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  <xs:element id="rkto_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsEmployeeOptionsIssued" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsEmployeeOptionsIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="rkto_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsEmployeeOptionsIssuedPeriodWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsEmployeeOptionsIssuedPeriodWeightedAverageExercisePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="rkto_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsEmployeeOptionsIssuedIntrinsicValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsEmployeeOptionsIssuedIntrinsicValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="rkto_ClassCCommonShareMember" name="ClassCCommonShareMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="rkto_ClassNCommonStockMember" name="ClassNCommonStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="rkto_FairValueofFinancialAssetsandLiabilitiesDetailsTable" name="FairValueofFinancialAssetsandLiabilitiesDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="rkto_PercentageOfVotingRights" name="PercentageOfVotingRights" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="rkto_ZylTherapeuticsMember" name="ZylTherapeuticsMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="rkto_PreferredStockSharesUndesignated" name="PreferredStockSharesUndesignated" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xs:element id="rkto_StockholdersEquityDetailsTable" name="StockholdersEquityDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="rkto_TwoThousandEighteenEquityIncentivePlanMember" name="TwoThousandEighteenEquityIncentivePlanMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="rkto_TwoThousandTwentyTwoEquityIncentivePlanMember" name="TwoThousandTwentyTwoEquityIncentivePlanMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="rkto_UnregisteredWarrantsToPurchaseShares" name="UnregisteredWarrantsToPurchaseShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xs:element id="rkto_SubsequentEventsDetailsTable" name="SubsequentEventsDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="rkto_CurrentOfferingPrice" name="CurrentOfferingPrice" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="rkto_StockholdersEquityScheduleofStockBasedCompensationExpenseDetailsTable" name="StockholdersEquityScheduleofStockBasedCompensationExpenseDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="rkto_ScheduleOfStockBasedCompensationExpenseAbstract" name="ScheduleOfStockBasedCompensationExpenseAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="rkto_NonemployeeStockWarrantAwardsMember" name="NonemployeeStockWarrantAwardsMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="rkto_OfficeLeaseRightofuseAssetGross" name="OfficeLeaseRightofuseAssetGross" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="rkto_AccumulatedAmortizationRightOfUseAsset" name="AccumulatedAmortizationRightOfUseAsset" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="rkto_CryptoAssetsClassification" name="CryptoAssetsClassification" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xs:element id="rkto_IncomeStatementLocationBalanceAxis" name="IncomeStatementLocationBalanceAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="rkto_GeneralAndAdministrativeMember" name="GeneralAndAdministrativeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="rkto_StockIssuedDuringPeriodSharesWarrantsExercised" name="StockIssuedDuringPeriodSharesWarrantsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="rkto_StockIssuedDuringPeriodValueCommonStockIssuedForPatent" name="StockIssuedDuringPeriodValueCommonStockIssuedForPatent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="rkto_LicenseAgreementsTextBlock" name="LicenseAgreementsTextBlock" type="dtr:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
</xs:schema>
