Offerings	Aug. 17, 2026 USD ($) shares
Offering: 1
Offering:
Fee Previously Paid	false
Other Rule	true
Security Type	Equity
Security Class Title	Common Stock, $0.001 par value per share
Amount Registered \| shares	443,883,560
Maximum Aggregate Offering Price	$ 147,961.19
Fee Rate	0.01381%
Amount of Registration Fee	$ 20.43
Offering Note	(A) Relates to common stock, $0.001 par value per share, of NextCure, Inc., a Delaware corporation ("NextCure"), issuable to holders of common stock, $0.0001 par value per share, of Avere Therapeutics, Inc., a Delaware corporation ("Avere"), and other Avere security holders in the proposed merger of Neptune Merger Sub Corp., a Delaware corporation and a direct, wholly owned subsidiary of NextCure, with and into Avere, with Avere surviving the merger, and as part of the same overall transaction, Avere will merge with and into Neptune Second Merger Sub, LLC, a Delaware limited liability company and a wholly owned subsidiary of NextCure, with Neptune Second Merger Sub, LLC continuing as a wholly owned subsidiary of NextCure and the surviving entity of the merger. The amount of common stock of NextCure to be registered includes the estimated maximum number of shares of common stock of NextCure that are expected to be issued (or become issuable) pursuant to the merger, without taking into account the effect of a reverse stock split of common stock of NextCure, assuming an estimated pre-split exchange ratio (which is subject to adjustment prior to the closing of the merger) of approximately 5.8265 shares of common stock of NextCure for each outstanding share of capital stock of Avere. The issuances of (i) all shares of NextCure Common Stock in exchange for each share of Avere Common Stock (including shares of Avere Common Stock issued in the Avere Pre-Closing Financing) and Avere Preferred Stock, (ii) all NextCure Pre-Funded Warrants issued in exchange for Avere Pre-Funded Warrants issued in the Avere Pre-Closing Financing, (iii) all NextCure Pre-Funded Warrants issued to certain Avere stockholders in lieu of shares of NextCure Common Stock otherwise issuable to such stockholders in the merger in excess of such stockholders' beneficial ownership limitations, and (iv) all shares of NextCure Common Stock issuable upon exercise of NextCure Pre-Funded Warrants described in clauses (ii) and (iii), are intended to be covered by this registration statement on Form S-4. In accordance with Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this registration statement shall be deemed to cover any securities that may from time to time be offered or issued resulting from forward or reverse stock splits, stock dividends or similar transactions. (B) Estimated solely for purposes of calculating the registration fee in accordance with Rule 457(f)(2) of the Securities Act. Avere is a private company, no market exists for its securities, and it has an accumulated capital deficit. Therefore, the proposed maximum aggregate offering price for the shares expected to be issued pursuant to the merger is one-third of the aggregate par value of the Avere securities expected to be exchanged in the proposed merger.
Offering: 2
Offering:
Fee Previously Paid	false
Other Rule	true
Security Type	Equity
Security Class Title	Warrants to purchase Common Stock
Amount Registered \| shares	67,579,821
Maximum Aggregate Offering Price	$ 0.00
Fee Rate	0.01381%
Amount of Registration Fee	$ 0.00
Offering Note	Consists of NextCure Pre-Funded Warrants issued in the merger in exchange for Avere Pre-Funded Warrants issued in the Avere Pre-Closing Financing and NextCure Pre-Funded Warrants issued to certain Avere stockholders in lieu of shares of NextCure Common Stock otherwise issuable to such stockholders in the merger in excess of such stockholders' beneficial ownership limitations, in each case, without taking into account the effect of a reverse stock split of common stock of NextCure, assuming an estimated pre-split exchange ratio (which is subject to adjustment prior to the closing of the merger) of approximately 5.8265 shares of common stock of NextCure for each outstanding share of capital stock of Avere. The registration fee with respect to the NextCure Pre-Funded Warrants has been allocated to the underlying shares of NextCure Common Stock issuable upon exercise of such NextCure Pre-Funded Warrants, as described in footnote (1).

