<?xml version="1.0" ?><inf:proxyVoteTable xmlns:inf="http://www.sec.gov/edgar/document/npxproxy/informationtable"><inf:proxyTable><inf:issuerName>Jazz Pharmaceuticals plc</inf:issuerName><inf:cusip>G50871105</inf:cusip><inf:isin>IE00B4Q5ZN47</inf:isin><inf:meetingDate>07/24/2025</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation of Jazz Pharmaceuticals pic's named executive officers as disclosed in the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>717837.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>717837.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>KalVista Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>483497103</inf:cusip><inf:isin>US4834971032</inf:isin><inf:meetingDate>10/01/2025</inf:meetingDate><inf:voteDescription>Approval, on a non-binding advisory basis, of the compensation paid by us to our named executive officers as disclosed in the Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1296235.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1296235.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Medtronic plc</inf:issuerName><inf:cusip>G5960L103</inf:cusip><inf:isin>IE00BTN1Y115</inf:isin><inf:meetingDate>10/16/2025</inf:meetingDate><inf:voteDescription>Approving, on an advisory basis, the Company's executive compensation;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>337570.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>337570.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Traws Pharma, Inc.</inf:issuerName><inf:cusip>68232V884</inf:cusip><inf:isin>US68232V8845</inf:isin><inf:meetingDate>11/21/2025</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>136535.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>136535.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Traws Pharma, Inc.</inf:issuerName><inf:cusip>68232V884</inf:cusip><inf:isin>US68232V8845</inf:isin><inf:meetingDate>11/21/2025</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the frequency of holding an advisory vote to approve the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>136535.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>136535.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Zymeworks Inc.</inf:issuerName><inf:cusip>98985Y108</inf:cusip><inf:isin>US98985Y1082</inf:isin><inf:meetingDate>12/30/2025</inf:meetingDate><inf:voteDescription>Advisory vote on the compensation of our named executive officers</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1022611.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1022611.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Arrowhead Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>04280A100</inf:cusip><inf:isin>US04280A1007</inf:isin><inf:meetingDate>03/19/2026</inf:meetingDate><inf:voteDescription>Advisory Vote to Approve Executive Compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>697700.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>697700.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Abbott Laboratories</inf:issuerName><inf:cusip>002824100</inf:cusip><inf:isin>US0028241000</inf:isin><inf:meetingDate>04/24/2026</inf:meetingDate><inf:voteDescription>Say on Pay - An Advisory Vote on the Approval of Executive Compensation</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>161219.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>161219.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Sanofi</inf:issuerName><inf:cusip>80105N105</inf:cusip><inf:isin>US80105N1054</inf:isin><inf:meetingDate>04/29/2026</inf:meetingDate><inf:voteDescription>Approve Compensation of Frederic Oudea, Chairman of the Board</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1400000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1400000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Sanofi</inf:issuerName><inf:cusip>80105N105</inf:cusip><inf:isin>US80105N1054</inf:isin><inf:meetingDate>04/29/2026</inf:meetingDate><inf:voteDescription>Approve Compensation of Paul Hudson, CEO</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1400000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1400000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Inspire Medical Systems, Inc.</inf:issuerName><inf:cusip>457730109</inf:cusip><inf:isin>US4577301090</inf:isin><inf:meetingDate>04/30/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory (non-binding) basis, of the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>380827.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>380827.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Inspire Medical Systems, Inc.</inf:issuerName><inf:cusip>457730109</inf:cusip><inf:isin>US4577301090</inf:isin><inf:meetingDate>04/30/2026</inf:meetingDate><inf:voteDescription>Approval, on a advisory (non-binding) basis, of the frequency of future advisory votes on the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>380827.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>380827.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>West Pharmaceutical Services, Inc.</inf:issuerName><inf:cusip>955306105</inf:cusip><inf:isin>US9553061055</inf:isin><inf:meetingDate>05/04/2026</inf:meetingDate><inf:voteDescription>Advisory vote to approve named executive officer compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>34331.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>34331.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Abivax SA</inf:issuerName><inf:cusip>00370M103</inf:cusip><inf:isin>US00370M1036</inf:isin><inf:meetingDate>05/11/2026</inf:meetingDate><inf:voteDescription>Approve Compensation of Sylvie Gregoire, Chairwoman of the Board</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1471926.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1471926.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Abivax SA</inf:issuerName><inf:cusip>00370M103</inf:cusip><inf:isin>US00370M1036</inf:isin><inf:meetingDate>05/11/2026</inf:meetingDate><inf:voteDescription>Approve Compensation of Marc de Garidel, CEO</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1471926.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1471926.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Surrozen, Inc.</inf:issuerName><inf:cusip>86889P208</inf:cusip><inf:isin>US86889P2083</inf:isin><inf:meetingDate>05/13/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory basis, of the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>284687.