<?xml version="1.0" encoding="UTF-8"?>
<npx:edgarSubmission xmlns:npx="http://www.sec.gov/edgar/npx" xmlns:com="http://www.sec.gov/edgar/common">
  <!--Generated by Workiva-->
  <npx:headerData>
    <npx:submissionType>N-PX</npx:submissionType>
    <npx:filerInfo>
      <npx:registrantType>RMIC</npx:registrantType>
      <npx:liveTestFlag>LIVE</npx:liveTestFlag>
      <npx:filer>
        <npx:issuerCredentials>
          <npx:cik>0000100334</npx:cik>
          <npx:ccc>XXXXXXXX</npx:ccc>
        </npx:issuerCredentials>
      </npx:filer>
      <npx:flags>
        <npx:overrideInternetFlag>false</npx:overrideInternetFlag>
        <npx:confirmingCopyFlag>false</npx:confirmingCopyFlag>
      </npx:flags>
      <npx:investmentCompanyType>N-1A</npx:investmentCompanyType>
      <npx:periodOfReport>06/30/2026</npx:periodOfReport>
    </npx:filerInfo>
    <npx:seriesClass>
      <npx:reportSeriesClass>
        <npx:rptSeriesClassInfo>
          <npx:seriesId>S000006192</npx:seriesId>
          <npx:classInfo>
            <npx:classId>C000017045</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017047</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000189734</npx:classId>
          </npx:classInfo>
        </npx:rptSeriesClassInfo>
        <npx:rptSeriesClassInfo>
          <npx:seriesId>S000006193</npx:seriesId>
          <npx:classInfo>
            <npx:classId>C000017048</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017049</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017050</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017052</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000055516</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000131596</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000189735</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000189736</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000212512</npx:classId>
          </npx:classInfo>
        </npx:rptSeriesClassInfo>
        <npx:rptSeriesClassInfo>
          <npx:seriesId>S000006194</npx:seriesId>
          <npx:classInfo>
            <npx:classId>C000017053</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017054</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017055</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017058</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017059</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000131597</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000189737</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000189738</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000247666</npx:classId>
          </npx:classInfo>
        </npx:rptSeriesClassInfo>
        <npx:rptSeriesClassInfo>
          <npx:seriesId>S000006195</npx:seriesId>
          <npx:classInfo>
            <npx:classId>C000017060</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017061</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017062</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017063</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017064</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000131598</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000189739</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000189740</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000214991</npx:classId>
          </npx:classInfo>
        </npx:rptSeriesClassInfo>
        <npx:rptSeriesClassInfo>
          <npx:seriesId>S000006203</npx:seriesId>
          <npx:classInfo>
            <npx:classId>C000017094</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017095</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017096</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017098</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017099</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000189741</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000189742</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000212513</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000212514</npx:classId>
          </npx:classInfo>
        </npx:rptSeriesClassInfo>
        <npx:rptSeriesClassInfo>
          <npx:seriesId>S000006205</npx:seriesId>
          <npx:classInfo>
            <npx:classId>C000017101</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017102</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017103</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017105</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000088050</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000131599</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000189743</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000189744</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000236113</npx:classId>
