" abstract="true" name="DisclosureOfNonFinancialAssetsAndLiabilitiesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfNonFinancialAssetsAndNonFinancialLiabilitiesExplanatoryTextBlock" abstract="false" name="DisclosureOfNonFinancialAssetsAndNonFinancialLiabilitiesExplanatoryTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfSignificantEstimatesJudgmentsAndErrorsAbstract" abstract="true" name="DisclosureOfSignificantEstimatesJudgmentsAndErrorsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfSignificantEstimatesJudgmentsAndErrorsExplanatoryTextBlock" abstract="false" name="DisclosureOfSignificantEstimatesJudgmentsAndErrorsExplanatoryTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfFinancialRiskManagementAbstract" abstract="true" name="DisclosureOfFinancialRiskManagementAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_CapitalManagementAbstract" abstract="true" name="CapitalManagementAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfCapitalManagementExplanatoryTextBlock" abstract="false" name="DisclosureOfCapitalManagementExplanatoryTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfContingentAssetsAndLiabilitiesAbstract" abstract="true" name="DisclosureOfContingentAssetsAndLiabilitiesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfContingentAssetsAndLiabilitiesExplanatoryTextBlock" abstract="false" name="DisclosureOfContingentAssetsAndLiabilitiesExplanatoryTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_CommitmentsAbstract" abstract="true" name="CommitmentsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfKeyManagementPersonnelCompensationAbstract" abstract="true" name="DisclosureOfKeyManagementPersonnelCompensationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfParentEntityFinancialInformationAbstract" abstract="true" name="DisclosureOfParentEntityFinancialInformationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfSummaryOfSignificantAccountingPoliciesAbstract" abstract="true" name="DisclosureOfSummaryOfSignificantAccountingPoliciesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DescriptionOfAccountingPolicyForBasisOfPreparationExplanatoryPolicyTextBlock" abstract="false" name="DescriptionOfAccountingPolicyForBasisOfPreparationExplanatoryPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DescriptionOfAccountingPolicyForChangeInAccountingPoliciesExplanatoryPolicyTextBlock" abstract="false" name="DescriptionOfAccountingPolicyForChangeInAccountingPoliciesExplanatoryPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DescriptionOfAccountingPolicyForPrinciplesOfConsolidationExplanatoryPolicyTextBlock" abstract="false" name="DescriptionOfAccountingPolicyForPrinciplesOfConsolidationExplanatoryPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DescriptionOfAccountingPolicyForInvestmentsAndOtherFinancialAssetsExplanatoryPolicyTextBlock" abstract="false" name="DescriptionOfAccountingPolicyForInvestmentsAndOtherFinancialAssetsExplanatoryPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DescriptionOfAccountingPolicyForContributedEquityExplanatoryPolicyTextBlock" abstract="false" name="DescriptionOfAccountingPolicyForContributedEquityExplanatoryPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DescriptionOfAccountingPolicyForRoundingOfAmountsExplanatoryPolicyTextBlock" abstract="false" name="DescriptionOfAccountingPolicyForRoundingOfAmountsExplanatoryPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfLossBeforeIncomeTaxExplanatoryTableTextBlock" abstract="false" name="DisclosureOfLossBeforeIncomeTaxExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfReconciliationOfIncomeTaxExpenseExplanatoryTableTextBlock" abstract="false" name="DisclosureOfReconciliationOfIncomeTaxExpenseExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDetailedInformationAboutIncomeTaxExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutIncomeTaxExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfAmountsThatWouldBeRecognizedDirectlyInEquityIfBroughtToAccountExplanatoryTableTextBlock" abstract="false" name="DisclosureOfAmountsThatWouldBeRecognizedDirectlyInEquityIfBroughtToAccountExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfAmountsThatWouldBeRecognizedDirectlyInEquityExplanatoryTableTextBlock" abstract="false" name="DisclosureOfAmountsThatWouldBeRecognizedDirectlyInEquityExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDeferredTaxAssetsNotBroughtToAccountExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDeferredTaxAssetsNotBroughtToAccountExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfTradeAndOtherReceivablesAndPrepaymentsExplanatoryTableTextBlock" abstract="false" name="DisclosureOfTradeAndOtherReceivablesAndPrepaymentsExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDetailedInformationAboutNetDebtExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutNetDebtExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDetailedInformationAboutNetDebtReconciliationExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutNetDebtReconciliationExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDetailedInformationAboutFairValueMeasurementExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutFairValueMeasurementExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfSignificantUnobservableInputsUsedInFairValueMeasurementOfAssetsAndLiabilitiesExplanatoryTableTextBlock" abstract="false" name="DisclosureOfSignificantUnobservableInputsUsedInFairValueMeasurementOfAssetsAndLiabilitiesExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfQuantitativeInformationAboutSignificantUnobservableInputsUsedInFairValueMeasurementsExplanatoryTableTextBlock" abstract="false" name="DisclosureOfQuantitativeInformationAboutSignificantUnobservableInputsUsedInFairValueMeasurementsExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDetailedInformationAboutValuationProcessesOfContingentConsiderationAtFairValueExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutValuationProcessesOfContingentConsiderationAtFairValueExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDetailedInformationAboutWarrantLiabilityExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutWarrantLiabilityExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDetailedInformationAboutFairValueOfWarrantsExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutFairValueOfWarrantsExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfLeaseLiabilitiesExplanatoryTableTextBlock" abstract="false" name="DisclosureOfLeaseLiabilitiesExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfCarryingValueOfInProcessResearchAndDevelopmentAcquiredByProductExplanatoryTableTextBlock" abstract="false" name="DisclosureOfCarryingValueOfInProcessResearchAndDevelopmentAcquiredByProductExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfNetMovementRelatedToDeferredTaxAssetsAndLiabilitiesExplanatoryTableTextBlock" abstract="false" name="DisclosureOfNetMovementRelatedToDeferredTaxAssetsAndLiabilitiesExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDeferredConsiderationExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDeferredConsiderationExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfMovementsInOrdinaryShareCapitalExplanatoryTableTextBlock" abstract="false" name="DisclosureOfMovementsInOrdinaryShareCapitalExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfMovementsOfSharesInShareTrustExplanatoryTableTextBlock" abstract="false" name="DisclosureOfMovementsOfSharesInShareTrustExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfReconciliationOfReservesExplanatoryTableTextBlock" abstract="false" name="DisclosureOfReconciliationOfReservesExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfSummaryOfCashFlowInformationExplanatoryTableTextBlock" abstract="false" name="DisclosureOfSummaryOfCashFlowInformationExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfExposureToFinancialRisksTableTextBlock" abstract="false" name="DisclosureOfExposureToFinancialRisksTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDepositsHeldWhichDeriveInterestRevenueWithMaximumAndMinimumInterestRatesBeingEarnedExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDepositsHeldWhichDeriveInterestRevenueWithMaximumAndMinimumInterestRatesBeingEarnedExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfBorrowingsDerivingPriceRiskExplanatoryTableTextBlock" abstract="false" name="DisclosureOfBorrowingsDerivingPriceRiskExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfSensitivityAnalysisEffectOfIncreaseDecreaseInSharePriceTableTextBlock" abstract="false" name="DisclosureOfSensitivityAnalysisEffectOfIncreaseDecreaseInSharePriceTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfTradeAndOtherReceivablesWithCreditRiskExplanatoryTableTextBlock" abstract="false" name="DisclosureOfTradeAndOtherReceivablesWithCreditRiskExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfPoliciesRelatedToTheNumberAndWeightedAverageExercisePricesOfShareOptionsTableTextBlock" abstract="false" name="DisclosureOfPoliciesRelatedToTheNumberAndWeightedAverageExercisePricesOfShareOptionsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfAuditFeesAndNonAuditFeesExplanatoryTableTextBlock" abstract="false" name="DisclosureOfAuditFeesAndNonAuditFeesExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfSummaryOfParentEntityFinancialInformationExplanatoryTableTextBlock" abstract="false" name="DisclosureOfSummaryOfParentEntityFinancialInformationExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_CreditLineFacilityMember" abstract="true" name="CreditLineFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_BorrowingFacilitiesMaximumBorrowingCapacity" abstract="false" name="BorrowingFacilitiesMaximumBorrowingCapacity" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_BorrowingsMaturityTerm" abstract="false" name="BorrowingsMaturityTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_BorrowingFacilitiesDrawdownNumberOfTranches" abstract="false" name="BorrowingFacilitiesDrawdownNumberOfTranches" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="meso_BorrowingFacilitiesRemainingBorrowingCapacity" abstract="false" name="BorrowingFacilitiesRemainingBorrowingCapacity" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_SeniorDebtFacilityMember" abstract="true" name="SeniorDebtFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_LoanAndSecurityAgreementMember" abstract="true" name="LoanAndSecurityAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_OaktreeCapitalManagementLPMember" abstract="true" name="OaktreeCapitalManagementLPMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_NovaQuestCapitalManagementLLCMember" abstract="true" name="NovaQuestCapitalManagementLLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_AmericanDepositarySharesMember" abstract="true" name="AmericanDepositarySharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_NumberOfWarrantsGrantedToPurchaseShares" abstract="false" name="NumberOfWarrantsGrantedToPurchaseShares" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="meso_NumberOfWarrantsGrantedToPurchaseAmericanDepositaryShares" abstract="false" name="NumberOfWarrantsGrantedToPurchaseAmericanDepositaryShares" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_WarrantsPricePerShare" abstract="false" name="WarrantsPricePerShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="meso_PercentageOfPremiumForVolumeWeightedAveragePrice" abstract="false" name="PercentageOfPremiumForVolumeWeightedAveragePrice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_ClinicalTrialRelatedResearchAndDevelopmentExpense" abstract="false" name="ClinicalTrialRelatedResearchAndDevelopmentExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ManufacturingProductionAndDevelopmentExpense" abstract="false" name="ManufacturingProductionAndDevelopmentExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CommercializationExpense" abstract="false" name="CommercializationExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DefinedContributionSuperannuationExpenses" abstract="false" name="DefinedContributionSuperannuationExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DepreciationAndAmortizationOfNonCurrentAssetsAbstract" abstract="true" name="DepreciationAndAmortizationOfNonCurrentAssetsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DepreciationPropertyPlantAndEquipmentIncludingLossOnDisposalsOfPropertyPlantAndEquipment" abstract="false" name="DepreciationPropertyPlantAndEquipmentIncludingLossOnDisposalsOfPropertyPlantAndEquipment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DepreciationRightOfUseAssetsExcludingDepreciationOnCapitalizedInventory" abstract="false" name="DepreciationRightOfUseAssetsExcludingDepreciationOnCapitalizedInventory" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IntellectualPropertyAmortization" abstract="false" name="IntellectualPropertyAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_OtherManagementAndAdministrationExpensesAbstract" abstract="true" name="OtherManagementAndAdministrationExpensesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_OverheadsAndAdministrationExpenses" abstract="false" name="OverheadsAndAdministrationExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ConsultancyExpenses" abstract="false" name="ConsultancyExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_LegalPatentAndOtherProfessionalFees" abstract="false" name="LegalPatentAndOtherProfessionalFees" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IntellectualPropertyExpenses" abstract="false" name="IntellectualPropertyExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_OtherSellingGeneralAndAdministrationExpense" abstract="false" name="OtherSellingGeneralAndAdministrationExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_FairValueRemeasurementOfContingentConsiderationAbstract" abstract="true" name="FairValueRemeasurementOfContingentConsiderationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_GainsLossesOnRemeasurementOfContingentConsideration" abstract="false" name="GainsLossesOnRemeasurementOfContingentConsideration" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_FairValueRemeasurementOfWarrantLiabilityAbstract" abstract="true" name="FairValueRemeasurementOfWarrantLiabilityAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_LossGainOnRemeasurementOfWarrantLiability" abstract="false" name="LossGainOnRemeasurementOfWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_OtherOperatingIncomeAndExpensesAbstract" abstract="true" name="OtherOperatingIncomeAndExpensesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_RDTaxIncentiveIncome" abstract="false" name="RDTaxIncentiveIncome" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ForeignExchangeGainsLosses" abstract="false" name="ForeignExchangeGainsLosses" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DerecognitionOfLeaseLiability" abstract="false" name="DerecognitionOfLeaseLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DerecognitionOfRightOfUseAsset" abstract="false" name="DerecognitionOfRightOfUseAsset" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ForeignWithholdingTaxesPaid" abstract="false" name="ForeignWithholdingTaxesPaid" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_FinanceCostsGainsAbstract" abstract="true" name="FinanceCostsGainsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_FinanceCostsGainsOnRemeasurementOfBorrowingArrangements" abstract="false" name="FinanceCostsGainsOnRemeasurementOfBorrowingArrangements" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_FacilityFees" abstract="false" name="FacilityFees" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_RyoncilMember" abstract="true" name="RyoncilMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_TotalGrossToNetAdjustmentsMember" abstract="true" name="TotalGrossToNetAdjustmentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_GovernmentRebatesAndChargebacksAdjustmentsMember" abstract="true" name="GovernmentRebatesAndChargebacksAdjustmentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_DiscountsAndDistributorFeesAdjustmentMember" abstract="true" name="DiscountsAndDistributorFeesAdjustmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_OtherSalesRelatedDeductionsAdjustmentMember" abstract="true" name="OtherSalesRelatedDeductionsAdjustmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_CoPayAssistanceAdjustmentMember" abstract="true" name="CoPayAssistanceAdjustmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_RevenueFromSaleOfGoodsGross" abstract="false" name="RevenueFromSaleOfGoodsGross" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_RevenueFromSaleOfGoodsGrossPercentage" abstract="false" name="RevenueFromSaleOfGoodsGrossPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_RevenueFromSaleOfGoodsTotalGrossToNetAdjustmentsPercentage" abstract="false" name="RevenueFromSaleOfGoodsTotalGrossToNetAdjustmentsPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="meso_GovernmentRebatesAndChargebacksMember" abstract="true" name="GovernmentRebatesAndChargebacksMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_DiscountsAndDistributorFeesMember" abstract="true" name="DiscountsAndDistributorFeesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_OtherSalesRelatedDeductionsMember" abstract="true" name="OtherSalesRelatedDeductionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_CoPayAssistanceMember" abstract="true" name="CoPayAssistanceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ContractLiabilitiesGrossToNetAdjustments" abstract="false" name="ContractLiabilitiesGrossToNetAdjustments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ContractLiabilitiesPayments" abstract="false" name="ContractLiabilitiesPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IncomeStatementLocationsAxis" abstract="true" name="IncomeStatementLocationsAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_IncomeStatementLocationsDomain" abstract="true" name="IncomeStatementLocationsDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_IncomeStatementFunctionalExpenseCategoriesMember" abstract="true" name="IncomeStatementFunctionalExpenseCategoriesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ResearchAndDevelopmentMember" abstract="true" name="ResearchAndDevelopmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_DisclosureOfReconciliationOfEffectiveIncomeTaxExpenseTable" abstract="true" name="DisclosureOfReconciliationOfEffectiveIncomeTaxExpenseTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfReconciliationOfEffectiveIncomeTaxExpenseLineItems" abstract="true" name="DisclosureOfReconciliationOfEffectiveIncomeTaxExpenseLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_TaxEffectOfShareBasedCompensationExpense" abstract="false" name="TaxEffectOfShareBasedCompensationExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TaxEffectOfBonusRestructureExpense" abstract="false" name="TaxEffectOfBonusRestructureExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TaxEffectOfNonDeductibleExecutiveCompensation" abstract="false" name="TaxEffectOfNonDeductibleExecutiveCompensation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TaxEffectOfResearchAndDevelopmentTaxConcessions" abstract="false" name="TaxEffectOfResearchAndDevelopmentTaxConcessions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TaxEffectOfForeignExchangeTranslationGainsLosses" abstract="false" name="TaxEffectOfForeignExchangeTranslationGainsLosses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TaxEffectOfContingentConsideration" abstract="false" name="TaxEffectOfContingentConsideration" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TaxEffectOfRemeasurementOfWarrants" abstract="false" name="TaxEffectOfRemeasurementOfWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IncomeTaxBenefitExpenseNotRecognized" abstract="false" name="IncomeTaxBenefitExpenseNotRecognized" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CurrentTaxAbstract" abstract="true" name="CurrentTaxAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_IncreaseDecreaseInCurrentTax" abstract="false" name="IncreaseDecreaseInCurrentTax" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IncreaseDecreaseInDeferredTaxAssets" abstract="false" name="IncreaseDecreaseInDeferredTaxAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IncreaseDecreaseInDeferredTaxLiabilities" abstract="false" name="IncreaseDecreaseInDeferredTaxLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CurrentAndDeferredTaxRelatingToItemsChargedOrCreditedAmountsThatWouldBeRecognizedDirectlyInEquityIfBroughtToAccountAbstract" abstract="true" name="CurrentAndDeferredTaxRelatingToItemsChargedOrCreditedAmountsThatWouldBeRecognizedDirectlyInEquityIfBroughtToAccountAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_CurrentTaxRelatingToItemsChargedOrCreditedAmountsThatWouldBeRecognizedDirectlyInEquityIfBroughtToAccount" abstract="false" name="CurrentTaxRelatingToItemsChargedOrCreditedAmountsThatWouldBeRecognizedDirectlyInEquityIfBroughtToAccount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredTaxRelatingToItemsChargedOrCreditedAmountsThatWouldBeRecognizedDirectlyInEquityIfBroughtToAccount" abstract="false" name="DeferredTaxRelatingToItemsChargedOrCreditedAmountsThatWouldBeRecognizedDirectlyInEquityIfBroughtToAccount" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CurrentAndDeferredTaxRelatingToItemsChargedOrCreditedAmountsThatWouldBeRecognizedDirectlyInEquityIfBroughtToAccount" abstract="false" name="CurrentAndDeferredTaxRelatingToItemsChargedOrCreditedAmountsThatWouldBeRecognizedDirectlyInEquityIfBroughtToAccount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredTaxAssetsNotBroughtToAccountForUnusedTaxLossesAbstract" abstract="true" name="DeferredTaxAssetsNotBroughtToAccountForUnusedTaxLossesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DeferredTaxAssetsNotBroughtToAccountForOtherTemporaryDifferencesAbstract" abstract="true" name="DeferredTaxAssetsNotBroughtToAccountForOtherTemporaryDifferencesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DeferredTaxAssetsNotBroughtToAccountForOtherTaxCreditsAbstract" abstract="true" name="DeferredTaxAssetsNotBroughtToAccountForOtherTaxCreditsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_OtherTaxCreditsForWhichNoDeferredTaxAssetRecognised" abstract="false" name="OtherTaxCreditsForWhichNoDeferredTaxAssetRecognised" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredTaxAssetsNotBroughtToAccount" abstract="false" name="DeferredTaxAssetsNotBroughtToAccount" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredTaxAssetExpirationPeriod" abstract="false" name="DeferredTaxAssetExpirationPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_DisclosureOfFinancialAssetsAndLiabilitiesTable" abstract="true" name="DisclosureOfFinancialAssetsAndLiabilitiesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfFinancialAssetsAndLiabilitiesLineItems" abstract="true" name="DisclosureOfFinancialAssetsAndLiabilitiesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_ContingentConsiderations" abstract="false" name="ContingentConsiderations" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DepositsAtCall" abstract="false" name="DepositsAtCall" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_InterestBearingDepositsAtCallHeldAsSecurity" abstract="false" name="InterestBearingDepositsAtCallHeldAsSecurity" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_GovernmentChargebacks" abstract="false" name="GovernmentChargebacks" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_PrepaidManufacturingCosts" abstract="false" name="PrepaidManufacturingCosts" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_PrepaidInsuranceAndSubscriptions" abstract="false" name="PrepaidInsuranceAndSubscriptions" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ClinicalTrialResearchAndDevelopmentExpenditure" abstract="false" name="ClinicalTrialResearchAndDevelopmentExpenditure" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_OtherPrepayments" abstract="false" name="OtherPrepayments" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TradeReceivablesFromProductSalesSettlementPeriod" abstract="false" name="TradeReceivablesFromProductSalesSettlementPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_TradeAndOtherReceivablesSettlementPeriod" abstract="false" name="TradeAndOtherReceivablesSettlementPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_BankGuaranteeMember" abstract="true" name="BankGuaranteeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_LetterOfCreditsMember" abstract="true" name="LetterOfCreditsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SecurityDepositMember" abstract="true" name="SecurityDepositMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_TrancheAxis" abstract="true" name="TrancheAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_TrancheDomain" abstract="true" name="TrancheDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_TrancheOneMember" abstract="true" name="TrancheOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_QuarterlyPaymentsMember" abstract="true" name="QuarterlyPaymentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_FairValueOfWarrantsIssued" abstract="false" name="FairValueOfWarrantsIssued" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_WarrantExerciseTerm" abstract="false" name="WarrantExerciseTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_GainLossRecognizedRemeasurementOfBorrowingArrangements" abstract="false" name="GainLossRecognizedRemeasurementOfBorrowingArrangements" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_BorrowingsInterestOnlyPeriod" abstract="false" name="BorrowingsInterestOnlyPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_BorrowingsAmortizationOverPeriodPercentageOfPrincipal" abstract="false" name="BorrowingsAmortizationOverPeriodPercentageOfPrincipal" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_BorrowingsPrincipalAmortizationPeriod" abstract="false" name="BorrowingsPrincipalAmortizationPeriod" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_UnpaidInterestPortionPerAnnum" abstract="false" name="UnpaidInterestPortionPerAnnum" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_FinanceCostsGainsLossOnRemeasurementOfBorrowingArrangements" abstract="false" name="FinanceCostsGainsLossOnRemeasurementOfBorrowingArrangements" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_BorrowingsTerm" abstract="false" name="BorrowingsTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_BorrowingsCovenantPercentageOfSalesExceedAnnualPaymentCap" abstract="false" name="BorrowingsCovenantPercentageOfSalesExceedAnnualPaymentCap" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_LoanCovenantMinimumUnrestrictedCashBalance" abstract="false" name="LoanCovenantMinimumUnrestrictedCashBalance" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CashFlowsAdjustmentsOnDebt" abstract="false" name="CashFlowsAdjustmentsOnDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_RemeasurementAdjustmentsOnDebt" abstract="false" name="RemeasurementAdjustmentsOnDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IncreaseDecreaseInBorrowingLiabilitiesClassifiedAsFinancingActivities" abstract="false" name="IncreaseDecreaseInBorrowingLiabilitiesClassifiedAsFinancingActivities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IncreaseDecreaseInLeaseLiabilitiesArisingFromFinancingActivities" abstract="false" name="IncreaseDecreaseInLeaseLiabilitiesArisingFromFinancingActivities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DecreaseInLiabilitiesFromFinancingActivitiesLeasesAcquisitions" abstract="false" name="DecreaseInLiabilitiesFromFinancingActivitiesLeasesAcquisitions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IncreaseDecreaseThroughEffectOfChangesInForeignExchangeRatesLiabilitiesArisingFromLeases" abstract="false" name="IncreaseDecreaseThroughEffectOfChangesInForeignExchangeRatesLiabilitiesArisingFromLeases" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_WarrantLiabilityAbstract" abstract="true" name="WarrantLiabilityAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_IncreaseDecreaseFromWarrantyLiabilityClassifiedAsFinancingActivities" abstract="false" name="IncreaseDecreaseFromWarrantyLiabilityClassifiedAsFinancingActivities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_RemeasurementAdjustmentsOnWarrants" abstract="false" name="RemeasurementAdjustmentsOnWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IncreaseDecreaseThroughEffectOfChangesInForeignExchangeRatesWarrantLiability" abstract="false" name="IncreaseDecreaseThroughEffectOfChangesInForeignExchangeRatesWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_SubTotalAbstract" abstract="true" name="SubTotalAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_RemeasurementAdjustmentsOnDebtAndWarrants" abstract="false" name="RemeasurementAdjustmentsOnDebtAndWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_OtherChangesOnDebtAndLeases" abstract="false" name="OtherChangesOnDebtAndLeases" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TotalAbstract" abstract="true" name="TotalAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_EffectOfForeignExchangeAdjustmentsOnLiabilitiesArisingFromFinancingActivitiesAndCashAndCashEquivalents" abstract="false" name="EffectOfForeignExchangeAdjustmentsOnLiabilitiesArisingFromFinancingActivitiesAndCashAndCashEquivalents" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_UnlistedEquitySecuritiesMember" abstract="true" name="UnlistedEquitySecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ContingentConsiderationProvisionMember" abstract="true" name="ContingentConsiderationProvisionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_PercentageOfAssetsMeasuredAtFairValue" abstract="false" name="PercentageOfAssetsMeasuredAtFairValue" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_PercentageOfLiabilitiesMeasuredAtFairValue" abstract="false" name="PercentageOfLiabilitiesMeasuredAtFairValue" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_OsirisTherapeuticsInc.Member" abstract="true" name="OsirisTherapeuticsInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ContingentConsiderationProvision" abstract="false" name="ContingentConsiderationProvision" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ContingentConsiderationProvisionAmountPaid" abstract="false" name="ContingentConsiderationProvisionAmountPaid" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ShareIssuedLockUpPeriod" abstract="false" name="ShareIssuedLockUpPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_GainsLossesOnRemeasurementOfContingentConsiderationChangesInKeyAssumptions" abstract="false" name="GainsLossesOnRemeasurementOfContingentConsiderationChangesInKeyAssumptions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_GainsLossesOnRemeasurementOfContingentConsiderationMilestonePayment" abstract="false" name="GainsLossesOnRemeasurementOfContingentConsiderationMilestonePayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ExpectedSalesVolumeMember" abstract="true" name="ExpectedSalesVolumeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ExpectedUnitSalesPriceMeasurementInputMember" abstract="true" name="ExpectedUnitSalesPriceMeasurementInputMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ExpectedSalesVolumesMeasurementInputMember" abstract="true" name="ExpectedSalesVolumesMeasurementInputMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ProbabilityOfSuccessMeasurementInputMember" abstract="true" name="ProbabilityOfSuccessMeasurementInputMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_PaymentAssumptionsMeasurementInputMember" abstract="true" name="PaymentAssumptionsMeasurementInputMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_PercentageOfWeightedAverageOfSignificantUnobservableInputsLiabilities" abstract="false" name="PercentageOfWeightedAverageOfSignificantUnobservableInputsLiabilities" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_PercentageOfReasonablyPossibleIncreaseDecreaseInUnobservableInputLiabilities" abstract="false" name="PercentageOfReasonablyPossibleIncreaseDecreaseInUnobservableInputLiabilities" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="meso_PercentageOfReasonablyPossibleIncreaseDecreaseInFairValueMeasurementDueToChangeInUnobservableInputLiabilities" abstract="false" name="PercentageOfReasonablyPossibleIncreaseDecreaseInFairValueMeasurementDueToChangeInUnobservableInputLiabilities" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="meso_ExercisePricePerShare" abstract="false" name="ExercisePricePerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="meso_ExpectedDividendAsAPercentageContingentConsiderationValuation" abstract="false" name="ExpectedDividendAsAPercentageContingentConsiderationValuation" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_ExpectedVolatilityContingentConsiderationValuation" abstract="false" name="ExpectedVolatilityContingentConsiderationValuation" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_RiskFreeInterestRateContingentConsiderationValuation" abstract="false" name="RiskFreeInterestRateContingentConsiderationValuation" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_FairValuePerShare" abstract="false" name="FairValuePerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="meso_CashOrStockPayableAtFairValueLiabilities" abstract="false" name="CashOrStockPayableAtFairValueLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_FinancialDerivativeLiabilityAtFairValueLiabilities" abstract="false" name="FinancialDerivativeLiabilityAtFairValueLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_RoyaltyPaymentsAtFairValueLiabilities" abstract="false" name="RoyaltyPaymentsAtFairValueLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_WarrantLiabilityFairValueAtGrantDate" abstract="false" name="WarrantLiabilityFairValueAtGrantDate" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_WarrantLiabilityRemeasurement" abstract="false" name="WarrantLiabilityRemeasurement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_WarrantLiabilityWarrantsExcercised" abstract="false" name="WarrantLiabilityWarrantsExcercised" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_WarrantLiabilityForeignCurrencyTranslationReserve" abstract="false" name="WarrantLiabilityForeignCurrencyTranslationReserve" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_November2021WarrantsMember" abstract="true" name="November2021WarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_December2022WarrantsMember" abstract="true" name="December2022WarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_RefinancingAndExpansionOfSeniorDebtFacilityMember" abstract="true" name="RefinancingAndExpansionOfSeniorDebtFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_NumberOfWarrantsIssuedToPurchaseAmericanDepositaryShares" abstract="false" name="NumberOfWarrantsIssuedToPurchaseAmericanDepositaryShares" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_IssuanceWarrantsExercisedPeriod" abstract="false" name="IssuanceWarrantsExercisedPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_NumberOfWarrantsExercised" abstract="false" name="NumberOfWarrantsExercised" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_NumberOfOrdinarySharesPerWarrant" abstract="false" name="NumberOfOrdinarySharesPerWarrant" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_WarrantsFairValueAtIssueDate" abstract="false" name="WarrantsFairValueAtIssueDate" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_GainLossOnRemeasurementOfWarrantLiability" abstract="false" name="GainLossOnRemeasurementOfWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_WarrantsCreditLineFacilityMember" abstract="true" name="WarrantsCreditLineFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ExercisePriceOfOtherEquityInstrumentsInShareBasedPaymentArrangement" abstract="false" name="ExercisePriceOfOtherEquityInstrumentsInShareBasedPaymentArrangement" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="meso_ExpectedTermOfOtherEquityInstrumentsGranted" abstract="false" name="ExpectedTermOfOtherEquityInstrumentsGranted" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_ExpectedDividendAsPercentageOtherEquityInstrumentsGranted" abstract="false" name="ExpectedDividendAsPercentageOtherEquityInstrumentsGranted" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_ExpectedVolatilityOtherEquityInstrumentsGranted" abstract="false" name="ExpectedVolatilityOtherEquityInstrumentsGranted" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_RiskFreeInterestRateOtherEquityInstruments" abstract="false" name="RiskFreeInterestRateOtherEquityInstruments" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_FairValuePerWarrant" abstract="false" name="FairValuePerWarrant" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="meso_FairValueOfWarrants" abstract="false" name="FairValueOfWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_PlantAndEquipmentMember" abstract="true" name="PlantAndEquipmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ManufacturingMember" abstract="true" name="ManufacturingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_IncreaseDecreaseThroughRemeasurementRightOfUseAssets" abstract="false" name="IncreaseDecreaseThroughRemeasurementRightOfUseAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ManufacturingExcludingDepreciationOnCapitalizedInventoryMember" abstract="true" name="ManufacturingExcludingDepreciationOnCapitalizedInventoryMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_LonzaBioscienceSingaporePteLtdMember" abstract="true" name="LonzaBioscienceSingaporePteLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ManufacturingServiceAgreementMember" abstract="true" name="ManufacturingServiceAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_DepreciationCapitalizedIntoInventory" abstract="false" name="DepreciationCapitalizedIntoInventory" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_NonCancellableTermOfLeaseAndNonLeaseComponents" abstract="false" name="NonCancellableTermOfLeaseAndNonLeaseComponents" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_MinimumFinancialCommitmentOfLeaseComponent" abstract="false" name="MinimumFinancialCommitmentOfLeaseComponent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_PrivatePlacementOfSharesMember" abstract="true" name="PrivatePlacementOfSharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SharesAvailableForAcquisitionOfIntangibleAssetShares" abstract="false" name="SharesAvailableForAcquisitionOfIntangibleAssetShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_CardiovascularProductsMember" abstract="true" name="CardiovascularProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_IntravenousProductsMember" abstract="true" name="IntravenousProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_PatentAndLicenseMember" abstract="true" name="PatentAndLicenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_MarketedProductsMember" abstract="true" name="MarketedProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_AngioblastSystemsIncMember" abstract="true" name="AngioblastSystemsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_OsirisMSCTwoThousandThirteenMember" abstract="true" name="OsirisMSCTwoThousandThirteenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_OsirisMSCTwoThousandFifteenMember" abstract="true" name="OsirisMSCTwoThousandFifteenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_TEMCELLAssetMember" abstract="true" name="TEMCELLAssetMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_MPCMICROIOAndMPCCBEMember" abstract="true" name="MPCMICROIOAndMPCCBEMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_NumberOfAcquisition" abstract="false" name="NumberOfAcquisition" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="meso_NumberOfReportableOperatingSegment" abstract="false" name="NumberOfReportableOperatingSegment" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="meso_InProcessResearchAndDevelopmentRecognized" abstract="false" name="InProcessResearchAndDevelopmentRecognized" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_PostTaxDiscountRates" abstract="false" name="PostTaxDiscountRates" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_ExpectedPatentExpiry" abstract="false" name="ExpectedPatentExpiry" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_EmployeeBenefits1Member" abstract="true" name="EmployeeBenefits1Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ProvisionForLicenseAgreementsMember" abstract="true" name="ProvisionForLicenseAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ProvisionsAndOtherLiabilities" abstract="false" name="ProvisionsAndOtherLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CurrentProvisionsForAccruedAnnualLeave" abstract="false" name="CurrentProvisionsForAccruedAnnualLeave" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CurrentProvisionsForShortTermIncentives" abstract="false" name="CurrentProvisionsForShortTermIncentives" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredTaxAssetsAbstract" abstract="true" name="DeferredTaxAssetsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DeferredTaxAssetsAttributableToTemporaryDifferencesFromTaxLosses" abstract="false" name="DeferredTaxAssetsAttributableToTemporaryDifferencesFromTaxLosses" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredTaxAssetsAttributableToOtherTemporaryDifferences" abstract="false" name="DeferredTaxAssetsAttributableToOtherTemporaryDifferences" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredTaxLiabilityAbstract" abstract="true" name="DeferredTaxLiabilityAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DeferredTaxLiabilitiesAttributableToTemporaryDifferencesFromIntangibleAssets" abstract="false" name="DeferredTaxLiabilitiesAttributableToTemporaryDifferencesFromIntangibleAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredTaxAssetsAndLiabilitiesTable" abstract="true" name="DeferredTaxAssetsAndLiabilitiesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_TaxLossesMember" abstract="true" name="TaxLossesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_IntangibleAssetsMember" abstract="true" name="IntangibleAssetsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_DeferredTaxAssetsAndLiabilitiesLineItems" abstract="true" name="DeferredTaxAssetsAndLiabilitiesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DeferredTaxAssetsAndLiabilitiesRelatingToChargedOrCreditedAbstract" abstract="true" name="DeferredTaxAssetsAndLiabilitiesRelatingToChargedOrCreditedAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_NetMovementInRegulatoryDeferralAccountBalancesRelatedToDirectlyToEquity" abstract="false" name="NetMovementInRegulatoryDeferralAccountBalancesRelatedToDirectlyToEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredConsideration" abstract="false" name="DeferredConsideration" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredConsiderationRevenueRecognized" abstract="false" name="DeferredConsiderationRevenueRecognized" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_MilestoneRevenue" abstract="false" name="MilestoneRevenue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_InventoriesGross" abstract="false" name="InventoriesGross" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_InventoriesObsoleteStockProvision" abstract="false" name="InventoriesObsoleteStockProvision" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TreasurySharesPurchased" abstract="false" name="TreasurySharesPurchased" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_OrdinarySharesPurchasedValue" abstract="false" name="OrdinarySharesPurchasedValue" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TreasurySharesPurchasedValue" abstract="false" name="TreasurySharesPurchasedValue" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_PlacementAgreementMember" abstract="true" name="PlacementAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ReconciliationOfShareCapitalNumberOfSharesAbstract" abstract="true" name="ReconciliationOfShareCapitalNumberOfSharesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_NumberOfSharesTransferredToEmployeeShareTrust" abstract="false" name="NumberOfSharesTransferredToEmployeeShareTrust" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_EntitlementOfferToExistingEligibleShareholdersAndInstitutionalPlacementShares" abstract="false" name="EntitlementOfferToExistingEligibleShareholdersAndInstitutionalPlacementShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_SharesAvailableForIssuanceUnderIssuancePlanShares" abstract="false" name="SharesAvailableForIssuanceUnderIssuancePlanShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_ShareBasedCompensationForContingentConsiderationShares" abstract="false" name="ShareBasedCompensationForContingentConsiderationShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="meso_PlacementOfSharesForExerciseOfWarrantsShares" abstract="false" name="PlacementOfSharesForExerciseOfWarrantsShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_TransactionCostsArisingOnShareIssueShare" abstract="false" name="TransactionCostsArisingOnShareIssueShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_NumberOfSharesReservedForIssueUnderSharePlacementAgreement" abstract="false" name="NumberOfSharesReservedForIssueUnderSharePlacementAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_NumberOfSharesUnissuedAndFullyPaid" abstract="false" name="NumberOfSharesUnissuedAndFullyPaid" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_ContributionsOfEquityDuringPeriodShares" abstract="false" name="ContributionsOfEquityDuringPeriodShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="meso_ShareOptionsReserveTransferredToEquityOnExerciseOfOptionsShares" abstract="false" name="ShareOptionsReserveTransferredToEquityOnExerciseOfOptionsShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_SharesTransferredToEmployeeShareTrustValue" abstract="false" name="SharesTransferredToEmployeeShareTrustValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_EntitlementOfferToExistingEligibleShareholdersAndInstitutionalPlacementValue" abstract="false" name="EntitlementOfferToExistingEligibleShareholdersAndInstitutionalPlacementValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_SharesReservedForAcquisitionOfIntangibleAssetValue" abstract="false" name="SharesReservedForAcquisitionOfIntangibleAssetValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_SharesReservedForIssueUnderSharePlacementAgreementValue" abstract="false" name="SharesReservedForIssueUnderSharePlacementAgreementValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ShareBasedCompensationForContingentConsiderationValue" abstract="false" name="ShareBasedCompensationForContingentConsiderationValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TransactionCostsArisingOnShareIssueValue" abstract="false" name="TransactionCostsArisingOnShareIssueValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_NumberOfSharesIssuedAndFullyPaidValue" abstract="false" name="NumberOfSharesIssuedAndFullyPaidValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_NumberOfUnissuedSharesReservedForIssueUnderSharePlacementAgreementValue" abstract="false" name="NumberOfUnissuedSharesReservedForIssueUnderSharePlacementAgreementValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_NumberOfSharesUnissuedValue" abstract="false" name="NumberOfSharesUnissuedValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ContributionsOfValueForEquityDuringPeriodValue" abstract="false" name="ContributionsOfValueForEquityDuringPeriodValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ShareOptionsReserveTransferredToEquityOnExerciseOfOptionsValue" abstract="false" name="ShareOptionsReserveTransferredToEquityOnExerciseOfOptionsValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ChiefMedicalOfficerMember" abstract="true" name="ChiefMedicalOfficerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_AmericanDepositorySharesMember" abstract="true" name="AmericanDepositorySharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ConversionRatioOfShares" abstract="false" name="ConversionRatioOfShares" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_SaleOfEquityPricePerShare" abstract="false" name="SaleOfEquityPricePerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="meso_NumberOfWarrantsExcercised" abstract="false" name="NumberOfWarrantsExcercised" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_NumberOfOrdinarySharesPerADSWarrant" abstract="false" name="NumberOfOrdinarySharesPerADSWarrant" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_DisclosureOfMovementsOfSharesInShareTrustTable" abstract="true" name="DisclosureOfMovementsOfSharesInShareTrustTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_MesoblastEmployeeShareTrustMember" abstract="true" name="MesoblastEmployeeShareTrustMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_DisclosureOfMovementsOfSharesInShareTrustLineItems" abstract="true" name="DisclosureOfMovementsOfSharesInShareTrustLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_SharesHeldInTrust" abstract="false" name="SharesHeldInTrust" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_SharesHeldInTrustValue" abstract="false" name="SharesHeldInTrustValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TransferToEmployeeShareTrust" abstract="false" name="TransferToEmployeeShareTrust" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ReserveOfWarrantsMember" abstract="true" name="ReserveOfWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ValueOfShareOptionsExercisedInSharebasedPaymentArrangement" abstract="false" name="ValueOfShareOptionsExercisedInSharebasedPaymentArrangement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_EquityReserveAtFairValue" abstract="false" name="EquityReserveAtFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ConvertibleNoteSubscriptionAgreementWarrantsMember" abstract="true" name="ConvertibleNoteSubscriptionAgreementWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_NumberOfVotesPerOrdinaryShareHeld" abstract="false" name="NumberOfVotesPerOrdinaryShareHeld" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="meso_MaturityTermOfShareBasedPaymentArrangement" abstract="false" name="MaturityTermOfShareBasedPaymentArrangement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_NumberOfWarrantsAtIssueDate" abstract="false" name="NumberOfWarrantsAtIssueDate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_FairValueRemeasurementOfContingentConsiderationAfterTax" abstract="false" name="FairValueRemeasurementOfContingentConsiderationAfterTax" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_OtherNonCashCostOfFinanceClassifiedAsFinancingActivities" abstract="false" name="OtherNonCashCostOfFinanceClassifiedAsFinancingActivities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_AdjustmentsForLossesGainsOnDisposalOfIntangibleAssets" abstract="false" name="AdjustmentsForLossesGainsOnDisposalOfIntangibleAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_RemeasurementOfWarrantLiabilities" abstract="false" name="RemeasurementOfWarrantLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_AdjustmentForGainOnDerecognitionOfLease" abstract="false" name="AdjustmentForGainOnDerecognitionOfLease" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_AdjustmentForLossOnDerecognitionOfSublease" abstract="false" name="AdjustmentForLossOnDerecognitionOfSublease" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_AdjustmentsForRestructureOfShortTermIncentive" abstract="false" name="AdjustmentsForRestructureOfShortTermIncentive" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_AdjustmentForPreLaunchInventory" abstract="false" name="AdjustmentForPreLaunchInventory" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ChangeInOperatingAssetsAndLiabilitiesAbstract" abstract="true" name="ChangeInOperatingAssetsAndLiabilitiesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_AdjustmentsForIncreaseDecreaseInPrepayments" abstract="false" name="AdjustmentsForIncreaseDecreaseInPrepayments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_AdjustmentsForIncreaseDecreaseInTradeCreditorsAndAccruals" abstract="false" name="AdjustmentsForIncreaseDecreaseInTradeCreditorsAndAccruals" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_PercentageOfCashHeld" abstract="false" name="PercentageOfCashHeld" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_RiskExposureAssociatedWithInstrumentsSharingCharacteristicConcentrationPercentage" abstract="false" name="RiskExposureAssociatedWithInstrumentsSharingCharacteristicConcentrationPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_NonInterestBearingFinancialLiabilitiesMaturityPeriod" abstract="false" name="NonInterestBearingFinancialLiabilitiesMaturityPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_DisclosureOfEffectOfChangesInForeignExchangeRatesTable" abstract="true" name="DisclosureOfEffectOfChangesInForeignExchangeRatesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_BankAccountsMember" abstract="true" name="BankAccountsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_TradeAndOtherReceivablesMember" abstract="true" name="TradeAndOtherReceivablesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_TradePayablesAndAccrualsMember" abstract="true" name="TradePayablesAndAccrualsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ProvisionsMember" abstract="true" name="ProvisionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_BorrowingMember" abstract="true" name="BorrowingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_IncreaseInTwentyPercentageMember" abstract="true" name="IncreaseInTwentyPercentageMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_DecreaseInTwentyPercentageMember" abstract="true" name="DecreaseInTwentyPercentageMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_DisclosureOfEffectOfChangesInForeignExchangeRatesLineItems" abstract="true" name="DisclosureOfEffectOfChangesInForeignExchangeRatesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfFinancialRiskManagementTable" abstract="true" name="DisclosureOfFinancialRiskManagementTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfFinancialRiskManagementLineItems" abstract="true" name="DisclosureOfFinancialRiskManagementLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_EffectOnProfitFromChangeInTaxRate" abstract="false" name="EffectOnProfitFromChangeInTaxRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_FundsInvestedPercentage" abstract="false" name="FundsInvestedPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_FundsInvestedWhichDerivesInterestRevenue" abstract="false" name="FundsInvestedWhichDerivesInterestRevenue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_EffectOnProfitFromChangeInInterestRateIncreaseOrDecrease" abstract="false" name="EffectOnProfitFromChangeInInterestRateIncreaseOrDecrease" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_IncreaseInInterestRatePercentage" abstract="false" name="IncreaseInInterestRatePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_IncreaseInInterestRateOnFundsInvestedWhichDerivesInterestRevenue" abstract="false" name="IncreaseInInterestRateOnFundsInvestedWhichDerivesInterestRevenue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DecreaseInInterestRatePercentage" abstract="false" name="DecreaseInInterestRatePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_DecreaseInInterestRateOnFundsInvestedWhichDerivesInterestRevenue" abstract="false" name="DecreaseInInterestRateOnFundsInvestedWhichDerivesInterestRevenue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_PercentageOfPriceRateChangesInCurrentBorrowings" abstract="false" name="PercentageOfPriceRateChangesInCurrentBorrowings" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_PercentageOfPriceRateChangesInNonCurrentBorrowings" abstract="false" name="PercentageOfPriceRateChangesInNonCurrentBorrowings" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_PercentageOfPriceRateChangesInBorrowings" abstract="false" name="PercentageOfPriceRateChangesInBorrowings" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_PercentageOfIncreaseAndDecreaseInSharePrice" abstract="false" name="PercentageOfIncreaseAndDecreaseInSharePrice" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_SensitivityAnalysisForTypesOfMarketRiskReasonablyPossibleIncreaseInRiskVariableImpactOnEarningsWarrantLiability" abstract="false" name="SensitivityAnalysisForTypesOfMarketRiskReasonablyPossibleIncreaseInRiskVariableImpactOnEarningsWarrantLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_SensitivityAnalysisForTypesOfMarketRiskReasonablyPossibleDecreaseInRiskVariableImpactOnEarningsWarrantLiability" abstract="false" name="SensitivityAnalysisForTypesOfMarketRiskReasonablyPossibleDecreaseInRiskVariableImpactOnEarningsWarrantLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_SensitivityAnalysisForTypesOfMarketRiskReasonablyPossibleIncreaseInRiskVariableImpactOnEarningsDerivativeFinancialLiabilities" abstract="false" name="SensitivityAnalysisForTypesOfMarketRiskReasonablyPossibleIncreaseInRiskVariableImpactOnEarningsDerivativeFinancialLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_SensitivityAnalysisForTypesOfMarketRiskReasonablyPossibleDecreaseInRiskVariableImpactOnEarningsDerivativeFinancialLiability" abstract="false" name="SensitivityAnalysisForTypesOfMarketRiskReasonablyPossibleDecreaseInRiskVariableImpactOnEarningsDerivativeFinancialLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ARatedMember" abstract="true" name="ARatedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_UnratedMember" abstract="true" name="UnratedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ReceivablesFromOtherParties" abstract="false" name="ReceivablesFromOtherParties" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ReceivablesFromForeignWithholdingTax" abstract="false" name="ReceivablesFromForeignWithholdingTax" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ReceivablesFromBankDeposits" abstract="false" name="ReceivablesFromBankDeposits" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ReceivablesFromIncomeTax" abstract="false" name="ReceivablesFromIncomeTax" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ReceivablesFromOtherNoncurrentTaxCredits" abstract="false" name="ReceivablesFromOtherNoncurrentTaxCredits" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TradePayablesMember" abstract="true" name="TradePayablesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_MesoblastIncMember" abstract="true" name="MesoblastIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_MesoblastInternationalSarlMember" abstract="true" name="MesoblastInternationalSarlMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_MesoblastAustraliaPtyLtdMember" abstract="true" name="MesoblastAustraliaPtyLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_MesoblastUKLtdMember" abstract="true" name="MesoblastUKLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_BeiCellLtdMember" abstract="true" name="BeiCellLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_DisclosureOfContingentAssetsAndLiabilitiesTable" abstract="true" name="DisclosureOfContingentAssetsAndLiabilitiesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_CentralAdelaideLocalHealthNetworkIncorporatedMember" abstract="true" name="CentralAdelaideLocalHealthNetworkIncorporatedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_DisclosureOfContingentAssetsAndLiabilitiesLineItems" abstract="true" name="DisclosureOfContingentAssetsAndLiabilitiesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_ContingentAssetsOutstanding" abstract="false" name="ContingentAssetsOutstanding" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_MilestonePayment" abstract="false" name="MilestonePayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CommitmentsTable" abstract="true" name="CommitmentsTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_CommitmentsLineItems" abstract="true" name="CommitmentsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_FutureCapitalExpenditureCommitmentsOutstanding" abstract="false" name="FutureCapitalExpenditureCommitmentsOutstanding" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_MinimumRemainingFinancialCommitmentOfNonLeaseComponentOnExerciseOfOptionToExtendNonCancellableTerm" abstract="false" name="MinimumRemainingFinancialCommitmentOfNonLeaseComponentOnExerciseOfOptionToExtendNonCancellableTerm" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_MinimumFinancialCommitmentOfLeaseComponentOnExerciseOfOptionToExtendNonCancellableTerm" abstract="false" name="MinimumFinancialCommitmentOfLeaseComponentOnExerciseOfOptionToExtendNonCancellableTerm" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_NonCancellablePurchaseCommitments" abstract="false" name="NonCancellablePurchaseCommitments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_OtherPurchaseCommitments" abstract="false" name="OtherPurchaseCommitments" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_StrategicAdvisoryRoleMember" abstract="true" name="StrategicAdvisoryRoleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_KeyManagementPersonnelCompensationMonthlyRetainerFee" abstract="false" name="KeyManagementPersonnelCompensationMonthlyRetainerFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_OriginalIssueDiscountOnCreditLineFacilityRelatedPartyTransaction" abstract="false" name="OriginalIssueDiscountOnCreditLineFacilityRelatedPartyTransaction" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TransactionCostOnCreditLineFacilityRelatedPartyTransaction" abstract="false" name="TransactionCostOnCreditLineFacilityRelatedPartyTransaction" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_AmountsPayableRelatedPartyTransactionsPercentagePayableOnSigning" abstract="false" name="AmountsPayableRelatedPartyTransactionsPercentagePayableOnSigning" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_TransactionCostsRelatedParties" abstract="false" name="TransactionCostsRelatedParties" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_AmortizationOfCarryingAmountRelatedParties" abstract="false" name="AmortizationOfCarryingAmountRelatedParties" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_InterestPaidRelatedParties" abstract="false" name="InterestPaidRelatedParties" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DisclosureOfReconciliationOfOutstandingShareBasedPaymentsTable" abstract="true" name="DisclosureOfReconciliationOfOutstandingShareBasedPaymentsTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_TrancheTwoMember" abstract="true" name="TrancheTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_TrancheThreeMember" abstract="true" name="TrancheThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_IssuesGrantedSinceJulyOneTwoThousandFifteenMember" abstract="true" name="IssuesGrantedSinceJulyOneTwoThousandFifteenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_DisclosureOfReconciliationOfOutstandingShareBasedPaymentsLineItems" abstract="true" name="DisclosureOfReconciliationOfOutstandingShareBasedPaymentsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_NumberOfTranches" abstract="false" name="NumberOfTranches" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="meso_VestingRequirementsForShareBasedPaymentArrangementVestingPercentage" abstract="false" name="VestingRequirementsForShareBasedPaymentArrangementVestingPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