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  <xsd:element name="ShareBasedCompensationArrangementPurchasePriceForSignificantShareholders." id="rnaz_ShareBasedCompensationArrangementPurchasePriceForSignificantShareholders." type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WarrantDisclosureTextBlock" id="rnaz_WarrantDisclosureTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="GrantIncomeOther" id="rnaz_GrantIncomeOther" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="GrantIncomePolicyPolicyTextBlock" id="rnaz_GrantIncomePolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DeferredGrantIncomeAbstract" id="rnaz_DeferredGrantIncomeAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DeferredGrantIncomeDisclosureTextBlock" id="rnaz_DeferredGrantIncomeDisclosureTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AggregateGrantReceivableEstimatedAmount" id="rnaz_AggregateGrantReceivableEstimatedAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="TermOfGrant" id="rnaz_TermOfGrant" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScheduleOfMilestonePaymentsCompanyShallPayToLicensorTableTextBlock" id="rnaz_ScheduleOfMilestonePaymentsCompanyShallPayToLicensorTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PrepaidExpensesAndOtherCurrentAssetsTableTextBlock" id="rnaz_PrepaidExpensesAndOtherCurrentAssetsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="StockOptionAndIncentivePlan2021Member" id="rnaz_StockOptionAndIncentivePlan2021Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AccruedInsurancePremiums" id="rnaz_AccruedInsurancePremiums" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="ComputerAndOfficeEquipmentMember" id="rnaz_ComputerAndOfficeEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LaboratoryEquipmentMember" id="rnaz_LaboratoryEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AccruedLicenseObligations" id="rnaz_AccruedLicenseObligations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DefinedEmployeeStockPurchasePlan" id="rnaz_DefinedEmployeeStockPurchasePlan" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="EmployeeStockPurchasePlanTextBlock" id="rnaz_EmployeeStockPurchasePlanTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="IncreaseDecreaseInGrantReceivable" id="rnaz_IncreaseDecreaseInGrantReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="UniversityOfTexasM.D.AndersonCancerCenterMdAndersonMember" id="rnaz_UniversityOfTexasM.D.AndersonCancerCenterMdAndersonMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ContractualObligationAmountCommittedToBePaidInYearOne" id="rnaz_ContractualObligationAmountCommittedToBePaidInYearOne" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AccruedGeneralExpenses" id="rnaz_AccruedGeneralExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeArrangementExpensesIncurred" id="rnaz_CollaborativeArrangementExpensesIncurred" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="StrategicCollaborationAgreementTerm" id="rnaz_StrategicCollaborationAgreementTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="AmountPayableToContractResearchOrganizationsAndContractManufacturingOrganizations" id="rnaz_AmountPayableToContractResearchOrganizationsAndContractManufacturingOrganizations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="GrantIncomeReceivable" id="rnaz_GrantIncomeReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="SecuritiesPurchaseAgreementMember" id="rnaz_SecuritiesPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ConsultingAgreementMember" id="rnaz_ConsultingAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ClassOfWarrantOrRightNumberOfWarrantsOrRightsIssued" id="rnaz_ClassOfWarrantOrRightNumberOfWarrantsOrRightsIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="WarrantsAndRightsExercisableCommencementPeriodForExerciseOfWarrants" id="rnaz_WarrantsAndRightsExercisableCommencementPeriodForExerciseOfWarrants" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PreFundedWarrantsMember" id="rnaz_PreFundedWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="JunePlacementAgentWarrantsMember" id="rnaz_JunePlacementAgentWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeriesaWarrantsMember" id="rnaz_SeriesaWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="Seriesa1WarrantsMember" id="rnaz_Seriesa1WarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="Seriesa2WarrantsMember" id="rnaz_Seriesa2WarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PrepaidFederalInsuranceContributionAct" id="rnaz_PrepaidFederalInsuranceContributionAct" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="PropertyPlantAndEquipmentEstimatedUsefulLifePolicyTableTextBlock" id="rnaz_PropertyPlantAndEquipmentEstimatedUsefulLifePolicyTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="IpoUnderwriterWarrantsMember" id="rnaz_IpoUnderwriterWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FebruaryPlacementAgentWarrantsMember" id="rnaz_FebruaryPlacementAgentWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="JanuaryWarrantsMember" id="rnaz_JanuaryWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="JanuaryPlacementAgentWarrantsMember" id="rnaz_JanuaryPlacementAgentWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ContractualObligationAmountPaidDuringYear" id="rnaz_ContractualObligationAmountPaidDuringYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="July2024OfferingMember" id="rnaz_July2024OfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="JulyPlacementAgentWarrantsMember" id="rnaz_JulyPlacementAgentWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FirstYearAwardMember" id="rnaz_FirstYearAwardMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SecondYearAwardMember" id="rnaz_SecondYearAwardMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="July2024PlacementAgentsWarrantsMember" id="rnaz_July2024PlacementAgentsWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeriesCWarrantsMember" id="rnaz_SeriesCWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeriesDWarrantsMember" id="rnaz_SeriesDWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DeemedDividendArisingFromWarrantModification" id="rnaz_DeemedDividendArisingFromWarrantModification" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="March2025RegisteredDirectOfferingMember" id="rnaz_March2025RegisteredDirectOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WarrantIssuanceCostsPrivateInvestmentInPublicEntity" id="rnaz_WarrantIssuanceCostsPrivateInvestmentInPublicEntity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="RelocationExpense" id="rnaz_RelocationExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ExerciseOfWarrantsFairValue" id="rnaz_ExerciseOfWarrantsFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="January2024WarrantsAtExercisePrice1127.28Member" id="rnaz_January2024WarrantsAtExercisePrice1127.28Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="March2025PlacementAgentsWarrantsMember" id="rnaz_March2025PlacementAgentsWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="March2025WarrantsMember" id="rnaz_March2025WarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="February2023PlacementAgentWarrantsMember" id="rnaz_February2023PlacementAgentWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="February2023ConsultantWarrantsMember" id="rnaz_February2023ConsultantWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="September2023UnderwriterWarrantsMember" id="rnaz_September2023UnderwriterWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="December2023PlacementAgentWarrantsMember" id="rnaz_December2023PlacementAgentWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="October2023UnderwriterOverallotmentWarrantsMember" id="rnaz_October2023UnderwriterOverallotmentWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="January2024WarrantsAtExercisePrice438.90Member" id="rnaz_January2024WarrantsAtExercisePrice438.90Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ClassOfWarrantOrRightNumberOfAdditionalWarrantsOrRightsIssued" id="rnaz_ClassOfWarrantOrRightNumberOfAdditionalWarrantsOrRightsIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ContingentValueRightsAgreementNumberOfContingentValueRightsPerShare" id="rnaz_ContingentValueRightsAgreementNumberOfContingentValueRightsPerShare" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ContingentValueRightsAgreementTerm" id="rnaz_ContingentValueRightsAgreementTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ContingentValueRightsAgreementPercentageOfNetProceeds" id="rnaz_ContingentValueRightsAgreementPercentageOfNetProceeds" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ContingentValueRightsAgreementPercentageOfHoldersEligible" id="rnaz_ContingentValueRightsAgreementPercentageOfHoldersEligible" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DividendsPreferredStockPaidInKindPercentage" id="rnaz_DividendsPreferredStockPaidInKindPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PreferredStockRightsFundamentalOrMergerMinimumPercentage" id="rnaz_PreferredStockRightsFundamentalOrMergerMinimumPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="BusinessCombinationProFormaInformationAdjustmentAxis" id="rnaz_BusinessCombinationProFormaInformationAdjustmentAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="BusinessCombinationProFormaInformationAdjustmentDomain" id="rnaz_BusinessCombinationProFormaInformationAdjustmentDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DefjLlcMember" id="rnaz_DefjLlcMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AbcjLlcMember" id="rnaz_AbcjLlcMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FinancingReceivableAggregatePrincipalAmount" id="rnaz_FinancingReceivableAggregatePrincipalAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="FinancingReceivableInterestRateStatedPercentage" id="rnaz_FinancingReceivableInterestRateStatedPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="PaymentOfLicenseAmendmentFees" id="rnaz_PaymentOfLicenseAmendmentFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ThresholdPeriodMilestonePaymentsPhaseIiClinicalTrial" id="rnaz_ThresholdPeriodMilestonePaymentsPhaseIiClinicalTrial" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ThresholdPeriodMilestonePaymentsPhaseIiiClinicalTrial" id="rnaz_ThresholdPeriodMilestonePaymentsPhaseIiiClinicalTrial" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ThresholdPeriodMilestonePaymentsFirstCommercialSale" id="rnaz_ThresholdPeriodMilestonePaymentsFirstCommercialSale" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ChangeOfControlEventTransactionValueBetweenFiftyMillionAndHundredMillionMember" id="rnaz_ChangeOfControlEventTransactionValueBetweenFiftyMillionAndHundredMillionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ChangeOfControlEventTransactionValueIsMoreThanHundredMillionMember" id="rnaz_ChangeOfControlEventTransactionValueIsMoreThanHundredMillionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SafetyTrialMinimumNumberOfPatients" id="rnaz_SafetyTrialMinimumNumberOfPatients" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PolynomaLlcMember" id="rnaz_PolynomaLlcMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PrepaidOperatingExpenses" id="rnaz_PrepaidOperatingExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="UnleashImmunoOncolyticsInc.Member" id="rnaz_UnleashImmunoOncolyticsInc.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="BusinessCombinationContingentConsiderationPolicyPolicyTextBlock" id="rnaz_BusinessCombinationContingentConsiderationPolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="BusinessAcquisitionCommonStockIssuedOrIssuableNumberOfShares" id="rnaz_BusinessAcquisitionCommonStockIssuedOrIssuableNumberOfShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="BusinessAcquisitionMaximumPercentageOfOutstandingSharesIssuable" id="rnaz_BusinessAcquisitionMaximumPercentageOfOutstandingSharesIssuable" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="BusinessAcquisitionPreferredStockIssuedOrIssuableNumberOfShares" id="rnaz_BusinessAcquisitionPreferredStockIssuedOrIssuableNumberOfShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="BusinessCombinationConsiderationTransferredCommonStockIssuedOrIssuable" id="rnaz_BusinessCombinationConsiderationTransferredCommonStockIssuedOrIssuable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
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  <xsd:element name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedGoodwill" id="rnaz_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedGoodwill" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayableAndAccruedExpenses" id="rnaz_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayableAndAccruedExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RelatedPartyTransactionMaximumReimbursableAmount" id="rnaz_RelatedPartyTransactionMaximumReimbursableAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ReimbursementExpenses" id="rnaz_ReimbursementExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="LicenseAgreementOneMember" id="rnaz_LicenseAgreementOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ChangeOfControlLiquidityEventThresholdTransactionValue" id="rnaz_ChangeOfControlLiquidityEventThresholdTransactionValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LicenseAgreementTwoMember" id="rnaz_LicenseAgreementTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="MilestonePaymentDueUponFilingOfNewDrugApplicationWithFdaProductsSubjectToSkiLicense" id="rnaz_MilestonePaymentDueUponFilingOfNewDrugApplicationWithFdaProductsSubjectToSkiLicense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ContingentConsiderationMeasurementInput" id="rnaz_ContingentConsiderationMeasurementInput" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ExpectedMilestoneEventOnJune302029Member" id="rnaz_ExpectedMilestoneEventOnJune302029Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExpectedMilestoneEventOnJune302036Member" id="rnaz_ExpectedMilestoneEventOnJune302036Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExpectedMilestoneEventOnJune302042Member" id="rnaz_ExpectedMilestoneEventOnJune302042Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExpectedMilestoneEventOnJune302043Member" id="rnaz_ExpectedMilestoneEventOnJune302043Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="BusinessCombinationContingentConsiderationTextBlock" id="rnaz_BusinessCombinationContingentConsiderationTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="MilestonePaymentUponFirstDosingOfPatientInUnitedStatesPhase3ClinicalStudyMember" id="rnaz_MilestonePaymentUponFirstDosingOfPatientInUnitedStatesPhase3ClinicalStudyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="MilestonePaymentUponPrimaryEndpointInUnitedStatesPhase3ClinicalStudyMember" id="rnaz_MilestonePaymentUponPrimaryEndpointInUnitedStatesPhase3ClinicalStudyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="MilestonePaymentUponFirstSubmissionOfBiologicsLicenseApplicationMember" id="rnaz_MilestonePaymentUponFirstSubmissionOfBiologicsLicenseApplicationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="MilestonePaymentUponFirstApprovalByFoodAndDrugAdministrationMember" id="rnaz_MilestonePaymentUponFirstApprovalByFoodAndDrugAdministrationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="BusinessCombinationMaximumContingentConsideration" id="rnaz_BusinessCombinationMaximumContingentConsideration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="MilestoneAchievementPeriod" id="rnaz_MilestoneAchievementPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ContingentConsiderationPaymentAmount" id="rnaz_ContingentConsiderationPaymentAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PreferredStockSharesAuthorizedButUnissued" id="