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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTax_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Income from discontinued operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Lease, Right-of-Use Asset, Periodic Reduction</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-cash lease expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Weighted Average Number of Shares Outstanding, Diluted, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted Average Number of Shares Outstanding, Diluted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Diluted shares used in calculation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_OtherSignificantAccountingPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other Significant Accounting Policies</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_OtherSignificantAccountingPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Significant Accounting Policy [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_OtherSignificantAccountingPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other significant accounting policy.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">APIC, Share-Based Payment Arrangement, Increase for Cost Recognition, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock-based compensation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">APIC, Share-Based Payment Arrangement, Increase for Cost Recognition</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_MinimumMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Minimum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_MinimumMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Minimum [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock issued upon vesting of restricted stock units (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PrivatePlacementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Private Placement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PrivatePlacementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Private Placement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LetterOfCreditMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Letter of Credit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LetterOfCreditMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Letter of Credit [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Preferred Stock, Shares Outstanding, Ending Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Preferred Stock, Shares Outstanding, Beginning Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Preferred stock, shares outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock, Shares Outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DeferredPaymentsIncreasePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred payments increase percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DeferredPaymentsIncreasePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Payments Increase Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DeferredPaymentsIncreasePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Deferred payments increase percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementInputsDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Measurement and Measurement Inputs, Recurring and Nonrecurring [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementInputsDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Fair Value of Common Warrants Prior to and Immediately After Exercise Price Adjustment, were Estimated Using Black-Scholes Option-Pricing Model Assumptions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementInputsDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Summary of Assumptions Used to Estimate the Fair Value of the Warrants Using The Black-scholes Option Pricing Model</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">2023 Common Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">2023 Common Warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2023 Common Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CreditAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Credit Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CreditAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Credit Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CreditAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Credit agreement member.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock, shares issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock, Shares, Issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Common stock issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SegmentReportingInformationLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Segment Reporting [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SegmentReportingInformationLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Segment Reporting Information [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_BroadridgeCorporateIssuerSolutionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Broadridge Corporate Issuer Solutions</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_BroadridgeCorporateIssuerSolutionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Broadridge Corporate Issuer Solutions [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_BroadridgeCorporateIssuerSolutionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Broadridge Corporate Issuer Solutions.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercisedWeightedAverageRemainingContractualTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted-Average Remaining Term, Exercised</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercisedWeightedAverageRemainingContractualTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Exercised Weighted Average Remaining Contractual Term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercisedWeightedAverageRemainingContractualTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class of warrant or right exercised weighted average remaining contractual term.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_RepurchaseAgreementCounterpartyNameDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Counterparty Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_RepurchaseAgreementCounterpartyNameDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Counterparty Name [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandTwentyFiveCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Two Thousand Twenty Five Common Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandTwentyFiveCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Two thousand twenty five common warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandTwentyFiveCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2025 Common Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DisposalGroupIncludingDiscontinuedOperationsDeferredRevenue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred payment from Medexus</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DisposalGroupIncludingDiscontinuedOperationsDeferredRevenue_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Deferred payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DisposalGroupIncludingDiscontinuedOperationsDeferredRevenue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disposal Group Including Discontinued Operations Deferred Revenue</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DisposalGroupIncludingDiscontinuedOperationsDeferredRevenue_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disposal group including discontinued operations deferred revenue.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RepaymentsOfDebt_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Repayment of debt</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RepaymentsOfDebt_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Repayments of Debt</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GovernmentAssistanceLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Government Assistance [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RelatedPartyTransactionLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Related Party Transaction [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RestrictedStockUnitsRSUMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Unvested RSUs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RestrictedStockUnitsRSUMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Restricted Stock Units (RSUs) [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RestrictedStockUnitsRSUMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Restricted Stock Units</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercisableWeightedAverageRemainingContractualTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted-Average Remaining Term, Exercisable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercisableWeightedAverageRemainingContractualTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Exercisable Weighted Average Remaining Contractual Term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercisableWeightedAverageRemainingContractualTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class of warrant or right exercisable weighted average remaining contractual term.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of Shares, Issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class of warrant or right issued.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ReverseStockSplitAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Reverse stock split.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ReverseStockSplitAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Reverse Stock Split [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of common stock to be issued up conversion of warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class of Warrant or Right, Number of Securities Called by Warrants or Rights</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Warrants to purchase common stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageGrantDateFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Share based compensation arrangement by share based payment award equity instruments other than options, expected to vest, weighted average grant date fair value.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageGrantDateFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Expected To Vest Weighted Average Grant Date Fair Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageGrantDateFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Weighted Average Fair Value per Unit, Expected to Vest</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageGrantDateFairValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted average fair value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GovernmentAssistanceTypeDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Government Assistance, Type [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Maximum borrowing capacity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Line of Credit Facility, Maximum Borrowing Capacity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventTypeDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsequent Event Type [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseLiabilityNoncurrentStatementOfFinancialPositionExtensibleList_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ResearchAndDevelopmentCostPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of cost related to research and development</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ResearchAndDevelopmentCostPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research And Development Cost Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ResearchAndDevelopmentCostPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Research and development cost percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RestrictedCashCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Current restricted cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RestrictedCashCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Restricted cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RestrictedCashCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Restricted Cash, Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WarrantDownRoundFeatureDecreaseInNetIncomeLossToCommonShareholderAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Dividend attributable to down round feature of warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WarrantDownRoundFeatureDecreaseInNetIncomeLossToCommonShareholderAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrant, Down Round Feature, Decrease in Net Income to Common Shareholder, Amount</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AssumptionsOfFairValueOfWarrantsTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Assumptions of fair value of warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Debt Instrument [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule of Long-Term Debt Instruments [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GeneralAndAdministrativeExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">General and Administrative Expense, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GeneralAndAdministrativeExpense_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">General and administrative</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GeneralAndAdministrativeExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">General and Administrative Expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncomeStatementAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Income Statement [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfGrossSalesPriceSharesSold_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of Gross Sales Price Shares Sold</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfGrossSalesPriceSharesSold_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of gross sales price shares sold.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfGrossSalesPriceSharesSold_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of gross sales price shares sold</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TransactionCostsForMilestonesRelatedToSaleOfRoyalties_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Transaction costs for milestones related to sale of royalties</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TransactionCostsForMilestonesRelatedToSaleOfRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Transaction costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TransactionCostsForMilestonesRelatedToSaleOfRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Transaction Costs For Milestones Related To Sale Of Royalties</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TransactionCostsForMilestonesRelatedToSaleOfRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Transaction costs for milestones related to sale of royalties.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExpiredWeightedAverageRemainingContractualTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted-Average Remaining Term, Expired</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExpiredWeightedAverageRemainingContractualTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class of warrant or right expired weighted average remaining contractual term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExpiredWeightedAverageRemainingContractualTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class of warrant or right expired weighted average remaining contractual term.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_StockPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stock Purchase Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_StockPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Stock Purchase Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareholdersEquityAndShareBasedPaymentsTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareholdersEquityAndShareBasedPaymentsTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Shareholders' Equity and Share-Based Payments [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CashEquivalentsMaturityPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash equivalents, maturity period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CashEquivalentsMaturityPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash Equivalents Maturity Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CashEquivalentsMaturityPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Cash equivalents maturity period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DividendDeclaredOfPreferredSharePurchaseRight_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Preferred share purchase right</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DividendDeclaredOfPreferredSharePurchaseRight_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Dividend Declared Of Preferred Share Purchase Right</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DividendDeclaredOfPreferredSharePurchaseRight_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Dividend declared of preferred share purchase right.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LeaseCostTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Components of Lease Expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LeaseCostTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lease, Cost [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AdditionalAmountToBeReceivedUponExerciseOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additional amount to be received upon exercise of warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AdditionalAmountToBeReceivedUponExerciseOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additional Amount To Be Received Upon Exercise Of Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AdditionalAmountToBeReceivedUponExerciseOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Additional amount to be received upon exercise of warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_GovernmentGrantReimbursements_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Government Grant Reimbursements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_GovernmentGrantReimbursements_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Governmentgrantreimbursements.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Basic net loss per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Basic net loss per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Earnings Per Share, Basic</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentPeriodEndDate_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Document Period End Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentPeriodEndDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Period End Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock plan termination period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Debt Instrument [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Debt Instrument [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesAuthorized_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock, shares authorized</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesAuthorized_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock, Shares Authorized</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementOfStockholdersEquityAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement of Stockholders' Equity [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WarrantsAndRightsOutstandingMeasurementInput_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrants and Rights Outstanding, Measurement Input</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WarrantsAndRightsOutstandingMeasurementInput_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrants measurement input</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PrepaidExpenseAndOtherAssetsCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Prepaid Expense and Other Assets, Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PrepaidExpenseAndOtherAssetsCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Prepaid expenses and other current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PrepaidExpenseAndOtherAssetsCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total prepaid expenses and other current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AccountingStandardUpdate201705Member_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Accounting standard update 2017 05.