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  <xs:element id="skye_NoncashFinancingOfInsurancePremium" abstract="false" name="NoncashFinancingOfInsurancePremium" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_StockIssuedDuringPeriodValueWarrantExercises" abstract="false" name="StockIssuedDuringPeriodValueWarrantExercises" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_StockIssuedDuringPeriodSharesWarrantExercises" abstract="false" name="StockIssuedDuringPeriodSharesWarrantExercises" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="skye_PrepaidExpensesOtherCurrentAssetsAndLiabilitiesTextBlock" abstract="false" name="PrepaidExpensesOtherCurrentAssetsAndLiabilitiesTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="skye_WarrantsAndDerivativeLiabilitiesTextBlock" abstract="false" name="WarrantsAndDerivativeLiabilitiesTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="skye_WorkingCapital" abstract="false" name="WorkingCapital" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_PrepaidClinicalExpenses" abstract="false" name="PrepaidClinicalExpenses" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_AccruedResearchAndDevelopmentCostsCurrent" abstract="false" name="AccruedResearchAndDevelopmentCostsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_LegalProfessionalFeeAccrual" abstract="false" name="LegalProfessionalFeeAccrual" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_ReusableManufacturingChromatographyMaterialsMember" abstract="true" name="ReusableManufacturingChromatographyMaterialsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_TwoThousandSixteenCommonStockWarrantsToServiceProvidersMember" abstract="true" name="TwoThousandSixteenCommonStockWarrantsToServiceProvidersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_TwoThousandAndTwentyOneInducementWarrantsMember" abstract="true" name="TwoThousandAndTwentyOneInducementWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_TwoThousandAndTwentyOneInducementWarrantsToPlacementAgentMember" abstract="true" name="TwoThousandAndTwentyOneInducementWarrantsToPlacementAgentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_TwoThousandAndTwentyOneCommonStockWarrantsMember" abstract="true" name="TwoThousandAndTwentyOneCommonStockWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_TwoThousandAndTwentyPreFundedWarrantsMember" abstract="true" name="TwoThousandAndTwentyPreFundedWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_August2023ConvertibleNoteCommonStockWarrantsMember" abstract="true" name="August2023ConvertibleNoteCommonStockWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_August2023PIPEFinancingCommonStockWarrantsMember" abstract="true" name="August2023PIPEFinancingCommonStockWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_January2024PreFundedWarrantsCommonStockMember" abstract="true" name="January2024PreFundedWarrantsCommonStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_ClassOfWarrantOrRightTermOfWarrant" abstract="false" name="ClassOfWarrantOrRightTermOfWarrant" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="skye_ClassOfWarrantOrRightWarrantsVestedAndOutstanding" abstract="false" name="ClassOfWarrantOrRightWarrantsVestedAndOutstanding" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="skye_January2024PIPEFinancingPreFundedWarrantsMember" abstract="true" name="January2024PIPEFinancingPreFundedWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_January2024PIPEFinancingMember" abstract="true" name="January2024PIPEFinancingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_A2024InducementEquityIncentivePlanMember" abstract="true" name="A2024InducementEquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_AmendedAndRestatedPlanMember" abstract="true" name="AmendedAndRestatedPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_AmendedAndRestatedPlanAnd2024InducementPlanMember" abstract="true" name="AmendedAndRestatedPlanAnd2024InducementPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_LoanPayableMonthlyInstallmentAmount" abstract="false" name="LoanPayableMonthlyInstallmentAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_WendyCunningVsSkyeBioscienceIncMember" abstract="true" name="WendyCunningVsSkyeBioscienceIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_EconomicDamagesMember" abstract="true" name="EconomicDamagesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_NonEconomicDamagesMember" abstract="true" name="NonEconomicDamagesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_PunitiveDamagesMember" abstract="true" name="PunitiveDamagesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_LossContingencyAppealBond" abstract="false" name="LossContingencyAppealBond" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_SBI100Member" abstract="true" name="SBI100Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_NimacimabMember" abstract="true" name="NimacimabMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_ResearchAndDevelopmentActivitiesSegmentMember" abstract="true" name="ResearchAndDevelopmentActivitiesSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_ExternalClinicalDevelopmentExpenses" abstract="false" name="ExternalClinicalDevelopmentExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_RedxMember" abstract="true" name="RedxMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_ExistingInvestorMember" abstract="true" name="ExistingInvestorMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_NonVotingCommonStockNumberOfSharesIssuedForEachShare" abstract="false" name="NonVotingCommonStockNumberOfSharesIssuedForEachShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="skye_ContingentValueRightsAgreementContingentValueRightIssuedForEachOutstandingCommonShare" abstract="false" name="ContingentValueRightsAgreementContingentValueRightIssuedForEachOutstandingCommonShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="skye_ContingentValueRightsAgreementCashPaymentPercentageOfNetProceeds" abstract="false" name="ContingentValueRightsAgreementCashPaymentPercentageOfNetProceeds" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="skye_ProceedsFromSecuritiesPurchaseAgreement" abstract="false" name="ProceedsFromSecuritiesPurchaseAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_ProceedsFromSecuritiesPurchaseAgreementMaximum" abstract="false" name="ProceedsFromSecuritiesPurchaseAgreementMaximum" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
