The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 7,613,620 30,256 SH DFND 1,2 30,256 0 0
ABIVAX SA SPONSORED ADS 00370M103 2,665,200 20,000 SH Put DFND 1,2 20,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 9,020,310 356,534 SH DFND 1,2 356,534 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 3,251,124 10,800 SH DFND 1,2 10,800 0 0
ALPHA COGNITION INC COM NEW 02074J501 3,940,792 545,816 SH DFND 1,2 545,816 0 0
AMGEN INC COM 031162100 2,715,900 7,500 SH DFND 1,2 7,500 0 0
APPLIED MATLS INC COM 038222105 7,981,920 11,040 SH DFND 11,040 0 0
APREA THERAPEUTICS INC COM NEW 03836J201 216,621 270,000 SH DFND 1,2 270,000 0 0
ASTRAZENECA PLC ORD G0593M107 11,856,939 62,530 SH DFND 1,2 62,530 0 0
AVALO THERAPEUTICS INC COM NEW 05338F306 4,292,793 232,294 SH DFND 1,2 232,294 0 0
BIOAGE LABS INC COM 09077V100 5,237,076 213,671 SH DFND 1,2 213,671 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 4,220,510 422,051 SH DFND 1,2 422,051 0 0
BIOGEN INC COM 09062X103 20,877,014 96,626 SH DFND 1,2 96,626 0 0
BIOGEN INC COM 09062X103 21,606,000 100,000 SH Call DFND 1,2 0 0 0
BIOHAVEN LTD COM G1110E107 2,446,823 164,437 SH DFND 1,2 164,437 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 18,799,631 328,550 SH DFND 1,2 328,550 0 0
BRIDGEBIO ONCOLOGY THERAPEUT COM NEW 107924102 3,512,706 460,985 SH DFND 1,2 460,985 0 0
BRIDGEBIO PHARMA INC COM 10806X102 18,273,370 245,346 SH DFND 1,2 245,346 0 0
CABALETTA BIO INC COM 12674W109 4,133,227 1,329,012 SH DFND 1,2 1,329,012 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 8,962,698 240,868 SH DFND 1,2 240,868 0 0
CLIMB BIO INC COM 28658R106 6,308,061 483,747 SH DFND 1,2 483,747 0 0
COGENT BIOSCIENCES INC COM 19240Q201 17,776,458 459,340 SH DFND 1,2 459,340 0 0
CONSTELLATION ENERGY CORP COM 21037T109 2,446,445 9,850 SH DFND 9,850 0 0
CONTINEUM THERAPEUTICS INC CL A 21217B100 3,007,155 183,475 SH DFND 1,2 183,475 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 3,659,717 244,961 SH DFND 1,2 244,961 0 0
CURIS INC COM 231269309 1,033,717 98,996 SH DFND 1,2 98,996 0 0
CYBIN INC COM NEW 23256X407 10,713,177 1,620,753 SH DFND 1,2 1,620,753 0 0
CYTOKINETICS INC COM NEW 23282W605 18,740,693 219,987 SH DFND 1,2 219,987 0 0
CYTOKINETICS INC COM NEW 23282W605 8,519,000 100,000 SH Call DFND 1,2 0 0 0
CYTOMX THERAPEUTICS INC. COM 23284F105 3,296,250 879,000 SH DFND 1,2 879,000 0 0
DISC MEDICINE INC COM 254604101 4,647,169 63,538 SH DFND 1,2 63,538 0 0
DYNE THERAPEUTICS INC COM 26818M108 4,432,983 199,594 SH DFND 1,2 199,594 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101 4,693,277 1,191,187 SH DFND 1,2 1,191,187 0 0
ELI LILLY & CO COM 532457108 9,643,417 8,040 SH DFND 1,2 8,040 0 0
ENLIVEN THERAPEUTICS INC COM 29337E102 5,722,824 112,765 SH DFND 1,2 112,765 0 0
EVOMMUNE INC COM SHS 30054Y107 300,779 22,632 SH DFND 1,2 22,632 0 0
