Exhibit 5.1

August 24, 2026

EBR Systems, Inc.

480 Oakmead Parkway

Sunnyvale, CA 94085

Ladies and Gentlemen:

At your request, we have examined the Registration Statement on Form S-8 (the “Registration Statement”) to be filed by EBR Systems, Inc., a Delaware corporation (the “Company”), with the Securities and Exchange Commission (the “Commission”), on or about the date hereof, relating to the registration under the Securities Act of 1933, as amended (the “Act”), of shares of your common stock, par value $0.0001 per share (the “Shares”), consisting of: 1,801,037 shares of common stock to be issued under the 2021 Equity Incentive Plan (the “2021 Plan”). As your legal counsel, we have reviewed the actions proposed to be taken by you in connection with the issuance and sale of the Shares to be issued under the 2021 Plan.

On the basis of the foregoing, and in reliance thereon, we are of the opinion that the Shares, when issued and sold in the manner described in the 2021 Plan and pursuant to the agreements that accompany the 2021 Plan, will be legally and validly issued, fully paid and nonassessable.

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austin    boston    BOULDER    brussels    century city    hong kong    london    los angeles    new york    palo alto
SALT LAKE CITY    san diego    san francisco    seattle    shanghai    washington, dc    wilmington, de

We hereby consent to the filing of this opinion as an exhibit to the above-referenced Registration Statement and to the use of our name wherever it appears in the Registration Statement and in any amendments thereto. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Act or the rules and regulations of the Commission thereunder.

austin    boston    BOULDER    brussels    century city    hong kong    london    los angeles    new york    palo alto
SALT LAKE CITY    san diego    san francisco    seattle    shanghai    washington, dc    wilmington, de