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>284687.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Surrozen, Inc.</inf:issuerName><inf:cusip>86889P208</inf:cusip><inf:isin>US86889P2083</inf:isin><inf:meetingDate>05/13/2026</inf:meetingDate><inf:voteDescription>Advisory vote on the preferred frequency of the advisory vote on the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>284687.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>284687.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Repligen Corporation</inf:issuerName><inf:cusip>759916109</inf:cusip><inf:isin>US7599161095</inf:isin><inf:meetingDate>05/14/2026</inf:meetingDate><inf:voteDescription>Advisory vote to approve the compensation paid to Repligen Corporation's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>305495.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>305495.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Nurix Therapeutics, Inc.</inf:issuerName><inf:cusip>67080M103</inf:cusip><inf:isin>US67080M1036</inf:isin><inf:meetingDate>05/15/2026</inf:meetingDate><inf:voteDescription>To approve, a non-binding advisory basis, the compensation of the Company's named executive officers as disclosed in the Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>3023716.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>3023716.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>MacroGenics, Inc.</inf:issuerName><inf:cusip>556099109</inf:cusip><inf:isin>US5560991094</inf:isin><inf:meetingDate>05/19/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers as disclosed in the proxy materials.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>280000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>280000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Passage Bio, Inc.</inf:issuerName><inf:cusip>702712209</inf:cusip><inf:isin>US7027122099</inf:isin><inf:meetingDate>05/19/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation of our named executive officers as disclosed in the proxy statement for the 2026 Annual Meeting.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>304384.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>304384.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Passage Bio, Inc.</inf:issuerName><inf:cusip>702712209</inf:cusip><inf:isin>US7027122099</inf:isin><inf:meetingDate>05/19/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the frequency of holding future advisory votes on named executive officer compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>304384.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>304384.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Viking Therapeutics, Inc.</inf:issuerName><inf:cusip>92686J106</inf:cusip><inf:isin>US92686J1060</inf:isin><inf:meetingDate>05/19/2026</inf:meetingDate><inf:voteDescription>TO APPROVE, ON AN ADVISORY BASIS, THE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE OFFICERS.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>583407.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>583407.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Geron Corporation</inf:issuerName><inf:cusip>374163103</inf:cusip><inf:isin>US3741631036</inf:isin><inf:meetingDate>05/20/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of our Named Executive Officers, as disclosed in our Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2266490.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2266490.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Insulet Corporation</inf:issuerName><inf:cusip>45784P101</inf:cusip><inf:isin>US45784P1012</inf:isin><inf:meetingDate>05/20/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation of certain executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>35964.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>35964.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Vera Therapeutics, Inc.</inf:issuerName><inf:cusip>92337R101</inf:cusip><inf:isin>US92337R1014</inf:isin><inf:meetingDate>05/21/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers, as disclosed in the Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1079213.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1079213.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Waters Corporation</inf:issuerName><inf:cusip>941848103</inf:cusip><inf:isin>US9418481035</inf:isin><inf:meetingDate>05/21/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation of the Company's executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>44408.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>44408.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Zimmer Biomet Holdings, Inc.</inf:issuerName><inf:cusip>98956P102</inf:cusip><inf:isin>US98956P1021</inf:isin><inf:meetingDate>05/22/2026</inf:meetingDate><inf:voteDescription>Approve, on a non-binding advisory basis, named executive officer compensation ("Say on Pay").</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>94987.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>94987.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Cytokinetics, Incorporated</inf:issuerName><inf:cusip>23282W605</inf:cusip><inf:isin>US23282W6057</inf:isin><inf:meetingDate>05/27/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers, as disclosed in the Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>219027.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>219027.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Immunocore Holdings Plc</inf:issuerName><inf:cusip>45258D105</inf:cusip><inf:isin>US45258D1054</inf:isin><inf:meetingDate>05/27/2026</inf:meetingDate><inf:voteDescription>To approve, on advisory basis, the compensation of the Company's named executive officers, as disclosed in the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1972943.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>1972943.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Neurocrine Biosciences, Inc.</inf:issuerName><inf:cusip>64125C109</inf:cusip><inf:isin>US64125C1099</inf:isin><inf:meetingDate>05/27/2026</inf:meetingDate><inf:voteDescription>Advisory vote on the compensation paid to the Company's named executive officers;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>983720.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>983720.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>REGENXBIO Inc.