FIRST TRACKS BIOTHERAPEUTICS ORD SHS 337185102 560,865 27,876 SH DFND 1,2 27,876 0 0
FORTE BIOSCIENCES INC COM NEW 34962G208 5,305,976 249,693 SH DFND 1,2 249,693 0 0
GENERATE BIOMEDICINES INC COM SHS 370920100 4,133,150 245,000 SH DFND 1,2 245,000 0 0
GLOBAL X FDS CLOUD COMPUTNG 37954Y442 4,454,766 195,900 SH DFND 195,900 0 0
GSK PLC SPONSORED ADR 37733W204 5,346,840 102,000 SH DFND 1,2 102,000 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 6,432,300 176,663 SH DFND 1,2 176,663 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 7,320,126 196,408 SH DFND 1,2 196,408 0 0
IMMATICS N.V SHS N44445109 7,294,177 720,057 SH DFND 1,2 720,057 0 0
IMMIX BIOPHARMA INC COM 45258H106 2,783,700 270,000 SH DFND 1,2 270,000 0 0
INHIBIKASE THERAPEUTICS INC COM NEW 45719W205 1,318,097 649,309 SH DFND 1,2 649,309 0 0
INSMED INC COM PAR $.01 457669307 12,666,456 118,800 SH DFND 1,2 118,800 0 0
ISHARES TR 20 YR TR BD ETF 464287432 4,061,740 47,000 SH Call DFND 0 0 0
JOHNSON & JOHNSON COM 478160104 7,322,209 28,831 SH DFND 1,2 28,831 0 0
KODIAK SCIENCES INC COM 50015M109 3,186,772 81,796 SH DFND 1,2 81,796 0 0
KURA ONCOLOGY INC COM 50127T109 3,236,578 295,039 SH DFND 1,2 295,039 0 0
LAM RESEARCH CORP COM NEW 512807306 8,003,605 18,470 SH DFND 18,470 0 0
LARIMAR THERAPEUTICS INC COM 517125100 2,824,312 926,004 SH DFND 1,2 926,004 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 9,353,132 17,419 SH DFND 1,2 17,419 0 0
MAZE THERAPEUTICS INC COM 578784100 12,460,110 417,564 SH DFND 1,2 417,564 0 0
MEDIWOUND LTD SHS NEW M68830112 4,015,922 273,192 SH DFND 1,2 273,192 0 0
MERCK & CO INC COM 58933Y105 7,530,100 58,600 SH DFND 1,2 58,600 0 0
MINERALYS THERAPEUTICS INC COM 603170101 39,659,818 1,469,971 SH DFND 1,2 1,469,971 0 0
NOVA LTD COM M7516K103 13,665,257 25,169 SH DFND 25,169 0 0
NOVARTIS AG SPONSORED ADR 66987V109 7,832,904 50,000 SH DFND 1,2 50,000 0 0
NOVO-NORDISK A S ADR 670100205 5,785,255 120,677 SH DFND 1,2 120,677 0 0
NUVECTIS PHARMA INC COM 67080T108 7,042,359 382,945 SH DFND 1,2 382,945 0 0
ORGANOGENESIS HLDGS INC COM 68621F102 1,336,500 550,000 SH DFND 1,2 550,000 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 8,154,806 752,983 SH DFND 1,2 752,983 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 1,083,000 100,000 SH Call DFND 1,2 0 0 0
ORMAT TECHNOLOGIES INC COM 686688102 3,050,834 28,015 SH DFND 28,015 0 0
OVID THERAPEUTICS INC COM 690469101 3,639,570 1,353,000 SH DFND 1,2 1,353,000 0 0
PALISADE BIO INC COM 696389402 4,717,352 2,257,106 SH DFND 1,2 2,257,106 0 0
PFIZER INC COM 717081103 6,886,880 286,000 SH DFND 1,2 286,000 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207 4,184,875 12,500 SH Call DFND 1,2 0 0 0
PRELUDE THERAPEUTICS INC COM 74065P101 5,435,705 1,019,832 SH DFND 1,2 1,019,832 0 0
