<?xml version="1.0" encoding="US-ASCII" standalone="no"?>
    <!-- Field: Doc-Info; Name: Generator; Value: GoFiler Complete; Version: 6.4b -->
    <!-- Field: Doc-Info; Name: VendorURI; Value: https://www.novaworks.com -->
    <!-- Field: Doc-Info; Name: Status; Value: 0x00000000 -->
<link:linkbase xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrli="http://www.xbrl.org/2003/instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#Cover" roleURI="http://onemednet.com/role/Cover" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#BalanceSheets" roleURI="http://onemednet.com/role/BalanceSheets" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#BalanceSheetsParenthetical" roleURI="http://onemednet.com/role/BalanceSheetsParenthetical" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#StatementsOfOperations" roleURI="http://onemednet.com/role/StatementsOfOperations" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#StatementsOfChangesInStockholdersDeficit" roleURI="http://onemednet.com/role/StatementsOfChangesInStockholdersDeficit" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#StatementsOfCashFlows" roleURI="http://onemednet.com/role/StatementsOfCashFlows" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#DescriptionOfBusiness" roleURI="http://onemednet.com/role/DescriptionOfBusiness" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#SummaryOfSignificantAccountingPolicies" roleURI="http://onemednet.com/role/SummaryOfSignificantAccountingPolicies" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#SegmentInformation" roleURI="http://onemednet.com/role/SegmentInformation" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#CryptoAssetsHeld" roleURI="http://onemednet.com/role/CryptoAssetsHeld" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#AccountsPayableAndAccruedExpenses" roleURI="http://onemednet.com/role/AccountsPayableAndAccruedExpenses" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#Debt" roleURI="http://onemednet.com/role/Debt" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#StockholdersDeficit" roleURI="http://onemednet.com/role/StockholdersDeficit" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#NetLossIncomePerShare" roleURI="http://onemednet.com/role/NetLossIncomePerShare" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#Stock-basedCompensation" roleURI="http://onemednet.com/role/Stock-basedCompensation" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#StockWarrants" roleURI="http://onemednet.com/role/StockWarrants" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#FairValueMeasurements" roleURI="http://onemednet.com/role/FairValueMeasurements" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#RelatedPartyTransactions" roleURI="http://onemednet.com/role/RelatedPartyTransactions" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#CommitmentsAndContingencies" roleURI="http://onemednet.com/role/CommitmentsAndContingencies" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#SubsequentEvents" roleURI="http://onemednet.com/role/SubsequentEvents" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#SummaryOfSignificantAccountingPoliciesPolicies" roleURI="http://onemednet.com/role/SummaryOfSignificantAccountingPoliciesPolicies" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#SegmentInformationTables" roleURI="http://onemednet.com/role/SegmentInformationTables" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#CryptoAssetsHeldTables" roleURI="http://onemednet.com/role/CryptoAssetsHeldTables" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#AccountsPayableAndAccruedExpensesTables" roleURI="http://onemednet.com/role/AccountsPayableAndAccruedExpensesTables" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#DebtTables" roleURI="http://onemednet.com/role/DebtTables" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#NetLossIncomePerShareTables" roleURI="http://onemednet.com/role/NetLossIncomePerShareTables" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#Stock-basedCompensationTables" roleURI="http://onemednet.com/role/Stock-basedCompensationTables" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#StockWarrantsTables" roleURI="http://onemednet.com/role/StockWarrantsTables" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#FairValueMeasurementsTables" roleURI="http://onemednet.com/role/FairValueMeasurementsTables" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#DescriptionOfBusinessDetailsNarrative" roleURI="http://onemednet.com/role/DescriptionOfBusinessDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#ScheduleOfRevenueByGeographicRegionDetails" roleURI="http://onemednet.com/role/ScheduleOfRevenueByGeographicRegionDetails" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#ScheduleOfCryptoAssetsHeldDetails" roleURI="http://onemednet.com/role/ScheduleOfCryptoAssetsHeldDetails" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#ScheduleOfCryptoAssetsReconciliationOfFairValuesDetails" roleURI="http://onemednet.com/role/ScheduleOfCryptoAssetsReconciliationOfFairValuesDetails" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#CryptoAssetsHeldDetailsNarrative" roleURI="http://onemednet.com/role/CryptoAssetsHeldDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#