| Schedule of significant expense categories |
| | | | | | | | | Three months ended June 30, | | | 2026 | | 2025 | Revenues, net | | $ | 8,700 | | $ | 1,505,322 | Cost of revenues | | | 16,965 | | | 439,815 | Gross profit | | | (8,265) | | | 1,065,507 | Operating expenses: | | | | | | | Research and development expenses | | | | | | | ONS-5010/LYTENAVA development | | | 2,187,470 | | | 5,847,020 | Compensation and related benefits | | | 567,189 | | | 906,195 | Stock-based compensation | | | 63,266 | | | 91,636 | Other research and development | | | 433,174 | | | 289,855 | | | | 3,251,099 | | | 7,134,706 | Selling, general and administrative expenses | | | | | | | Professional fees | | | 1,173,827 | | | 1,315,395 | Compensation and related benefits | | | 1,520,593 | | | 1,943,321 | Stock-based compensation | | | 728,405 | | | 1,579,176 | Europe commercial expenses | | | 3,042,474 | | | 3,867,013 | Facilities, fees and other related costs | | | 1,085,546 | | | 974,576 | | | | 7,550,845 | | | 9,679,481 | | | | | | | | Segment loss from operations | | | (10,810,209) | | | (15,748,680) | Other segment items (i) | | | (9,509,063) | | | (4,403,822) | Segment loss before income taxes | | $ | (20,319,272) | | $ | (20,152,502) |
| | | | | | | | | Nine months ended June 30, | | | 2026 | | 2025 | | | | | | | | Revenues, net | | $ | (1,071,694) | | $ | 1,505,322 | Cost of revenues | | | 195,918 | | | 439,815 | Gross profit | | | (1,267,612) | | | 1,065,507 | Operating expenses: | | | | | | | Research and development expenses | | | | | | | ONS-5010/LYTENAVA development | | | 8,317,752 | | | 18,282,667 | Compensation and related benefits | | | 1,725,206 | | | 1,831,860 | Stock-based compensation | | | 254,202 | | | 289,889 | Other research and development | | | 1,088,811 | | | 797,459 | | | | 11,385,971 | | | 21,201,875 | Selling, general and administrative expenses | | | | | | | Professional fees | | | 4,667,134 | | | 5,120,664 | Compensation and related benefits | | | 4,101,809 | | | 5,806,232 | Stock-based compensation | | | 2,176,102 | | | 6,757,008 | Europe commercial expenses | | | 11,919,248 | | | 9,177,513 | Facilities, fees and other related costs | | | 2,803,272 | | | 2,749,275 | | | | 25,667,565 | | | 29,610,692 | | | | | | | | Segment loss from operations | | | (38,321,148) | | | (49,747,060) | Other segment items (i) | | | (9,509,339) | | | 617,766 | Segment loss before income taxes | | $ | (47,830,487) | | $ | (49,129,294) |
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