PROMIS NEUROSCIENCES INC COM SHS 74346M505 4,284,784 325,591 SH DFND 1,2 325,591 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 3,268,872 1,757,458 SH DFND 1,2 1,757,458 0 0
RELAY THERAPEUTICS INC COM 75943R102 4,375,072 233,836 SH DFND 1,2 233,836 0 0
REVOLUTION MEDICINES INC COM 76155X100 4,195,072 22,400 SH DFND 1,2 22,400 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 8,926,812 80,400 SH DFND 1,2 80,400 0 0
SANOFI SA SPONSORED ADR 80105N105 11,497,510 269,515 SH DFND 1,2 269,515 0 0
SATELLOS BIOSCIENCE INC COM 80401L803 5,073,887 652,590 SH DFND 1,2 652,590 0 0
SAVARA INC COM 805111101 4,657,970 756,164 SH DFND 1,2 756,164 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 5,184,575 94,265 SH DFND 1,2 94,265 0 0
SHATTUCK LABS INC COM 82024L103 600,039 86,461 SH DFND 1,2 86,461 0 0
SKYE BIOSCIENCE INC COM NEW 83086J200 470,701 678,928 SH DFND 1,2 678,928 0 0
SOLAREDGE TECHNOLOGIES INC NOTE 2.250% 7/0 83417MAE4 7,747,190 4,000,000 SH DFND 4,000,000 0 0
SPDR SERIES TRUST ST STR SP BIOT 78464A870 23,737,500 150,000 SH Put DFND 1,2 150,000 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 1,534,962 28,600 SH DFND 1,2 28,600 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 22,179,287 1,014,606 SH DFND 1,2 1,014,606 0 0
TALEN ENERGY CORP COM 87422Q109 4,662,995 12,135 SH DFND 12,135 0 0
TANGO THERAPEUTICS INC COM 87583X109 7,947,855 254,250 SH DFND 1,2 254,250 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106 1,702,500 250,000 SH DFND 1,2 250,000 0 0
TENAX THERAPEUTICS INC COM NEW 88032L605 1,748,910 120,200 SH DFND 1,2 120,200 0 0
TENAX THERAPEUTICS INC COM NEW 88032L605 1,856,580 127,600 SH Call DFND 1,2 0 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 47,773,578 1,410,082 SH DFND 1,410,082 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 3,049,200 90,000 SH DFND 1,2 90,000 0 0
TOWER SEMICONDUCTOR LTD SHS NEW M87915274 28,218,190 108,265 SH DFND 108,265 0 0
TRAWS PHARMA INC COM NEW 68232V884 336,043 398,486 SH DFND 1,2 398,486 0 0
TREVI THERAPEUTICS INC COM 89532M101 9,306,891 499,029 SH DFND 1,2 499,029 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 19,649,815 588,494 SH DFND 1,2 588,494 0 0
UPSTREAM BIO INC COM 91678A107 1,520,324 219,700 SH DFND 1,2 219,700 0 0
VERASTEM INC COM NEW 92337C203 2,416,654 632,632 SH DFND 1,2 632,632 0 0
VISTRA CORP COM 92840M102 4,671,654 29,450 SH DFND 29,450 0 0
VOR BIOPHARMA INC COM NEW 929033207 7,666,237 416,417 SH DFND 1,2 416,417 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 1,496,439 427,554 SH DFND 1,2 427,554 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 3,708,360 638,272 SH DFND 1,2 638,272 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 225,589 626,810 SH DFND 1,2 626,810 0 0
XENON PHARMACEUTICALS INC COM 98420N105 6,337,800 105,000 SH DFND 1,2 105,000 0 0
ZENAS BIOPHARMA INC COM 98937L105 5,858,567 230,834 SH DFND 1,2 230,834 0 0