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AccountingStandardUpdate201705Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accounting Standard Update 2017 05 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AccountingStandardUpdate201705Member_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">ASC 610-20</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfEntitlementToReceiveCanadianApprovalMilestonePayment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of entitlement to receive Canadian approval milestone payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfEntitlementToReceiveCanadianApprovalMilestonePayment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of entitlement to receive Canadian Approval Milestone Payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfEntitlementToReceiveCanadianApprovalMilestonePayment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of entitlement to receive Canadian approval milestone payment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonClassBMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Common Class B [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonClassBMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series B</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Assets_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Assets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_Security12bTitle_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Title of 12(b) Security</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_Security12bTitle_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Title of 12(b) Security</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromEquityMethodInvestmentDividendsOrDistributionsReturnOfCapital_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds from Equity Method Investment, Distribution, Return of Capital</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromEquityMethodInvestmentDividendsOrDistributionsReturnOfCapital_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds from a strategic equity investment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ReverseStockSplitTable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Reverse stock split.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ReverseStockSplitTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Reverse Stock Split [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Preferred stock: $0.001 par value; 15,000,000 shares authorized, zero shares issued or outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock, Value, Issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RelatedPartyTransactionAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Related Party Transaction</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RelatedPartyTransactionAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Related Party Transaction [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PriorPeriodReclassificationAdjustmentDescription_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Reclassification, Comparability Adjustment [Policy Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PriorPeriodReclassificationAdjustmentDescription_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Reclassification</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Stock-based Compensation Expense Includes Amortization of Stock Options and Restricted Stock Units Granted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_TitleOfIndividualWithRelationshipToEntityDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Title of Individual</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_TitleOfIndividualWithRelationshipToEntityDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Title and Position [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeasePayments_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">For operating leases</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeasePayments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Lease, Payments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfShareBasedCompensationRestrictedStockUnitsAwardActivityTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of RSU Activity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfShareBasedCompensationRestrictedStockUnitsAwardActivityTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AntidilutiveSecuritiesNameDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Antidilutive Securities, Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AntidilutiveSecuritiesNameDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Antidilutive Securities, Name [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ScheduleOfEarningsPerShareBasicAndDilutedTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Earnings Per Share Basic And Diluted [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ScheduleOfEarningsPerShareBasicAndDilutedTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Earnings Per Share Basic And Diluted [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ScheduleOfEarningsPerShareBasicAndDilutedTable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Schedule of earnings per share basic and diluted.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stockholders' Equity Note, Stock Split, Conversion Ratio</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Reverse stock split</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_VariableRateAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Variable Rate [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_VariableRateAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Variable Rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MeasurementInputOptionVolatilityMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Measurement Input, Option Volatility [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MeasurementInputOptionVolatilityMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected Volatility</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsForRoyalties_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">RUXIENCE royalties paid by Pfizer to HCR</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PaymentsForRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Payments for Royalties</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_LincolnParkMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Lincoln Park</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_LincolnParkMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lincoln Park [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_LincolnParkMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Lincoln Park Member</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInOperatingLeaseLiability_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (Decrease) in Operating Lease Liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInOperatingLeaseLiability_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating lease liability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Cash_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Cash_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LesseeOperatingLeasesTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Leases</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LesseeOperatingLeasesTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lessee, Operating Leases [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity, Attributable to Parent</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total stockholders' equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressAddressLine2_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Address, Address Line Two</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressAddressLine2_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address, Address Line Two</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ArrangementsAndNonarrangementTransactionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Collaborative Arrangement and Arrangement Other than Collaborative</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ArrangementsAndNonarrangementTransactionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Collaborative Arrangement and Arrangement Other than Collaborative [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Earnings Per Share [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net Loss per Share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_RegisteredDirectOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Registered Direct Offering</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_RegisteredDirectOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Registered Direct Offering [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_RegisteredDirectOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Registered Direct Offering.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_WarrantInducementAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrant Inducement Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_WarrantInducementAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrant Inducement Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_WarrantInducementAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Warrant inducement agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRighstDateFromWhichWarrantsOrRightsExercisable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class of Warrant or Right, Date from which Warrants or Rights Exercisable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRighstDateFromWhichWarrantsOrRightsExercisable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrants exercisable date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_BeneficialOwnershipLimitation_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Beneficial ownership limitation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_BeneficialOwnershipLimitation_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Beneficial ownership limitation.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_LiabilityRelatedToSaleOfRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Liability related to sale of royalties, beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_LiabilityRelatedToSaleOfRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Liability related to sale of royalties, ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_LiabilityRelatedToSaleOfRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liability Related To Sale Of Royalties</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_LiabilityRelatedToSaleOfRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Liability related to sale of royalties.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LongTermDebt_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Debt outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LongTermDebt_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Long-Term Debt</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LongTermDebt_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Long-Term Debt, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CreditFacilityAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Credit Facility</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CreditFacilityAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Credit Facility [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_KamadaMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Kamada [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_KamadaMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Kamada.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AndyHillCancerResearchEndowmentCAREFundMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Andy Hill Cancer Research Endowment (CARE) Fund [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AndyHillCancerResearchEndowmentCAREFundMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Andyhillcancerresearchendowment(CARE)fundmember</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AccruedClinicalResearchAndDevelopmentCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accrued clinical, research and development costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AccruedClinicalResearchAndDevelopmentCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Accrued clinical, research and development costs.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AccruedClinicalResearchAndDevelopmentCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accrued clinical, research and development costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdjustmentsToAdditionalPaidInCapitalStockSplit_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustments to Additional Paid in Capital, Stock Split</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdjustmentsToAdditionalPaidInCapitalStockSplit_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Payment in lieu of fractional shares in connection with the 1-for-44 reverse stock split effected on March 5, 2024</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdjustmentsToAdditionalPaidInCapitalStockSplit_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Payment in lieu of fractional shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WarrantsAndRightsOutstandingMaturityDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrants expiration date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WarrantsAndRightsOutstandingMaturityDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrants and Rights Outstanding, Maturity Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightIssuedWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted-Average Exercise Price, Issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightIssuedWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Issued Weighted Average Exercise Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightIssuedWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class of warrant or right issued weighted average exercise price.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PaymentOfRoyaltyPurchaseAgreementPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Payment of royalty purchase agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PaymentOfRoyaltyPurchaseAgreementPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Payment Of Royalty Purchase Agreement Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PaymentOfRoyaltyPurchaseAgreementPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Payment of Royalty Purchase Agreement, Percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ExercisePriceOf1798200Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Exercise Price of 17,982.00 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ExercisePriceOf1798200Member_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Exercise price of 17,982.00.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ExercisePriceOf1798200Member_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise Price of 17,982.00</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_RangeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Statistical Measurement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_RangeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statistical Measurement [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityInteractiveDataCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Interactive Data Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityInteractiveDataCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Interactive Data Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_FirstAndSecondSEPAMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">First and Second SEPA</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_FirstAndSecondSEPAMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">First and Second SEPA [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_FirstAndSecondSEPAMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">First and Second SEPA.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock, Value, Issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockValue_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Common stock value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock: $0.001 par value; 500,000,000 shares authorized; 1,418,952 and 997,830 shares issued and outstanding at June 30, 2026 and December 31, 2025, respectively</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Computation of Basic and Diluted Net Loss per Share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NonRule10B51ArrModifiedFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non Rule 10b51 Arr Modified [Flag]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NonRule10B51ArrModifiedFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non Rule 10b51 Arr Modified [Flag]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NonRule10B51ArrModifiedFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-Rule 10b5-1 Arrangement Modified</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Liabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Liabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfDisposalGroupsIncludingDiscontinuedOperationsIncomeStatementBalanceSheetAndAdditionalDisclosuresTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Reconciliation of Carrying Amounts of Assets and Liabilities and Income (Loss) from Discontinued Operation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfDisposalGroupsIncludingDiscontinuedOperationsIncomeStatementBalanceSheetAndAdditionalDisclosuresTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disposal Groups, Including Discontinued Operations [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Retained Earnings (Accumulated Deficit), Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Accumulated deficit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accumulated deficit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Retained Earnings (Accumulated Deficit)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfEntitlementToReceiveDeferredPayments_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of entitlement to receive deferred payments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfEntitlementToReceiveDeferredPayments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of entitlement to receive deferred payments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfEntitlementToReceiveDeferredPayments_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of entitlement to receive deferred payments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueInputsLevel3Member_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Level Three</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueInputsLevel3Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value, Inputs, Level 3 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherNonoperatingIncomeExpenseAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other income:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherNonoperatingIncomeExpenseAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Nonoperating Income (Expense) [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfCommitmentFee_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of Commitment Fee</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfCommitmentFee_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of commitment fee.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfCommitmentFee_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of commitment fee</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInAccountsPayable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accounts payable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInAccountsPayable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (Decrease) in Accounts Payable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInAccountsPayable_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Increase (Decrease) in Accounts Payable, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Share price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightIssuedWeightedAverageRemainingContractualTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted-Average Remaining Term, Issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightIssuedWeightedAverageRemainingContractualTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Issued Weighted Average Remaining Contractual Term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightIssuedWeightedAverageRemainingContractualTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class of warrant or right issued weighted average remaining contractual term.