="meso_VestingRequirementsForShareBasedPaymentArrangementVestingPeriod" abstract="false" name="VestingRequirementsForShareBasedPaymentArrangementVestingPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_PercentageOfPremiumAttachedWithTimeBasedVestingConditionOptions" abstract="false" name="PercentageOfPremiumAttachedWithTimeBasedVestingConditionOptions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_PercentageOfPremiumAttachedWithPerformanceBasedVestingConditionOptions" abstract="false" name="PercentageOfPremiumAttachedWithPerformanceBasedVestingConditionOptions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_EmployeeShareOptionPlanMaximumNumberOfOptionsAvailableForIssuance" abstract="false" name="EmployeeShareOptionPlanMaximumNumberOfOptionsAvailableForIssuance" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_MaximumPercentageOfTotalIssuedCapitalFromESOPOptionsGranted" abstract="false" name="MaximumPercentageOfTotalIssuedCapitalFromESOPOptionsGranted" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_WeightedAverageRemainingContractualLifeOfOutstandingShareOptionsAndLoanFunded" abstract="false" name="WeightedAverageRemainingContractualLifeOfOutstandingShareOptionsAndLoanFunded" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_NumberOfTranchesOfSharePlanGranted" abstract="false" name="NumberOfTranchesOfSharePlanGranted" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="meso_ExpiryTermOfOptions" abstract="false" name="ExpiryTermOfOptions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_TrancheVestingTerm" abstract="false" name="TrancheVestingTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_OptionExerciseTermInConnectionWithCessationOfEmployment" abstract="false" name="OptionExerciseTermInConnectionWithCessationOfEmployment" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_ExercisePriceOfOutstandingShareOptionsReductionPerOptionModificationsToShareBasedPaymentArrangements" abstract="false" name="ExercisePriceOfOutstandingShareOptionsReductionPerOptionModificationsToShareBasedPaymentArrangements" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="meso_DividendYieldOnSharesUnderlyingOptions" abstract="false" name="DividendYieldOnSharesUnderlyingOptions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_ClosingShareMarketPriceOfOrdinaryShare" abstract="false" name="ClosingShareMarketPriceOfOrdinaryShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="meso_SeriesThirtyFiveAMember" abstract="true" name="SeriesThirtyFiveAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesThirtySixMember" abstract="true" name="SeriesThirtySixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_Series36aMember" abstract="true" name="Series36aMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesThirtyEightMember" abstract="true" name="SeriesThirtyEightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesThirtyNineMember" abstract="true" name="SeriesThirtyNineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_Series39aMember" abstract="true" name="Series39aMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFortyMember" abstract="true" name="SeriesFortyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFortyAMember" abstract="true" name="SeriesFortyAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFortyOneMember" abstract="true" name="SeriesFortyOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFortyTwoMember" abstract="true" name="SeriesFortyTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFortyThreeMember" abstract="true" name="SeriesFortyThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFortyThreeBMember" abstract="true" name="SeriesFortyThreeBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFortyFiveMember" abstract="true" name="SeriesFortyFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFortySixMember" abstract="true" name="SeriesFortySixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFortySevenMember" abstract="true" name="SeriesFortySevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFortyEightMember" abstract="true" name="SeriesFortyEightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFortyNineMember" abstract="true" name="SeriesFortyNineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFortyNineAMember" abstract="true" name="SeriesFortyNineAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFortyNineBMember" abstract="true" name="SeriesFortyNineBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFortyNineCMember" abstract="true" name="SeriesFortyNineCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFiftyMember" abstract="true" name="SeriesFiftyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFiftyFourMember" abstract="true" name="SeriesFiftyFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_Series55Member" abstract="true" name="Series55Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFiftySixMember" abstract="true" name="SeriesFiftySixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFiftySevenMember" abstract="true" name="SeriesFiftySevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFiftyEightMember" abstract="true" name="SeriesFiftyEightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesFiftyNineMember" abstract="true" name="SeriesFiftyNineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSixtyThreeMember" abstract="true" name="SeriesSixtyThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_Series63aMember" abstract="true" name="Series63aMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSixtyFourMember" abstract="true" name="SeriesSixtyFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSixtyFourAMember" abstract="true" name="SeriesSixtyFourAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSixtyFourCMember" abstract="true" name="SeriesSixtyFourCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSixtyFourDMember" abstract="true" name="SeriesSixtyFourDMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSixtyFourEMember" abstract="true" name="SeriesSixtyFourEMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSixtySixMember" abstract="true" name="SeriesSixtySixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSixtyEightMember" abstract="true" name="SeriesSixtyEightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSixtyNineMember" abstract="true" name="SeriesSixtyNineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSeventyOneMember" abstract="true" name="SeriesSeventyOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSeventyTwoMember" abstract="true" name="SeriesSeventyTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSeventyFourMember" abstract="true" name="SeriesSeventyFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSeventyFourOneMember" abstract="true" name="SeriesSeventyFourOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSeventyFourAMember" abstract="true" name="SeriesSeventyFourAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSeventyFourBMember" abstract="true" name="SeriesSeventyFourBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSeventyFiveMember" abstract="true" name="SeriesSeventyFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSeventySixMember" abstract="true" name="SeriesSeventySixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSeventySevenMember" abstract="true" name="SeriesSeventySevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSeventyEightMember" abstract="true" name="SeriesSeventyEightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSeventyNineMember" abstract="true" name="SeriesSeventyNineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSeventyNineOneMember" abstract="true" name="SeriesSeventyNineOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSeventyNineAMember" abstract="true" name="SeriesSeventyNineAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSeventyNineBMember" abstract="true" name="SeriesSeventyNineBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSeventyNineCMember" abstract="true" name="SeriesSeventyNineCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesSeventyNineDMember" abstract="true" name="SeriesSeventyNineDMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesEightyMember" abstract="true" name="SeriesEightyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesEightyOneMember" abstract="true" name="SeriesEightyOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesEightyTwoMember" abstract="true" name="SeriesEightyTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesEightyThreeMember" abstract="true" name="SeriesEightyThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesEightyFourMember" abstract="true" name="SeriesEightyFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesEightyFiveMember" abstract="true" name="SeriesEightyFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesEightySixMember" abstract="true" name="SeriesEightySixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesEightySevenMember" abstract="true" name="SeriesEightySevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesEightySevenAMember" abstract="true" name="SeriesEightySevenAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_Series87bMember" abstract="true" name="Series87bMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_Series87cMember" abstract="true" name="Series87cMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesEightyEightMember" abstract="true" name="SeriesEightyEightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesEightyNineMember" abstract="true" name="SeriesEightyNineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetyMember" abstract="true" name="SeriesNinetyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetyOneMember" abstract="true" name="SeriesNinetyOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetyTwoMember" abstract="true" name="SeriesNinetyTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetyThreeMember" abstract="true" name="SeriesNinetyThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetyFourMember" abstract="true" name="SeriesNinetyFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetyFiveMember" abstract="true" name="SeriesNinetyFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetySixMember" abstract="true" name="SeriesNinetySixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetySixAMember" abstract="true" name="SeriesNinetySixAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetySixAOneMember" abstract="true" name="SeriesNinetySixAOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetySixBMember" abstract="true" name="SeriesNinetySixBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetySixCMember" abstract="true" name="SeriesNinetySixCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetySixDMember" abstract="true" name="SeriesNinetySixDMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetySixDOneMember" abstract="true" name="SeriesNinetySixDOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetySevenMember" abstract="true" name="SeriesNinetySevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_Series97aMember" abstract="true" name="Series97aMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_Series97bMember" abstract="true" name="Series97bMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetySevenCMember" abstract="true" name="SeriesNinetySevenCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetySevenDMember" abstract="true" name="SeriesNinetySevenDMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetyEightMember" abstract="true" name="SeriesNinetyEightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesNinetyNineMember" abstract="true" name="SeriesNinetyNineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredMember" abstract="true" name="SeriesOneHundredMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndOneMember" abstract="true" name="SeriesOneHundredAndOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndTwoMember" abstract="true" name="SeriesOneHundredAndTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndThreeMember" abstract="true" name="SeriesOneHundredAndThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndFourMember" abstract="true" name="SeriesOneHundredAndFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_Series105Member" abstract="true" name="Series105Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndSixMember" abstract="true" name="SeriesOneHundredAndSixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndSevenMember" abstract="true" name="SeriesOneHundredAndSevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndEightMember" abstract="true" name="SeriesOneHundredAndEightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndNineMember" abstract="true" name="SeriesOneHundredAndNineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndTenMember" abstract="true" name="SeriesOneHundredAndTenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndTenAMember" abstract="true" name="SeriesOneHundredAndTenAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndTenBMember" abstract="true" name="SeriesOneHundredAndTenBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndTenCMember" abstract="true" name="SeriesOneHundredAndTenCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndElevenMember" abstract="true" name="SeriesOneHundredAndElevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndTwelveMember" abstract="true" name="SeriesOneHundredAndTwelveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndThirteenMember" abstract="true" name="SeriesOneHundredAndThirteenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndFourteenMember" abstract="true" name="SeriesOneHundredAndFourteenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndFifteenMember" abstract="true" name="SeriesOneHundredAndFifteenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndSixteenMember" abstract="true" name="SeriesOneHundredAndSixteenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndSeventeenMember" abstract="true" name="SeriesOneHundredAndSeventeenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndEighteenMember" abstract="true" name="SeriesOneHundredAndEighteenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_SeriesOneHundredAndNineteenMember" abstract="true" name="SeriesOneHundredAndNineteenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_WeightedAverageSharePriceExercisableInShareBasedPaymentArrangement" abstract="false" name="WeightedAverageSharePriceExercisableInShareBasedPaymentArrangement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="meso_Series109Member" abstract="true" name="Series109Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_Series110aMember" abstract="true" name="Series110aMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_Series110bMember" abstract="true" name="Series110bMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_Series110cAnd111Member" abstract="true" name="Series110cAnd111Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_Series116Member" abstract="true" name="Series116Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_Series119Member" abstract="true" name="Series119Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_TrancheFourMember" abstract="true" name="TrancheFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_TrancheSevenMember" abstract="true" name="TrancheSevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_NumberOfEqualTranchesVestOnDate" abstract="false" name="NumberOfEqualTranchesVestOnDate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="meso_NumberOfTranchesOfShareBasedPaymentArrangement" abstract="false" name="NumberOfTranchesOfShareBasedPaymentArrangement" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="meso_SharePriceAtValuationDate" abstract="false" name="SharePriceAtValuationDate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="meso_ExpectedLifeAfterFactoring" abstract="false" name="ExpectedLifeAfterFactoring" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_DisclosureOfAuditorsRemunerationTable" abstract="true" name="DisclosureOfAuditorsRemunerationTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_PriceWaterHouseCoopersMember" abstract="true" name="PriceWaterHouseCoopersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_NetworkFirmsOfPriceWaterHouseCoopersMember" abstract="true" name="NetworkFirmsOfPriceWaterHouseCoopersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_DisclosureOfAuditorsRemunerationLineItems" abstract="true" name="DisclosureOfAuditorsRemunerationLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_AuditorsRemunerationForOtherAuditServices" abstract="false" name="AuditorsRemunerationForOtherAuditServices" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_AuditorsRemunerationAuditAndOtherAssuranceServices" abstract="false" name="AuditorsRemunerationAuditAndOtherAssuranceServices" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_AuditorsRemunerationOtherNonAuditServices" abstract="false" name="AuditorsRemunerationOtherNonAuditServices" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DisclosureOfParentEntityFinancialInformationTable" abstract="true" name="DisclosureOfParentEntityFinancialInformationTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfParentEntityFinancialInformationLineItems" abstract="true" name="DisclosureOfParentEntityFinancialInformationLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_OtherReservesAbstract" abstract="true" name="OtherReservesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_NumberOfOperatingSegment" abstract="false" name="NumberOfOperatingSegment" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="meso_DisclosureOfSummaryOfSignificantAccountingPoliciesTable" abstract="true" name="DisclosureOfSummaryOfSignificantAccountingPoliciesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_GrunenthalGmbHMember" abstract="true" name="GrunenthalGmbHMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_TaslyMember" abstract="true" name="TaslyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_TiGenixNVMember" abstract="true" name="TiGenixNVMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_JCRPharmaceuticalsCoLTDMember" abstract="true" name="JCRPharmaceuticalsCoLTDMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ClinicalManufacturingRegulatoryAndReimbursementApprovalMember" abstract="true" name="ClinicalManufacturingRegulatoryAndReimbursementApprovalMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_DisclosureOfSummaryOfSignificantAccountingPoliciesLineItems" abstract="true" name="DisclosureOfSummaryOfSignificantAccountingPoliciesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_NonRefundableUpFrontPaymentReceived" abstract="false" name="NonRefundableUpFrontPaymentReceived" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_MilestonePaymentReceived" abstract="false" name="MilestonePaymentReceived" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_NonRefundableUpfrontPaymentsReceivable" abstract="false" name="NonRefundableUpfrontPaymentsReceivable" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CumulativeMilestonePaymentsReachableAmount" abstract="false" name="CumulativeMilestonePaymentsReachableAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_RevenueRecognizedRelationToPatentLicenseAgreement" abstract="false" name="RevenueRecognizedRelationToPatentLicenseAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredConsiderationMilestoneConsiderationRecognized" abstract="false" name="DeferredConsiderationMilestoneConsiderationRecognized" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_RevenueRecognizedFromUpfrontPaymentAsDeferredConsideration" abstract="false" name="RevenueRecognizedFromUpfrontPaymentAsDeferredConsideration" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_AmountEntitledToBeReceivedOnNonRefundableUpfrontPaymentUponReachingProductRegulatoryMilestone" abstract="false" name="AmountEntitledToBeReceivedOnNonRefundableUpfrontPaymentUponReachingProductRegulatoryMilestone" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_NumberOfEscalatingMilestonePayments" abstract="false" name="NumberOfEscalatingMilestonePayments" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="meso_MilestoneRevenueInRelationToPatentLicenseAgreement" abstract="false" name="MilestoneRevenueInRelationToPatentLicenseAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_RegulatoryMilestonePaymentReceivable" abstract="false" name="RegulatoryMilestonePaymentReceivable" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_AmountOfRoyaltiesEntitledToBeReceivedUponReachingSalesBasedMilestones" abstract="false" name="AmountOfRoyaltiesEntitledToBeReceivedUponReachingSalesBasedMilestones" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CollaborationAgreementProfitSharingPercentage" abstract="false" name="CollaborationAgreementProfitSharingPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_RoyaltiesReceivableUnderSalesBasedMilestones" abstract="false" name="RoyaltiesReceivableUnderSalesBasedMilestones" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TradeAndOtherPayablesMaturityPeriod" abstract="false" name="TradeAndOtherPayablesMaturityPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
</xs:schema>
