The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AbCellera Biologics Inc. COM 00288U106 259,145,283 33,012,138 SH SOLE 33,012,138 0 0
Absci Corporation COM 00091E109 24,742,367 2,134,803 SH SOLE 2,134,803 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 1,085,696,471 42,912,904 SH SOLE 42,912,904 0 0
Aktis Oncology, Inc. COM 01021M104 32,112,393 996,351 SH SOLE 996,351 0 0
Aligos Therapeutics, Inc. COM 01626L204 479,227 83,055 SH SOLE 83,055 0 0
Alkermes plc SHS G01767105 524,592,729 10,012,267 SH SOLE 10,012,267 0 0
Alumis Inc. COM 022307102 56,631,750 2,012,500 SH SOLE 2,012,500 0 0
Arcus Biosciences, Inc. COM 03969F109 26,045,677 844,816 SH SOLE 844,816 0 0
Arrowhead Pharmaceuticals, Inc. COM 04280A100 162,431,742 1,992,783 SH SOLE 1,992,783 0 0
Avalo Therapeutics, Inc. COM 05338F306 10,164,000 550,000 SH SOLE 550,000 0 0
Avalyn Pharma Inc. COM SHS 05348Y105 11,522,000 350,000 SH SOLE 350,000 0 0
BeOne Medicines Ltd. SPONSORED ADS 07725L102 2,508,182,548 8,801,567 SH SOLE 8,801,567 0 0
Bicycle Therapeutics plc SPONSORED ADS 088786108 46,153,914 10,885,357 SH SOLE 10,885,357 0 0
BioNTech SE SPONSORED ADS 09075V102 11,142,086 119,743 SH SOLE 119,743 0 0
Celcuity Inc. COM 15102K100 828,150,159 7,915,792 SH SOLE 7,915,792 0 0
Celldex Therapeutics, Inc. COM 15117B202 44,004,955 1,182,611 SH SOLE 1,182,611 0 0
Cerus Corporation COM 157085101 18,674,659 6,395,431 SH SOLE 6,395,431 0 0
Crinetics Pharmaceuticals, Inc. COM 22663K107 87,991,820 2,351,465 SH SOLE 2,351,465 0 0
Cytokinetics, Incorporated COM 23282W605 17,997,836 211,267 SH SOLE 211,267 0 0
CytomX Therapeutics, Inc. COM 23284F105 18,659,348 4,975,826 SH SOLE 4,975,826 0 0
DBV Technologies S.A. SPONSORED ADS 23306J309 23,967,370 1,461,425 SH SOLE 1,461,425 0 0
Denali Therapeutics Inc. COM 24823R105 96,047,122 3,734,336 SH SOLE 3,734,336 0 0
Design Therapeutics, Inc. COM 25056L103 38,756,882 2,678,430 SH SOLE 2,678,430 0 0
Dianthus Therapeutics, Inc. COM 252828108 83,068,947 852,164 SH SOLE 852,164 0 0
Disc Medicine, Inc. COM 254604101 25,573,913 349,657 SH SOLE 349,657 0 0
Dyne Therapeutics, Inc. COM 26818M108 18,066,702 813,449 SH SOLE 813,449 0 0
Edgewise Therapeutics, Inc. COM 28036F105 150,400,843 3,701,719 SH SOLE 3,701,719 0 0
Eikon Therapeutics, Inc. COM 282564103 7,249,993 555,555 SH SOLE 555,555 0 0
Enliven Therapeutics, Inc. COM 29337E102 45,938,443 905,191 SH SOLE 905,191 0 0
Entrada Therapeutics, Inc. COM 29384C108 37,335,293 5,072,730 SH SOLE 5,072,730 0 0
Evommune, Inc. COM SHS 30054Y107 11,261,813 847,390 SH SOLE 847,390 0 0
Faeth Therapeutics, Inc. COM 81728A207 32,160,275 1,286,411 SH SOLE 1,286,411 0 0
Generate Biomedicines, Inc. COM SHS 370920100 24,016,166 1,423,602 SH SOLE 1,423,602 0 0
GRAIL, Inc. COM 384747101 275,033,478 4,028,614 SH SOLE 4,028,614 0 0
IDEAYA Biosciences, Inc. COM 45166A102 186,723,818 5,010,030 SH SOLE 5,010,030 0 0
Immatics N.V. SHS N44445109 96,321,763 9,508,565 SH SOLE 9,508,565 0 0
Immunome, Inc. COM 45257U108 1,171,934 55,306 SH SOLE 55,306 0 0
Immunovant, Inc. COM 45258J102 209,419,027 5,435,220 SH SOLE 5,435,220 0 0
Incyte Corporation COM 45337C102 3,487,217,729 30,762,330 SH SOLE 30,762,330 0 0
Insmed Incorporated COM PAR $.01 457669307 937,841,355 8,796,111 SH SOLE 8,796,111 0 0
Intellia Therapeutics, Inc. COM 45826J105 15,739,525 930,232 SH SOLE 930,232 0 0
Ionis Pharmaceuticals, Inc. COM 462222100 162,364,274 2,047,727 SH SOLE 2,047,727 0 0
Jade Biosciences, Inc. COM 008064206 27,340,066 1,230,426 SH SOLE 1,230,426 0 0
