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  <element name="EmployeesMember" id="slgl_EmployeesMember" type="dtr-types:domainItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="EpsolayMember" id="slgl_EpsolayMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="ExclusiveLicenseAgreementWithSearchlightPharmaIncMember" id="slgl_ExclusiveLicenseAgreementWithSearchlightPharmaIncMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="ExpectedRevenueReceivableOverTwentyFourMonths" id="slgl_ExpectedRevenueReceivableOverTwentyFourMonths" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit"/>
  <element name="FinanceExpensesNet" id="slgl_FinanceExpensesNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit"/>
  <element name="FinancialIncomeExpensesNet" id="slgl_FinancialIncomeExpensesNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="FirstDevelopmentMilestoneMember" id="slgl_FirstDevelopmentMilestoneMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="FPOMember" id="slgl_FPOMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="GeneralAndAdministrativeExpensesMember" id="slgl_GeneralAndAdministrativeExpensesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="IncreaseDecreaseInRestrictedLongTermDeposits" id="slgl_IncreaseDecreaseInRestrictedLongTermDeposits" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="IncreaseInOperatingLeaseRouAssetsAndLiabilities" id="slgl_IncreaseInOperatingLeaseRouAssetsAndLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit"/>
  <element name="IncreaseInSalesMilestoneAmountDueToSalesExceedDollar500Million" id="slgl_IncreaseInSalesMilestoneAmountDueToSalesExceedDollar500Million" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="InstallmentOneMember" id="slgl_InstallmentOneMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="InstallmentTwoMember" id="slgl_InstallmentTwoMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="InstitutionsExpenses" id="slgl_InstitutionsExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="InsuranceCompaniesMember" id="slgl_InsuranceCompaniesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="IsraelInnovationAuthorityMember" id="slgl_IsraelInnovationAuthorityMember" type="dtr-types:domainItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="IssuanceOfSharesAndWarrantsThroughPrivatePlacementFromControllingShareholder" id="slgl_IssuanceOfSharesAndWarrantsThroughPrivatePlacementFromControllingShareholder" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="IssuanceOfSharesAndWarrantsThroughPrivatePlacementFromControllingShareholderShares" id="slgl_IssuanceOfSharesAndWarrantsThroughPrivatePlacementFromControllingShareholderShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="IssuanceOfSharesAndWarrantsThroughPublicOfferingNetOfIssuanceCosts" id="slgl_IssuanceOfSharesAndWarrantsThroughPublicOfferingNetOfIssuanceCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="IssuanceOfSharesAndWarrantsThroughPublicOfferingNetOfIssuanceCostsShares" id="slgl_IssuanceOfSharesAndWarrantsThroughPublicOfferingNetOfIssuanceCostsShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="IssuanceOfSharesDueToInProcessResearchAndDevelopmentAcquiredShares" id="slgl_IssuanceOfSharesDueToInProcessResearchAndDevelopmentAcquiredShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="IssuanceOfSharesThroughAtmNetOfIssuanceCosts" id="slgl_IssuanceOfSharesThroughAtmNetOfIssuanceCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="IssuanceOfSharesThroughAtmNetOfIssuanceCostsShares" id="slgl_IssuanceOfSharesThroughAtmNetOfIssuanceCostsShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="IssuanceOfSharesThroughInitialPublicOfferingNetOfIssuanceCosts" id="slgl_IssuanceOfSharesThroughInitialPublicOfferingNetOfIssuanceCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="IssuanceOfSharesThroughInitialPublicOfferingNetOfIssuanceCostsShares" id="slgl_IssuanceOfSharesThroughInitialPublicOfferingNetOfIssuanceCostsShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="JefferiesLlcMember" id="slgl_JefferiesLlcMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="LaboratoryEquipmentMember" id="slgl_LaboratoryEquipmentMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="LicenseAgreementsAbstract" id="slgl_LicenseAgreementsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="LicenseAgreementsWithGaldermaMember" id="slgl_LicenseAgreementsWithGaldermaMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="LicenseRevenue" id="slgl_LicenseRevenue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="MainlyMember" id="slgl_MainlyMember" type="dtr-types:domainItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="MasterClinicalTrialServicesAgreementMember" id="slgl_MasterClinicalTrialServicesAgreementMember" type="dtr-types:domainItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="MaximumAmountToBePaidForCommercialMilestonesAndSingleDigitRoyalties" id="slgl_MaximumAmountToBePaidForCommercialMilestonesAndSingleDigitRoyalties" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit"/>
