<?xml version="1.0" encoding="UTF-8"?>
<npx:edgarSubmission xmlns:npx="http://www.sec.gov/edgar/npx" xmlns:com="http://www.sec.gov/edgar/common">
  <!--Generated by Workiva-->
  <npx:headerData>
    <npx:submissionType>N-PX</npx:submissionType>
    <npx:filerInfo>
      <npx:registrantType>IM</npx:registrantType>
      <npx:liveTestFlag>LIVE</npx:liveTestFlag>
      <npx:filer>
        <npx:issuerCredentials>
          <npx:cik>0001698287</npx:cik>
          <npx:ccc>XXXXXXXX</npx:ccc>
        </npx:issuerCredentials>
      </npx:filer>
      <npx:flags>
        <npx:overrideInternetFlag>false</npx:overrideInternetFlag>
        <npx:confirmingCopyFlag>false</npx:confirmingCopyFlag>
      </npx:flags>
      <npx:periodOfReport>06/30/2026</npx:periodOfReport>
    </npx:filerInfo>
  </npx:headerData>
  <npx:formData>
    <npx:coverPage>
      <npx:yearOrQuarter>YEAR</npx:yearOrQuarter>
      <npx:reportCalendarYear>2026</npx:reportCalendarYear>
      <npx:reportingPerson>
        <npx:name>Banco Santander Mexico S.A., Institucion de Banca Multiple, Grupo Financiero Santander Mexico</npx:name>
        <npx:phoneNumber>55-9177-1339</npx:phoneNumber>
        <npx:address>
          <com:street1>Prolongacion Paseo De La Reforma No. 500</com:street1>
          <com:street2>Piso 2, Modulo 206</com:street2>
          <com:city>Mexico</com:city>
          <com:stateOrCountry>O5</com:stateOrCountry>
          <com:zipCode>00000</com:zipCode>
        </npx:address>
      </npx:reportingPerson>
      <npx:agentForService>
        <npx:name>Juan Carlos Garcia Contreras</npx:name>
        <npx:address>
          <com:street1>Prolongacion Paseo De La Reforma No. 500</com:street1>
          <com:street2>Piso 2, Modulo 206</com:street2>
          <com:city>Mexico</com:city>
          <com:stateOrCountry>O5</com:stateOrCountry>
          <com:zipCode>00000</com:zipCode>
        </npx:address>
      </npx:agentForService>
      <npx:reportInfo>
        <npx:reportType>INSTITUTIONAL MANAGER NOTICE REPORT</npx:reportType>
        <npx:noticeExplanation>REPORTING PERSON HAS POLICY TO NOT VOTE</npx:noticeExplanation>
        <npx:confidentialTreatment>N</npx:confidentialTreatment>
      </npx:reportInfo>
      <npx:fileNumber>028-17978</npx:fileNumber>
      <npx:explanatoryInformation>
        <npx:explanatoryChoice>N</npx:explanatoryChoice>
      </npx:explanatoryInformation>
    </npx:coverPage>
    <npx:summaryPage>
      <npx:otherIncludedManagersCount>0</npx:otherIncludedManagersCount>
    </npx:summaryPage>
    <npx:signaturePage>
      <npx:reportingPerson>Banco Santander Mexico S.A., Institucion de Banca Multiple, Grupo Financiero Santander Mexico</npx:reportingPerson>
      <npx:txSignature>Juan Carlos Garcia Contreras</npx:txSignature>
      <npx:txPrintedSignature>Juan Carlos Garcia Contreras</npx:txPrintedSignature>
      <npx:txTitle>Executive Director Controller Finance</npx:txTitle>
      <npx:txAsOfDate>07/23/2026</npx:txAsOfDate>
    </npx:signaturePage>
  </npx:formData>
</npx:edgarSubmission>
