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  <xs:element id="bfrg_ExercisePriceFiveMember" abstract="false" name="ExercisePriceFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_MaterialAgreementsTable" abstract="true" name="MaterialAgreementsTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="bfrg_JHUAPLTechnologyLicenseAgreementMember" abstract="false" name="JHUAPLTechnologyLicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_NewLicenseAgreementMember" abstract="false" name="NewLicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_GeorgeWashingtonUniversityBeta2SpectrinSiRNALicenseMember" abstract="false" name="GeorgeWashingtonUniversityBeta2SpectrinSiRNALicenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_JohnsHopkinsUniversityMebendazoleLicenseMember" abstract="false" name="JohnsHopkinsUniversityMebendazoleLicenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_JohnsHopkinsUniversityProdrugLicenseMember" abstract="false" name="JohnsHopkinsUniversityProdrugLicenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_LieberInstituteForBrainDevelopmentPartnershipMember" abstract="true" name="LieberInstituteForBrainDevelopmentPartnershipMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_FeasibilityAgreementMember" abstract="true" name="FeasibilityAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_OtherPartiesMember" abstract="false" name="OtherPartiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_InternallyDevelopmentDrugProjectsMember" abstract="false" name="InternallyDevelopmentDrugProjectsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_TwoThousandTwentyTwoYearMember" abstract="false" name="TwoThousandTwentyTwoYearMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_TwoThousandTwentyThreeYearMember" abstract="false" name="TwoThousandTwentyThreeYearMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_TwoThousandTwentyFourYearAndBeyondMember" abstract="false" name="TwoThousandTwentyFourYearAndBeyondMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_JulyTwoThousandTwentyThreeMember" abstract="false" name="JulyTwoThousandTwentyThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_TwoThousandTwentyFiveYearMember" abstract="false" name="TwoThousandTwentyFiveYearMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_TwoThousandTwentySixYearMember" abstract="false" name="TwoThousandTwentySixYearMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_TwoThousandTwentySevenYearMember" abstract="false" name="TwoThousandTwentySevenYearMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_JuneTwoThousandTwentySixMember" abstract="false" name="JuneTwoThousandTwentySixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_TwoThousandTwentyFourYearMember" abstract="false" name="TwoThousandTwentyFourYearMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_TwoThousandTwentyEightYearMember" abstract="false" name="TwoThousandTwentyEightYearMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_TwoThousandTwentyNineYearMember" abstract="false" name="TwoThousandTwentyNineYearMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_TwoThousandThirtyYearMember" abstract="false" name="TwoThousandThirtyYearMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_FromTwoThousandAndTwentyThreeThroughTwoThousandAndTwentySevenMember" abstract="false" name="FromTwoThousandAndTwentyThreeThroughTwoThousandAndTwentySevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="bfrg_MaterialAgreementsLineItems" abstract="true" name="MaterialAgreementsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="bfrg_LicensingArrangementNumberOfPatentsIssued" abstract="false" name="LicensingArrangementNumberOfPatentsIssued" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="bfrg_LicensingArrangementNumberOfPatentApplications" abstract="false" name="LicensingArrangementNumberOfPatentApplications" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="bfrg_WarrantIssuancePercentage" abstract="false" name="WarrantIssuancePercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="bfrg_PercentageOfRoyaltyOnNetSales" abstract="false" name="PercentageOfRoyaltyOnNetSales" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="bfrg_SublicensePercentage" abstract="false" name="SublicensePercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="bfrg_IncreaseDecreaseInSublicensePercentage" abstract="false" name="IncreaseDecreaseInSublicensePercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="bfrg_LicensingArrangementCurePeriodForMaterialBreach" abstract="false" name="LicensingArrangementCurePeriodForMaterialBreach" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="bfrg_LicensePayments" abstract="false" name="LicensePayments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="bfrg_AccruedannualLicenseFee" abstract="false" name="AccruedannualLicenseFee" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="bfrg_AnnualLicenseFee" abstract="false" name="AnnualLicenseFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="bfrg_LicenseInitiationFee" abstract="false" name="LicenseInitiationFee" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="bfrg_AccruedPortionOfAnnualLicenseFees" abstract="false" name="AccruedPortionOfAnnualLicenseFees" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="bfrg_AnnualLicenseMaintenanceFees" abstract="false" name="AnnualLicenseMaintenanceFees" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="bfrg_ClinicalTrialNumberOfPatientsEnrolled" abstract="false" name="ClinicalTrialNumberOfPatientsEnrolled" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="bfrg_ClinicalTrialNumberOfPatientsExperiencingAdverseEffects" abstract="false" name="ClinicalTrialNumberOfPatientsExperiencingAdverseEffects" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="bfrg_ClinicalTrialNumberOfPatientsReceivingMaximumDose" abstract="false" name="ClinicalTrialNumberOfPatientsReceivingMaximumDose" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="bfrg_ClinicalTrialTwoYearOverallSurvivalRatePercentage" abstract="false" name="ClinicalTrialTwoYearOverallSurvivalRatePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="bfrg_ClinicalTrialMeasurementPeriod" abstract="false" name="ClinicalTrialMeasurementPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="bfrg_ClinicalTrialFourYearOverallSurvivalRatePercentage" abstract="false" name="ClinicalTrialFourYearOverallSurvivalRatePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="bfrg_UpfrontLicenseFee" abstract="false" name="UpfrontLicenseFee" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="bfrg_LicenseFeePaymentMadeAfterIPO" abstract="false" name="LicenseFeePaymentMadeAfterIPO" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="bfrg_CollaborativeArrangementTerm" abstract="false" name="CollaborativeArrangementTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="bfrg_CollaborativeArrangementResearchAndDevelopmentPeriod" abstract="false" name="CollaborativeArrangementResearchAndDevelopmentPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
</xs:schema>