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Measurement Inputs and Valuation Techniques [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Changes in operating assets and liabilities:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsFromIssuancesOfPreFundedWarrantsShares_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Issuances of pre-funded warrants, shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsFromIssuancesOfPreFundedWarrantsShares_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Proceeds from issuances of pre-funded warrants, shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsFromIssuancesOfPreFundedWarrantsShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds From Issuances Of Pre-funded Warrants, Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock plan vesting period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharesIssuedPricePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock price per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharesIssuedPricePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Shares Issued, Price Per Share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharesIssuedPricePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Offering price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesNewIssues_lbl" xlink:role="http://www.xbrl.org/2009/role/netLabel">Issuance of common stock shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesNewIssues_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Issuance of common stock ,shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesNewIssues_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Issuance of common stock, shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesNewIssues_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Private placement share agreed to sell</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfReturningSharesFromOldPlanToBeAddedToSharesReserve_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Maximum number of returning shares from old plan to be add to shares reserve</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfReturningSharesFromOldPlanToBeAddedToSharesReserve_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Maximum Number Of Returning Shares From Old Plan To Be Added To Shares Reserve</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfReturningSharesFromOldPlanToBeAddedToSharesReserve_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Share based compensation arrangement by share based payment award maximum number of returning shares from old plan to be added to shares reserve.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueInputsQuantitativeInformationAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Measurement Inputs and Valuation Techniques [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercisableWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted-Average Exercise Price, Exercisable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercisableWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Exercisable Weighted Average Exercise Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercisableWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class of warrant or right exercisable weighted average exercise price.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Number of Shares, Outstanding, Ending Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Number of Shares, Outstanding, Beginning Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrants outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class of Warrant or Right, Outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Outstanding warrants issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PrepaidExpensesOtherCurrentAssetsAccruedExpensesAndOtherCurrentLiabilitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Prepaid Expenses, Other Current Assets, Accrued Expenses, and Other Current Liabilities [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PrepaidExpensesOtherCurrentAssetsAccruedExpensesAndOtherCurrentLiabilitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Prepaid expenses, other current assets, accrued expenses, and other current liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IPOMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Public Offering</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IPOMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">IPO [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_VariableRateDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Variable Rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_VariableRateDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Variable Rate [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RelatedPartyTransactionsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Related Party Transactions [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseCost_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating lease cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseCost_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Lease, Cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DividendAttributableToDownRoundFeatureOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Dividend Attributable To Down Round Feature Of Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DividendAttributableToDownRoundFeatureOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Dividend Attributable To Down Round Feature Of Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DividendAttributableToDownRoundFeatureOfWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Dividend attributable to down round feature of warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PropertyPlantAndEquipmentByTypeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Long-Lived Tangible Asset</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PropertyPlantAndEquipmentByTypeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Long-Lived Asset, Class [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_WarrantModificationIncrementalValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrant modification - incremental value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_WarrantModificationIncrementalValue_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Warrant modification incremental value.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_WarrantModificationIncrementalValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrant modification incremental value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventsTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsequent Events [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventsTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Subsequent Events</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueByFairValueHierarchyLevelAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair Value Hierarchy and NAV</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueByFairValueHierarchyLevelAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Hierarchy and NAV [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GovernmentAssistanceAwardAmount_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Government Assistance, Award Amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ReverseStockSplitLineItem_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Reverse stock split.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ReverseStockSplitLineItem_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Reverse Stock Split [Line Item]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DiscontinuedOperatingGainOnContingentConsideration_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Gain on contingent consideration</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DiscontinuedOperatingGainOnContingentConsideration_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Discontinued Operating Gain On Contingent Consideration</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DiscontinuedOperatingGainOnContingentConsideration_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Discontinued Operating Gain on Contingent Consideration.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseLiabilityCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Lease, Liability, Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseLiabilityCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating lease liability, current portion</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseLiabilityCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Current portion of operating lease liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_IXINITYMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">IXINITY.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_IXINITYMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">IXINITY</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_IXINITYMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">I X I N I T Y [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Income (Loss) from Continuing Operations, Net of Tax, Including Portion Attributable to Noncontrolling Interest</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LesseeOperatingLeaseExistenceOfOptionToExtend_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating lease option to extend</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LesseeOperatingLeaseExistenceOfOptionToExtend_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lessee, Operating Lease, Existence of Option to Extend [true false]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LiabilitiesAndStockholdersEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liabilities and Equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LiabilitiesAndStockholdersEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total liabilities and stockholders' equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Research and Development Expense, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Research and development</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Research and Development Expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsOfWarrantsIssuedDuringPeriodNet_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds of warrants issued during period net</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsOfWarrantsIssuedDuringPeriodNet_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds Of Warrants Issued During Period Net</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsOfWarrantsIssuedDuringPeriodNet_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Proceeds of warrants issued during period net.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesAAndSeriesBCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series A and Series B Common Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesAAndSeriesBCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Series A and Series B common warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesAAndSeriesBCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Series A and Series B common warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LesseeLeaseDescriptionTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Lessee Lease Description [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LesseeLeaseDescriptionTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lessee, Lease, Description [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentFiscalPeriodFocus_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Document Fiscal Period Focus</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentFiscalPeriodFocus_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Fiscal Period Focus</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_OfficeSpaceLeaseMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Office Space Lease</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_OfficeSpaceLeaseMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Office Space Lease [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_OfficeSpaceLeaseMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Office space lease.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesATwoCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Series a two common warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesATwoCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Series A Two Common Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesATwoCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series A-2 Common Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Assumptions used in Valuing the Stock Options Granted under Black-Scholes Valuation Model</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_BeneficialOwnershipLimitationPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Beneficial Ownership Limitation Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_BeneficialOwnershipLimitationPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Beneficial ownership limitation percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_BeneficialOwnershipLimitationPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Beneficial ownership limitation percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CommonStockSharesIssuanceApprovalThresholdPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock Shares Issuance Approval Threshold Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CommonStockSharesIssuanceApprovalThresholdPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Common stock shares issuance approval threshold percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CommonStockSharesIssuanceApprovalThresholdPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of outstanding shares approved for potential issuance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_TitleOfIndividualAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Title of Individual</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_TitleOfIndividualAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Title and Position [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandTwentyFourCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Two Thousand Twenty Four Common Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandTwentyFourCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">2024 Common Warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandTwentyFourCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2024 Common Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LineOfCreditFacilityCurrentBorrowingCapacity_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Line of credit facility, used borrowing capacity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LineOfCreditFacilityCurrentBorrowingCapacity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Line of Credit Facility, Current Borrowing Capacity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsidiarySaleOfStockAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sale of Stock [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PIPEWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">PIPE Warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PIPEWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">PIPE Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Increase (decrease) in cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCurrentReportingStatus_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Current Reporting Status</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCurrentReportingStatus_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Current Reporting Status</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_UseOfEstimates_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Use of Estimates</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_UseOfEstimates_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Use of Estimates, Policy [Policy Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfStockDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class of Stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfStockDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class of Stock [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GovernmentAssistanceTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Grant Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GovernmentAssistanceTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Government Assistance [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AccountsPayableCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accounts Payable, Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AccountsPayableCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Accounts Payable, Current, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AccountsPayableCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accounts payable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AptevoBiotherapeuticsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Aptevo BioTherapeutics</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AptevoBiotherapeuticsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Aptevo BioTherapeutics [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AptevoBiotherapeuticsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Aptevo BioTherapeutics.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Potentially Dilutive Shares Excluded from Calculation of Net Loss Per Share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsFairValueDisclosure_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Assets, Fair Value Disclosure</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsFairValueDisclosure_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Assets, Fair Value Disclosure, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsFairValueDisclosure_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_FirstStandbyEquityPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">First Standby Equity Purchase Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_FirstStandbyEquityPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">First standby equity purchase agreement member.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_FirstStandbyEquityPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">First Standby Equity Purchase Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentTransitionReport_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Transition Report</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentTransitionReport_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Transition Report</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueByLiabilityClassAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Liability Class</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueByLiabilityClassAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liability Class [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsequent Event [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class of Warrant or Right [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TypeOfAdoptionMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accounting Standards Update [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClosingPaymentsReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Closing payments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClosingPaymentsReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Closing payments received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClosingPaymentsReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Closing payments received.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LiabilitiesCurrentAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current liabilities:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LiabilitiesCurrentAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liabilities, Current [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Unrecognized compensation expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SecuritiesPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Securities Purchase Agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SecuritiesPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Securities Purchase Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disposal Group Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disposal Group Name [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common Stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accounting Standards Update [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_BeneficialOwnershipExceedingPercentageOfOutstandingCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Beneficial ownership exceeding percentage of outstanding common stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_BeneficialOwnershipExceedingPercentageOfOutstandingCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Beneficial ownership exceeding percentage of outstanding common stock.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_BeneficialOwnershipExceedingPercentageOfOutstandingCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Beneficial ownership exceeding percentage of outstanding common stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CreditFacilityDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Credit Facility</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CreditFacilityDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Credit Facility [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_RangeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Statistical Measurement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_RangeMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statistical Measurement [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Measurement Inputs and Valuation Techniques [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SecondStandbyEquityPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Second Standby Equity Purchase Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SecondStandbyEquityPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Second Standby Equity Purchase Agreement member.