The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 1,640,579 18,080 SH SOLE 18,080 0 0
ABBVIE INC COM 00287Y109 3,070,008 12,200 SH SOLE 12,200 0 0
ABIVAX SA SPONSORED ADS 00370M103 311,828 2,340 SH SOLE 2,340 0 0
AGOMAB THERAPEUTICS SPONSORED ADS 00860C102 564,630 43,500 SH SOLE 43,500 0 0
ALNYLAM PHARMACUETCL COM 02043Q107 695,379 2,310 SH SOLE 2,310 0 0
ALPHATEC HLDGS INC COM NEW 02081G201 1,608,035 185,900 SH SOLE 0 0 185,900
AMGEN INC COM 031162100 3,335,125 9,210 SH SOLE 9,210 0 0
ARDELYX INC COM 039697107 624,209 122,394 SH SOLE 122,394 0 0
ARCUS BIOSCIENCES COM 03969F109 3,418,122 110,870 SH SOLE 39,870 0 71,000
ARGENX SE SP ADR 04016X101 2,626,517 2,831 SH SOLE 2,831 0 0
ARRIVENT BIOPHARMA COM 04272N102 2,745,954 79,043 SH SOLE 28,013 0 51,030
AVALO THERAPEUTICS INC COM NEW 05338F306 2,216,177 119,923 SH SOLE 31,329 0 88,594
AXSOME THERAPEUTIC COM 05464T104 367,155 1,500 SH SOLE 1,500 0 0
BEONE MEDICINES LTD SP ADR 07725L102 532,894 1,870 SH SOLE 1,870 0 0
BIOMARIN PHARMAC COM 09061G101 540,729 9,450 SH SOLE 9,450 0 0
BIOGEN INC COM 09062X103 399,711 1,850 SH SOLE 1,850 0 0
BIONTECH SE SP ADR 09075V102 3,895,910 41,869 SH SOLE 17,664 0 24,205
BOSTON SCIENTIFIC COM 101137107 1,550,564 36,330 SH SOLE 36,330 0 0
BRIDGEBIO PHARMA COM 10806X102 305,368 4,100 SH SOLE 4,100 0 0
BRISTOL MYERS SQUIBB COM 110122108 1,218,663 21,150 SH SOLE 21,150 0 0
CVS HEALTH CORP COM 126650100 1,344,850 13,000 SH SOLE 13,000 0 0
CENTENE CORP DEL COM 15135B101 770,280 12,000 SH SOLE 12,000 0 0
COGENT BIOSCIENCES COM 19240Q201 1,034,838 26,740 SH SOLE 26,740 0 0
CONTINEUM THERAPEUTICS CL A 21217B100 11,925,151 727,587 SH SOLE 727,587 0 0
ORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301 187,600 20,000 SH SOLE 20,000 0 0
CYTOKINETICS INC COM NEW 23282W605 1,391,153 16,330 SH SOLE 16,330 0 0
DANAHER CORP COM 235851102 1,830,726 9,597 SH SOLE 9,597 0 0
DEFINIUM THERAPEUTICS INC COM SHS 24477V105 3,683,702 78,310 SH SOLE 31,310 0 47,000
DEXCOM INC COM 252131107 3,418,417 50,756 SH SOLE 21,906 0 28,850
EDWARDS LIFESCIENCES COM 28176E108 1,341,160 14,826 SH SOLE 14,826 0 0
ENGENE THERAPEUTICS INC COM 29286X101 37,541 21,700 SH SOLE 21,700 0 0
GILEAD SCIENCES INC COM 375558103 2,605,131 20,620 SH SOLE 20,620 0 0
GUARDANT HEALTH INC COM 40131M109 297,059 1,980 SH SOLE 1,980 0 0
HINGE HEALTH INC CL A 433313103 725,752 8,744 SH SOLE 8,744 0 0
HUMANA INC INC 444859102 497,299 1,250 SH SOLE 1,250 0 0
IRHYTHM HOLDINGS INC COM 450056106 3,101,027 26,070 SH SOLE 6,660 0 19,410
ILLUMINA INC COM 452327109 374,870 2,132 SH SOLE 2,132 0 0
INCYTE CORPORATION COM 45337C102 266,396 2,350 SH SOLE 2,350 0 0
INSMED INC COM PAR $.01 457669307 2,475,290 23,216 SH SOLE 23,216 0 0
INTUITIVE SURGIC INC COM NEW 46120E602 2,326,428 5,850 SH SOLE 5,850 0 0
IONIS PHARMACEUTICAL COM 462222100 570,888 7,200 SH SOLE 7,200 0 0
