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  <xs:element id="cris_ReclassificationOfCommonWarrantsLiabilityToEquity" abstract="false" name="ReclassificationOfCommonWarrantsLiabilityToEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_ConversionOfPreferredStockToCommonStockAndWarrants" abstract="false" name="ConversionOfPreferredStockToCommonStockAndWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_IncreaseDecreaseInAccruedExpensesAndAccountsPayableNonCashIssuanceCosts" abstract="false" name="IncreaseDecreaseInAccruedExpensesAndAccountsPayableNonCashIssuanceCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_FairValueMeasurementInputsAndValuationTechniqueForEquityInstrumentTableTextBlock" abstract="false" name="FairValueMeasurementInputsAndValuationTechniqueForEquityInstrumentTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="cris_ScheduleOfEmployeeAndNonEmployeeShareBasedCompensationAllocationOfRecognizedPeriodCostsTableTextBlock" abstract="false" name="ScheduleOfEmployeeAndNonEmployeeShareBasedCompensationAllocationOfRecognizedPeriodCostsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="cris_August2026PublicOfferingMember" abstract="true" name="August2026PublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_SaleOfEquityConsiderationReceivedOnTransaction" abstract="false" name="SaleOfEquityConsiderationReceivedOnTransaction" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_WarrantLiabilityFairValueDisclosure" abstract="false" name="WarrantLiabilityFairValueDisclosure" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_ResearchAndDevelopmentCostsCurrent" abstract="false" name="ResearchAndDevelopmentCostsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_AurigeneDiscoveryTechnologiesLtdMember" abstract="true" name="AurigeneDiscoveryTechnologiesLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_IRAK4PD1VISTAPD1TIM3ProgramMember" abstract="true" name="IRAK4PD1VISTAPD1TIM3ProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_CollaborationAgreementTermsPercentageOfRoyaltyFeesReceivable" abstract="false" name="CollaborationAgreementTermsPercentageOfRoyaltyFeesReceivable" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cris_CantorFitzgeraldAndCoMember" abstract="true" name="CantorFitzgeraldAndCoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_October2024OfferingsMember" abstract="true" name="October2024OfferingsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_March2025OfferingsMember" abstract="true" name="March2025OfferingsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_RegisteredDirectOfferingMember" abstract="true" name="RegisteredDirectOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_July2025OfferingsMember" abstract="true" name="July2025OfferingsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_January2026PIPEFinancingMember" abstract="true" name="January2026PIPEFinancingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_UnregisteredWarrantsMember" abstract="true" name="UnregisteredWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_PreFundedUnregisteredWarrantsMember" abstract="true" name="PreFundedUnregisteredWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_PreFundedWarrantsMember" abstract="true" name="PreFundedWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_SeriesBWarrantsMember" abstract="true" name="SeriesBWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_January2026CommonWarrantsMember" abstract="true" name="January2026CommonWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_January2026PreFundedWarrantsMember" abstract="true" name="January2026PreFundedWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_August2026WarrantsMember" abstract="true" name="August2026WarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_August2026PreFundedWarrantAndCommonWarrantMember" abstract="true" name="August2026PreFundedWarrantAndCommonWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_August2026CommonWarrantsMember" abstract="true" name="August2026CommonWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_August2026PreFundedWarrantsMember" abstract="true" name="August2026PreFundedWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_SaleOfStockAuthorizedMaximumAmount" abstract="false" name="SaleOfStockAuthorizedMaximumAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_StockSaleAgreementCompensationFeePercentageOfGrossProceeds" abstract="false" name="StockSaleAgreementCompensationFeePercentageOfGrossProceeds" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cris_StockSaleAgreementRemainingAuthorizedAmount" abstract="false" name="StockSaleAgreementRemainingAuthorizedAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_StockSaleAgreementSaleRestrictionMaximumPublicFloat" abstract="false" name="StockSaleAgreementSaleRestrictionMaximumPublicFloat" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_StockSaleAgreementSaleRestrictionPeriod" abstract="false" name="StockSaleAgreementSaleRestrictionPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cris_ClassOfWarrantOrRightExpirationPeriod" abstract="false" name="ClassOfWarrantOrRightExpirationPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cris_PurchasePriceShare" abstract="false" name="PurchasePriceShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cris_SaleOfEquityPricePerShare" abstract="false" name="SaleOfEquityPricePerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="cris_ClassOfWarrantOrRightPurchasePrice" abstract="false" name="ClassOfWarrantOrRightPurchasePrice" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