Exhibit 3.4

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CERTIFICATE OF AMENDMENT TO THE

AMENDED AND RESTATED CERTIFICATE OF INCORPORATION

OF

AVERE THERAPEUTICS, INC.

Avere Therapeutics, Inc., a corporation organized and existing under the laws of the State of Delaware (the “Corporation”), certifies that:

1.The current name of the Corporation is Avere Therapeutics, Inc.

2.The amendment set forth in this Certificate of Amendment to the Second Amended and Restated Certificate of Incorporation of the Corporation (this “Certificate of Amendment”) has been duly adopted in accordance with Section 242 of the Delaware General Corporation Law by the board of directors of the Corporation and by the stockholders of the Corporation. This Certificate of Amendment hereby amends the Corporation’s Second Amended and Restated Certificate of Incorporation, as currently in effect (the “Certificate of Incorporation”), as set forth below.

3.The first paragraph of ARTICLE IV in the Certificate of Incorporation is hereby amended and restated in its entirety as follows:

“The total number of shares of all classes of stock which the Corporation shall have the authority to issue is 89,480,072. The Corporation has two classes of stock, referred to as Common Stock and Preferred Stock. There are 64,188,405 shares of authorized Common Stock, $0.0001 par value per share (“Common Stock”), and 25,291,667 shares of authorized Preferred Stock, $0.0001 par value per share (“Preferred Stock”), of which (i) 10,000,000 shares are hereby designated as “Series Seed Preferred Stock” and (ii) 15,291,667 shares are hereby designated as “Series Seed-1 Preferred Stock.”.”

4.Except as amended hereby, the provisions of the Certificate of Incorporation shall remain in full force and effect.

5.This Certificate of Amendment shall be effective as of July 31, 2026.

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IN WITNESS WHEREOF, this Certificate of Amendment has been signed by an authorized officer of the Corporation on July 31, 2026.

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