The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100 7,595,723 571,107 SH SOLE 571,107 0 0
ABIVAX SA SPONSORED ADS 00370M103 46,534,392 349,200 SH Call SOLE 349,200 0 0
ABIVAX SA SPONSORED ADS 00370M103 33,634,824 252,400 SH Put SOLE 252,400 0 0
ABIVAX SA SPONSORED ADS 00370M103 21,598,038 163,644 SH SOLE 163,644 0 0
ADMA BIOLOGICS INC COM 000899104 1,674,000 200,000 SH Call SOLE 200,000 0 0
ALUMIS INC COM 022307102 5,628,000 200,000 SH Call SOLE 200,000 0 0
AMGEN INC COM 031162100 3,621,200 10,000 SH Call SOLE 10,000 0 0
AMGEN INC COM 031162100 214,645 102,701 SH SOLE 102,701 0 0
ANNEXON INC COM 03589W102 2,016,772 353,200 SH Call SOLE 353,200 0 0
ANNEXON INC COM 03589W102 157,116 27,516 SH SOLE 27,516 0 0
APREA THERAPEUTICS INC COM NEW 03836J201 36,029 44,907 SH SOLE 44,907 0 0
AQUESTIVE THERAPEUTICS INC COM 03843E104 892,736 214,600 SH Call SOLE 214,600 0 0
ARCUS BIOSCIENCES INC COM 03969F109 6,900,062 223,810 SH SOLE 223,810 0 0
ARCUS BIOSCIENCES INC COM 03969F109 3,822,920 124,000 SH Call SOLE 124,000 0 0
ARDELYX INC COM 039697107 1,545,428 303,025 SH SOLE 303,025 0 0
ARS PHARMACEUTICALS INC COM 82835W108 38,929 4,860 SH SOLE 4,860 0 0
ATYR PHARMA INC COM NEW 002120202 7,460 12,500 SH Put SOLE 12,500 0 0
AYTU BIOPHARMA INC COM 054754858 319,374 148,546 SH SOLE 148,546 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 1,961,950 462,724 SH SOLE 462,724 0 0
BIOAGE LABS INC COM 09077V100 3,586,646 146,334 SH SOLE 146,334 0 0
BIOAGE LABS INC COM 09077V100 4,904,451 200,100 SH Call SOLE 200,100 0 0
BIOGEN INC COM 09062X103 12,963,600 60,000 SH Call SOLE 60,000 0 0
BIOHAVEN LTD COM G1110E107 4,716,960 317,000 SH Call SOLE 317,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 17,901,048 312,846 SH SOLE 312,846 0 0
BIONTECH SE SPONSORED ADS 09075V102 9,305,000 100,000 SH Call SOLE 100,000 0 0
BRIDGEBIO PHARMA INC NOTE 1.750% 3/0 10806XAJ1 18,620,000 250,000 PRN SOLE 250,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 19,049,172 330,600 SH Put SOLE 330,600 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 34,572,000 600,000 SH Call SOLE 600,000 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309 12,868,352 534,400 SH Put SOLE 534,400 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309 7,929,544 329,300 SH Call SOLE 329,300 0 0
CARTESIAN THERAPEUTICS INC COM NEW 816212302 907,134 87,057 SH SOLE 87,057 0 0
CELCUITY INC COM 15102K100 2,092,400 20,000 SH Call SOLE 20,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 3,200,060 86,000 SH Put SOLE 86,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 1,893,989 50,900 SH Call SOLE 50,900 0 0
CELLECTAR BIOSCIENCES INC COM NEW 15117F880 384,588 138,341 SH SOLE 138,341 0 0
CG ONCOLOGY INC COM 156944100 518,665 7,300 SH Call SOLE 7,300 0 0
COGENT BIOSCIENCES INC COM 19240Q201 19,104,797 493,664 SH SOLE 493,664 0 0
