The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIVAX SA SPONSORED ADS 00370M103 43,352,978 328,635 SH SOLE 328,635 0 0
ABIVAX SA SPONSORED ADS 00370M103 45,454,986 341,100 SH Call SOLE 341,100 0 0
ABIVAX SA SPONSORED ADS 00370M103 33,315,000 250,000 SH Put SOLE 250,000 0 0
ABSCI CORPORATION COM 00091E109 4,100,217 353,772 SH SOLE 353,772 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 710,905 28,099 SH SOLE 28,099 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209 2,813,638 1,053,797 SH SOLE 1,053,797 0 0
ADLAI NORTYE LTD SPONSORED ADS 00704R109 389,839 33,899 SH SOLE 33,899 0 0
AETHLON MED INC COM NEW 00808Y604 11,827 14,364 SH SOLE 14,364 0 0
AIRSCULPT TECHNOLOGIES INC COM 009496100 73,792 16,398 SH SOLE 16,398 0 0
ALECTOR INC COM 014442107 3,985,038 1,982,606 SH SOLE 1,982,606 0 0
ALPHA COGNITION INC COM NEW 02074J501 6,037,790 836,259 SH SOLE 836,259 0 0
ALTO NEUROSCIENCE INC COM SHS 02157Q109 10,749,651 407,338 SH SOLE 407,338 0 0
ALUMIS INC COM 022307102 24,497,220 870,548 SH SOLE 870,548 0 0
ALUMIS INC COM 022307102 10,026,282 356,300 SH Call SOLE 356,300 0 0
AMANAT ACQUISITION CORP CL A ORD G0375M101 1,524,000 150,000 SH SOLE 150,000 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101 2,110,301 117,500 SH SOLE 117,500 0 0
ANI PHARMACEUTICALS INC COM 00182C103 22,523,196 272,085 SH SOLE 272,085 0 0
ANNEXON INC COM 03589W102 2,456,693 430,244 SH SOLE 430,244 0 0
ANTERIS TECHNOLOGIES GLOBAL COM 03675P102 1,640,724 166,571 SH SOLE 166,571 0 0
ARCUS BIOSCIENCES INC COM 03969F109 15,555,555 504,559 SH SOLE 504,559 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 3,120,040 38,278 SH SOLE 38,278 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 8,151,000 100,000 SH Put SOLE 100,000 0 0
ARVINAS INC COM 04335A105 2,977,115 358,257 SH SOLE 358,257 0 0
AVALO THERAPEUTICS INC COM NEW 05338F306 1,666,581 90,183 SH SOLE 90,183 0 0
BIOAGE LABS INC COM 09077V100 4,901,999 200,000 SH SOLE 200,000 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 167,560 16,756 SH SOLE 16,756 0 0
BIOHAVEN LTD COM G1110E107 11,132,933 748,181 SH SOLE 748,181 0 0
BIOMX INC COM NEW 09090D509 6,773 19,473 SH SOLE 19,473 0 0
BRIDGEBIO PHARMA INC COM 10806X102 4,276,418 57,417 SH SOLE 57,417 0 0
BRIGHT MINDS BIOSCIENCES INC COM NEW 10919W405 6,244,361 88,951 SH SOLE 88,951 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 2,448,850 42,500 SH Put SOLE 42,500 0 0
C4 THERAPEUTICS INC COM STK 12529R107 11,362,110 2,433,000 SH SOLE 2,433,000 0 0
CABALETTA BIO INC COM 12674W109 2,177,000 700,000 SH SOLE 700,000 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309 14,549,497 604,215 SH SOLE 604,215 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309 8,428,000 350,000 SH Call SOLE 350,000 0 0
CARDIOL THERAPEUTICS INC COM CL A 14161Y200 3,524,500 3,325,000 SH SOLE 3,325,000 0 0
CARTESIAN THERAPEUTICS INC COM NEW 816212302 216,809 20,807 SH SOLE 20,807 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 17,804,985 478,500 SH SOLE 478,500 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 4,241,940 114,000 SH Put SOLE 114,000 0 0