ScheduleOfAccountsPayableAndAccruedExpensesDetails" roleURI="http://onemednet.com/role/ScheduleOfAccountsPayableAndAccruedExpensesDetails" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#AccountsPayableAndAccruedExpensesDetailsNarrative" roleURI="http://onemednet.com/role/AccountsPayableAndAccruedExpensesDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#ScheduleOfOutstandingDebtDetails" roleURI="http://onemednet.com/role/ScheduleOfOutstandingDebtDetails" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#StockholdersDeficitDetailsNarrative" roleURI="http://onemednet.com/role/StockholdersDeficitDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#ScheduleOfBasicAndDilutedNetIncomeLossPerShareDetails" roleURI="http://onemednet.com/role/ScheduleOfBasicAndDilutedNetIncomeLossPerShareDetails" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#ScheduleOfAntidilutiveEarningsPerShareDetails" roleURI="http://onemednet.com/role/ScheduleOfAntidilutiveEarningsPerShareDetails" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#ScheduleOfStock-basedCompensationDetails" roleURI="http://onemednet.com/role/ScheduleOfStock-basedCompensationDetails" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#ScheduleOfWarrantsOutstandingDetails" roleURI="http://onemednet.com/role/ScheduleOfWarrantsOutstandingDetails" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#StockWarrantsDetailsNarrative" roleURI="http://onemednet.com/role/StockWarrantsDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#ScheduleOfAssetsAndLiabilitiesMeasuredAtFairValueDetails" roleURI="http://onemednet.com/role/ScheduleOfAssetsAndLiabilitiesMeasuredAtFairValueDetails" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#ScheduleOfWarrantsAndNotesMeasuredAtFairValueDetails" roleURI="http://onemednet.com/role/ScheduleOfWarrantsAndNotesMeasuredAtFairValueDetails" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#ScheduleOfFairValueAssumptionsAndValuationDetails" roleURI="http://onemednet.com/role/ScheduleOfFairValueAssumptionsAndValuationDetails" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#FairValueMeasurementsDetailsNarrative" roleURI="http://onemednet.com/role/FairValueMeasurementsDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#RelatedPartyTransactionsDetailsNarrative" roleURI="http://onemednet.com/role/RelatedPartyTransactionsDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#CommitmentsAndContingenciesDetailsNarrative" roleURI="http://onemednet.com/role/CommitmentsAndContingenciesDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="onmd-20260630.xsd#SubsequentEventsDetailsNarrative" roleURI="http://onemednet.com/role/SubsequentEventsDetailsNarrative" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/Cover" xlink:title="00000001 - Document - Cover" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/BalanceSheets" xlink:title="00000002 - Statement - Condensed Consolidated Balance Sheets (Unaudited)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaapAssetsCurrent" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaapCashAndCashEquivalentsAtCarryingValue" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapCashAndCashEquivalentsAtCarryingValue" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CryptoAssetFairValue" xlink:label="loc_us-gaapCryptoAssetFairValue" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapCryptoAssetFairValue" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaapAccountsReceivableNetCurrent" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapAccountsReceivableNetCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaapPrepaidExpenseAndOtherAssetsCurrent" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssetsCurrent" xlink:to="loc_us-gaapPrepaidExpenseAndOtherAssetsCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets" xlink:label="loc_us-gaapAssets" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapAssetsCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaapPropertyPlantAndEquipmentNet" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAssets" xlink:to="loc_us-gaapPropertyPlantAndEquipmentNet" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaapLiabilitiesCurrent" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredRevenueCurrent" xlink:label="loc_us-gaapDeferredRevenueCurrent" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapDeferredRevenueCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LoansPayableCurrent" xlink:label="loc_us-gaapLoansPayableCurrent" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_us-gaapLoansPayableCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="onmd-20260630.xsd#ONMD_SEPAPutOptionLiabilityCurrent" xlink:label="loc_ONMDSEPAPutOptionLiabilityCurrent" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesCurrent" xlink:to="loc_ONMDSEPAPutOptionLiabilityCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaapLiabilities" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_us-gaapLiabilitiesCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermLoansPayable" xlink:label="loc_us-gaapLongTermLoansPayable" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_us-gaapLongTermLoansPayable" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="onmd-20260630.xsd#ONMD_WarrantLiabilityNonCurrent" xlink:label="loc_ONMDWarrantLiabilityNonCurrent" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilities" xlink:to="loc_ONMDWarrantLiabilityNonCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaapStockholdersEquity" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaapPreferredStockValue" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapPreferredStockValue" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaapCommonStockValue" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapCommonStockValue" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaapAdditionalPaidInCapital" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapAdditionalPaidInCapital" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockCommonValue" xlink:label="loc_us-gaapTreasuryStockCommonValue" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapTreasuryStockCommonValue" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaapRetainedEarningsAccumulatedDeficit" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapStockholdersEquity" xlink:to="loc_us-gaapRetainedEarningsAccumulatedDeficit" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaapLiabilitiesAndStockholdersEquity" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquity" xlink:to="loc_us-gaapLiabilities" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="loc_us-gaapCommitmentsAndContingencies" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquity" xlink:to="loc_us-gaapCommitmentsAndContingencies" xlink:type="arc" weight="1" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapLiabilitiesAndStockholdersEquity" xlink:to="loc_us-gaapStockholdersEquity" xlink:type="arc" weight="1" />
    </link:calculationLink>
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/BalanceSheetsParenthetical" xlink:title="00000003 - Statement - Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/StatementsOfOperations" xlink:title="00000004 - Statement - Condensed Consolidated Statements of Operations (Unaudited)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit" xlink:label="loc_us-gaapGrossProfit" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaapRevenueFromContractWithCustomerExcludingAssessedTax" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapGrossProfit" xlink:to="loc_us-gaapRevenueFromContractWithCustomerExcludingAssessedTax" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfRevenue" xlink:label="loc_us-gaapCostOfRevenue" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapGrossProfit" xlink:to="loc_us-gaapCostOfRevenue" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaapOperatingExpenses" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GeneralAndAdministrativeExpense" xlink:label="loc_us-gaapGeneralAndAdministrativeExpense" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingExpenses" xlink:to="loc_us-gaapGeneralAndAdministrativeExpense" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingAndMarketingExpense" xlink:label="loc_us-gaapSellingAndMarketingExpense" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingExpenses" xlink:to="loc_us-gaapSellingAndMarketingExpense" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaapResearchAndDevelopmentExpense" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingExpenses" xlink:to="loc_us-gaapResearchAndDevelopmentExpense" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaapOperatingIncomeLoss" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingIncomeLoss" xlink:to="loc_us-gaapGrossProfit" xlink:type="arc" weight="1" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapOperatingIncomeLoss" xlink:to="loc_us-gaapOperatingExpenses" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaapNonoperatingIncomeExpense" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseNonoperating" xlink:label="loc_us-gaapInterestExpenseNonoperating" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_us-gaapInterestExpenseNonoperating" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAdjustmentOfWarrants" xlink:label="loc_us-gaapFairValueAdjustmentOfWarrants" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_us-gaapFairValueAdjustmentOfWarrants" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="onmd-20260630.xsd#ONMD_FairValueAdjustmentOfConvertiblePromissoryNotes" xlink:label="loc_ONMDFairValueAdjustmentOfConvertiblePromissoryNotes" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_ONMDFairValueAdjustmentOfConvertiblePromissoryNotes" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CryptoAssetRealizedAndUnrealizedGainLossNonoperating" xlink:label="loc_us-gaapCryptoAssetRealizedAndUnrealizedGainLossNonoperating" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_us-gaapCryptoAssetRealizedAndUnrealizedGainLossNonoperating" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainsLossesOnSalesOfAssets" xlink:label="loc_us-gaapGainsLossesOnSalesOfAssets" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_us-gaapGainsLossesOnSalesOfAssets" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeGainLossOnDerivativeNet" xlink:label="loc_us-gaapDerivativeGainLossOnDerivativeNet" />