</inf:issuerName><inf:cusip>75901B107</inf:cusip><inf:isin>US75901B1070</inf:isin><inf:meetingDate>05/29/2026</inf:meetingDate><inf:voteDescription>Advisory vote on the compensation paid to the Company's executive employees.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>76882.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>76882.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Taysha Gene Therapies, Inc.</inf:issuerName><inf:cusip>877619106</inf:cusip><inf:isin>US8776191061</inf:isin><inf:meetingDate>06/01/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>12119056.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>12119056.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Taysha Gene Therapies, Inc.</inf:issuerName><inf:cusip>877619106</inf:cusip><inf:isin>US8776191061</inf:isin><inf:meetingDate>06/01/2026</inf:meetingDate><inf:voteDescription>To indicate, on a non-binding advisory basis, the preferred frequency of future stockholder advisory votes on the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>12119056.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>12119056.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>BioMarin Pharmaceutical Inc.</inf:issuerName><inf:cusip>09061G101</inf:cusip><inf:isin>US09061G1013</inf:isin><inf:meetingDate>06/02/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's Named Executive Officers as disclosed in the Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2620148.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2620148.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Crescent Biopharma, Inc.</inf:issuerName><inf:cusip>G2545C104</inf:cusip><inf:isin>KYG2545C1042</inf:isin><inf:meetingDate>06/02/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation of Crescent Biopharma, Inc. 's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>104136.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>104136.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Crescent Biopharma, Inc.</inf:issuerName><inf:cusip>G2545C104</inf:cusip><inf:isin>KYG2545C1042</inf:isin><inf:meetingDate>06/02/2026</inf:meetingDate><inf:voteDescription>To vote, on a non-binding advisory basis, on the frequency of future advisory votes to approve compensation for Crescent Biopharma, Inc.'s named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>104136.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>104136.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Xenon Pharmaceuticals Inc.</inf:issuerName><inf:cusip>98420N105</inf:cusip><inf:isin>CA98420N1050</inf:isin><inf:meetingDate>06/02/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Corporation's named executive officers;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>639900.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>639900.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Xenon Pharmaceuticals Inc.</inf:issuerName><inf:cusip>98420N105</inf:cusip><inf:isin>CA98420N1050</inf:isin><inf:meetingDate>06/02/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the frequency of future shareholder advisory votes to approve the compensation of the Corporation's named executive officers;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>639900.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>639900.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Denali Therapeutics Inc.</inf:issuerName><inf:cusip>24823R105</inf:cusip><inf:isin>US24823R1059</inf:isin><inf:meetingDate>06/03/2026</inf:meetingDate><inf:voteDescription>Advisory vote on executive compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>846762.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>846762.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Globus Medical, Inc.</inf:issuerName><inf:cusip>379577208</inf:cusip><inf:isin>US3795772082</inf:isin><inf:meetingDate>06/03/2026</inf:meetingDate><inf:voteDescription>Approval, on a non-binding, advisory basis, of the 2025 compensation of the company's named executive officers (the "Say-on-Pay" Vote).</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>225713.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>225713.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>NovoCure Limited</inf:issuerName><inf:cusip>G6674U108</inf:cusip><inf:isin>JE00BYSS4X48</inf:isin><inf:meetingDate>06/03/2026</inf:meetingDate><inf:voteDescription>A non-binding advisory vote to approve executive compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>160324.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>160324.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Trevi Therapeutics, Inc.</inf:issuerName><inf:cusip>89532M101</inf:cusip><inf:isin>US89532M1018</inf:isin><inf:meetingDate>06/03/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory basis, of the compensation paid to our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1113973.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1113973.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Myriad Genetics, Inc.</inf:issuerName><inf:cusip>62855J104</inf:cusip><inf:isin>US62855J1043</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of our named executive officers, as disclosed in the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1309148.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1309148.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Nektar Therapeutics</inf:issuerName><inf:cusip>640268306</inf:cusip><inf:isin>US6402683063</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>To approve a non-binding advisory resolution regarding our executive compensation (a "say-on-pay" vote).</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>257418.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>257418.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Savara Inc.</inf:issuerName><inf:cusip>805111101</inf:cusip><inf:isin>US8051111016</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of our named executives.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1336558.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1336558.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Scholar Rock Holding Corporation</inf:issuerName><inf:cusip>80706P103</inf:cusip><inf:isin>US80706P1030</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>567450.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>567450.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Dyne Therapeutics, Inc.