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SecondStandbyEquityPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Second Standby Equity Purchase Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PrepaidExpenseCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Prepaid Expense, Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PrepaidExpenseCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Prepaid Expense, Current, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PrepaidExpenseCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Prepaid clinical expenses</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquityAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity, Attributable to Parent [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquityAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stockholders' equity:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Weighted Average Number of Shares Outstanding, Basic, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted Average Number of Shares Outstanding, Basic</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Basic shares used in calculation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">ASSETS</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Assets [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCentralIndexKey_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Central Index Key</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCentralIndexKey_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Central Index Key</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsOfWarrantsIssuedDuringPeriodGross_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Proceeds of warrants issued during period gross.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsOfWarrantsIssuedDuringPeriodGross_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds Of Warrants Issued During Period Gross</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsOfWarrantsIssuedDuringPeriodGross_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Gross proceeds from the offering</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsOfWarrantsIssuedDuringPeriodGross_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Gross proceeds</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Antidilutive Securities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Antidilutive Securities [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LineOfCreditFacilityTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Line Of Credit Facility [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LineOfCreditFacilityTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Line of Credit Facility [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CurrentFiscalYearEndDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current Fiscal Year End Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CurrentFiscalYearEndDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Current Fiscal Year End Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_EquityDistributionAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Equity Distribution Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_EquityDistributionAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Distribution Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_EquityDistributionAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity distribution agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class of Warrant or Right [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentQuarterlyReport_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Quarterly Report</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentQuarterlyReport_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Quarterly Report</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExpired_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class of warrant or right, expired.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExpired_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Number of Shares, Expired</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExpired_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class of warrant or right, expired</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PaymentInterestPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Payment Interest Purchase Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PaymentInterestPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Payment Interest Purchase Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PaymentInterestPurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Payment interest purchase agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsFromMilestonesRelatedToSaleOfRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds from milestones related to sale of royalties</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsFromMilestonesRelatedToSaleOfRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds From Milestones Related To Sale Of Royalties</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsFromMilestonesRelatedToSaleOfRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Proceeds from milestones related to sale of royalties.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SummaryOfRightOfUseAssetsAcquiredUnderOperatingLeasesTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Right of Use Assets Acquired Under Operating Leases</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SummaryOfRightOfUseAssetsAcquiredUnderOperatingLeasesTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Summary Of Right Of Use Assets Acquired Under Operating Leases Table [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SummaryOfRightOfUseAssetsAcquiredUnderOperatingLeasesTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Summary of right of use assets acquired under operating leases.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Disposal Group Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disposal Group Name [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueInputsLevel2Member_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Level Two</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueInputsLevel2Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value, Inputs, Level 2 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_WarrantInducementAndReloadLettersMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Warrant Inducement and Reload Letters.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_WarrantInducementAndReloadLettersMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrant Inducement and Reload Letters</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net cash used in operating activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net cash used in operating activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash Provided by (Used in) Operating Activity, Including Discontinued Operation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Net cash used in operating activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityIncorporationStateCountryCode_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Incorporation, State or Country Code</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityIncorporationStateCountryCode_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Incorporation, State or Country Code</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PaymentOfRoyaltyRevenuePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Payment of royalty revenue</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PaymentOfRoyaltyRevenuePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Payment of royalty revenue, percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PaymentOfRoyaltyRevenuePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Payment Of Royalty Revenue Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PaymentOfRoyaltyRevenuePercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Payment of royalty revenue, percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareDiluted_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Diluted net loss per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareDiluted_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Diluted net loss per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareDiluted_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Earnings Per Share, Diluted</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Issued in Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of shares issued under share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of shares sold</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sale of Stock, Number of Shares Issued in Transaction</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Dividends_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Dividends</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Dividends_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Dividends, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_Dividends_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deemed dividend</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockParOrStatedValuePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Preferred stock, par value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PreferredStockParOrStatedValuePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock, Par or Stated Value Per Share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted discount rate for operating leases</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Lease, Weighted Average Discount Rate, Percent</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DisposalGroupIncludingDiscontinuedOperationsAccountsReceivableAndDeferredRevenue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accounts receivable and deferred payments from Medexus</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DisposalGroupIncludingDiscontinuedOperationsAccountsReceivableAndDeferredRevenue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disposal Group Including Discontinued Operations Accounts Receivable And Deferred Revenue</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_DisposalGroupIncludingDiscontinuedOperationsAccountsReceivableAndDeferredRevenue_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Disposal group including discontinued operations accounts receivable and deferred revenue.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetIncomeLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetIncomeLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Net loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PropertyPlantAndEquipmentTypeDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Long-Lived Tangible Asset</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PropertyPlantAndEquipmentTypeDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Long-Lived Asset, Class [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesACommonWarrantMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Series A common warrant.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesACommonWarrantMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Series A Common Warrant [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesACommonWarrantMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series A Common Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandTwentyThreeCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Two Thousand Twenty Three Common Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandTwentyThreeCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">2023 Common Warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandTwentyThreeCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2023 Common Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_Rule10B51ArrModifiedFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Rule 10b51 Arr Modified [Flag]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_Rule10B51ArrModifiedFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Rule 10b51 arr modified flag.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_Rule10B51ArrModifiedFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Rule 10b5-1 Arrangement Modified</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ExercisePriceOf309600Member_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise Price of 3,096.00</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ExercisePriceOf309600Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Exercise Price of 3,096.00 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ExercisePriceOf309600Member_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Exercise price of 3,096.00.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ReductionInResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Research and development expense</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ReductionInResearchAndDevelopmentExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Reduction in research and development expense.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightOutstandingWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Weighted-Average Exercise Price, Outstanding, Ending Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightOutstandingWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Weighted-Average Exercise Price, Outstanding, Beginning Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightOutstandingWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Outstanding Weighted Average Exercise Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightOutstandingWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class of warrant or right outstanding weighted average exercise&#160;price.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OrganizationConsolidationBasisOfPresentationBusinessDescriptionAndAccountingPoliciesTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Nature of Business and Significant Accounting Policies</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OrganizationConsolidationBasisOfPresentationBusinessDescriptionAndAccountingPoliciesTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Organization, Consolidation, Basis of Presentation, Business Description and Accounting Policies [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_RightToPurchaseAdditionalShares_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Right to purcahse additional shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_RightToPurchaseAdditionalShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Right to Purchase Additional Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_RightToPurchaseAdditionalShares_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Right to purchase additional shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_ScenarioUnspecifiedDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Scenario</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_ScenarioUnspecifiedDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Scenario [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PaymentOfCommitmentFee_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Payment of commitment fees</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PaymentOfCommitmentFee_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Payment of Commitment Fee</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PaymentOfCommitmentFee_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Payment of commitment fee.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementEquityComponentsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Equity Components</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementEquityComponentsAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Components [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investing Activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CollaborativeArrangementDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Collaboration Agreements</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementOfCashFlowsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement of Cash Flows [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PrepaidExpensesOtherCurrentAssetsAccruedExpensesAndOtherCurrentLiabilitiesTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Prepaid Expenses, Other Current Assets, Accrued Expenses, and Other Current Liabilities [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PrepaidExpensesOtherCurrentAssetsAccruedExpensesAndOtherCurrentLiabilitiesTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">The entire disclosure for prepaid expenses, other current assets, accrued expenses, and other current liabilities.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PrepaidExpensesOtherCurrentAssetsAccruedExpensesAndOtherCurrentLiabilitiesTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Prepaid Expenses, Other Current Assets, Accrued Expenses, and Other Current Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementsFairValueHierarchyDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair Value Hierarchy and NAV</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueMeasurementsFairValueHierarchyDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Hierarchy and NAV [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockholdersEquityReverseStockSplit_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stockholders' Equity, Reverse Stock Split</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Prepaid expenses and other current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (Decrease) in Prepaid Expense and Other Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesAJuniorParticipatingPreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Series A Junior Participating Preferred Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesAJuniorParticipatingPreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series A Junior Participating Preferred Stock [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesAJuniorParticipatingPreferredStockMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Series A Junior Participating Preferred Stock.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueDisclosuresTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair Value Measurements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueDisclosuresTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Disclosures [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_StockOfferingAggregatePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stock Offering Aggregate Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_StockOfferingAggregatePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Stock offering aggregate price.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_StockOfferingAggregatePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock offering aggregate price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DepreciationDepletionAndAmortization_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Depreciation, Depletion and Amortization, Total</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_InvestorRightsAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Investor Rights Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_InvestorRightsAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Investor rights agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementClassOfStockAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class of Stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementClassOfStockAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class of Stock [Axis]</link:label>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_CounterpartyNameAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Counterparty Name [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MeasurementInputExpectedTermMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Measurement Input, Expected Term [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MeasurementInputExpectedTermMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expected Average Life of Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NumberOfOperatingSegments_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of operating segments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NumberOfOperatingSegments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number of Operating Segments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of shares available for grant</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_September2024RegisteredDirectOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">September 2024 Registered Direct Offering [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_September2024RegisteredDirectOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">September 2024 Registered Direct Offering [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_September2024RegisteredDirectOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">September 2024 Registered Direct Offering</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_BasicAndDilutedNetIncomeLossPerShareAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Basic and Diluted Net Income (Loss) per Share [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_BasicAndDilutedNetIncomeLossPerShareAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Basic and diluted net income (loss) per share.