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C203 83,904 51,793 SH SOLE 51,793 0 0
CLIMB BIO INC COM 28658R106 3,912,000 300,000 SH SOLE 300,000 0 0
CNS PHARMACEUTICALS INC COM 18978H508 649,267 135,830 SH SOLE 135,830 0 0
COGENT BIOSCIENCES INC COM 19240Q201 14,322,251 370,084 SH SOLE 370,084 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 212,250 15,000 SH SOLE 15,000 0 0
COMPASS THERAPEUTICS INC COM 20454B104 39,419 18,000 SH SOLE 18,000 0 0
CONNECT BIOPHARMA HLDGS LTD SHS G23549101 10,801,710 4,538,534 SH SOLE 4,538,534 0 0
CONTINEUM THERAPEUTICS INC CL A 21217B100 13,241,056 807,874 SH SOLE 807,874 0 0
CUE BIOPHARMA INC COM 22978P205 3,293,728 104,364 SH SOLE 104,364 0 0
CUMBERLAND PHARMACEUTICALS I COM 230770109 3,260,431 503,153 SH SOLE 503,153 0 0
CYBIN INC COM NEW 23256X407 873,532 132,153 SH SOLE 132,153 0 0
DAMORA THERAPEUTICS INC COM NEW 36322Q206 8,731,816 335,710 SH SOLE 335,710 0 0
DBV TECHNOLOGIES S A SPONSORED ADS 23306J309 1,690,953 525,000 SH SOLE 525,000 0 0
DELCATH SYS INC COM NEW 24661P807 2,337,548 185,667 SH SOLE 185,667 0 0
DIREXION SHARES ETF TRUST DAI BIO BEA ETF 25461H853 815,887 105,822 SH SOLE 105,822 0 0
DISC MEDICINE INC COM 254604101 972,762 13,300 SH Call SOLE 13,300 0 0
DISC MEDICINE INC COM 254604101 972,762 13,300 SH Put SOLE 13,300 0 0
ELICIO THERAPEUTICS INC COM 28657F103 391,000 100,000 SH SOLE 100,000 0 0
ELICIO THERAPEUTICS INC COM 28657F103 418,761 107,100 SH Call SOLE 107,100 0 0
ELICIO THERAPEUTICS INC COM 28657F103 418,761 107,100 SH Put SOLE 107,100 0 0
ENLIVEN THERAPEUTICS INC COM 29337E102 6,421,957 126,541 SH SOLE 126,541 0 0
ENVERIC BIOSCIENCES INC COM SHS 29405E505 138,003 100,002 SH SOLE 100,002 0 0
EQUILLIUM INC COM 29446K106 971,376 303,555 SH SOLE 303,555 0 0
EUPRAXIA PHARMACEUTICALS INC COM 29842P105 5,352,388 809,741 SH SOLE 809,741 0 0
EVAXION AS SPONSORED ADS 29970R303 231,564 74,698 SH SOLE 74,698 0 0
EYEPOINT INC COM NEW 30233G209 5,296,720 370,400 SH Call SOLE 370,400 0 0
EYEPOINT INC COM NEW 30233G209 5,296,720 370,400 SH Put SOLE 370,400 0 0
FAETH THERAPEUTICS INC COM NEW 81728A207 884,650 35,386 SH SOLE 35,386 0 0
FIRST TRACKS BIOTHERAPEUTICS ORD SHS 337185102 860,633 42,775 SH SOLE 42,775 0 0
FORTE BIOSCIENCES INC COM NEW 34962G208 445,655 20,972 SH SOLE 20,972 0 0
FRACTYL HEALTH INC COM 35168W103 873,840 1,100,000 SH SOLE 1,100,000 0 0
FULCRUM THERAPEUTICS INC COM 359616109 3,839,929 1,049,161 SH SOLE 1,049,161 0 0
GLUCOTRACK INC COM NEW 45824Q804 14,621 45,830 SH SOLE 45,830 0 0
HARROW INC COM 415858109 5,766,364 135,775 SH SOLE 135,775 0 0
HIMS & HERS HEALTH INC COM CL A 433000106 6,531,170 188,381 SH SOLE 188,381 0 0
HYPERLIQUID STRATEGIES INC COM 44916Y106 236,108 30,001 SH SOLE 30,001 0 0
IBIO INC COM NEW 451033708 1,674,859 957,062 SH SOLE 957,062 0 0
IMMATICS N.V SHS N44445109 492,003 48,569 SH SOLE 48,569 0 0
IMMUNIC INC COM NEW 4525EP200 1,036,922 67,464 SH SOLE 67,464 0 0
