The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABORATORIES COM 002824100 3,800,000 40,000 SH Call SOLE 40,000 0 0
ABEONA THERAPEUTICS INC COM NEW 00289Y206 3,444,015 557,284 SH SOLE 557,284 0 0
ADICET BIO INC COM NEW 007002207 2,121,276 245,518 SH SOLE 245,518 0 0
ADLAI NORTYE LTD SPONSORED ADS 00704R109 278,956 24,257 SH SOLE 24,257 0 0
ADMA BIOLOGICS INC COM 000899104 6,193,800 740,000 SH SOLE 740,000 0 0
ADMA BIOLOGICS INC COM 000899104 7,950,000 650,000 SH Call SOLE 650,000 0 0
AN2 THERAPEUTICS INC COM 037326105 2,670,190 551,692 SH SOLE 551,692 0 0
ARDELYX INC COM 039697107 1,050,000 150,000 SH Call SOLE 150,000 0 0
ARVINAS INC COM 04335A105 498,600 60,000 SH SOLE 60,000 0 0
AYTU BIOPHARMA INC COM 054754858 1,962,780 912,921 SH SOLE 912,921 0 0
AZITRA INC COM NEW 05479L302 886,903 5,285,476 SH SOLE 5,285,476 0 0
BIOAGE LABS INC COM 09077V100 490,200 20,000 SH SOLE 20,000 0 0
BIOATLA INC COM NEW 09077B203 68,028 16,432 SH SOLE 16,432 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 3,125,000 50,000 SH Call SOLE 50,000 0 0
BOSTON SCIENTIFIC CORP COM 101137107 3,250,000 50,000 SH Call SOLE 50,000 0 0
BOUNDLESS BIO INC COM 10170A100 386,488 154,595 SH SOLE 154,595 0 0
CABALETTA BIO INC COM 12674W109 2,852,181 917,100 SH SOLE 917,100 0 0
CALCIMEDICA INC COM NEW 38942Q202 544,939 622,432 SH SOLE 622,432 0 0
CAMP4 THERAPEUTICS CORP COM 13469V AB 4 CAMTEK LTD NOTE 12/0 13463J101 6,072,648 1,389,622 SH SOLE 1,389,622 0 0
CELLECTAR BIOSCIENCES INC COM NEW 15117F880 290,649 104,550 SH SOLE 104,550 0 0
CNS PHARMACEUTICALS INC COM 18978H508 198,719 41,573 SH SOLE 41,573 0 0
CODEXIS INC COM 192005106 247,836 109,662 SH SOLE 109,662 0 0
COMPUGEN LTD ORD M25722105 67,168 31,387 SH SOLE 31,387 0 0
CONNECT BIOPHARMA HLDGS LTD SHS G23549101 866,925 364,254 SH SOLE 364,254 0 0
CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301 3,986,500 425,000 SH SOLE 425,000 0 0
CRESCENT BIOPHARMA INC. COM G2545C104 720,000 40,000 SH SOLE 40,000 0 0
CURIS INC COM 231269309 1,729,292 3,312,185 SH SOLE 3,312,185 0 0
CYBIN INC COM NEW 23256X407 854,541 129,280 SH SOLE 129,280 0 0
CYTOMX THERAPEUTICS INC. COM 23284F105 768,750 205,000 SH SOLE 205,000 0 0
DELCATH SYS INC COM NEW 24661P807 1,000,000 100,000 SH Call SOLE 100,000 0 0
EDESA BIOTECH INC COM NEW 27966L306 3,190,807 456,439 SH SOLE 456,439 0 0
ELOXX PHARMACEUTICALS INC COM NEW 29014R301 5,512,581 397,160 SH SOLE 397,160 0 0
EUPRAXIA PHARMACEUTICALS INC COM 298736 AL 3 EURONET WORLDWIDE INC NOTE 0.750% 3/1 29842P105 287,476 43,491 SH SOLE 43,491 0 0
EVAXION AS SPONSORED ADS 29970R303 54,442 17,562 SH SOLE 17,562 0 0
EVOLUS INC COM 30052C107 11,035,724 1,590,162 SH SOLE 1,590,162 0 0
EVOLUS INC COM 30052C107 3,150,000 420,000 SH Call SOLE 420,000 0 0
HERON THERAPEUTICS INC COM 427746102 209,468 490,787 SH SOLE 490,787 0 0
HERON THERAPEUTICS INC COM 427746102 1,500,000 1,000,000 SH Call SOLE 1,000,000 0 0
HUMACYTE INC COM 44486Q103 180,506 231,299 SH SOLE 231,299 0 0
IN8BIO INC COM NEW 45674E208 980,355 695,287 SH SOLE 695,287 0 0
INDIVIOR PHARMACEUTICALS INC COM 45579U109 4,103,000 100,000 SH SOLE 100,000 0 0
INHIBIKASE THERAPEUTICS INC COM NEW 45719W205 804,243 396,179 SH SOLE 396,179 0 0
INSMED INC COM PAR $.01 457669307 5,600,000 40,000 SH Call SOLE 40,000 0 0
KALARIS THERAPEUTICS INC COM 482929106 122,597 30,122 SH SOLE 30,122 0 0