rnaz_PreferredStockSharesAuthorizedButUnissued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="StandbyEquityPurchaseAgreementMember" id="rnaz_StandbyEquityPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ConvertibleNotesPayableTrancheOneMember" id="rnaz_ConvertibleNotesPayableTrancheOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ConvertibleNotesPayableTrancheTwoMember" id="rnaz_ConvertibleNotesPayableTrancheTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CommonStockMaximumSharesAgreedToSellValue" id="rnaz_CommonStockMaximumSharesAgreedToSellValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="EquityPurchaseDiscountRate" id="rnaz_EquityPurchaseDiscountRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="VolumeWeightedAveragePriceCalculationNumberOfConsecutiveTradingDays" id="rnaz_VolumeWeightedAveragePriceCalculationNumberOfConsecutiveTradingDays" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentNumberOfTranches" id="rnaz_DebtInstrumentNumberOfTranches" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentDiscountRate" id="rnaz_DebtInstrumentDiscountRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="DebtInstrumentOriginalDiscountAmount" id="rnaz_DebtInstrumentOriginalDiscountAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DebtInstrumentConversionPriceMultiplier" id="rnaz_DebtInstrumentConversionPriceMultiplier" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="DebtInstrumentConversionPriceMultiplierOfLowestDailyVwap" id="rnaz_DebtInstrumentConversionPriceMultiplierOfLowestDailyVwap" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="DebtInstrumentInterestRateEventOfDefault" id="rnaz_DebtInstrumentInterestRateEventOfDefault" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="DebtInstrumentExtensionTerm" id="rnaz_DebtInstrumentExtensionTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="BeneficialOwnershipLimitationMinimumAdvanceNoticePeriod" id="rnaz_BeneficialOwnershipLimitationMinimumAdvanceNoticePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="FairValuePaymentNumberOfBusinessDays" id="rnaz_FairValuePaymentNumberOfBusinessDays" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="RepurchaseAgreementPercentageOfShareConsideration" id="rnaz_RepurchaseAgreementPercentageOfShareConsideration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="TemporaryEquityStockIssuedDuringPeriodSharesNewIssues" id="rnaz_TemporaryEquityStockIssuedDuringPeriodSharesNewIssues" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DeferredOfferingCostsIncludedInAccountsPayableAndAccruedExpenses" id="rnaz_DeferredOfferingCostsIncludedInAccountsPayableAndAccruedExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="TungstenAdvisorsMember" id="rnaz_TungstenAdvisorsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LicensingAgreementMember" id="rnaz_LicensingAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="Rule10b51ArrangementModifiedFlag" id="rnaz_Rule10b51ArrangementModifiedFlag" type="xbrli:booleanItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NonRule10b51ArrangementModifiedFlag" id="rnaz_NonRule10b51ArrangementModifiedFlag" type="xbrli:booleanItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="FinancingIssuanceCosts" id="rnaz_FinancingIssuanceCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="TemporaryEquityReclassificationFromPermanentEquityToTemporaryEquityShares" id="rnaz_TemporaryEquityReclassificationFromPermanentEquityToTemporaryEquityShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="TemporaryEquityReclassificationFromPermanentToTemporaryEquityValue" id="rnaz_TemporaryEquityReclassificationFromPermanentToTemporaryEquityValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="StockReclassificationFromPermanentEquityToTemporaryEquityShares" id="rnaz_StockReclassificationFromPermanentEquityToTemporaryEquityShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="StockIssuedDuringPeriodStandbyEquityPurchaseAgreementCommitmentFeeValueNewIssues" id="rnaz_StockIssuedDuringPeriodStandbyEquityPurchaseAgreementCommitmentFeeValueNewIssues" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="StockIssuedDuringPeriodStandbyEquityPurchaseAgreementCommitmentFeeSharesNewIssues" id="rnaz_StockIssuedDuringPeriodStandbyEquityPurchaseAgreementCommitmentFeeSharesNewIssues" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="TemporaryEquityAccretionOfDividendsShares" id="rnaz_TemporaryEquityAccretionOfDividendsShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="IncreaseDecreaseInReimbursementRightAsset" id="rnaz_IncreaseDecreaseInReimbursementRightAsset" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ReclassificationOfSeriesBPreferredStockFromPermanentEquityToTemporaryEquity" id="rnaz_ReclassificationOfSeriesBPreferredStockFromPermanentEquityToTemporaryEquity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="FairValueAdjustmentOfConvertibleDebt" id="rnaz_FairValueAdjustmentOfConvertibleDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DebtInstrumentConvertibleFloorPrice" id="rnaz_DebtInstrumentConvertibleFloorPrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="December2024OfferingMember" id="rnaz_December2024OfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
</xsd:schema>