IMMUNOME INC COM 45257U108 1,271,401 60,000 SH SOLE 60,000 0 0
INMED PHARMACEUTICALS INC COM NEW 457637700 379,788 245,025 SH SOLE 245,025 0 0
INVENTIVA SA ADS 46124U107 4,152,521 1,129,101 SH SOLE 1,129,101 0 0
INVIVYD INC COM 00534A102 2,317,592 2,656,570 SH SOLE 2,656,570 0 0
IONIS PHARMACEUTICALS INC COM 462222100 31,716,000 400,000 SH Call SOLE 400,000 0 0
IONIS PHARMACEUTICALS INC COM 462222100 23,787,000 300,000 SH Put SOLE 300,000 0 0
JADE BIOSCIENCES INC COM NEW 008064206 9,495,694 427,349 SH SOLE 427,349 0 0
JASPER THERAPEUTICS INC COM NEW 471871202 10,144 24,093 SH SOLE 24,093 0 0
JOURNEY MED CORP COM 48115J109 1,780,168 251,436 SH SOLE 251,436 0 0
KALARIS THERAPEUTICS INC COM 482929106 1,465,201 360,000 SH SOLE 360,000 0 0
KAZIA THERAPEUTICS LTD SPONSORED ADS 48669G303 5,578,510 396,201 SH SOLE 396,201 0 0
KODIAK SCIENCES INC COM 50015M109 41,287,080 1,059,730 SH SOLE 1,059,730 0 0
KODIAK SCIENCES INC COM 50015M109 8,481,592 217,700 SH Call SOLE 217,700 0 0
KYMERA THERAPEUTICS INC COM 501575104 5,779,368 50,400 SH Put SOLE 50,400 0 0
LEXEO THERAPEUTICS INC COM 52886X107 2,388,066 513,011 SH SOLE 513,011 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 395,218 164,674 SH SOLE 164,674 0 0
LIPOCINE INC NEW COM NEW 53630X203 1,301,902 508,556 SH SOLE 508,556 0 0
LYELL IMMUNOPHARMA INC COM NEW 55083R203 577,188 41,081 SH SOLE 41,081 0 0
MACROGENICS INC COM 556099109 346,006 74,893 SH SOLE 74,893 0 0
MANGOCEUTICALS INC COM NEW 56270V205 52,496 138,146 SH SOLE 138,146 0 0
MAZE THERAPEUTICS INC COM 578784100 11,309,331 378,999 SH SOLE 378,999 0 0
MODERNA INC COM 60770K107 28,012,000 400,000 SH Put SOLE 400,000 0 0
MONOPAR THERAPEUTICS INC COM NEW 61023L207 4,431,450 47,861 SH SOLE 47,861 0 0
NEUMORA THERAPEUTICS INC. COM 640979100 2,173,294 1,278,408 SH SOLE 1,278,408 0 0
NEUPHORIA THERAPEUTICS INC COM 64136E102 207,326 47,443 SH SOLE 47,443 0 0
NEURONETICS INC COM 64131A105 911,537 701,182 SH SOLE 701,182 0 0
NEWAMSTERDAM PHARMA COMPANY PUT N62509959 13,556,000 400,000 SH Put SOLE 400,000 0 0
NEXTCURE INC COM NEW 65343E207 461,284 288,303 SH SOLE 288,303 0 0
NYXOAH S A SHS B6S7WD106 80,035 47,358 SH SOLE 47,358 0 0
OCUGEN INC COM 67577C105 6,063,348 3,962,972 SH SOLE 3,962,972 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 4,794,845 383,281 SH SOLE 383,281 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 2,502,000 200,000 SH Call SOLE 200,000 0 0
OVID THERAPEUTICS INC COM 690469101 6,105,503 2,269,704 SH SOLE 2,269,704 0 0
PALISADE BIO INC COM 696389402 1,567,500 750,000 SH SOLE 750,000 0 0
PASSAGE BIO INC COM NEW 702712209 485,643 99,517 SH SOLE 99,517 0 0
PELTHOS THERAPEUTICS INC COM SHS 171126204 7,251,459 256,598 SH SOLE 256,598 0 0
PEPGEN INC COM 713317105 804,897 447,165 SH SOLE 447,165 0 0
PHARVARIS N V COM N69605108 10,680,241 308,856 SH SOLE 308,856 0 0