IQVIA HOLDINGS INC COM 46266C105 2,096,051 10,848 SH SOLE 10,848 0 0
JOHNSON & JOHNSON COM 478160104 4,626,825 18,218 SH SOLE 18,218 0 0
KURA ONCOLOGY INC COM 50127T109 784,136 71,480 SH SOLE 71,480 0 0
ELI LILLY & CO COM 532457108 7,621,178 6,354 SH SOLE 6,354 0 0
MEDPACE HOLDINGS COM 58506Q109 227,724 430 SH SOLE 430 0 0
MERCK & CO INC COM 58933Y105 2,772,981 21,480 SH SOLE 21,480 0 0
MINERALYS THERAPEUTICS COM 603170101 392,964 14,565 SH SOLE 14,565 0 0
MODERNA INC COM 60770K107 304,631 4,350 SH SOLE 4,350 0 0
NEKTAR THERAPEUTICS COM NEW 640268306 705,849 10,111 SH SOLE 10,111 0 0
ORIC PHARMACEUTICALS COM 68622P109 254,505 23,500 SH SOLE 23,500 0 0
ORUKA THERAPEUTICS INC COM 687604108 3,995,903 41,987 SH SOLE 15,987 0 26,000
PTC THERAPEUTICS INC COM 69366J200 609,328 7,470 SH SOLE 7,470 0 0
PALISADE BIO INC COM 696389402 183,920 88,000 SH SOLE 88,000 0 0
PFIZER INC COM 717081103 662,200 27,500 SH SOLE 27,500 0 0
PRIVIA HEALTH GROUP COM 74276R102 621,019 24,136 SH SOLE 24,136 0 0
PULSE BIOSCIENCES INC COM 74587B101 1,882,728 67,895 SH SOLE 0 0 67,895
REGENERON PHARMCTCLS COM 75886F107 1,352,458 2,169 SH SOLE 2,169 0 0
REVOLUTION MEDICINES COM 76155X100 342,722 1,830 SH SOLE 1,830 0 0
SHOULDER INNOVATIONS COMMON STOCK 82537J108 8,728,654 430,407 SH SOLE 430,407 0 0
ARS PHARMACEUTICALS COM 82835W108 239,499 29,900 SH SOLE 29,900 0 0
STRYKER CORP COM 863667101 2,248,893 7,129 SH SOLE 7,129 0 0
STRUCTURE THERAPEUTICS SP ADR 86366E106 232,123 4,325 SH SOLE 4,325 0 0
SUMMIT THERAPEUTICS COM 86627T108 3,208,023 220,180 SH SOLE 91,805 0 128,375
SYNDAX PHARMACEUTICS COM 87164F105 342,765 15,680 SH SOLE 15,680 0 0
TARSUS PHARMACEUTICALS COM 87650L103 836,158 13,285 SH SOLE 13,285 0 0
TECTONIC THERAPEUTIC COM 878972108 2,440,934 71,009 SH SOLE 24,059 0 46,950
TEMPUS AI INC CL A 88023B103 224,768 3,880 SH SOLE 3,880 0 0
THERMO FISHER SCIENTIFIC COM 883556102 1,759,926 3,508 SH SOLE 3,508 0 0
TRANSMEDICS GROUP INC COM 89377M109 1,457,919 21,950 SH SOLE 0 0 21,950
TREVI THERAPEUTICS COM 89532M101 1,223,365 65,596 SH SOLE 65,596 0 0
UNITED THERAPEUTICS COM 91307C102 742,307 1,370 SH SOLE 1,370 0 0
UNITEDHEALTH GRP INC COM 91324P102 5,500,863 13,235 SH SOLE 13,235 0 0
VERA THERAPEUTICS CL A 92337R101 1,097,337 25,573 SH SOLE 25,573 0 0
VERTEX PHARMA COM 92532F100 2,698,237 5,432 SH SOLE 5,432 0 0
CRESCENT BIOPHARMA INC. COM G2545C104 2,183,400 121,300 SH SOLE 34,700 0 86,600
JAZZ PHARMA PLC SHS USD G50871105 421,698 1,750 SH SOLE 1,750 0 0
MEDTRONIC PLC SHS G5960L103 876,345 11,100 SH SOLE 11,100 0 0
ROIVANT SCIENCES LTD SHS G76279101 2,162,329 61,100 SH SOLE 61,100 0 0
ROYALTY PHARMA PLC SHS CLASS A G7709Q104 403,704 7,200 SH SOLE 7,200 0 0
ASCENDIS PHARMA A/S ORD SHS K08588103 685,470 2,570 SH SOLE 2,570 0 0
IMMATICS NV SHS N44445109 2,278,521 224,928 SH SOLE 66,830 0 158,098