The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC COM NEW 00289Y206 672,786 108,865 SH SOLE 108,865 0 0
ACADIA PHARMACEUTICALS INC COM 00404A109 72,461,629 2,864,096 SH SOLE 2,864,096 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 8,535,045 1,613,430 SH SOLE 1,613,430 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 7,926,733 213,601 SH SOLE 213,601 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 331,660 155,709 SH SOLE 155,709 0 0
ALIGN TECHNOLOGY INC COM 016255101 5,294,069 31,389 SH SOLE 31,389 0 0
ALKERMES PLC SHS G01767105 12,708,931 242,560 SH SOLE 242,560 0 0
ANAPTYSBIO INC COM 032724106 40,735,508 603,489 SH SOLE 603,489 0 0
ANNEXON INC COM 03589W102 16,833,594 2,948,090 SH SOLE 2,948,090 0 0
BICARA THERAPEUTICS INC COM 055477103 16,341,614 550,408 SH SOLE 550,408 0 0
BICYCLE THERAPEUTICS PLC-ADR SPONSORED ADS 088786108 856,014 201,890 SH SOLE 201,890 0 0
BIOGEN INC COM 09062X103 30,308,681 140,279 SH SOLE 140,279 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 39,068,500 682,777 SH SOLE 682,777 0 0
BIONTECH SE-ADR SPONSORED ADS 09075V102 1,825,083 19,614 SH SOLE 19,614 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309 5,532,693 229,763 SH SOLE 229,763 0 0
CAREDX INC COM 14167L103 15,158,295 531,870 SH SOLE 531,870 0 0
CELLDEX THERAPEUTICS INC COM NEW 15117B202 14,878,642 399,856 SH SOLE 399,856 0 0
COMPASS PATHWAYS PLC ADR SPONSORED ADS 20451W101 1,635,966 115,616 SH SOLE 115,616 0 0
COMPASS THERAPEUTICS INC COM 20454B104 12,771,670 5,831,813 SH SOLE 5,831,813 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 2,160,057 39,605 SH SOLE 39,605 0 0
CYTOKINETICS INC COM NEW 23282W605 2,742,692 32,195 SH SOLE 32,195 0 0
DISC MEDICINE INC COM 254604101 30,473,488 416,646 SH SOLE 416,646 0 0
DYNE THERAPEUTICS INC COM 26818M108 36,591,441 1,647,521 SH SOLE 1,647,521 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 3,043,074 33,640 SH SOLE 33,640 0 0
EHEALTH INC COM 28238P109 2,209,368 1,482,797 SH SOLE 1,482,797 0 0
FIRST TRACKS BIOTHERAPEUTICS ORD SHS 337185102 12,142,199 603,489 SH SOLE 603,489 0 0
HUMANA INC COM 444859102 1,582,922 3,985 SH SOLE 3,985 0 0
INSMED INC COM PAR $.01 457669307 44,138,548 413,980 SH SOLE 413,980 0 0
INSPIRE MEDICAL SYSTEMS INC COM 457730109 391,319 8,772 SH SOLE 8,772 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 22,032,229 5,296,209 SH SOLE 5,296,209 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 959,530 1,787 SH SOLE 1,787 0 0
MIRUM PHARMACEUTICALS INC NOTE 4.000% 5/0 604749AB7 40,834,953 348,808 PRN SOLE 348,808 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 3,053,349 18,117 SH SOLE 18,117 0 0
NEWAMSTERDAM PHARMA CO NV ORDINARY SHARES N62509109 1,503,327 44,359 SH SOLE 44,359 0 0
NOVOCURE LTD ORD SHS G6674U108 19,398,651 1,280,439 SH SOLE 1,280,439 0 0
NUVATION BIO INC COM CL A 67080N101 1,855,139 326,609 SH SOLE 326,609 0 0
ORUKA THERAPEUTICS INC - Restricted COM 687604108 3,192,573 33,546 SH SOLE 33,546 0 0
PROQR THERAPEUTICS NV SHS EURO N71542109 351,181 188,807 SH SOLE 188,807 0 0
PROTHENA CORP PLC SHS G72800108 11,191,487 1,143,155 SH SOLE 1,143,155 0 0
PTC THERAPEUTICS INC COM 69366J200 74,950,268 918,846 SH SOLE 918,846 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101 2,601,474 864,277 SH SOLE 864,277 0 0
SAGIMET BIOSCIENCES INC-A COM SER A 786700104 1,932,500 250,000 SH SOLE 250,000 0 0
STOKE THERAPEUTICS INC COM 86150R107 2,769,126 84,631 SH SOLE 84,631 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 18,908,594 864,986 SH SOLE 864,986 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106 9,475,311 1,391,382 SH SOLE 1,391,382 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 9,517,095 167,525 SH SOLE 167,525 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 19,916,968 596,495 SH SOLE 596,495 0 0
UNITED THERAPEUTICS CORP COM 91307C102 33,911,514 62,587 SH SOLE 62,587 0 0
UROGEN PHARMA LTD COM M96088105 901,600 24,500 SH SOLE 24,500 0 0
VERASTEM INC COM NEW 92337C203 1,182,997 309,685 SH SOLE 309,685 0 0
XENON PHARMACEUTICALS INC COM 98420N105 3,099,184 51,345 SH SOLE 51,345 0 0
XERIS BIOPHARMA HOLDINGS INC COM 98422E103 826,927 104,410 SH SOLE 104,410 0 0