<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144/A</submissionType>
    <previousAccessionNumber>0002108105-26-000001</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: GU CHUNFANG -->
          <cik>0002108105</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>
      
      
      
    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001818838</issuerCik>
      <issuerName>Adagene Inc.</issuerName>
      <secFileNumber>001-39997</secFileNumber>
      <issuerAddress>
        <com:street1>4F, BUILDING C14, NO. 218, XINGHU STREET</com:street1>
        <com:street2>SUZHOU INDUSTRIAL PARK</com:street2>
        <com:city>SUZHOU</com:city>
        <com:stateOrCountry>F4</com:stateOrCountry>
        <com:zipCode>215123</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>86-512-87773632</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Adagene Inc.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>ADS EACH REPRESENTING 1.25 ORDINARY SHARES, SOLD TO COVER COST</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Futu SecuritiesInternational (HongKong) Ltd</name>
        <address>
          <com:street1>34/F, United Centre</com:street1>
          <com:street2>95 Queensway</com:street2>
          <com:city>Admiralty</com:city>
          <com:stateOrCountry>K3</com:stateOrCountry>
          <com:zipCode>000000</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>40000</noOfUnitsSold>
      <aggregateMarketValue>158000.00</aggregateMarketValue>
      <noOfUnitsOutstanding>67143344</noOfUnitsOutstanding>
      <approxSaleDate>08/21/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesInformation>
      <securitiesClassTitle>ADS EACH REPRESENTING 1.25 ORDINARY SHARES, SOLD TO COVER COST</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Futu SecuritiesInternational (HongKong) Ltd</name>
        <address>
          <com:street1>34/F, United Centre</com:street1>
          <com:street2>95 Queensway</com:street2>
          <com:city>Admiralty</com:city>
          <com:stateOrCountry>K3</com:stateOrCountry>
          <com:zipCode>000000</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>40000</noOfUnitsSold>
      <aggregateMarketValue>158000.00</aggregateMarketValue>
      <noOfUnitsOutstanding>67143344</noOfUnitsOutstanding>
      <approxSaleDate>08/24/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesInformation>
      <securitiesClassTitle>ADS EACH REPRESENTING 1.25 ORDINARY SHARES, SOLD TO COVER COST</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Futu SecuritiesInternational (HongKong) Ltd</name>
        <address>
          <com:street1>34/F, United Centre</com:street1>
          <com:street2>95 Queensway</com:street2>
          <com:city>Admiralty</com:city>
          <com:stateOrCountry>K3</com:stateOrCountry>
          <com:zipCode>000000</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>40000</noOfUnitsSold>
      <aggregateMarketValue>158000.00</aggregateMarketValue>
      <noOfUnitsOutstanding>67143344</noOfUnitsOutstanding>
      <approxSaleDate>08/25/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesInformation>
      <securitiesClassTitle>ADS EACH REPRESENTING 1.25 ORDINARY SHARES, SOLD TO COVER COST</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Futu SecuritiesInternational (HongKong) Ltd</name>
        <address>
          <com:street1>34/F, United Centre</com:street1>
          <com:street2>95 Queensway</com:street2>
          <com:city>Admiralty</com:city>
          <com:stateOrCountry>K3</com:stateOrCountry>
          <com:zipCode>000000</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>11000</noOfUnitsSold>
      <aggregateMarketValue>43450.00</aggregateMarketValue>
      <noOfUnitsOutstanding>67143344</noOfUnitsOutstanding>
      <approxSaleDate>08/26/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>ADS EACH REPRESENTING 1.25 ORDINARY SHARES, SOLD TO COVER COST</securitiesClassTitle>
      <acquiredDate>08/21/2026</acquiredDate>
      <natureOfAcquisitionTransaction>VESTING OF OPTIONS GRANTED PURSUANT TO ISSUER ESOP PLAN</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Adagene Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>40000</amountOfSecuritiesAcquired>
      <paymentDate>08/21/2026</paymentDate>
      <natureOfPayment>VESTING OF OPTIONS</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>ADS EACH REPRESENTING 1.25 ORDINARY SHARES, SOLD TO COVER COST</securitiesClassTitle>
      <acquiredDate>08/24/2026</acquiredDate>
      <natureOfAcquisitionTransaction>VESTING OF OPTIONS GRANTED PURSUANT TO ISSUER ESOP PLAN</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Adagene Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>40000</amountOfSecuritiesAcquired>
      <paymentDate>08/24/2026</paymentDate>
      <natureOfPayment>VESTING OF OPTIONS</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>ADS EACH REPRESENTING 1.25 ORDINARY SHARES, SOLD TO COVER COST</securitiesClassTitle>
      <acquiredDate>08/25/2026</acquiredDate>
      <natureOfAcquisitionTransaction>VESTING OF OPTIONS GRANTED PURSUANT TO ISSUER ESOP PLAN</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Adagene Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>40000</amountOfSecuritiesAcquired>
      <paymentDate>08/25/2026</paymentDate>
      <natureOfPayment>VESTING OF OPTIONS</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>ADS EACH REPRESENTING 1.25 ORDINARY SHARES, SOLD TO OVER COST</securitiesClassTitle>
      <acquiredDate>08/26/2026</acquiredDate>
      <natureOfAcquisitionTransaction>VESTING OF OPTIONS GRANTED PURSUANT TO ISSUER ESOP PLAN</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Adagene Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>11000</amountOfSecuritiesAcquired>
      <paymentDate>08/26/2026</paymentDate>
      <natureOfPayment>VESTING OF OPTIONS</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>CHUNFANG GU</name>
        <address>
          <com:street1>4F, Building C14, No. 218</com:street1>
          <com:street2>Xinghu Street, Suzhou Industrial Park</com:street2>
          <com:city>Suzhou, Jiangsu Province</com:city>
          <com:stateOrCountry>F4</com:stateOrCountry>
          <com:zipCode>215123</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ADS</securitiesClassTitle>
      <saleDate>07/28/2026</saleDate>
      <amountOfSecuritiesSold>475</amountOfSecuritiesSold>
      <grossProceeds>1634.19</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>The securities set forth herein are being sold pursuant to a sell-to-cover arrangement to satisfy the cost including tax withholding obligations arising in connection with the vesting of the options.</remarks>
    <noticeSignature>
      <noticeDate>08/20/2026</noticeDate>
      <signature>/s/ CHUNFANG GU</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