CONNECT BIOPHARMA HLDGS LTD SHS G23549101 468,824 196,985 SH SOLE 196,985 0 0
CONTINEUM THERAPEUTICS INC CL A 21217B100 1,962,424 119,733 SH SOLE 119,733 0 0
CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301 2,825,856 301,264 SH SOLE 301,264 0 0
CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301 5,945,044 633,800 SH Call SOLE 633,800 0 0
CORCEPT THERAPEUTICS INC COM 218352102 17,937,785 206,300 SH Call SOLE 206,300 0 0
CORMEDIX INC COM 21900C308 1,314,875 167,500 SH Put SOLE 167,500 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 4,404,476 294,811 SH SOLE 294,811 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 1,992,996 133,400 SH Call SOLE 133,400 0 0
CUE BIOPHARMA INC COM 22978P205 1,526,526 48,369 SH SOLE 48,369 0 0
CUE BIOPHARMA INC COM 22978P205 6 6 SH Call SOLE 6 0 0
CYBIN INC COM NEW 23256X407 661,000 100,000 SH Call SOLE 100,000 0 0
CYBIN INC COM NEW 23256X407 1,322,000 200,000 SH SOLE 200,000 0 0
CYTOKINETICS INC COM NEW 23282W605 2,555,700 30,000 SH Put SOLE 30,000 0 0
DEFINIUM THERAPEUTICS INC COM SHS 24477V105 726,815 15,451 SH SOLE 15,451 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 11,060,055 272,214 SH SOLE 272,214 0 0
EDITAS MEDICINE INC COM 28106W103 1,296,000 400,000 SH Call SOLE 400,000 0 0
ELI LILLY & CO COM 532457108 11,994,300 10,000 SH Put SOLE 10,000 0 0
ELICIO THERAPEUTICS INC COM 28657F103 391,000 100,000 SH Put SOLE 100,000 0 0
ELICIO THERAPEUTICS INC COM 28657F103 438,311 112,100 SH Call SOLE 112,100 0 0
ENLIVEN THERAPEUTICS INC COM 29337E102 507,500 10,000 SH SOLE 10,000 0 0
ENTERA BIO LTD SHS M40527109 41,170 23,260 SH SOLE 23,260 0 0
EQUILLIUM INC COM 29446K106 1,280,902 400,282 SH SOLE 400,282 0 0
ERASCA INC COM 29479A108 1,832 100 SH Call SOLE 100 0 0
EVOLUS INC COM 30052C107 1,388,000 200,000 SH Call SOLE 200,000 0 0
EYEPOINT INC COM NEW 30233G209 1,520,090 106,300 SH Call SOLE 106,300 0 0
FOGHORN THERAPEUTICS INC COM 344174107 326,511 66,908 SH SOLE 66,908 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 978,118 26,864 SH SOLE 26,864 0 0
HERON THERAPEUTICS INC COM 427746102 195,783 458,723 SH SOLE 458,723 0 0
HIMS & HERS HEALTH INC COM CL A 433000106 6,715,579 193,700 SH Put SOLE 193,700 0 0
HIMS & HERS HEALTH INC COM CL A 433000106 6,934,000 200,000 SH Call SOLE 200,000 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 8,091,900 254,863 SH SOLE 254,863 0 0
INCYTE CORP COM 45337C102 11,948,144 105,400 SH Put SOLE 105,400 0 0
INDIVIOR PHARMACEUTICALS INC COM 45579U109 2,770,017 67,512 SH SOLE 67,512 0 0
INOVIO PHARMACEUTICALS INC COM SHS 45773H409 302,720 275,200 SH Call SOLE 275,200 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 3,384,000 200,000 SH Call SOLE 200,000 0 0
INVENTIVA SA ADS 46124U107 2,725,718 740,786 SH SOLE 740,786 0 0
JADE BIOSCIENCES INC COM NEW 008064206 3,174 1,046 SH Put SOLE 1,046 0 0
