<?xml version="1.0" encoding="UTF-8"?><own:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:own="http://www.sec.gov/edgar/ownership">
  <!-- Generated by Workiva -->
  <own:headerData>
    <own:submissionType>144/A</own:submissionType>
    <own:previousAccessionNumber>0001628280-26-058006</own:previousAccessionNumber>
    <own:filerInfo>
      <own:filer>
        <own:filerCredentials>
          <own:cik>0001288952</own:cik>
          <own:ccc>XXXXXXXX</own:ccc>
        </own:filerCredentials>
      </own:filer>
      <own:liveTestFlag>LIVE</own:liveTestFlag>
      
      
      
    </own:filerInfo>
  </own:headerData>
  <own:formData>
    <own:issuerInfo>
      <own:issuerCik>0001070081</own:issuerCik>
      <own:issuerName>PTC THERAPEUTICS, INC.</own:issuerName>
      <own:secFileNumber>001-35969</own:secFileNumber>
      <own:issuerAddress>
        <com:street1>500 Warren Corporate Center Drive</com:street1>
        <com:city>Warren</com:city>
        <com:stateOrCountry>NJ</com:stateOrCountry>
        <com:zipCode>07059</com:zipCode>
      </own:issuerAddress>
      <own:issuerContactPhone>9082227000</own:issuerContactPhone>
      <own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Section Six Partners,  L.P.</own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <own:relationshipsToIssuer>
        <own:relationshipToIssuer>Affiliate of Director</own:relationshipToIssuer>
      </own:relationshipsToIssuer>
    </own:issuerInfo>
    <own:securitiesInformation>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:brokerOrMarketmakerDetails>
        <own:name>Merrill Lynch</own:name>
        <own:address>
          <com:street1>225 Liberty Street</com:street1>
          <com:street2>Fl 39</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10281</com:zipCode>
        </own:address>
      </own:brokerOrMarketmakerDetails>
      <own:noOfUnitsSold>50000</own:noOfUnitsSold>
      <own:aggregateMarketValue>3650000</own:aggregateMarketValue>
      <own:noOfUnitsOutstanding>83460802</own:noOfUnitsOutstanding>
      <own:approxSaleDate>08/19/2026</own:approxSaleDate>
      <own:securitiesExchangeName>NASDAQ</own:securitiesExchangeName>
    </own:securitiesInformation>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:acquiredDate>06/25/2013</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Automatic Conversion of Preferred Stock into Common Stock Upon IPO</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>50000</own:amountOfSecuritiesAcquired>
      <own:paymentDate>06/25/2013</own:paymentDate>
      <own:natureOfPayment>Automatic Conversion of Preferred Stock into Common Stock upon IPO (Preferred Stock acquired from Issuer for cash)</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</own:nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <own:remarks>This amendment is being filed to revise the name of the seller and certain information related to certain securities to be sold. Michael Schmertzler is a member of the Board of Directors of the Issuer. He is also a general partner and limited partner of Section Six Partners, L.P. Mr. Schmertzler disclaims beneficial ownership of the shares held by Section Six Partners, L.P., except to the extent of his pecuniary interest therein.</own:remarks>
    <own:noticeSignature>
      <own:noticeDate>08/25/2026</own:noticeDate>
      <own:planAdoptionDates>
        <own:planAdoptionDate>05/14/2026</own:planAdoptionDate>
      </own:planAdoptionDates>
      <own:signature>Michael Schmertzler, as President of S6 GP Holding, LLC, the General Partner of, and on behalf of, Section Six Partners, LP</own:signature>
    </own:noticeSignature>
  </own:formData>
</own:edgarSubmission>