</inf:issuerName><inf:cusip>26818M108</inf:cusip><inf:isin>US26818M1080</inf:isin><inf:meetingDate>06/05/2026</inf:meetingDate><inf:voteDescription>To vote, on an advisory basis, to approve the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2416199.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2416199.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Tectonic Therapeutic, Inc.</inf:issuerName><inf:cusip>878972108</inf:cusip><inf:isin>US8789721086</inf:isin><inf:meetingDate>06/08/2026</inf:meetingDate><inf:voteDescription>Advisory approval of the compensation of the Company's Named Executive Officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>140032.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>140032.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Apogee Therapeutics, Inc.</inf:issuerName><inf:cusip>03770N101</inf:cusip><inf:isin>US03770N1019</inf:isin><inf:meetingDate>06/09/2026</inf:meetingDate><inf:voteDescription>Approval, on a non-binding advisory basis, of the compensation of our named executive officers as disclosed in the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>668829.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>668829.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Biogen Inc.</inf:issuerName><inf:cusip>09062X103</inf:cusip><inf:isin>US09062X1037</inf:isin><inf:meetingDate>06/09/2026</inf:meetingDate><inf:voteDescription>Say on Pay - To hold an advisory vote on executive compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>61270.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>61270.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Cogent Biosciences, Inc.</inf:issuerName><inf:cusip>19240Q201</inf:cusip><inf:isin>US19240Q2012</inf:isin><inf:meetingDate>06/09/2026</inf:meetingDate><inf:voteDescription>Approval, on a non-binding, advisory basis, of the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1523381.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1523381.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Enliven Therapeutics, Inc.</inf:issuerName><inf:cusip>29337E102</inf:cusip><inf:isin>US29337E1029</inf:isin><inf:meetingDate>06/09/2026</inf:meetingDate><inf:voteDescription>To approve, in an advisory (non-binding) vote, the compensation of our named executive officers as disclosed in our proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2356333.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2356333.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Enliven Therapeutics, Inc.</inf:issuerName><inf:cusip>29337E102</inf:cusip><inf:isin>US29337E1029</inf:isin><inf:meetingDate>06/09/2026</inf:meetingDate><inf:voteDescription>To approve, in an advisory (non-binding) vote, the frequency of future stockholder advisory votes on the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2356333.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>2356333.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Voyager Therapeutics, Inc.</inf:issuerName><inf:cusip>92915B106</inf:cusip><inf:isin>US92915B1061</inf:isin><inf:meetingDate>06/09/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2179004.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2179004.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Palisade Bio, Inc.</inf:issuerName><inf:cusip>696389402</inf:cusip><inf:isin>US6963894026</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation of our named executive officers, as disclosed in the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1455519.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>1455519.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Solid Biosciences Inc.</inf:issuerName><inf:cusip>83422E204</inf:cusip><inf:isin>US83422E2046</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>The approval of an advisory vote on executive compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2505604.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>2505604.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>uniQure N.V.</inf:issuerName><inf:cusip>N90064101</inf:cusip><inf:isin>NL0010696654</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory basis, of the compensation of the named executive officers of the Company.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>456693.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>456693.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>uniQure N.V.</inf:issuerName><inf:cusip>N90064101</inf:cusip><inf:isin>NL0010696654</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory basis, of the frequency of advisory votes on the compensation of the named  executive officers of the Company.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>456693.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>456693.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Veracyte, Inc.</inf:issuerName><inf:cusip>92337F107</inf:cusip><inf:isin>US92337F1075</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>The approval, on a non-binding advisory basis, of the compensation of our named executive officers, as disclosed in our proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>64570.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>64570.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>BioCryst Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>09058V103</inf:cusip><inf:isin>US09058V1035</inf:isin><inf:meetingDate>06/11/2026</inf:meetingDate><inf:voteDescription>To hold a non-binding, advisory vote regarding executive compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>4158394.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>4158394.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Aprea Therapeutics, Inc.</inf:issuerName><inf:cusip>03836J201</inf:cusip><inf:isin>US03836J2015</inf:isin><inf:meetingDate>06/16/2026</inf:meetingDate><inf:voteDescription>To approve, by non-binding advisory vote, the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>293943.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>293943.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Aprea Therapeutics, Inc.</inf:issuerName><inf:cusip>03836J201</inf:cusip><inf:isin>US03836J2015</inf:isin><inf:meetingDate>06/16/2026</inf:meetingDate><inf:voteDescription>To approve, by non-binding advisory vote, the frequency of future votes on the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>293943.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>293943.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Nuvalent, Inc.