JATT II ACQUISITION CORP ORD SHS G50765109 102,479 9,021 SH SOLE 9,021 0 0
JOHNSON & JOHNSON COM 478160104 5,587,340 22,000 SH SOLE 22,000 0 0
KAILERA THERAPEUTICS INC COMMON STOCK 482931102 79,771 3,621 SH SOLE 3,621 0 0
KODIAK SCIENCES INC COM 50015M109 7,663,432 196,700 SH Call SOLE 196,700 0 0
KODIAK SCIENCES INC COM 50015M109 5,723,224 146,900 SH Put SOLE 146,900 0 0
KODIAK SCIENCES INC COM 50015M109 8,497,838 218,117 SH SOLE 218,117 0 0
KYMERA THERAPEUTICS INC COM 501575104 17,166,099 149,700 SH Call SOLE 149,700 0 0
LAKELAND INDS INC COM 511795106 150,815 14,108 SH SOLE 14,108 0 0
LARIMAR THERAPEUTICS INC COM 517125100 447,243 146,637 SH SOLE 146,637 0 0
MACROGENICS INC COM 556099109 1,729,742 374,403 SH SOLE 374,403 0 0
MANNKIND CORP COM NEW 56400P706 68,173 16,003 SH SOLE 16,003 0 0
MEIRAGTX HLDGS PLC COM G59665102 6,755 500 SH Call SOLE 500 0 0
MEIRAGTX HLDGS PLC COM G59665102 113,052 8,368 SH SOLE 8,368 0 0
MINERALYS THERAPEUTICS INC COM 603170101 1,520,242 56,347 SH SOLE 56,347 0 0
MODERNA INC COM 60770K107 7,003,000 100,000 SH Put SOLE 100,000 0 0
MONOPAR THERAPEUTICS INC COM NEW 61023L207 150,922 1,630 SH SOLE 1,630 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102 4,116,420 170,100 SH Call SOLE 170,100 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102 1,897,062 78,391 SH SOLE 78,391 0 0
NEXTCURE INC COM NEW 65343E207 12,387 7,742 SH SOLE 7,742 0 0
NOVARTIS AG SPONSORED ADR 66987V109 7,836,000 50,000 SH Call SOLE 50,000 0 0
NOVARTIS AG SPONSORED ADR 66987V109 15,672,000 100,000 SH Put SOLE 100,000 0 0
NOVO-NORDISK A S ADR 670100205 2,679,846 55,900 SH Put SOLE 55,900 0 0
NOVO-NORDISK A S ADR 670100205 4,809,442 100,000 SH SOLE 100,000 0 0
NURIX THERAPEUTICS INC COM 67080M103 2,948,536 121,539 SH SOLE 121,539 0 0
OCUGEN INC COM 67577C105 306,000 200,000 SH SOLE 200,000 0 0
ORUKA THERAPEUTICS INC COM 687604108 2,645,631 27,799 SH SOLE 27,799 0 0
PELTHOS THERAPEUTICS INC COM SHS 171126204 700,085 24,773 SH SOLE 24,773 0 0
PEPGEN INC COM 713317105 671,911 373,284 SH SOLE 373,284 0 0
PHARVARIS N V COM N69605108 1,013,920 29,321 SH SOLE 29,321 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 1,409,958 129,950 SH SOLE 129,950 0 0
PRECIGEN INC COM 74017N105 771,170 135,293 SH SOLE 135,293 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 1,722,390 926,016 SH SOLE 926,016 0 0
PROTHENA CORP PLC SHS G72800108 1,463,429 149,482 SH SOLE 149,482 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101 1,168,482 388,200 SH Call SOLE 388,200 0 0
RELAY THERAPEUTICS INC COM 75943R102 4,315,967 230,677 SH SOLE 230,677 0 0
RELMADA THERAPEUTICS INC COM 75955J402 2,500,660 361,367 SH SOLE 361,367 0 0
REPLIMUNE GROUP INC COM 76029N106 7,708,041 696,300 SH Call SOLE 696,300 0 0
REPLIMUNE GROUP INC COM 76029N106 5,562,675 502,500 SH Put SOLE 502,500 0 0