KAZIA THERAPEUTICS LTD SPONSORED ADS 48669G303 4,860,120 345,179 SH SOLE 345,179 0 0
MANNKIND CORP COM NEW 56400P706 750,000 250,000 SH Call SOLE 250,000 0 0
MAXCYTE INC COM 57777K106 924,475 751,606 SH SOLE 751,606 0 0
MEDTRONIC PLC SHS G5960L103 4,375,000 50,000 SH Call SOLE 50,000 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104 973,500 50,000 SH SOLE 50,000 0 0
NEKTAR THERAPEUTICS COM NEW 640268306 8,422,856 120,654 SH SOLE 120,654 0 0
NERVGEN PHARMA CORP COM 64082X203 559,657 271,678 SH SOLE 271,678 0 0
NEUMORA THERAPEUTICS INC. COM 640979100 1,250,000 500,000 SH Call SOLE 500,000 0 0
NUVECTIS PHARMA INC COM 67080T108 735,600 40,000 SH SOLE 40,000 0 0
OKYO PHARMA LTD SHS NEW G6724L116 1,294,494 862,996 SH SOLE 862,996 0 0
ONKURE THERAPEUTICS INC COM CL A 68277Q105 595,919 130,684 SH SOLE 130,684 0 0
OPUS GENETICS INC COM 67577R102 413,951 100,718 SH SOLE 100,718 0 0
ORUKA THERAPEUTICS INC COM 687604108 713,775 7,500 SH SOLE 7,500 0 0
OVID THERAPEUTICS INC COM 690469101 57,297 21,300 SH SOLE 21,300 0 0
PASITHEA THERAPEUTICS CORP COM NEW 70261F202 1,134,637 2,201,468 SH SOLE 2,201,468 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 922,358 85,010 SH SOLE 85,010 0 0
PLIANT THERAPEUTICS INC COM 729139105 262,813 230,538 SH SOLE 230,538 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 718,355 536,086 SH SOLE 536,086 0 0
PRECISION OPTICS CORP INC MA COM NEW 740294400 236,589 46,390 SH SOLE 46,390 0 0
PROCESSA PHARMACEUTICALS INC COM SHS 74275C403 105,600 55,000 SH SOLE 55,000 0 0
PULMONX CORP COM 745848101 1,060,067 815,436 SH SOLE 815,436 0 0
QT IMAGING HLDGS INC COM 746962307 407,000 100,000 SH SOLE 100,000 0 0
QUOIN PHARMACEUTICALS LTD SPONSORED ADS 74907L409 965,512 199,486 SH SOLE 199,486 0 0
RADIOPHARM THERANOSTICS LTD SPONSORED ADS 75041J101 670,500 51,000,000 SH SOLE 51,000,000 0 0
REIN THERAPEUTICS INC COM NEW 00887A204 226,760 218,038 SH SOLE 218,038 0 0
SAB BIOTHERAPEUTICS INC COM NEW 78397T202 285,757 73,271 SH SOLE 73,271 0 0
SATELLOS BIOSCIENCE INC COM 80401L803 3,723,291 491,624 SH SOLE 491,624 0 0
SENSEONICS HLDGS INC COM 81727U303 276,502 48,680 SH SOLE 48,680 0 0
SI BONE INC COM 825704109 1,500,000 100,000 SH Call SOLE 100,000 0 0
SINTX TECHNOLOGIES INC COM NEW 829392703 332,531 209,205 SH SOLE 209,205 0 0
SOL-GEL TECHNOLOGIES LTD SHS NEW M8694L137 1,072,732 14,469 SH SOLE 14,469 0 0
SPRUCE BIOSCIENCES INC COM NEW 85209E208 1,554,930 28,795 SH SOLE 28,795 0 0
TELA BIO INC COM 872381108 1,996,820 2,662,427 SH SOLE 2,662,427 0 0
TENAX THERAPEUTICS INC COM NEW 88032L605 9,603,000 660,000 SH SOLE 660,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 834,750 25,000 SH SOLE 25,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 5,500,000 200,000 SH Call SOLE 200,000 0 0
UPSTREAM BIO INC COM 91678A107 231,349 33,432 SH SOLE 33,432 0 0
VERASTEM INC COM NEW 92337C203 12,795,575 3,349,627 SH SOLE 3,349,627 0 0
X4 PHARMACEUTICALS INC COM NEW 98420X202 1,050,699 224,989 SH SOLE 224,989 0 0
XERIS BIOPHARMA HOLDINGS INC COM 98422E103 2,100,000 280,000 SH Call SOLE 280,000 0 0
XILIO THERAPEUTICS INC COM 98422T209 2,165,023 225,994 SH SOLE 225,994 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 783,678 161,583 SH SOLE 161,583 0 0
ZEVRA THERAPEUTICS INC COM NEW 488445206 3,709,772 258,701 SH SOLE 258,701 0 0