<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:01a02001-60b1-7e59-8ed1-b521bd39aab7,g:4cf3d0cc-1894-4784-a203-1724ea5eccda-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.sentibio.com/role/Cover" xlink:type="simple" xlink:href="snti-20260814.xsd#Cover"/>
  <link:presentationLink xlink:role="http://www.sentibio.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_01a02001-60b1-7499-b412-cc4faccae23d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_DocumentType_01a02001-60b1-7499-b412-cc4faccae23d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_01a02001-60b1-7cbc-bf8f-e70fc804a328" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_DocumentPeriodEndDate_01a02001-60b1-7cbc-bf8f-e70fc804a328" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_01a02001-60b1-71c2-a6f0-3d72c19a12ca" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_EntityRegistrantName_01a02001-60b1-71c2-a6f0-3d72c19a12ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_01a02001-60b1-75a3-af1c-2d2001faf611" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_EntityIncorporationStateCountryCode_01a02001-60b1-75a3-af1c-2d2001faf611" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_01a02001-60b1-7077-9c18-d2902c5feff3" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_EntityFileNumber_01a02001-60b1-7077-9c18-d2902c5feff3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_01a02001-60b1-7f6e-8d64-ad4d6c8b6489" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_EntityTaxIdentificationNumber_01a02001-60b1-7f6e-8d64-ad4d6c8b6489" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_01a02001-60b1-7bb9-abc6-f956c60ffd32" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_EntityAddressAddressLine1_01a02001-60b1-7bb9-abc6-f956c60ffd32" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_01a02001-60b1-7e37-94d0-a6c1e233079a" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_EntityAddressCityOrTown_01a02001-60b1-7e37-94d0-a6c1e233079a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_01a02001-60b1-76df-8beb-6ab392060371" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_EntityAddressStateOrProvince_01a02001-60b1-76df-8beb-6ab392060371" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_01a02001-60b1-7c5a-a3cf-54f5f289bc04" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_EntityAddressPostalZipCode_01a02001-60b1-7c5a-a3cf-54f5f289bc04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_01a02001-60b1-7e80-ac4f-630cb8e1400b" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_CityAreaCode_01a02001-60b1-7e80-ac4f-630cb8e1400b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_01a02001-60b1-794a-90d4-0dd43a876b71" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_LocalPhoneNumber_01a02001-60b1-794a-90d4-0dd43a876b71" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_01a02001-60b1-78ce-aadb-b613c4403212" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_WrittenCommunications_01a02001-60b1-78ce-aadb-b613c4403212" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_01a02001-60b1-7599-a3d4-74fcc0e4c37d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_SolicitingMaterial_01a02001-60b1-7599-a3d4-74fcc0e4c37d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_01a02001-60b1-7217-8e1a-ee823744fea6" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_PreCommencementTenderOffer_01a02001-60b1-7217-8e1a-ee823744fea6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_01a02001-60b1-7a91-8644-4c79c7f88fa8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_01a02001-60b1-7a91-8644-4c79c7f88fa8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_01a02001-60b1-7f46-a097-94f3c76687d4" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_Security12bTitle_01a02001-60b1-7f46-a097-94f3c76687d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_01a02001-60b1-7a16-b7c7-ff428cb9225d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_TradingSymbol_01a02001-60b1-7a16-b7c7-ff428cb9225d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_01a02001-60b1-7cb2-9cec-5c64a5e4d4b1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_SecurityExchangeName_01a02001-60b1-7cb2-9cec-5c64a5e4d4b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_01a02001-60b1-7577-be2c-64e08ab3af5b" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_EntityEmergingGrowthCompany_01a02001-60b1-7577-be2c-64e08ab3af5b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_01a02001-60b1-7b1c-999f-45b65153b1c3" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_EntityExTransitionPeriod_01a02001-60b1-7b1c-999f-45b65153b1c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_01a02001-60b1-732e-9214-7994776a3a6b" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_EntityCentralIndexKey_01a02001-60b1-732e-9214-7994776a3a6b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_01a02001-60b1-7ad6-a11f-6849b0b1f4d0" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_01a02001-60b1-701f-bbe4-a844dc67687c" xlink:to="loc_dei_AmendmentFlag_01a02001-60b1-7ad6-a11f-6849b0b1f4d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