Offerings

Aug. 17, 2026

USD ($)

Offering:

false

true

Equity

Common Stock, $0.001 par value per share

Amount Registered | shares

443,883,560

Maximum Aggregate Offering Price

$ 147,961.19

Fee Rate

0.01381%

Amount of Registration Fee

$ 20.43

Offering Note

(A) Relates to common stock, $0.001 par value per share, of NextCure, Inc., a Delaware corporation ("NextCure"), issuable to holders of common stock, $0.0001 par value per share, of Avere Therapeutics, Inc., a Delaware corporation ("Avere"), and other Avere security holders in the proposed merger of Neptune Merger Sub Corp., a Delaware corporation and a direct, wholly owned subsidiary of NextCure, with and into Avere, with Avere surviving the merger, and as part of the same overall transaction, Avere will merge with and into Neptune Second Merger Sub, LLC, a Delaware limited liability company and a wholly owned subsidiary of NextCure, with Neptune Second Merger Sub, LLC continuing as a wholly owned subsidiary of NextCure and the surviving entity of the merger. The amount of common stock of NextCure to be registered includes the estimated maximum number of shares of common stock of NextCure that are expected to be issued (or become issuable) pursuant to the merger, without taking into account the effect of a reverse stock split of common stock of NextCure, assuming an estimated pre-split exchange ratio (which is subject to adjustment prior to the closing of the merger) of approximately 5.8265 shares of common stock of NextCure for each outstanding share of capital stock of Avere. The issuances of (i) all shares of NextCure Common Stock in exchange for each share of Avere Common Stock (including shares of Avere Common Stock issued in the Avere Pre-Closing Financing) and Avere Preferred Stock, (ii) all NextCure Pre-Funded Warrants issued in exchange for Avere Pre-Funded Warrants issued in the Avere Pre-Closing Financing, (iii) all NextCure Pre-Funded Warrants issued to certain Avere stockholders in lieu of shares of NextCure Common Stock otherwise issuable to such stockholders in the merger in excess of such stockholders' beneficial ownership limitations, and (iv) all shares of NextCure Common Stock issuable upon exercise of NextCure Pre-Funded Warrants described in clauses (ii) and (iii), are intended to be covered by this registration statement on Form S-4. In accordance with Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this registration statement shall be deemed to cover any securities that may from time to time be offered or issued resulting from forward or reverse stock splits, stock dividends or similar transactions. (B) Estimated solely for purposes of calculating the registration fee in accordance with Rule 457(f)(2) of the Securities Act. Avere is a private company, no market exists for its securities, and it has an accumulated capital deficit. Therefore, the proposed maximum aggregate offering price for the shares expected to be issued pursuant to the merger is one-third of the aggregate par value of the Avere securities expected to be exchanged in the proposed merger.

Offering:

false

true

Equity

Warrants to purchase Common Stock

Amount Registered | shares

67,579,821

Maximum Aggregate Offering Price

$ 0.00

Fee Rate

0.01381%

Amount of Registration Fee

$ 0.00

Offering Note

Consists of NextCure Pre-Funded Warrants issued in the merger in exchange for Avere Pre-Funded Warrants issued in the Avere Pre-Closing Financing and NextCure Pre-Funded Warrants issued to certain Avere stockholders in lieu of shares of NextCure Common Stock otherwise issuable to such stockholders in the merger in excess of such stockholders' beneficial ownership limitations, in each case, without taking into account the effect of a reverse stock split of common stock of NextCure, assuming an estimated pre-split exchange ratio (which is subject to adjustment prior to the closing of the merger) of approximately 5.8265 shares of common stock of NextCure for each outstanding share of capital stock of Avere. The registration fee with respect to the NextCure Pre-Funded Warrants has been allocated to the underlying shares of NextCure Common Stock issuable upon exercise of such NextCure Pre-Funded Warrants, as described in footnote (1).