REVOLUTION MEDICINES INC COM 76155X100 26,072,747 139,218 SH SOLE 139,218 0 0
RIGEL PHARMACEUTICALS INC COM 766559702 892,562 22,816 SH SOLE 22,816 0 0
ROYALTY PHARMA PLC SHS CLASS A G7709Q104 5,607,000 100,000 SH Call SOLE 100,000 0 0
SELLAS LIFE SCIENCES GROUP I COM NEW 81642T209 5,904,000 400,000 SH Call SOLE 400,000 0 0
SELLAS LIFE SCIENCES GROUP I COM NEW 81642T209 1,476,000 100,000 SH Put SOLE 100,000 0 0
SEPTERNA INC COM 81734D104 1,999,353 59,700 SH Put SOLE 59,700 0 0
SPRUCE BIOSCIENCES INC COM NEW 85209E208 1,620,000 30,000 SH SOLE 30,000 0 0
SPYRE THERAPEUTICS INC COM NEW 00773J202 1,331,700 15,000 SH SOLE 15,000 0 0
SUMMIT THERAPEUTICS INC COM 86627T108 2,914,000 200,000 SH Put SOLE 200,000 0 0
SUMMIT THERAPEUTICS INC COM 86627T108 874,200 60,000 SH SOLE 60,000 0 0
SUMMIT THERAPEUTICS INC COM 86627T108 12,533,114 860,200 SH Call SOLE 860,200 0 0
TALPHERA INC COM NEW 00444T209 158,170 153,563 SH SOLE 153,563 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106 3,559,035 522,619 SH SOLE 522,619 0 0
TENAX THERAPEUTICS INC COM NEW 88032L605 4,466,850 307,000 SH Call SOLE 307,000 0 0
TG THERAPEUTICS INC COM 88322Q108 4,158,958 75,700 SH Call SOLE 75,700 0 0
TVARDI THERAPEUTICS INC COM 140755307 31,553 16,607 SH SOLE 16,607 0 0
UNICYCIVE THERAPEUTICS INC COM NEW 90466Y202 3,717,294 792,600 SH Call SOLE 792,600 0 0
UNICYCIVE THERAPEUTICS INC COM NEW 90466Y202 1,424,240 303,676 SH SOLE 303,676 0 0
UNIQURE NV SHS N90064101 13,771,940 299,000 SH Put SOLE 299,000 0 0
UNIQURE NV SHS N90064101 10,842,524 235,400 SH Call SOLE 235,400 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 28,711,030 52,989 SH SOLE 52,989 0 0
UPSTREAM BIO INC COM 91678A107 132,124 19,093 SH SOLE 19,093 0 0
UROGEN PHARMA LTD COM M96088105 262,642 7,137 SH SOLE 7,137 0 0
VAXCYTE INC COM 92243G108 2,842,557 48,900 SH Put SOLE 48,900 0 0
VAXCYTE INC COM 92243G108 2,619,977 45,071 SH SOLE 45,071 0 0
VAXCYTE INC COM 92243G108 3,086,703 53,100 SH Call SOLE 53,100 0 0
VERA THERAPEUTICS INC CL A 92337R101 2,471,959 57,608 SH SOLE 57,608 0 0
VERA THERAPEUTICS INC CL A 92337R101 2,145,500 50,000 SH Put SOLE 50,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 17,234,930 441,808 SH SOLE 441,808 0 0
VIKING THERAPEUTICS INC COM 92686J106 13,673,005 350,500 SH Put SOLE 350,500 0 0
VIKING THERAPEUTICS INC COM 92686J106 47,623,408 1,220,800 SH Call SOLE 1,220,800 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 1,837,000 100,000 SH SOLE 100,000 0 0
VISTAGEN THERAPEUTICS INC COM 92840H400 13,040 57,700 SH Call SOLE 57,700 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 1,447,747 413,642 SH SOLE 413,642 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 525,000 150,000 SH Call SOLE 150,000 0 0
XERIS BIOPHARMA HOLDINGS INC COM 98422E103 1,051,348 132,746 SH SOLE 132,746 0 0
ZYMEWORKS INC COM 98985Y108 3,715,330 142,132 SH SOLE 142,132 0 0