</inf:issuerName><inf:cusip>670703107</inf:cusip><inf:isin>US6707031075</inf:isin><inf:meetingDate>06/16/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation paid to our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>193681.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>193681.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Damora Therapeutics, Inc.</inf:issuerName><inf:cusip>G2646Y104</inf:cusip><inf:isin>KYG2646Y1044</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>570081.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>570081.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Damora Therapeutics, Inc.</inf:issuerName><inf:cusip>G2646Y104</inf:cusip><inf:isin>KYG2646Y1044</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>To conduct an advisory vote to determine the frequency of future advisory votes on the compensation of the Company's named executive officers;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>570081.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>570081.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Olema Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>68062P106</inf:cusip><inf:isin>US68062P1066</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory basis, of the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>249041.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>249041.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Protagonist Therapeutics, Inc.</inf:issuerName><inf:cusip>74366E102</inf:cusip><inf:isin>US74366E1029</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>165972.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>165972.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Disc Medicine, Inc.</inf:issuerName><inf:cusip>254604101</inf:cusip><inf:isin>US2546041011</inf:isin><inf:meetingDate>06/18/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation paid to the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>491110.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>491110.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>GeneDx Holdings Corp.</inf:issuerName><inf:cusip>81663L200</inf:cusip><inf:isin>US81663L2007</inf:isin><inf:meetingDate>06/18/2026</inf:meetingDate><inf:voteDescription>Approval, on a non-binding advisory basis, the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>226968.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>226968.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>GeneDx Holdings Corp.</inf:issuerName><inf:cusip>81663L200</inf:cusip><inf:isin>US81663L2007</inf:isin><inf:meetingDate>06/18/2026</inf:meetingDate><inf:voteDescription>Indicate, on a non-binding advisory basis, whether future advisory votes on the compensation paid by us to our named executive officers should be held every one, two, or three years.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>226968.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>226968.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Revolution Medicines, Inc.</inf:issuerName><inf:cusip>76155X100</inf:cusip><inf:isin>US76155X1000</inf:isin><inf:meetingDate>06/18/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation of the Company's named executive officers as disclosed in the Proxy Statement pursuant to the compensation disclosure rules of the Securities and Exchange Commission ("Say-on-Pay").</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1231298.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1231298.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Monopar Therapeutics Inc.</inf:issuerName><inf:cusip>61023L207</inf:cusip><inf:isin>US61023L2079</inf:isin><inf:meetingDate>06/22/2026</inf:meetingDate><inf:voteDescription>To approve the compensation of our named executive officers on an advisory, non-binding basis.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>30472.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>30472.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>UroGen Pharma Ltd.</inf:issuerName><inf:cusip>M96088105</inf:cusip><inf:isin>IL0011407140</inf:isin><inf:meetingDate>06/22/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers, as disclosed in the Company's proxy statement for the Annual Meeting.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>115813.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>115813.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Arvinas, Inc.</inf:issuerName><inf:cusip>04335A105</inf:cusip><inf:isin>US04335A1051</inf:isin><inf:meetingDate>06/24/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>438076.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>438076.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Fulcrum Therapeutics, Inc.</inf:issuerName><inf:cusip>359616109</inf:cusip><inf:isin>US3596161097</inf:isin><inf:meetingDate>06/24/2026</inf:meetingDate><inf:voteDescription>A non-binding advisory vote to approve the compensation of our named executive officers;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>725246.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>725246.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Celldex Therapeutics, Inc.</inf:issuerName><inf:cusip>15117B202</inf:cusip><inf:isin>US15117B2025</inf:isin><inf:meetingDate>06/25/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's Named Executive Officers as disclosed in the Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>465294.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>465294.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Tarsus Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>87650L103</inf:cusip><inf:isin>US87650L1035</inf:isin><inf:meetingDate>06/25/2026</inf:meetingDate><inf:voteDescription>To hold an advisory vote to approve, on a non-binding basis, our named executive officer compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>181053.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>181053.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>United Therapeutics Corporation</inf:issuerName><inf:cusip>91307C102</inf:cusip><inf:isin>US91307C1027</inf:isin><inf:meetingDate>06/26/2026</inf:meetingDate><inf:voteDescription>Advisory resolution to approve executive compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>147003.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>147003.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable></inf:proxyVoteTable>