Kiniksa Pharmaceuticals International, plc ORD SHS CL A G52694109 181,275,420 2,834,643 SH SOLE 2,834,643 0 0
Kodiak Sciences Inc. COM 50015M109 776,051,487 19,919,186 SH SOLE 19,919,186 0 0
Kymera Therapeutics, Inc. COM 501575104 992,725,940 8,657,242 SH SOLE 8,657,242 0 0
LB Pharmaceuticals Inc. COM SHS 50180M108 6,491,000 200,000 SH SOLE 200,000 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 1,150,754,190 2,143,131 SH SOLE 2,143,131 0 0
MapLight Therapeutics, Inc. COM 56565P103 13,071,027 364,705 SH SOLE 364,705 0 0
Mirum Pharmaceuticals, Inc. COM 604749101 52,210,293 445,975 SH SOLE 445,975 0 0
Monte Rosa Therapeutics, Inc. COM 61225M102 105,166,811 4,345,736 SH SOLE 4,345,736 0 0
Neurogene Inc. COM 64135M105 31,188,682 991,691 SH SOLE 991,691 0 0
Nurix Therapeutics, Inc. COM 67080M103 113,016,569 4,658,556 SH SOLE 4,658,556 0 0
Parabilis Medicines, Inc. COM 698955101 13,685,000 500,000 SH SOLE 500,000 0 0
Praxis Precision Medicines, Inc. COM 74006W207 586,953,158 1,753,198 SH SOLE 1,753,198 0 0
Prelude Therapeutics Inc. COM 74065P101 53,959,982 10,123,824 SH SOLE 10,123,824 0 0
Protara Therapeutics, Inc. COM STK 74365U107 3,711,565 971,614 SH SOLE 971,614 0 0
Rapport Therapeutics, Inc. COM 75383L102 64,467,240 1,547,090 SH SOLE 1,547,090 0 0
Relay Therapeutics, Inc. COM 75943R102 52,889,110 2,826,783 SH SOLE 2,826,783 0 0
Replimune Group, Inc. COM 76029N106 122,271,870 11,045,336 SH SOLE 11,045,336 0 0
Revolution Medicines, Inc. COM 76155X100 2,143,111,899 11,443,357 SH SOLE 11,443,357 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 622,265,747 5,604,483 SH SOLE 5,604,483 0 0
Roivant Sciences Ltd. SHS G76279101 166,928,649 4,716,831 SH SOLE 4,716,831 0 0
Sagimet Biosciences Inc. COM SER A 786700104 7,366,659 952,996 SH SOLE 952,996 0 0
Sana Biotechnology, Inc. COM 799566104 1,083,586 310,483 SH SOLE 310,483 0 0
Sera Prognostics, Inc. CLASS A COM 81749D107 10,006,669 5,498,170 SH SOLE 5,498,170 0 0
Sionna Therapeutics, Inc. COM 829401108 17,596,000 400,000 SH SOLE 400,000 0 0
Skye Bioscience, Inc. COM 83086J200 1,092,116 1,575,243 SH SOLE 1,575,243 0 0
Stoke Therapeutics, Inc. COM 86150R107 109,176,726 3,336,697 SH SOLE 3,336,697 0 0
Structure Therapeutics Inc. SPONSORED ADS 86366E106 76,883,831 1,432,529 SH SOLE 1,432,529 0 0
Summit Therapeutics Inc. COM 86627T108 477,697,090 32,786,348 SH SOLE 32,786,348 0 0
Surrozen, Inc. Warrants @ $172.50 8/11/2026 (15 FOR 1) W EXP 8/11/2026 86889P117 13,750 833,333 SH SOLE 833,333 0 0
Tango Therapeutics, Inc. COM 87583X109 10,419,990 333,333 SH SOLE 333,333 0 0
Taysha Gene Therapies, Inc. COM SHS 877619106 27,272,388 4,004,756 SH SOLE 4,004,756 0 0
Tectonic Therapeutic, Inc. COM 878972108 20,892,713 607,788 SH SOLE 607,788 0 0
TScan Therapeutics, Inc. COM 89854M101 2,729,375 2,784,792 SH SOLE 2,784,792 0 0
Tyra Biosciences, Inc. COM 90240B106 338,788 10,607 SH SOLE 10,607 0 0
Verastem, Inc. COM 92337C203 9,547,471 2,499,338 SH SOLE 2,499,338 0 0
Viridian Therapeutics, Inc. COM 92790C104 43,776,169 2,383,025 SH SOLE 2,383,025 0 0
vTv Therapeutics, Inc. CL A 918385204 5,584,022 148,314 SH SOLE 148,314 0 0
Wave Life Sciences Ltd. SHS Y95308105 4,779,527 822,638 SH SOLE 822,638 0 0
Xencor, Inc. COM 98401F105 17,743,907 1,102,106 SH SOLE 1,102,106 0 0
Xenon Pharmaceuticals Inc. COM 98420N105 22,345,755 370,208 SH SOLE 370,208 0 0
Celcuity Inc. Note 2.75% 8/1/2031 15102KAA8 69,158,687 30,750,000 PRN SOLE 30,750,000 0 0