      <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_us-gaapDerivativeGainLossOnDerivativeNet" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TroubledDebtRestructuringDebtorCurrentPeriodGainLossOnRestructuringNetOfTax" xlink:label="loc_us-gaapTroubledDebtRestructuringDebtorCurrentPeriodGainLossOnRestructuringNetOfTax" />
      <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_us-gaapTroubledDebtRestructuringDebtorCurrentPeriodGainLossOnRestructuringNetOfTax" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaapOtherNonoperatingIncomeExpense" />
      <link:calculationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNonoperatingIncomeExpense" xlink:to="loc_us-gaapOtherNonoperatingIncomeExpense" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaapNetIncomeLoss" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetIncomeLoss" xlink:to="loc_us-gaapOperatingIncomeLoss" xlink:type="arc" weight="1" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetIncomeLoss" xlink:to="loc_us-gaapNonoperatingIncomeExpense" xlink:type="arc" weight="1" />
    </link:calculationLink>
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/StatementsOfChangesInStockholdersDeficit" xlink:title="00000005 - Statement - Condensed Consolidated Statements of Changes in Stockholders&apos; Deficit (Unaudited)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/StatementsOfCashFlows" xlink:title="00000006 - Statement - Condensed Consolidated Statements of Cash Flows (Unaudited)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaapNetIncomeLoss" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapNetIncomeLoss" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationAndAmortization" xlink:label="loc_us-gaapDepreciationAndAmortization" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapDepreciationAndAmortization" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaapShareBasedCompensation" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapShareBasedCompensation" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAdjustmentOfWarrants" xlink:label="loc_us-gaapFairValueAdjustmentOfWarrants" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapFairValueAdjustmentOfWarrants" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="onmd-20260630.xsd#ONMD_FairValueAdjustmentOfConvertiblePromissoryNotes" xlink:label="loc_ONMDFairValueAdjustmentOfConvertiblePromissoryNotes" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_ONMDFairValueAdjustmentOfConvertiblePromissoryNotes" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CryptoAssetRealizedAndUnrealizedGainLossNonoperating" xlink:label="loc_us-gaapCryptoAssetRealizedAndUnrealizedGainLossNonoperating" />
      <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapCryptoAssetRealizedAndUnrealizedGainLossNonoperating" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeGainLossOnDerivativeNet" xlink:label="loc_us-gaapDerivativeGainLossOnDerivativeNet" />
      <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapDerivativeGainLossOnDerivativeNet" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainsLossesOnSalesOfAssets" xlink:label="loc_us-gaapGainsLossesOnSalesOfAssets" />
      <link:calculationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapGainsLossesOnSalesOfAssets" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TroubledDebtRestructuringDebtorCurrentPeriodGainLossOnRestructuringNetOfTax" xlink:label="loc_us-gaapTroubledDebtRestructuringDebtorCurrentPeriodGainLossOnRestructuringNetOfTax" />
      <link:calculationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapTroubledDebtRestructuringDebtorCurrentPeriodGainLossOnRestructuringNetOfTax" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="onmd-20260630.xsd#ONMD_NoncashInterest" xlink:label="loc_ONMDNoncashInterest" />
      <link:calculationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_ONMDNoncashInterest" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_us-gaapIncreaseDecreaseInAccountsReceivable" />
      <link:calculationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInAccountsReceivable" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="loc_us-gaapIncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" />
      <link:calculationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaapIncreaseDecreaseInAccountsPayableAndAccruedLiabilities" />
      <link:calculationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue" xlink:label="loc_us-gaapIncreaseDecreaseInDeferredRevenue" />
      <link:calculationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:to="loc_us-gaapIncreaseDecreaseInDeferredRevenue" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:label="loc_us-gaapPaymentsToAcquirePropertyPlantAndEquipment" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:to="loc_us-gaapPaymentsToAcquirePropertyPlantAndEquipment" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentForAcquisitionCryptoAsset" xlink:label="loc_us-gaapPaymentForAcquisitionCryptoAsset" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:to="loc_us-gaapPaymentForAcquisitionCryptoAsset" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromDisposalCryptoAsset" xlink:label="loc_us-gaapProceedsFromDisposalCryptoAsset" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:to="loc_us-gaapProceedsFromDisposalCryptoAsset" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromRelatedPartyDebt" xlink:label="loc_us-gaapProceedsFromRelatedPartyDebt" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapProceedsFromRelatedPartyDebt" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="onmd-20260630.xsd#ONMD_ProceedsFromSubscriptionAgreements" xlink:label="loc_ONMDProceedsFromSubscriptionAgreements" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_ONMDProceedsFromSubscriptionAgreements" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromWarrantExercises" xlink:label="loc_us-gaapProceedsFromWarrantExercises" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapProceedsFromWarrantExercises" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfPrivatePlacement" xlink:label="loc_us-gaapProceedsFromIssuanceOfPrivatePlacement" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapProceedsFromIssuanceOfPrivatePlacement" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfRelatedPartyDebt" xlink:label="loc_us-gaapRepaymentsOfRelatedPartyDebt" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapRepaymentsOfRelatedPartyDebt" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="onmd-20260630.xsd#ONMD_RepaymentOfDeferredUnderwriterFeesPayable" xlink:label="loc_ONMDRepaymentOfDeferredUnderwriterFeesPayable" />
      <link:calculationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_ONMDRepaymentOfDeferredUnderwriterFeesPayable" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfNotesPayable" xlink:label="loc_us-gaapRepaymentsOfNotesPayable" />
      <link:calculationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:to="loc_us-gaapRepaymentsOfNotesPayable" xlink:type="arc" weight="-1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:label="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="loc_us-gaapNetCashProvidedByUsedInOperatingActivities" xlink:type="arc" weight="1" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="loc_us-gaapNetCashProvidedByUsedInInvestingActivities" xlink:type="arc" weight="1" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="loc_us-gaapNetCashProvidedByUsedInFinancingActivities" xlink:type="arc" weight="1" />
    </link:calculationLink>
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/DescriptionOfBusiness" xlink:title="999012 - Disclosure - Description of Business" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/SummaryOfSignificantAccountingPolicies" xlink:title="999013 - Disclosure - Summary of Significant Accounting Policies" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/SegmentInformation" xlink:title="999014 - Disclosure - Segment Information" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/CryptoAssetsHeld" xlink:title="999015 - Disclosure - Crypto Assets Held" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/AccountsPayableAndAccruedExpenses" xlink:title="999016 - Disclosure - Accounts Payable and Accrued Expenses" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/Debt" xlink:title="999017 - Disclosure - Debt" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/StockholdersDeficit" xlink:title="999018 - Disclosure - Stockholders&#8217; Deficit" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/NetLossIncomePerShare" xlink:title="999019 - Disclosure - Net (Loss) Income per Share" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/Stock-basedCompensation" xlink:title="999020 - Disclosure - Stock-Based Compensation" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/StockWarrants" xlink:title="999021 - Disclosure - Stock Warrants" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/FairValueMeasurements" xlink:title="999022 - Disclosure - Fair Value Measurements" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/RelatedPartyTransactions" xlink:title="999023 - Disclosure - Related Party Transactions" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/CommitmentsAndContingencies" xlink:title="999024 - Disclosure - Commitments and Contingencies" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/SubsequentEvents" xlink:title="999025 - Disclosure - Subsequent Events" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/SummaryOfSignificantAccountingPoliciesPolicies" xlink:title="999026 - Disclosure - Summary of Significant Accounting Policies (Policies)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/SegmentInformationTables" xlink:title="999027 - Disclosure - Segment Information (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/CryptoAssetsHeldTables" xlink:title="999028 - Disclosure - Crypto Assets Held (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/AccountsPayableAndAccruedExpensesTables" xlink:title="999029 - Disclosure - Accounts Payable and Accrued Expenses (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/DebtTables" xlink:title="999030 - Disclosure - Debt (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/NetLossIncomePerShareTables" xlink:title="999031 - Disclosure - Net (Loss) Income per Share (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/Stock-basedCompensationTables" xlink:title="999032 - Disclosure - Stock-Based Compensation (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/StockWarrantsTables" xlink:title="999033 - Disclosure - Stock Warrants (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/FairValueMeasurementsTables" xlink:title="999034 - Disclosure - Fair Value Measurements (Tables)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/DescriptionOfBusinessDetailsNarrative" xlink:title="999035 - Disclosure - Description of Business (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/ScheduleOfRevenueByGeographicRegionDetails" xlink:title="999036 - Disclosure - Schedule of Revenue by Geographic Region (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/ScheduleOfCryptoAssetsHeldDetails" xlink:title="999037 - Disclosure - Schedule of Crypto Assets Held (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/ScheduleOfCryptoAssetsReconciliationOfFairValuesDetails" xlink:title="999038 - Disclosure - Schedule of Crypto Assets Reconciliation of Fair Values (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/CryptoAssetsHeldDetailsNarrative" xlink:title="999039 - Disclosure - Crypto Assets Held (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/ScheduleOfAccountsPayableAndAccruedExpensesDetails" xlink:title="999040 - Disclosure - Schedule of Accounts Payable and Accrued Expenses (Details)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedProfessionalFeesCurrent" xlink:label="loc_us-gaapAccruedProfessionalFeesCurrent" />
      <link:calculationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent" xlink:to="loc_us-gaapAccruedProfessionalFeesCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="onmd-20260630.xsd#ONMD_AccruedSoftwareAndTechnologyCurrent" xlink:label="loc_ONMDAccruedSoftwareAndTechnologyCurrent" />
      <link:calculationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent" xlink:to="loc_ONMDAccruedSoftwareAndTechnologyCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedSalariesCurrent" xlink:label="loc_us-gaapAccruedSalariesCurrent" />
      <link:calculationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent" xlink:to="loc_us-gaapAccruedSalariesCurrent" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="onmd-20260630.xsd#ONMD_AccruedDataProviderCosts" xlink:label="loc_ONMDAccruedDataProviderCosts" />
      <link:calculationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent" xlink:to="loc_ONMDAccruedDataProviderCosts" xlink:type="arc" weight="1" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaapOtherAccountsPayableAndAccruedLiabilities" />
      <link:calculationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaapAccountsPayableAndAccruedLiabilitiesCurrent" xlink:to="loc_us-gaapOtherAccountsPayableAndAccruedLiabilities" xlink:type="arc" weight="1" />
    </link:calculationLink>
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/AccountsPayableAndAccruedExpensesDetailsNarrative" xlink:title="999041 - Disclosure - Accounts Payable and Accrued Expenses (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/ScheduleOfOutstandingDebtDetails" xlink:title="999042 - Disclosure - Schedule of Outstanding Debt (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/StockholdersDeficitDetailsNarrative" xlink:title="999043 - Disclosure - Stockholders&#8217; Deficit (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/ScheduleOfBasicAndDilutedNetIncomeLossPerShareDetails" xlink:title="999044 - Disclosure - Schedule of Basic and Diluted Net Income (Loss) per Share (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/ScheduleOfAntidilutiveEarningsPerShareDetails" xlink:title="999045 - Disclosure - Schedule of Antidilutive Earnings Per Share (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/ScheduleOfStock-basedCompensationDetails" xlink:title="999046 - Disclosure - Schedule of Stock-Based Compensation (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/ScheduleOfWarrantsOutstandingDetails" xlink:title="999047 - Disclosure - Schedule of Warrants Outstanding (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/StockWarrantsDetailsNarrative" xlink:title="999048 - Disclosure - Stock Warrants (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/ScheduleOfAssetsAndLiabilitiesMeasuredAtFairValueDetails" xlink:title="999049 - Disclosure - Schedule of Assets and Liabilities Measured at Fair Value (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/ScheduleOfWarrantsAndNotesMeasuredAtFairValueDetails" xlink:title="999050 - Disclosure - Schedule of Warrants and Notes Measured at Fair Value (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/ScheduleOfFairValueAssumptionsAndValuationDetails" xlink:title="999051 - Disclosure - Schedule of Fair Value Assumptions and Valuation (Details)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/FairValueMeasurementsDetailsNarrative" xlink:title="999052 - Disclosure - Fair Value Measurements (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/RelatedPartyTransactionsDetailsNarrative" xlink:title="999053 - Disclosure - Related Party Transactions (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/CommitmentsAndContingenciesDetailsNarrative" xlink:title="999054 - Disclosure - Commitments and Contingencies (Details Narrative)" />
    <link:calculationLink xlink:type="extended" xlink:role="http://onemednet.com/role/SubsequentEventsDetailsNarrative" xlink:title="999055 - Disclosure - Subsequent Events (Details Narrative)" />
</link:linkbase>
