0001782223 1 2026-08-20 2026-08-20 0001782223 2026-08-20 2026-08-20 pure shares iso4217:USD N/A 0001782223 N/A EX-FILING FEES S-3 S-3 Pyxis Oncology, Inc. false Equity Common Stock, par value$0.001per share true 39200306 3.28 128577003.68 0.0001381 17756.48 128577003.68 17756.48 0 0 17756.48 <p style="margin-left:1.52%;text-indent:-4.525%;padding-left:4.067%;font-size:10pt;margin-top:1pt;font-family:Times New Roman;margin-bottom:0;margin-right:4.546%;text-align:justify;"><span style="color:#000000;white-space:pre-wrap;font-size:9pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">(1)</span><span style="color:#000000;white-space:pre-wrap;font-size:10pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;"> </span><span style="color:#000000;white-space:pre-wrap;font-size:9pt;font-family:Times New Roman;font-kerning:none;min-width:fit-content;">Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(c) under the Securities Act of 1933, as amended. The offering price per share and aggregate offering price are based upon the average of the high and low prices for the Registrant’s Common Stock as reported on the Nasdaq Global Select Market on August 19, 2026, a date within five business days prior to the filing of this Registration Statement.</span></p>