  <element name="MaximumAmountToBePaidForDevelopmentAndNdaAcceptanceMilestones" id="slgl_MaximumAmountToBePaidForDevelopmentAndNdaAcceptanceMilestones" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit"/>
  <element name="MaximumUpfrontPaymentsAndRegulatoryApprovalMilestonePaymentsPerProduct" id="slgl_MaximumUpfrontPaymentsAndRegulatoryApprovalMilestonePaymentsPerProduct" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="MaynePharmaGroupLimitedMember" id="slgl_MaynePharmaGroupLimitedMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="MilestonePaymentsAxis" id="slgl_MilestonePaymentsAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" nillable="true"/>
  <element name="MilestonePaymentsDomain" id="slgl_MilestonePaymentsDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="NationalAuthorityForTechnologicalInnovationMember" id="slgl_NationalAuthorityForTechnologicalInnovationMember" type="dtr-types:domainItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="NatureOfOperationsLineItems" id="slgl_NatureOfOperationsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="NatureOfOperationsTable" id="slgl_NatureOfOperationsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" nillable="true"/>
  <element name="NetChangesInOperatingLeases" id="slgl_NetChangesInOperatingLeases" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="NewlyIssuedAccountingPronouncementsNotYetAdoptedPolicyTextBlock" id="slgl_NewlyIssuedAccountingPronouncementsNotYetAdoptedPolicyTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="NonEmployeesMember" id="slgl_NonEmployeesMember" type="dtr-types:domainItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="NonEmployeesOneMember" id="slgl_NonEmployeesOneMember" type="dtr-types:domainItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="NumberOfApprovedGenericDrugProducts" id="slgl_NumberOfApprovedGenericDrugProducts" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="NumberOfEqualQuarterlyInstalments" id="slgl_NumberOfEqualQuarterlyInstalments" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="NumberOfGenericCollaborativeAgreementsToSellRights" id="slgl_NumberOfGenericCollaborativeAgreementsToSellRights" type="xbrli:integerItemType" abstract="false" xbrli:periodType="instant" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="NumberOfGenericDrugCandidates" id="slgl_NumberOfGenericDrugCandidates" type="xbrli:integerItemType" abstract="false" xbrli:periodType="instant" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="NumberOfGenericProgramsRetainedForCollaborationRights" id="slgl_NumberOfGenericProgramsRetainedForCollaborationRights" type="xbrli:integerItemType" abstract="false" xbrli:periodType="instant" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="NumberOfUnapprovedGenericPrograms" id="slgl_NumberOfUnapprovedGenericPrograms" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="OfficeFurnitureAndEquipmentMember" id="slgl_OfficeFurnitureAndEquipmentMember" type="dtr-types:domainItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="OmnichemMember" id="slgl_OmnichemMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="OperatingLeasesAbstract" id="slgl_OperatingLeasesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="OtherForeignGovernmentBondsMember" id="slgl_OtherForeignGovernmentBondsMember" type="dtr-types:domainItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="OutstandingPrincipalAmount" id="slgl_OutstandingPrincipalAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="PaidUpfrontAmount" id="slgl_PaidUpfrontAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit"/>
  <element name="PaymentReceivableInInstalments" id="slgl_PaymentReceivableInInstalments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit"/>
  <element name="PellepharmMember" id="slgl_PellepharmMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="PercentageOfExpenseRecognized" id="slgl_PercentageOfExpenseRecognized" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="PercentageOfFutureGrossProfitProductSold" id="slgl_PercentageOfFutureGrossProfitProductSold" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="PercentageOfGrossProceedsFromSaleOfShares" id="slgl_PercentageOfGrossProceedsFromSaleOfShares" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="PercentageOfGrossProfitsRelatedToSaleOfProduct" id="slgl_PercentageOfGrossProfitsRelatedToSaleOfProduct" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="PercentageOfGrossProfitsRelatedToSaleOfSecondProduct" id="slgl_PercentageOfGrossProfitsRelatedToSaleOfSecondProduct" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="PercentageOfGrossProfitsRelatedToSaleProducts" id="slgl_PercentageOfGrossProfitsRelatedToSaleProducts" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="PercentageOfProceedsReceivedForSubLicense" id="slgl_PercentageOfProceedsReceivedForSubLicense" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="PercentageOfReimburseOutOfPocketExpense" id="slgl_PercentageOfReimburseOutOfPocketExpense" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="PercentageOfRoyaltiesPaymentsShallNotExceedAggregateRantReceived" id="slgl_PercentageOfRoyaltiesPaymentsShallNotExceedAggregateRantReceived" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="PercentageOfSignificantFinancingComponentReceiptExcludedFromRevenueAndInterestIncome" id="slgl_PercentageOfSignificantFinancingComponentReceiptExcludedFromRevenueAndInterestIncome" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="PreferredEnterpriseMember" id="slgl_PreferredEnterpriseMember" type="dtr-types:domainItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="PresentValueOfFutureMinimumLeasePayments" id="slgl_PresentValueOfFutureMinimumLeasePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="ProceedFromSaleOrMaturityOfMarketableSecurities" id="slgl_ProceedFromSaleOrMaturityOfMarketableSecurities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit"/>
  <element name="ProceedsFromShortTermDeposits" id="slgl_ProceedsFromShortTermDeposits" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit"/>
  <element name="ProductLicenseAgreementConsideration" id="slgl_ProductLicenseAgreementConsideration" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="ProductPurchaseAgreementMember" id="slgl_ProductPurchaseAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="PropertyAndEquipmentDepreciationPercentage" id="slgl_PropertyAndEquipmentDepreciationPercentage" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="PublicOfferingCosts" id="slgl_PublicOfferingCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit"/>
  <element name="PurchaseAgreementAxis" id="slgl_PurchaseAgreementAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" nillable="true"/>
  <element name="PurchaseAgreementDomain" id="slgl_PurchaseAgreementDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="PurchaseAgreementMember" id="slgl_PurchaseAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="PurchaseAgreementWithArmisticeCapitalMember" id="slgl_PurchaseAgreementWithArmisticeCapitalMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="PurchaseAgreementWithBeimeiMember" id="slgl_PurchaseAgreementWithBeimeiMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="ReceivablesFromCollaborativeArrangementsCurrent" id="slgl_ReceivablesFromCollaborativeArrangementsCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit"/>
  <element name="RecognitionOfOperatingLeaseRightOfUseAssetsAndLiabilities" id="slgl_RecognitionOfOperatingLeaseRightOfUseAssetsAndLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="RefundableUpfrontPayment" id="slgl_RefundableUpfrontPayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="RefundUpfrontPayment" id="slgl_RefundUpfrontPayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit"/>
  <element name="ResearchAndDevelopmentExpensesMember" id="slgl_ResearchAndDevelopmentExpensesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="RestrictedBankDeposit" id="slgl_RestrictedBankDeposit" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit"/>
  <element name="RestrictedLongTermDepositsAndCash" id="slgl_RestrictedLongTermDepositsAndCash" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit"/>
  <element name="RevenueFromContinuingServices" id="slgl_RevenueFromContinuingServices" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="RevenueFromUpfrontPayments" id="slgl_RevenueFromUpfrontPayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="RevenuesFromGeographicAreasDiclsoureTextBlock" id="slgl_RevenuesFromGeographicAreasDiclsoureTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="RoyaltiesMaturity" id="slgl_RoyaltiesMaturity" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="RoyaltiesPayableOnSaleOfProductsDeveloped" id="slgl_RoyaltiesPayableOnSaleOfProductsDeveloped" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="RoyaltiesPayForNetSalesRelatedToPatents" id="slgl_RoyaltiesPayForNetSalesRelatedToPatents" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="RoyaltiesPercentage" id="slgl_RoyaltiesPercentage" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="RoyaltyPaymentsOnNetSales" id="slgl_RoyaltyPaymentsOnNetSales" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="SalesMilestonePayments" id="slgl_SalesMilestonePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="ScheduleOfDisclosureOfAccountingPolicyTableTextBlock" id="slgl_ScheduleOfDisclosureOfAccountingPolicyTableTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="ScheduleOfLeaseRelatedAssetsAndLiabilitiesRecordedOnConsolidatedBalanceSheetTableTextBlock" id="slgl_ScheduleOfLeaseRelatedAssetsAndLiabilitiesRecordedOnConsolidatedBalanceSheetTableTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="ScheduleOfLeaseRelatedAssetsAndLiabilitiesTableTextBlock" id="slgl_ScheduleOfLeaseRelatedAssetsAndLiabilitiesTableTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="ScheduleOfResearchAndDevelopmentExpensesTableTextBlock" id="slgl_ScheduleOfResearchAndDevelopmentExpensesTableTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="ScheduleOfSupplementalCashFlowInformationRelatedToLeasesTableTextBlock" id="slgl_ScheduleOfSupplementalCashFlowInformationRelatedToLeasesTableTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="SegmentGeographicalGroupsOfCountriesGroupFiveMember" id="slgl_SegmentGeographicalGroupsOfCountriesGroupFiveMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingForfeitedWeightedAverageRemainingContractualTerm2" id="slgl_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingForfeitedWeightedAverageRemainingContractualTerm2" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingGrantWeightedAverageRemainingContractualTerm2" id="slgl_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingGrantWeightedAverageRemainingContractualTerm2" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="ShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition" id="slgl_ShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="SharesIssuedInPublicOffering" id="slgl_SharesIssuedInPublicOffering" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="ShortTermDepositsBearInterest" id="slgl_ShortTermDepositsBearInterest" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="ShorttermDepositsBearInterestAtAverageAnnualRate" id="slgl_ShorttermDepositsBearInterestAtAverageAnnualRate" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="StatementOfIncomeLocationAxis" id="slgl_StatementOfIncomeLocationAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" nillable="true"/>
  <element name="StatementOfIncomeLocationDomain" id="slgl_StatementOfIncomeLocationDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="SubscriptionAgreementMArkinDermatologyLtdMember" id="slgl_SubscriptionAgreementMArkinDermatologyLtdMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="SubscriptionAgreementMember" id="slgl_SubscriptionAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="SupplementaryFinancialStatementInformationAbstract" id="slgl_SupplementaryFinancialStatementInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="SupplementaryFinancialStatementInformationLineItems" id="slgl_SupplementaryFinancialStatementInformationLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="SupplementaryFinancialStatementInformationTable" id="slgl_SupplementaryFinancialStatementInformationTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" nillable="true"/>
  <element name="SupplementaryFinancialStatementInformationTextBlock" id="slgl_SupplementaryFinancialStatementInformationTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="SupplierLedManufacturingDevelopmentExpenses" id="slgl_SupplierLedManufacturingDevelopmentExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit"/>
  <element name="TaxBenefitPeriod" id="slgl_TaxBenefitPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="TaxesOnIncomeRollForwardOfValuationAllowanceDetailsAbstract" id="slgl_TaxesOnIncomeRollForwardOfValuationAllowanceDetailsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="TerminationAgreementMember" id="slgl_TerminationAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="TermOfCommercialSaleOfProduct" id="slgl_TermOfCommercialSaleOfProduct" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="TotalConsideration" id="slgl_TotalConsideration" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit"/>
  <element name="TwyneoMember" id="slgl_TwyneoMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="UnderwriterMember" id="slgl_UnderwriterMember" type="dtr-types:domainItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
  <element name="UpfrontPaymentReceived" id="slgl_UpfrontPaymentReceived" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit"/>
  <element name="UpfrontPaymentsForAssetPurchase" id="slgl_UpfrontPaymentsForAssetPurchase" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit"/>
  <element name="YissumMember" id="slgl_YissumMember" type="dtr-types:domainItemType" abstract="false" xbrli:periodType="duration" substitutionGroup="xbrli:item" nillable="true"/>
</schema>
