v3.26.1
Segment Reporting - Schedule of Segment Loss, Including Significant Segment Expenses (Detail) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2026
Mar. 31, 2026
Jun. 30, 2025
Mar. 31, 2025
Jun. 30, 2026
Jun. 30, 2025
Segment Reporting [Line Items]            
Revenue $ 0   $ 0   $ 0 $ 0
Research and development expenses 3,638   4,292   6,711 7,346
General and administrative expenses 2,438   2,579   4,595 5,134
Other income 162   60   178 182
Other expense (461)   (11)   (1,085) (25)
Net loss (6,375) $ (5,838) (6,822) $ (5,501) (12,213) (12,323)
Employee Related Expenses [Member]            
Segment Reporting [Line Items]            
Research and development expenses 500   521   1,000 1,143
General and administrative expenses 859   935   1,718 1,882
Professional Fees for Services [Member]            
Segment Reporting [Line Items]            
Research and development expenses 0   21   0 38
General and administrative expenses 1,070   1,036   1,860 2,174
Facilities and Other Expenses [Member]            
Segment Reporting [Line Items]            
Research and development expenses 49   21   74 37
General and administrative expenses 509   608   1,017 1,078
LTI-01 Program-Related Expenses [Member]            
Segment Reporting [Line Items]            
Research and development expenses 208   463   275 1,065
LTI-01 Program-Related Expenses [Member] | CMC Activities [Member]            
Segment Reporting [Line Items]            
Research and development expenses 89   247   156 784
LTI-01 Program-Related Expenses [Member] | Clinical Operation Activities [Member]            
Segment Reporting [Line Items]            
Research and development expenses 2,094   2,162   4,055 2,835
LTI-03 Program-Related Expenses [Member]            
Segment Reporting [Line Items]            
Research and development expenses 2,839   3,265   5,320 5,054
LTI-03 Program-Related Expenses [Member] | Preclinical Study Costs [Member]            
Segment Reporting [Line Items]            
Research and development expenses 1   267   1 823
LTI-03 Program-Related Expenses [Member] | CMC Activities [Member]            
Segment Reporting [Line Items]            
Research and development expenses 744   836   1,264 1,396
LTI-03 Program-Related Expenses [Member] | Clinical Operation Activities [Member]            
Segment Reporting [Line Items]            
Research and development expenses 119   216   119 281
Other Program-Related Expenses [Member]            
Segment Reporting [Line Items]            
Research and development expenses $ 42   $ 1   $ 42 $ 9