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  <xsd:element name="DeemedDividends" id="xxii_DeemedDividends" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DeemedDividendsNonCash" id="xxii_DeemedDividendsNonCash" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="WarrantExercisesStockIssuanceCosts" id="xxii_WarrantExercisesStockIssuanceCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="GvbbiopharmaMember" id="xxii_GvbbiopharmaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="VariousMember" id="xxii_VariousMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationOperatingExpenseAbstract" id="xxii_DisposalGroupIncludingDiscontinuedOperationOperatingExpenseAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationSellingGeneralAndAdministrativeExpense" id="xxii_DisposalGroupIncludingDiscontinuedOperationSellingGeneralAndAdministrativeExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationResearchAndDevelopmentExpense" id="xxii_DisposalGroupIncludingDiscontinuedOperationResearchAndDevelopmentExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationOtherOperatingExpensesNet" id="xxii_DisposalGroupIncludingDiscontinuedOperationOtherOperatingExpensesNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationOtherIncomeExpenseAbstract" id="xxii_DisposalGroupIncludingDiscontinuedOperationOtherIncomeExpenseAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationOtherIncomeExpenses" id="xxii_DisposalGroupIncludingDiscontinuedOperationOtherIncomeExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AccruedLiabilitiesSettled" id="xxii_AccruedLiabilitiesSettled" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="StockIssuedDuringPeriodValueSettledIndebtedness" id="xxii_StockIssuedDuringPeriodValueSettledIndebtedness" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="StockIssuedDuringPeriodSharesSettledIndebtedness" id="xxii_StockIssuedDuringPeriodSharesSettledIndebtedness" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ContractManufacturingMember" id="xxii_ContractManufacturingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CigarettesMember" id="xxii_CigarettesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FilteredCigarsMember" id="xxii_FilteredCigarsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="VlnMember" id="xxii_VlnMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="Omnia2024WarrantsMember" id="xxii_Omnia2024WarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="Rule10b51ArrModifiedFlag" id="xxii_Rule10b51ArrModifiedFlag" type="xbrli:booleanItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NonRule10b51ArrModifiedFlag" id="xxii_NonRule10b51ArrModifiedFlag" type="xbrli:booleanItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ScheduleOfAmountsRecordedAsDeemedDividendInDeterminingNetIncomeLossAvailableToCommonShareholdersTableTextBlock" id="xxii_ScheduleOfAmountsRecordedAsDeemedDividendInDeterminingNetIncomeLossAvailableToCommonShareholdersTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DepreciationOfPropertyPlantAndEquipmentAndAmortizationOfIntangibleAssets" id="xxii_DepreciationOfPropertyPlantAndEquipmentAndAmortizationOfIntangibleAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="SingleReportableSegmentMember" id="xxii_SingleReportableSegmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ExciseTaxesAndFeesOnProducts" id="xxii_ExciseTaxesAndFeesOnProducts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ConversionOptionRemeasurement" id="xxii_ConversionOptionRemeasurement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="April2025InducementWarrantsMember" id="xxii_April2025InducementWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ClassOfWarrantOrRightPercentageOfWarrantsIssued" id="xxii_ClassOfWarrantOrRightPercentageOfWarrantsIssued" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ClassOfWarrantOrRightInitialExercisePercentage" id="xxii_ClassOfWarrantOrRightInitialExercisePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ClassOfWarrantOrRightExercisePercentageAfterEffectivenessDate" id="xxii_ClassOfWarrantOrRightExercisePercentageAfterEffectivenessDate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ClassOfWarrantOrRightExerciseTermAfterEffectivenessDate" id="xxii_ClassOfWarrantOrRightExerciseTermAfterEffectivenessDate" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ClassOfWarrantOrRightAdditionallyIssuedForAntiDilutionAdjustment" id="xxii_ClassOfWarrantOrRightAdditionallyIssuedForAntiDilutionAdjustment" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ClassOfWarrantsOrRightsIncrementalFairValueAsIssuanceCostsUnderCashlessExerciseOption" id="xxii_ClassOfWarrantsOrRightsIncrementalFairValueAsIssuanceCostsUnderCashlessExerciseOption" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="PipeWarrantsAndPipePlacementAgentWarrants2024Member" id="xxii_PipeWarrantsAndPipePlacementAgentWarrants2024Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="StockIssuedDuringPeriodSharesCashlessExerciseOfWarrants" id="xxii_StockIssuedDuringPeriodSharesCashlessExerciseOfWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="StockIssuedDuringPeriodSharesShareHeldInAbeyance" id="xxii_StockIssuedDuringPeriodSharesShareHeldInAbeyance" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="StockIssuedDuringPeriodSharesConversionOfConvertiblePreferredShares" id="xxii_StockIssuedDuringPeriodSharesConversionOfConvertiblePreferredShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="GvbPromissoryNote2023Member" id="xxii_GvbPromissoryNote2023Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtInstrumentNumberOfMonthlyInstallments" id="xxii_DebtInstrumentNumberOfMonthlyInstallments" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="GvbPromissoryNote2025Member" id="xxii_GvbPromissoryNote2025Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="August2025SeriesaConvertiblePreferredStockOfferingMember" id="xxii_August2025SeriesaConvertiblePreferredStockOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="August2025PreferredStockWarrantsMember" id="xxii_August2025PreferredStockWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WarrantOutstandingExcludingPreFundedWarrants" id="xxii_WarrantOutstandingExcludingPreFundedWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="MezzanineEquityAbstract" id="xxii_MezzanineEquityAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AccruedLiabilitiesAndOtherLiabilitiesCurrent" id="xxii_AccruedLiabilitiesAndOtherLiabilitiesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="IncreaseDecreaseInAccruedLiabilitiesAndOtherCurrentLiabilities" id="xxii_IncreaseDecreaseInAccruedLiabilitiesAndOtherCurrentLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ReclassificationComparabilityAdjustmentTableTextBlock" id="xxii_ReclassificationComparabilityAdjustmentTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="TemporaryEquityConvertibleConversionPrice" id="xxii_TemporaryEquityConvertibleConversionPrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="TemporaryEquityConvertibleSharesIssuable" id="xxii_TemporaryEquityConvertibleSharesIssuable" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="OtherTobaccoProductsMember" id="xxii_OtherTobaccoProductsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FinancingReceivableExcludingAccruedInterestAmountReceivablePerInstallment" id="xxii_FinancingReceivableExcludingAccruedInterestAmountReceivablePerInstallment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="FinancingReceivableExcludingAccruedInterestRemainingAmountReceivable" id="xxii_FinancingReceivableExcludingAccruedInterestRemainingAmountReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ConsiderationPayableAndDeferredIncome" id="xxii_ConsiderationPayableAndDeferredIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="March2026SeriesBConvertiblePreferredStockOfferingMember" id="xxii_March2026SeriesBConvertiblePreferredStockOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="March2026PreferredStockWarrantsMember" id="xxii_March2026PreferredStockWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AggregateOfferingPrice" id="xxii_AggregateOfferingPrice" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="TemporaryEquityStockReclassifiedDuringPeriodShares" id="xxii_TemporaryEquityStockReclassifiedDuringPeriodShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="TemporaryEquityStockReclassifiedDuringPeriodValue" id="xxii_TemporaryEquityStockReclassifiedDuringPeriodValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="StockReclassifiedDuringPeriodFromTemporaryEquityValue" id="xxii_StockReclassifiedDuringPeriodFromTemporaryEquityValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="StockReclassifiedDuringPeriodFromTemporaryEquityShares" id="xxii_StockReclassifiedDuringPeriodFromTemporaryEquityShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="OfferingCostsPolicyTextBlock" id="xxii_OfferingCostsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DisposalGroupIncludingDiscontinuedOperationCosts" id="xxii_DisposalGroupIncludingDiscontinuedOperationCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="March2026SeriesBConvertiblePreferredStockOfferingTrancheOneMember" id="xxii_March2026SeriesBConvertiblePreferredStockOfferingTrancheOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="March2026SeriesBConvertiblePreferredStockOfferingTrancheTwoMember" id="xxii_March2026SeriesBConvertiblePreferredStockOfferingTrancheTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PreferredStockStatedValuePerShare" id="xxii_PreferredStockStatedValuePerShare" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="PreferredStockConvertibleConversionPriceFloorPricePerShare" id="xxii_PreferredStockConvertibleConversionPriceFloorPricePerShare" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PreferredStockConvertibleConversionPriceDiscountPercent" id="xxii_PreferredStockConvertibleConversionPriceDiscountPercent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PreferredStockConvertibleConversionPriceThresholdTradingDays" id="xxii_PreferredStockConvertibleConversionPriceThresholdTradingDays" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="StockIssuable" id="xxii_StockIssuable" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="PreferredStockPeriodForOfferingFromPreviousTranche" id="xxii_PreferredStockPeriodForOfferingFromPreviousTranche" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PreferredStockThresholdPurchaseOfPreviousTrancheRequiredForNewOfferingPercent" id="xxii_PreferredStockThresholdPurchaseOfPreviousTrancheRequiredForNewOfferingPercent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PreferredStockEquityConditionsThresholdTradingDays" id="xxii_PreferredStockEquityConditionsThresholdTradingDays" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PreferredStockEquityConditionsFloorPriceThresholdMultiplier" id="xxii_PreferredStockEquityConditionsFloorPriceThresholdMultiplier" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PreferredStockEquityConditionsMinimumDailyDollarTradingVolume" id="xxii_PreferredStockEquityConditionsMinimumDailyDollarTradingVolume" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ProceedsFromPreferredStockUsedForRepurchaseOfTemporaryEquity" id="xxii_ProceedsFromPreferredStockUsedForRepurchaseOfTemporaryEquity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ProceedsFromPreferredStockNetOfAmountUsedForRepurchaseOfTemporaryEquityAndPlacementAgentCaseFees" id="xxii_ProceedsFromPreferredStockNetOfAmountUsedForRepurchaseOfTemporaryEquityAndPlacementAgentCaseFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="TestingServicesAgreementMember" id="xxii_TestingServicesAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ScheduleOfPreferredStockTransactionActivityTableTextBlock" id="xxii_ScheduleOfPreferredStockTransactionActivityTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ScheduleOfNumberOfSharesSoldAtMarketProgramTableTextBlock" id="xxii_ScheduleOfNumberOfSharesSoldAtMarketProgramTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PreferredStockEquityConditionsMinimumRequiredDays" id="xxii_PreferredStockEquityConditionsMinimumRequiredDays" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="June2026InducementWarrantsMember" id="xxii_June2026InducementWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="June2026ExistingWarrantsMember" id="xxii_June2026ExistingWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ClassOfWarrantOrRightSecuritiesCalledByWarrantsOrRightsPercentage" id="xxii_ClassOfWarrantOrRightSecuritiesCalledByWarrantsOrRightsPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
</xsd:schema>