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_BasicAndDilutedNetIncomeLossPerShareAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Basic and diluted net loss per share:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SaleOfRoyaltiesLiabilityDisclosureAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sale Of Royalties Liability Disclosure [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SaleOfRoyaltiesLiabilityDisclosureAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Sale of royalties liability disclosure abstract.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SummaryOfSignificantAssetCategoriesTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Summary Of Significant Asset Categories [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SummaryOfSignificantAssetCategoriesTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Summary of significant asset categories.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SummaryOfSignificantAssetCategoriesTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Significant Asset Categories</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accrued expenses and other current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Accrued expenses and other current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsFromSaleOfInvestments_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds from sale of investments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsFromSaleOfInvestments_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds From Sale Of Investments</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsFromSaleOfInvestments_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Proceeds from Sale of Investments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Share Based Compensation Arrangement By Share Based Payment Award [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Number of Shares, Outstanding, Beginning balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Number of Shares, Outstanding, Ending balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of shares outstanding under share-based payment arrangement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentType_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Document Type</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentType_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Type</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NonEmployeeDirectorsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-employee Directors</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NonEmployeeDirectorsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non Employee Directors [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NonEmployeeDirectorsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non-employee directors.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating Activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Income Statement Balance Sheet And Additional Disclosures By Disposal Groups Including Discontinued Operations [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disposal Group, Including Discontinued Operations [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SegmentReportingCodmIndividualTitleAndPositionOrGroupOrCommitteeNameExtensibleEnumeration_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LiabilitiesAndStockholdersEquityAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liabilities and Equity [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LiabilitiesAndStockholdersEquityAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">LIABILITIES AND STOCKHOLDERS' EQUITY</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LesseeLeaseDescriptionLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Lessee Lease Description [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LesseeLeaseDescriptionLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lessee, Lease, Description [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EmployeeStockOptionMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Outstanding Options to Purchase Common Stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsequent Event [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Subsequent Events</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingIncomeLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Loss from operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingIncomeLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Income (Loss)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MeasurementInputRiskFreeInterestRateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Measurement Input, Risk Free Interest Rate [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MeasurementInputRiskFreeInterestRateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Risk-free Interest Rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SaleOfStockPricePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Sale of stock per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SaleOfStockPricePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sale of Stock, Price Per Share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SaleOfStockPricePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Average price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandEighteenStockIncentivePlanMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2018 Stock Incentive Plan</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandEighteenStockIncentivePlanMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Two Thousand Eighteen Stock Incentive Plan [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandEighteenStockIncentivePlanMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Two thousand eighteen stock incentive plan.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DisposalGroupClassificationAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disposal Group Classification [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityFileNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity File Number</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityFileNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Securities Act File Number</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AprilTwoThousandTwentyFourWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">April Two Thousand Twenty Four Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AprilTwoThousandTwentyFourWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">April two thousand twenty four warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AprilTwoThousandTwentyFourWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">April 2024 Warrant</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock issued upon vesting of restricted stock units</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MeasurementInputExercisePriceMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Measurement Input, Exercise Price [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MeasurementInputExercisePriceMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AccruedLiabilitiesAndOtherLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accrued Liabilities and Other Liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AccruedLiabilitiesAndOtherLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accrued expenses and other current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AccruedLiabilitiesAndOtherLiabilities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total accrued expenses and other current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_LiabilityRelatedToSaleOfRoyaltiesDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Liability Related to Sale of Royalties</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_LiabilityRelatedToSaleOfRoyaltiesDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liability Related To Sale Of Royalties Disclosure [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_LiabilityRelatedToSaleOfRoyaltiesDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Liability related to sale of royalties disclosure.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_HCRMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">HCR [member].</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_HCRMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">H C R [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_HCRMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">HCR</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_MilestonePayment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Milestone payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_MilestonePayment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Milestone Payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_MilestonePayment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Milestone payments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RetainedEarningsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accumulated Deficit</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RetainedEarningsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Retained Earnings [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityRegistrantName_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Entity Registrant Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityRegistrantName_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Registrant Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Shares issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SharesIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Shares, Issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AccountingPoliciesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accounting Policies [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_WarrantIssueDuringPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrant Issue During Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_WarrantIssueDuringPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Warrant Issue During Period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_WarrantIssueDuringPeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrant issued during period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProfitLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net loss</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProfitLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProfitLoss_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Net Income (Loss), Including Portion Attributable to Noncontrolling Interest</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromRoyaltiesReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds from royalties received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromRoyaltiesReceived_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds from Royalties Received</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LesseeOperatingLeaseRenewalTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating lease renewal option term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LesseeOperatingLeaseRenewalTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lessee, Operating Lease, Renewal Term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NiowaveAdditionalSharePurchaseRightMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Niowave Additional Share Purchase Right [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NiowaveAdditionalSharePurchaseRightMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Niowave Additional Share Purchase Right</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NiowaveAdditionalSharePurchaseRightMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Niowave additional share purchase right.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SignificantAccountingPoliciesPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Significant Accounting Policies [Policy Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SignificantAccountingPoliciesPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Significant accounting policies.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SignificantAccountingPoliciesPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Significant Accounting Policies</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CommonStockIssuanceCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Issuance costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CommonStockIssuanceCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock Issuance Costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CommonStockIssuanceCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Common stock issuance costs.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressAddressLine1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Address, Address Line One</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressAddressLine1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address, Address Line One</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Discontinued Operations</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DisposalGroupsIncludingDiscontinuedOperationsDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disposal Groups, Including Discontinued Operations, Disclosure [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_OwnershipPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Ownership Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_OwnershipPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Ownership percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_OwnershipPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Ownership percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExpectedToVestWeightedAveragePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Options expected to vest, weighted average period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExpectedToVestWeightedAveragePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sharebased Compensation Arrangement By Sharebased Payment Award Options Expected To Vest Weighted Average Period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExpectedToVestWeightedAveragePeriod_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Sharebased compensation arrangement by sharebased payment award options expected to vest weighted average period.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_LiabilityRelatedToSaleOfRoyaltiesNonCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Liability related to sale of royalties, non-current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_LiabilityRelatedToSaleOfRoyaltiesNonCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liability Related To Sale Of Royalties Non Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_LiabilityRelatedToSaleOfRoyaltiesNonCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Liability related to sale of royalties non current.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromIssuanceOrSaleOfEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net proceeds from sale of stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromIssuanceOrSaleOfEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds from Issuance or Sale of Equity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromIssuanceOrSaleOfEquity_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Proceeds from Issuance or Sale of Equity, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total current assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Assets, Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value, Recurring and Nonrecurring [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SupplementalCashFlowInformationAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Supplemental Cash Flow Information [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SupplementalCashFlowInformationAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Supplemental Cash Flow Information</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Purchase Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Purchase Agreement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PurchaseAgreementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Purchase agreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RelatedPartyTransactionsDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">XOMA Transaction</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RelatedPartyTransactionsDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Related Party Transactions Disclosure [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentOtherThanOptionsNonvestedAndExpectedToVestNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of Units, Outstanding and expected to vest</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentOtherThanOptionsNonvestedAndExpectedToVestNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Equity Instrument Other Than Options Nonvested And Expected To Vest Number</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentOtherThanOptionsNonvestedAndExpectedToVestNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Share based compensation arrangement by share based payment award equity instrument other than options nonvested and expected to vest number.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ReverseStockSplit_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Reverse stock split.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ReverseStockSplit_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Reverse Stock Split</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntitySmallBusiness_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Small Business</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntitySmallBusiness_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Small Business</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesBOneCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Series b one common warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesBOneCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Series B One Common Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesBOneCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series B-1 Common Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GovernmentAssistanceAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Government Assistance [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Unrecognized compensation expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightOutstandingWeightedAverageRemainingContractualTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted-Average Remaining Term, Outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightOutstandingWeightedAverageRemainingContractualTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Outstanding Weighted Average Remaining Contractual Term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightOutstandingWeightedAverageRemainingContractualTerm_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class of warrant or right outstanding weighted average remaining contractual term.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EmployeeRelatedLiabilitiesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Employee-related Liabilities, Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EmployeeRelatedLiabilitiesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Employee-related Liabilities, Current, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EmployeeRelatedLiabilitiesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accrued compensation and benefits</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NonCashInterestExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non-cash interest expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NonCashInterestExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Non Cash Interest Expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NonCashInterestExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non cash interest expense.