PLIANT THERAPEUTICS INC COM 729139105 1,140,000 1,000,000 SH SOLE 1,000,000 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 119,442 89,136 SH SOLE 89,136 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207 24,386,773 72,842 SH SOLE 72,842 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207 6,695,800 20,000 SH Call SOLE 20,000 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207 301,311 900 SH Put SOLE 900 0 0
PROMIS NEUROSCIENCES INC COM SHS 74346M505 2,697,801 205,000 SH SOLE 205,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 6,372,230 3,425,930 SH SOLE 3,425,930 0 0
Q32 BIO INC COM 746964105 5,478,200 430,000 SH SOLE 430,000 0 0
Q32 BIO INC COM 746964105 2,548,000 200,000 SH Put SOLE 200,000 0 0
QUINCE THERAPEUTICS INC COM 22053A305 1,314,245 72,251 SH SOLE 72,251 0 0
QUOIN PHARMACEUTICALS LTD SPONSORED ADS 74907L409 1,023,844 211,538 SH SOLE 211,538 0 0
REIN THERAPEUTICS INC COM NEW 00887A204 3,068,000 2,950,000 SH SOLE 2,950,000 0 0
RELMADA THERAPEUTICS INC COM 75955J402 14,866,644 2,148,359 SH SOLE 2,148,359 0 0
REZOLUTE INC COM NEW 76200L309 4,862,062 935,012 SH SOLE 935,012 0 0
SELLAS LIFE SCIENCES GROUP I COM NEW 81642T209 5,235,372 354,700 SH Put SOLE 354,700 0 0
SILENCE THERAPEUTICS PLC ADS 82686Q101 1,827,725 830,784 SH SOLE 830,784 0 0
SIONNA THERAPEUTICS INC COM 829401108 4,728,925 107,500 SH Put SOLE 107,500 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204 429,130 42,956 SH SOLE 42,956 0 0
SPDR SERIES TRUST ST STR SP BIOT 78464A870 47,475,000 300,000 SH Put SOLE 300,000 0 0
SPRUCE BIOSCIENCES INC COM NEW 85209E208 6,553,224 121,356 SH SOLE 121,356 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 1,961,588 31,166 SH SOLE 31,166 0 0
TECTONIC THERAPEUTIC INC COM 878972108 7,075,647 205,837 SH SOLE 205,837 0 0
TENAX THERAPEUTICS INC COM NEW 88032L605 11,459,580 787,600 SH SOLE 787,600 0 0
TENAX THERAPEUTICS INC COM NEW 88032L605 5,428,605 373,100 SH Call SOLE 373,100 0 0
TENAX THERAPEUTICS INC COM NEW 88032L605 240,075 16,500 SH Put SOLE 16,500 0 0
THERIVA BIOLOGICS INC COM NEW 87164U508 28,041 112,076 SH SOLE 112,076 0 0
TRAWS PHARMA INC COM NEW 68232V884 403,217 478,142 SH SOLE 478,142 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 5,529,952 165,617 SH SOLE 165,617 0 0
UNIQURE NV CALL N90064901 2,293,788 49,800 SH Call SOLE 49,800 0 0
VAXCYTE INC COM 92243G108 22,594,085 388,682 SH SOLE 388,682 0 0
VERA THERAPEUTICS INC CL A 92337R101 13,302,100 310,000 SH SOLE 310,000 0 0
VERA THERAPEUTICS INC CL A 92337R101 3,076,647 71,700 SH Call SOLE 71,700 0 0
VERASTEM INC COM NEW 92337C203 816,965 213,865 SH SOLE 213,865 0 0
VIKING THERAPEUTICS INC COM 92686J106 379,061 9,717 SH SOLE 9,717 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 7,807,251 425,000 SH SOLE 425,000 0 0
VISTAGEN THERAPEUTICS INC COM 92840H400 117,311 519,077 SH SOLE 519,077 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 185,722 53,063 SH SOLE 53,063 0 0
VYNE THERAPEUTICS INC COM 92941V308 172,379 264,912 SH SOLE 264,912 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 495,507 85,285 SH SOLE 85,285 0 0
ZURA BIO LTD CLASS A ORD SHS G9TY5A101 7,189,102 1,218,492 SH SOLE 1,218,492 0 0