="cris_StockIssuedDuringPeriodCommonStockFairValue" abstract="false" name="StockIssuedDuringPeriodCommonStockFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_ClassOfWarrantOrRightExerciseOfWarrantNumberOfSharesIssued" abstract="false" name="ClassOfWarrantOrRightExerciseOfWarrantNumberOfSharesIssued" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cris_SaleOfStockAgreementMaximumPercentageOfPublicFloat" abstract="false" name="SaleOfStockAgreementMaximumPercentageOfPublicFloat" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cris_ConvertiblePreferredStockMaximumBeneficialOwnershipOptionOne" abstract="false" name="ConvertiblePreferredStockMaximumBeneficialOwnershipOptionOne" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cris_ConvertiblePreferredStockMaximumBeneficialOwnershipOptionTwo" abstract="false" name="ConvertiblePreferredStockMaximumBeneficialOwnershipOptionTwo" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cris_ConvertiblePreferredStockMaximumBeneficialOwnershipOptionThree" abstract="false" name="ConvertiblePreferredStockMaximumBeneficialOwnershipOptionThree" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cris_ClassOfWarrantOrRightNumberOfWarrantsIssued" abstract="false" name="ClassOfWarrantOrRightNumberOfWarrantsIssued" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cris_WarrantAndRightsOutstandingTermFollowingAnnouncement" abstract="false" name="WarrantAndRightsOutstandingTermFollowingAnnouncement" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cris_ClassOfWarrantOrRightPercentageOfExercisePriceOfWarrantsOrRightsReducedMinimum" abstract="false" name="ClassOfWarrantOrRightPercentageOfExercisePriceOfWarrantsOrRightsReducedMinimum" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="cris_WarrantsAndRightsOutstandingAdditionalExtensionTerm" abstract="false" name="WarrantsAndRightsOutstandingAdditionalExtensionTerm" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cris_StockIssuedDuringPeriodPreferredStockFairValue" abstract="false" name="StockIssuedDuringPeriodPreferredStockFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_StockIssuedDuringPeriodSharesStockExchangeOffer" abstract="false" name="StockIssuedDuringPeriodSharesStockExchangeOffer" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cris_StockOptionsorStockAppreciationRightsMember" abstract="true" name="StockOptionsorStockAppreciationRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_RestrictedStockRSUsOtherStockBasedAwardsOrPerformanceAwardsMember" abstract="true" name="RestrictedStockRSUsOtherStockBasedAwardsOrPerformanceAwardsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_A2026IncentivePlanMember" abstract="true" name="A2026IncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_AmendedAndRestatedTwoThousandTenStockIncentivePlanMember" abstract="true" name="AmendedAndRestatedTwoThousandTenStockIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_TwoThousandAndTenPlanMember" abstract="true" name="TwoThousandAndTenPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_EmployeeStockPurchasePlanMember" abstract="true" name="EmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_ShareBasedCompensationPlans" abstract="false" name="ShareBasedCompensationPlans" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="cris_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesRemovedFromAvailableSharePoolPerShare" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesRemovedFromAvailableSharePoolPerShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="cris_EmployeeStockPurchasePlanEnrollmentPeriod" abstract="false" name="EmployeeStockPurchasePlanEnrollmentPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cris_NumberOfPurchasePeriodsPerEnrollmentPeriod" abstract="false" name="NumberOfPurchasePeriodsPerEnrollmentPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="cris_SharebasedCompensationArrangementBySharebasedPaymentAwardStockPlanOfferingPeriod" abstract="false" name="SharebasedCompensationArrangementBySharebasedPaymentAwardStockPlanOfferingPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cris_StockAvailableForFuturePurchaseUnderEmployeeStockPurchasePlans" abstract="false" name="StockAvailableForFuturePurchaseUnderEmployeeStockPurchasePlans" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cris_July2025PreFundedWarrntsMember" abstract="true" name="July2025PreFundedWarrntsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_April2026PreFundedWarrantsMember" abstract="true" name="April2026PreFundedWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_October2024CommonWarrantsMember" abstract="true" name="October2024CommonWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_July2025CommonWarrantsMember" abstract="true" name="July2025CommonWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_January2026SeriesACommonWarrantsMember" abstract="true" name="January2026SeriesACommonWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_January2026SeriesBCommonWarrantsMember" abstract="true" name="January2026SeriesBCommonWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_January2026SeriesCCommonWarrantsMember" abstract="true" name="January2026SeriesCCommonWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cris_ResearchAndDevelopmentEmployeeRelatedCosts" abstract="false" name="ResearchAndDevelopmentEmployeeRelatedCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cris_GeneralAndAdministrativeEmployeeRelatedCosts" abstract="false" name="GeneralAndAdministrativeEmployeeRelatedCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