          </npx:classInfo>
        </npx:rptSeriesClassInfo>
        <npx:rptSeriesClassInfo>
          <npx:seriesId>S000006206</npx:seriesId>
          <npx:classInfo>
            <npx:classId>C000017106</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017107</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017108</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000017109</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000055524</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000129042</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000189745</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000189746</npx:classId>
          </npx:classInfo>
          <npx:classInfo>
            <npx:classId>C000236114</npx:classId>
          </npx:classInfo>
        </npx:rptSeriesClassInfo>
      </npx:reportSeriesClass>
    </npx:seriesClass>
  </npx:headerData>
  <npx:formData>
    <npx:coverPage>
      <npx:yearOrQuarter>YEAR</npx:yearOrQuarter>
      <npx:reportCalendarYear>2026</npx:reportCalendarYear>
      <npx:reportingPerson>
        <npx:name>American Century Mutual Funds, Inc.</npx:name>
        <npx:phoneNumber>816-531-5575</npx:phoneNumber>
        <npx:address>
          <com:street1>4500 Main Street</com:street1>
          <com:city>Kansas City</com:city>
          <com:stateOrCountry>MO</com:stateOrCountry>
          <com:zipCode>64111</com:zipCode>
        </npx:address>
      </npx:reportingPerson>
      <npx:agentForService>
        <npx:name>John Pak</npx:name>
        <npx:address>
          <com:street1>4500 Main Street</com:street1>
          <com:city>Kansas City</com:city>
          <com:stateOrCountry>MO</com:stateOrCountry>
          <com:zipCode>64111</com:zipCode>
        </npx:address>
      </npx:agentForService>
      <npx:reportInfo>
        <npx:reportType>FUND VOTING REPORT</npx:reportType>
        <npx:confidentialTreatment>N</npx:confidentialTreatment>
      </npx:reportInfo>
      <npx:fileNumber>811-00816</npx:fileNumber>
      <npx:explanatoryInformation>
        <npx:explanatoryChoice>N</npx:explanatoryChoice>
      </npx:explanatoryInformation>
    </npx:coverPage>
    <npx:summaryPage>
      <npx:otherIncludedManagersCount>0</npx:otherIncludedManagersCount>
    </npx:summaryPage>
    <npx:seriesPage>
      <npx:seriesCount>7</npx:seriesCount>
      <npx:seriesDetails>
        <npx:seriesReports>
          <npx:idOfSeries>S000006206</npx:idOfSeries>
          <npx:nameOfSeries>Heritage Fund</npx:nameOfSeries>
          <npx:leiOfSeries>YRIFZJY5F41ZG438VU07</npx:leiOfSeries>
        </npx:seriesReports>
        <npx:seriesReports>
          <npx:idOfSeries>S000006205</npx:idOfSeries>
          <npx:nameOfSeries>Growth Fund</npx:nameOfSeries>
          <npx:leiOfSeries>ZXFN03M6QOTUGN6K4H37</npx:leiOfSeries>
        </npx:seriesReports>
        <npx:seriesReports>
          <npx:idOfSeries>S000006195</npx:idOfSeries>
          <npx:nameOfSeries>Ultra Fund</npx:nameOfSeries>
          <npx:leiOfSeries>F6OVJ18MFLNHYYI4ZV69</npx:leiOfSeries>
        </npx:seriesReports>
        <npx:seriesReports>
          <npx:idOfSeries>S000006194</npx:idOfSeries>
          <npx:nameOfSeries>Select Fund</npx:nameOfSeries>
          <npx:leiOfSeries>YBV2RHBLCMLT5C6UGK81</npx:leiOfSeries>
        </npx:seriesReports>
        <npx:seriesReports>
          <npx:idOfSeries>S000006193</npx:idOfSeries>
          <npx:nameOfSeries>Small Cap Growth Fund</npx:nameOfSeries>
          <npx:leiOfSeries>Q68CQ4I0XKGZWJ8GYU12</npx:leiOfSeries>
        </npx:seriesReports>
        <npx:seriesReports>
          <npx:idOfSeries>S000006192</npx:idOfSeries>
          <npx:nameOfSeries>Balanced Fund</npx:nameOfSeries>
          <npx:leiOfSeries>TEE5XU4ZMMYOHLLT7896</npx:leiOfSeries>
        </npx:seriesReports>
        <npx:seriesReports>
          <npx:idOfSeries>S000006203</npx:idOfSeries>
          <npx:nameOfSeries>Large Cap Equity Fund</npx:nameOfSeries>
          <npx:leiOfSeries>90UIHXL6GP381WUEP655</npx:leiOfSeries>
        </npx:seriesReports>
      </npx:seriesDetails>
    </npx:seriesPage>
    <npx:signaturePage>
      <npx:reportingPerson>American Century Mutual Funds, Inc.</npx:reportingPerson>
      <npx:txSignature>Patrick Bannigan</npx:txSignature>
      <npx:txPrintedSignature>Patrick Bannigan</npx:txPrintedSignature>
      <npx:txTitle>President</npx:txTitle>
      <npx:txAsOfDate>08/26/2026</npx:txAsOfDate>
    </npx:signaturePage>
  </npx:formData>
</npx:edgarSubmission>