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="exch_XNCM_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Nasdaq Capital Market</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="exch_XNCM_lbl" xlink:role="http://www.xbrl.org/2003/role/label">NASDAQ CAPITAL MARKET [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Earnings Per Share [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EarningsPerShareAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Basic and diluted net loss per share:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Stock Option Activity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Payment Arrangement, Option, Activity [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_InitialOperatingLeaseTermDate_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Initial operating lease term date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_InitialOperatingLeaseTermDate_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Initial Operating Lease Term Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_InitialOperatingLeaseTermDate_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Initial operating lease term date.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_April42025RegisteredDirectOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">April 4 2025 Registered Direct Offering [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_April42025RegisteredDirectOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">April 4 2025 registered direct offering.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_April42025RegisteredDirectOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">April 4, 2025 Registered Direct Offering</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PlanNameAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Plan Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PlanNameAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Plan Name [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventTypeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsequent Event Type [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EquityAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsFromIssuancesOfPreFundedWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Proceeds from issuances of pre-funded warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsFromIssuancesOfPreFundedWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds From Issuances Of Pre funded Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ProceedsFromIssuancesOfPreFundedWarrants_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Issuances of pre-funded warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financing Activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair Value by Liability Class</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value by Liability Class [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandTwentySixNiowaveCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Two Thousand Twenty Six Niowave Common Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandTwentySixNiowaveCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Two thousand twenty six niowave common warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandTwentySixNiowaveCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2026 Niowave Common Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_MilestonePaymentReceivedNetOfTransactionCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds from milestone payments, net of transaction costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_MilestonePaymentReceivedNetOfTransactionCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Milestone Payment Received Net Of Transaction Costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_MilestonePaymentReceivedNetOfTransactionCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Milestone payment received net of transaction costs.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PaymentsInLieuOfFractionalShares_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Payments in lieu of fractional shares.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PaymentsInLieuOfFractionalShares_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Payments In Lieu Of Fractional Shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PaymentsInLieuOfFractionalShares_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Payments in lieu of fractional shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CommonWarrantIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Common Warrant Issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CommonWarrantIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Common warrant issued.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CommonWarrantIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common warrant issued</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AdditionalPostClosingPayment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additional post-closing payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AdditionalPostClosingPayment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additional post-closing payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AdditionalPostClosingPayment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Additional post-closing payment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercisable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of Shares, Exercisable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercisable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Exercisable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercisable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class of warrant or right exercisable</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AccountingPronouncementsPendingAdoptionPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accounting Pronouncements Pending Adoption</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AccountingPronouncementsPendingAdoptionPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accounting Pronouncements Pending Adoption [Policy Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AccountingPronouncementsPendingAdoptionPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Accounting pronouncements pending adoption.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityTaxIdentificationNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Tax Identification Number</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityTaxIdentificationNumber_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Tax Identification Number</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AtTheMarketOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">At The Market Offering [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AtTheMarketOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">At The Market Offering.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AtTheMarketOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">At-The-Market Offering</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AtTheMarketOfferingMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">At The Market Offering</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EquityComponentDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Equity Component</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_EquityComponentDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Equity Component [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressCityOrTown_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Address, City or Town</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressCityOrTown_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address, City or Town</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_OtherSegmentItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Segment Items</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_OtherSegmentItems_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Other segment items.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_OtherSegmentItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other segment items</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_HyperimmuneBusinessMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Hyperimmune Business</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_HyperimmuneBusinessMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Hyperimmune Business [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_HyperimmuneBusinessMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Hyperimmune business.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MeasurementInputTypeDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Measurement Input Type [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodValueNewIssues_lbl" xlink:role="http://www.xbrl.org/2003/role/label">proceeds from issuance of common stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodValueNewIssues_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Issuance of common stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodValueNewIssues_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Issuance of common stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesBTwoCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Series b two common warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesBTwoCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Series B Two Common Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesBTwoCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series B-2 Common Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NewWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">New Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NewWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">New Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NewWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">New warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCommonStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Common Stock, Shares Outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCommonStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Common Stock, Shares Outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AdditionalMilestonePayment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additional milestone payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AdditionalMilestonePayment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additional Milestone Payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AdditionalMilestonePayment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Additional milestone payment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ExercisePriceOf860Member_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise Price of $8.60</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ExercisePriceOf860Member_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Exercise Price Of 8.60 [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ExercisePriceOf860Member_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Exercise price of 8.60.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NumberOfOperatingLeaseRenewalOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of operating lease renewal option</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NumberOfOperatingLeaseRenewalOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Operating Lease Renewal Options</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NumberOfOperatingLeaseRenewalOptions_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of operating lease renewal options.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Shares used in calculation:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Weighted Average Number of Shares Outstanding, Diluted [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LesseeOperatingLeaseOptionToExtend_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating lease renewal option description</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LesseeOperatingLeaseOptionToExtend_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lessee, Operating Lease, Option to Extend</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Statement [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LeaseCost_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total lease cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LeaseCost_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Lease, Cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AllocatedShareBasedCompensationExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock-based compensation expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AllocatedShareBasedCompensationExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Payment Arrangement, Expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PrivatePlacementAndWarrantInducementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Private Placement and Warrant Inducement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PrivatePlacementAndWarrantInducementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Private Placement And Warrant Inducement [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PrivatePlacementAndWarrantInducementMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Private placement and warrant inducement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AggregateBeneficialOwnershipLimitationPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Aggregate Beneficial Ownership Limitation Percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AggregateBeneficialOwnershipLimitationPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Aggregate beneficial ownership limitation percentage.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AggregateBeneficialOwnershipLimitationPercentage_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Aggregate beneficial ownership limitation percentage</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityShellCompany_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Shell Company</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityShellCompany_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Shell Company</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash Provided by (Used in) Investing Activity, Including Discontinued Operation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net cash from investing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_InducementWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Inducement Warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_InducementWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Inducement Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercisedWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted-Average Exercise Price, Exercised</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercisedWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Exercised Weighted Average Exercise Price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercisedWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class of warrant or right exercised weighted average exercise price.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Statement [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StatementLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Statement [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_MaximumMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Maximum</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_MaximumMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Maximum [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtDisclosureAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Debt Disclosure [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SaleOfStockNameOfTransactionDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sale of Stock [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ScheduleOfEarningsPerShareBasicAndDilutedLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Earnings Per Share Basic And Diluted [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ScheduleOfEarningsPerShareBasicAndDilutedLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Earnings Per Share Basic And Diluted [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ScheduleOfEarningsPerShareBasicAndDilutedLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Schedule of earnings per share basic and diluted.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Income Statement Balance Sheet And Additional Disclosures By Disposal Groups Including Discontinued Operations [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disposal Groups, Including Discontinued Operations [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DeferredFinanceCostsGross_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Transaction costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DeferredFinanceCostsGross_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Debt Issuance Costs, Gross</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SharePortionEntitledToPurchaseByRights1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Share portion entitled to purchase by rights</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SharePortionEntitledToPurchaseByRights1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Portion Entitled To Purchase By Rights1</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SharePortionEntitledToPurchaseByRights1_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Share portion entitled to purchase by rights.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsequent Events [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NatureOfBusinessLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Nature Of Business [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NatureOfBusinessLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Nature Of Business [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NatureOfBusinessLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Nature Of Business [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsCurrentAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current assets:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AssetsCurrentAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Assets, Current [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AccruedProfessionalFeesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Accrued Professional Fees, Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AccruedProfessionalFeesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accrued professional service costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SaleOfStockConsiderationReceivedOnTransaction_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Sale of Stock, Consideration Received on Transaction</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SaleOfStockConsiderationReceivedOnTransaction_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Gross proceeds</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SaleOfStockConsiderationReceivedOnTransaction_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net/gross proceeds</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RelatedPartyTransactionDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Related Party Transaction</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RelatedPartyTransactionDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Related Party Transaction [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LeasesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Leases [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentFiscalYearFocus_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Fiscal Year Focus</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentFiscalYearFocus_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Fiscal Year Focus</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NovemberTwoThousandTwentyThreeWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">November Two Thousand Twenty Three Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NovemberTwoThousandTwentyThreeWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">November two thousand twenty three warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NovemberTwoThousandTwentyThreeWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">November 2023 Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Common stock outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Common Stock, Shares, Outstanding, Ending Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Common Stock, Shares, Outstanding, Beginning Balance</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock, shares outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockSharesOutstanding_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock, Shares, Outstanding</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Collaborative Arrangement and Arrangement Other than Collaborative [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Restricted Cash And Cash Equivalents [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Restrictions on Cash and Cash Equivalents [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_GainOnExtinguishmentOfLiabilityRelatedToSaleOfRoyalties_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Gain on extinguishment of liability related to sale of royalties</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_GainOnExtinguishmentOfLiabilityRelatedToSaleOfRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Gain from extinguishment of liability related to sale of royalties</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_GainOnExtinguishmentOfLiabilityRelatedToSaleOfRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Gain On Extinguishment Of Liability Related To Sale Of Royalties</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_GainOnExtinguishmentOfLiabilityRelatedToSaleOfRoyalties_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Gain on extinguishment of liability related to sale of royalties.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GovernmentAssistanceTypeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Government Assistance, Type [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ScheduleOfChangesInLiabilityRelatedToSaleOfRoyaltiesTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Schedule of changes in the liability related to the sale of royalties.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ScheduleOfChangesInLiabilityRelatedToSaleOfRoyaltiesTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule of Changes in the Liability Related to the Sale of Royalties</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ScheduleOfChangesInLiabilityRelatedToSaleOfRoyaltiesTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Changes In Liability Related To Sale Of Royalties Table [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_April2024CommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">April 2024 Common Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_April2024CommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">April 2024 common warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_April2024CommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">April 2024 Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_ScenarioForecastMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Forecast</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="srt_ScenarioForecastMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Forecast [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_WarrantActivityTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrant Activity [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_WarrantActivityTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Warrant activity.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_WarrantActivityTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Common Warrant Activity</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandTwentyThreeAndTwoThousandTwentyFourCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Two Thousand Twenty Three and Two Thousand Twenty Four Common Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandTwentyThreeAndTwoThousandTwentyFourCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Two thousand twenty three and two thousand twenty four common warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_TwoThousandTwentyThreeAndTwoThousandTwentyFourCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2023 and 2024 Common Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesBCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series B Common Warrants 2023</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesBCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Series B Common Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesBCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Series B Common Warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesBCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Series B Common Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseLiabilityNoncurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Long term portion of operating lease liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseLiabilityNoncurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Lease, Liability, Noncurrent</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseLiabilityNoncurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating lease liability, current portion</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ModifiedWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Modified warrants member.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ModifiedWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Modified Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ModifiedWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Modified Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_GainRelatedToSaleOfNonfinancialAssetPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Gain Related to Sale of Nonfinancial Asset</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_GainRelatedToSaleOfNonfinancialAssetPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Gain Related to Sale of Nonfinancial Asset [Policy Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_GainRelatedToSaleOfNonfinancialAssetPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Gain related to sale of nonfinancial asset.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NumberOfTechnologyPlatforms_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of technology platforms</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NumberOfTechnologyPlatforms_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Technology Platforms</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NumberOfTechnologyPlatforms_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of technology platforms.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NiowaveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Niowave [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NiowaveMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Niowave.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherAccruedLiabilitiesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Accrued Liabilities, Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherAccruedLiabilitiesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other accruals</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdditionalPaidInCapitalCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additional paid-in capital</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdditionalPaidInCapitalCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additional Paid in Capital, Common Stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_SecurityExchangeName_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Security Exchange Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_SecurityExchangeName_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Security Exchange Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MeasurementInputTypeAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Measurement Input Type [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">New Accounting Pronouncements, Policy [Policy Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Recently Adopted Accounting Pronouncements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Recently Adopted Accounting Pronouncements</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WarrantMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WarrantMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrant [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_WarrantMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Common Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_RUXIENCEMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">RUXIENCE</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_RUXIENCEMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">R U X I E N C E [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_RUXIENCEMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">RUXIENCE</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_GovernmentAssistanceTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Government Assistance [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrants exercise price, per share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class of Warrant or Right, Exercise Price of Warrants or Rights</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Share of common stock underlying common warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressStateOrProvince_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Address, State or Province</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityAddressStateOrProvince_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address, State or Province</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfEntitlementToReceiveEuropeanApprovalMilestonePayment_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of entitlement to receive European approval milestone payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfEntitlementToReceiveEuropeanApprovalMilestonePayment_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage of entitlement to receive European approval milestone payment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfEntitlementToReceiveEuropeanApprovalMilestonePayment_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of entitlement to receive European approval milestone payment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfBeneficialOwnership_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of beneficial ownership</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfBeneficialOwnership_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Percentage Of Beneficial Ownership</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PercentageOfBeneficialOwnership_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage Of Beneficial Ownership.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercised_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Number of Shares, Exercised</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercised_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Exercised</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercised_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class of warrant or right exercised.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExercised_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common warrants exercised</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock authorized for issuance under Stock Plan</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Stock authorized for issuance under the plan</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseRightOfUseAsset_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating lease right-of-use asset</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseRightOfUseAsset_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Lease, Right-of-Use Asset</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_AmendmentFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Amendment Flag</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_AmendmentFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Amendment Flag</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Debt Instrument</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Debt Instrument [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherNonoperatingIncomeExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Other Nonoperating Income (Expense), Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherNonoperatingIncomeExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Other Nonoperating Income (Expense)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OtherNonoperatingIncomeExpense_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other income, net</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SecuredOvernightFinancingRateSofrOvernightIndexSwapRateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SecuredOvernightFinancingRateSofrOvernightIndexSwapRateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_StructuringFee_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Structuring Fee</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_StructuringFee_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Structuring fee.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_StructuringFee_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Structuring fee</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeattleOfficeLeaseIncludingAmendmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Seattle Office Lease, Including Amendment</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeattleOfficeLeaseIncludingAmendmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Seattle Office Lease Including Amendment [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeattleOfficeLeaseIncludingAmendmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Seattle office lease including amendment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CityAreaCode_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">City Area Code</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CityAreaCode_lbl" xlink:role="http://www.xbrl.org/2003/role/label">City Area Code</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseLiabilityCurrentStatementOfFinancialPositionExtensibleList_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Organization, Consolidation and Presentation of Financial Statements [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromIssuanceOfCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Gross proceeds</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromIssuanceOfCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Costs from issuance of common stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromIssuanceOfCommonStock_lbl" xlink:role="http://www.xbrl.org/2009/role/netLabel">Proceeds from issuance of common stock and pre-funded warrants exercise, net of issuance costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ProceedsFromIssuanceOfCommonStock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds from issuance of common stock</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingExpensesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating expenses:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingExpensesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Expenses [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_December2024WarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">December 2024 Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_December2024WarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">December 2024 Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_December2024WarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">December 2024 Warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExpiredWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted-Average Exercise Price, Expired</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExpiredWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Class of warrant or right expired weighted average exercise price</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_ClassOfWarrantOrRightExpiredWeightedAverageExercisePrice_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Class of warrant or right expired weighted average exercise price.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockParOrStatedValuePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock, par value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockParOrStatedValuePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock, Par or Stated Value Per Share</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonStockParOrStatedValuePerShare_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Par value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_BusinessExitCosts1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exit fees</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_BusinessExitCosts1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Business Exit Costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashAndCashEquivalentsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash and Cash Equivalents [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CostsUnderTheGrantAwardAgreement_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Costs Under the Grant Award Agreement</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_CostsUnderTheGrantAwardAgreement_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Costsunderthegrantawardagreement.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LiabilitiesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total current liabilities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_LiabilitiesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liabilities, Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Cash and cash equivalents at beginning of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_lbl" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Cash and cash equivalents at end of period</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_VariableLeaseCost_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Variable expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_VariableLeaseCost_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Variable Lease, Cost</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SegmentReportingDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Segment Information</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SegmentReportingDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Segment Reporting [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesReverseStockSplits_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Stock Issued During Period, Shares, Reverse Stock Splits</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesReverseStockSplits_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Payment in lieu of fractional shares in connection with the 1-for-44 reverse stock split effected on March 5, 2024 (in shares)</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesReverseStockSplits_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Payment in lieu of fractional shares, shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockIssuedDuringPeriodSharesReverseStockSplits_lbl" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Payment in lieu of fractional shares, shares</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TypeOfArrangementAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Collaborative Arrangement and Arrangement Other than Collaborative</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_TypeOfArrangementAxis_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Collaborative Arrangement and Arrangement Other than Collaborative [Axis]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_TradingSymbol_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Trading Symbol</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_TradingSymbol_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Trading Symbol</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_WarrantsIssuanceCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Warrants issuance costs.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_WarrantsIssuanceCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Warrants Issuance Costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_WarrantsIssuanceCosts_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Total issuance costs</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RestrictedCashAndCashEquivalentsItemsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Restricted Cash And Cash Equivalents Items [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_RestrictedCashAndCashEquivalentsItemsLineItems_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Restricted Cash and Cash Equivalent Item [Line Items]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SubsequentEventTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Subsequent Event [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NatureOfBusinessTable_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Nature Of Business [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NatureOfBusinessTable_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Nature Of Business [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_NatureOfBusinessTable_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Nature Of Business [Table]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityEmergingGrowthCompany_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Emerging Growth Company</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityEmergingGrowthCompany_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Emerging Growth Company</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdditionalPaidInCapitalMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additional Paid-In Capital</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdditionalPaidInCapitalMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Additional Paid-in Capital [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DeferredCostsCapitalizedPrepaidAndOtherAssetsDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Prepaid Expenses and Other Current Assets</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DeferredCostsCapitalizedPrepaidAndOtherAssetsDisclosureTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MoneyMarketFundsAtCarryingValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Money market funds</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_MoneyMarketFundsAtCarryingValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash Equivalent, Money Market Fund, Carrying Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PlanNameDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Plan Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_PlanNameDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Plan Name [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DisposalGroupClassificationDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Disposal Group Classification [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PreFundedWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Pre-funded Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PreFundedWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Pre-funded Warrants 2023</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PreFundedWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Pre-funded Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_PreFundedWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Pre-funded Warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AugustTwoThousandTwentyThreeWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">August Two Thousand Twenty Three Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AugustTwoThousandTwentyThreeWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">August wo thousand twenty three warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_AugustTwoThousandTwentyThreeWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">August 2023 Warrant</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonClassAMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Common Class A [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CommonClassAMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series A</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesAOneCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Series a one common warrants.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesAOneCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Series A One Common Warrants [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SeriesAOneCommonWarrantsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series A-1 Common Warrants</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CoverAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cover [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfCashAndCashEquivalentsTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Schedule of Cash and Cash Equivalents [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ScheduleOfCashAndCashEquivalentsTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule of Cash and Cash Equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SummaryOfSignificantExpenseCategoriesTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Significant Expense Categories</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SummaryOfSignificantExpenseCategoriesTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Summary Of Significant Expense Categories [Table Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_SummaryOfSignificantExpenseCategoriesTableTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Summary of significant expense categories.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_LiabilityRelatedToSaleOfRoyaltiesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current portion of liability related to sale of royalties</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_LiabilityRelatedToSaleOfRoyaltiesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Liability Related To Sale Of Royalties Current</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="apvo_LiabilityRelatedToSaleOfRoyaltiesCurrent_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Liability related to sale of royalties current.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted average remaining lease term for operating leases</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Operating Lease, Weighted Average Remaining Lease Term</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensation_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Share-Based Payment Arrangement, Noncash Expense, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensation_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock-based compensation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_ShareBasedCompensation_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share-Based Payment Arrangement, Noncash Expense</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Adjustments to reconcile net loss to net cash used in operating activities:</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_FairValueDisclosuresAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Disclosures [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash and Cash Equivalent</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total cash and cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Share Repurchase Program, Remaining Authorized, Amount</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Remaining availability under SEPA</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Remaining availability</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash Provided by (Used in) Financing Activity, Including Discontinued Operation</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivities_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net cash provided by financing activities</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DiscontinuedOperationsAndDisposalGroupsAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Discontinued Operations and Disposal Groups [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Net Income (Loss) Available to Common Stockholders, Basic</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net loss attributable to common stockholders</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net loss attributable to common stockholders</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashEquivalentsAtCarryingValue_lbl" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Cash Equivalents, at Carrying Value, Total</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashEquivalentsAtCarryingValue_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash equivalents</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_CashEquivalentsAtCarryingValue_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cash Equivalents, at Carrying Value</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityFilerCategory_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Filer Category</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityFilerCategory_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Filer Category</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentNameDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Debt Instrument, Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_DebtInstrumentNameDomain_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Debt Instrument, Name [Domain]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_SegmentReportingCodmProfitLossMeasureHowUsedDescription_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrant modification - incremental fair value</link:label>
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  <xsd:element id="apvo_ClassOfWarrantOrRightIssued" name="ClassOfWarrantOrRightIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_PaymentOfCommitmentFee" name="PaymentOfCommitmentFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageGrantDateFairValue" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="apvo_SecuritiesPurchaseAgreementMember" name="SecuritiesPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_SeriesACommonWarrantMember" name="SeriesACommonWarrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_SummaryOfSignificantExpenseCategoriesTableTextBlock" name="SummaryOfSignificantExpenseCategoriesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_PurchaseAgreementMember" name="PurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_PercentageOfEntitlementToReceiveEuropeanApprovalMilestonePayment" name="PercentageOfEntitlementToReceiveEuropeanApprovalMilestonePayment" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ReverseStockSplitLineItem" name="ReverseStockSplitLineItem" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_AssumptionsOfFairValueOfWarrantsTableTextBlock" name="AssumptionsOfFairValueOfWarrantsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_NewWarrantsMember" name="NewWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_December2024WarrantsMember" name="December2024WarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_SummaryOfSignificantAssetCategoriesTableTextBlock" name="SummaryOfSignificantAssetCategoriesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ProceedsFromIssuancesOfPreFundedWarrants" name="ProceedsFromIssuancesOfPreFundedWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_SeriesAOneCommonWarrantsMember" name="SeriesAOneCommonWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_PaymentsInLieuOfFractionalShares" name="PaymentsInLieuOfFractionalShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_RUXIENCEMember" name="RUXIENCEMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_ClassOfWarrantOrRightExpiredWeightedAverageRemainingContractualTerm" name="ClassOfWarrantOrRightExpiredWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ClassOfWarrantOrRightExercisableWeightedAverageRemainingContractualTerm" name="ClassOfWarrantOrRightExercisableWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_Rule10B51ArrModifiedFlag" name="Rule10B51ArrModifiedFlag" type="xbrli:booleanItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_SeriesATwoCommonWarrantsMember" name="SeriesATwoCommonWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_TwoThousandTwentyFiveCommonWarrantsMember" name="TwoThousandTwentyFiveCommonWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_NovemberTwoThousandTwentyThreeWarrantsMember" name="NovemberTwoThousandTwentyThreeWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_BroadridgeCorporateIssuerSolutionsMember" name="BroadridgeCorporateIssuerSolutionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_ClassOfWarrantOrRightExercisedWeightedAverageRemainingContractualTerm" name="ClassOfWarrantOrRightExercisedWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_PIPEWarrantsMember" name="PIPEWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_NonEmployeeDirectorsMember" name="NonEmployeeDirectorsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_ProceedsOfWarrantsIssuedDuringPeriodNet" name="ProceedsOfWarrantsIssuedDuringPeriodNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="apvo_AtTheMarketOfferingMember" name="AtTheMarketOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_TransactionCostsForMilestonesRelatedToSaleOfRoyalties" name="TransactionCostsForMilestonesRelatedToSaleOfRoyalties" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_EquityDistributionAgreementMember" name="EquityDistributionAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_BeneficialOwnershipLimitation" name="BeneficialOwnershipLimitation" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ScheduleOfChangesInLiabilityRelatedToSaleOfRoyaltiesTableTextBlock" name="ScheduleOfChangesInLiabilityRelatedToSaleOfRoyaltiesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_FirstStandbyEquityPurchaseAgreementMember" name="FirstStandbyEquityPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_ExercisePriceOf309600Member" name="ExercisePriceOf309600Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_ScheduleOfEarningsPerShareBasicAndDilutedLineItems" name="ScheduleOfEarningsPerShareBasicAndDilutedLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_PaymentOfRoyaltyPurchaseAgreementPercentage" name="PaymentOfRoyaltyPurchaseAgreementPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExpectedToVestWeightedAveragePeriod" name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExpectedToVestWeightedAveragePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_InducementWarrantsMember" name="InducementWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_PaymentOfRoyaltyRevenuePercentage" name="PaymentOfRoyaltyRevenuePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_OtherSegmentItems" name="OtherSegmentItems" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="apvo_GainOnExtinguishmentOfLiabilityRelatedToSaleOfRoyalties" name="GainOnExtinguishmentOfLiabilityRelatedToSaleOfRoyalties" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_September2024RegisteredDirectOfferingMember" name="September2024RegisteredDirectOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_ClassOfWarrantOrRightIssuedWeightedAverageRemainingContractualTerm" name="ClassOfWarrantOrRightIssuedWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_NumberOfOperatingLeaseRenewalOptions" name="NumberOfOperatingLeaseRenewalOptions" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_NatureOfBusinessLineItems" name="NatureOfBusinessLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_IXINITYMember" name="IXINITYMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_StandbyEquityPurchaseAgreementMember" name="StandbyEquityPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_ReverseStockSplitAbstract" name="ReverseStockSplitAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_ClassOfWarrantOrRightExercised" name="ClassOfWarrantOrRightExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ReverseStockSplit" name="ReverseStockSplit" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ClassOfWarrantOrRightExercisable" name="ClassOfWarrantOrRightExercisable" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ProceedsFromMilestonesRelatedToSaleOfRoyalties" name="ProceedsFromMilestonesRelatedToSaleOfRoyalties" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="apvo_PrivatePlacementAndWarrantInducementMember" name="PrivatePlacementAndWarrantInducementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_SharePortionEntitledToPurchaseByRights1" name="SharePortionEntitledToPurchaseByRights1" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ExercisePriceOf1798200Member" name="ExercisePriceOf1798200Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_RegisteredDirectOfferingMember" name="RegisteredDirectOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_GainRelatedToSaleOfNonfinancialAssetPolicyTextBlock" name="GainRelatedToSaleOfNonfinancialAssetPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_CommonStockSharesIssuanceApprovalThresholdPercentage" name="CommonStockSharesIssuanceApprovalThresholdPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ProceedsFromIssuancesOfPreFundedWarrantsShares" name="ProceedsFromIssuancesOfPreFundedWarrantsShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_WarrantsIssuanceCosts" name="WarrantsIssuanceCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="apvo_StockPurchaseAgreementMember" name="StockPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_AggregateBeneficialOwnershipLimitationPercentage" name="AggregateBeneficialOwnershipLimitationPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="apvo_BeneficialOwnershipExceedingPercentageOfOutstandingCommonStock" name="BeneficialOwnershipExceedingPercentageOfOutstandingCommonStock" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_MilestonePaymentReceivedNetOfTransactionCosts" name="MilestonePaymentReceivedNetOfTransactionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="apvo_AdditionalMilestonePayment" name="AdditionalMilestonePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_NonRule10B51ArrModifiedFlag" name="NonRule10B51ArrModifiedFlag" type="xbrli:booleanItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_PercentageOfGrossSalesPriceSharesSold" name="PercentageOfGrossSalesPriceSharesSold" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_SaleOfRoyaltiesLiabilityDisclosureAbstract" name="SaleOfRoyaltiesLiabilityDisclosureAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_April42025RegisteredDirectOfferingMember" name="April42025RegisteredDirectOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_InvestorRightsAgreementMember" name="InvestorRightsAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_PaymentInterestPurchaseAgreementMember" name="PaymentInterestPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_GovernmentGrantReimbursements" name="GovernmentGrantReimbursements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_SecondStandbyEquityPurchaseAgreementMember" name="SecondStandbyEquityPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_LiabilityRelatedToSaleOfRoyaltiesDisclosureTextBlock" name="LiabilityRelatedToSaleOfRoyaltiesDisclosureTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_CostsUnderTheGrantAwardAgreement" name="CostsUnderTheGrantAwardAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="apvo_DisposalGroupIncludingDiscontinuedOperationsDeferredRevenue" name="DisposalGroupIncludingDiscontinuedOperationsDeferredRevenue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_LiabilityRelatedToSaleOfRoyalties" name="LiabilityRelatedToSaleOfRoyalties" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_WarrantIssueDuringPeriod" name="WarrantIssueDuringPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfReturningSharesFromOldPlanToBeAddedToSharesReserve" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfReturningSharesFromOldPlanToBeAddedToSharesReserve" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="apvo_PreFundedWarrantsMember" name="PreFundedWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_ScheduleOfEarningsPerShareBasicAndDilutedTable" name="ScheduleOfEarningsPerShareBasicAndDilutedTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_LincolnParkMember" name="LincolnParkMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_TwoThousandTwentySixNiowaveCommonWarrantsMember" name="TwoThousandTwentySixNiowaveCommonWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_AdditionalAmountToBeReceivedUponExerciseOfWarrants" name="AdditionalAmountToBeReceivedUponExerciseOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="apvo_NumberOfTechnologyPlatforms" name="NumberOfTechnologyPlatforms" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="apvo_CashEquivalentsMaturityPeriod" name="CashEquivalentsMaturityPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_KamadaMember" name="KamadaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_NiowaveAdditionalSharePurchaseRightMember" name="NiowaveAdditionalSharePurchaseRightMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_PercentageOfBeneficialOwnership" name="PercentageOfBeneficialOwnership" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_AdditionalPostClosingPayment" name="AdditionalPostClosingPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_TwoThousandTwentyThreeAndTwoThousandTwentyFourCommonWarrantsMember" name="TwoThousandTwentyThreeAndTwoThousandTwentyFourCommonWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_NatureOfBusinessTable" name="NatureOfBusinessTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_ReductionInResearchAndDevelopmentExpense" name="ReductionInResearchAndDevelopmentExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_SignificantAccountingPoliciesPolicyTextBlock" name="SignificantAccountingPoliciesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_AccountingStandardUpdate201705Member" name="AccountingStandardUpdate201705Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_PrepaidExpensesOtherCurrentAssetsAccruedExpensesAndOtherCurrentLiabilitiesAbstract" name="PrepaidExpensesOtherCurrentAssetsAccruedExpensesAndOtherCurrentLiabilitiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_SeriesBOneCommonWarrantsMember" name="SeriesBOneCommonWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_HyperimmuneBusinessMember" name="HyperimmuneBusinessMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_NiowaveMember" name="NiowaveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_TwoThousandTwentyThreeCommonWarrantsMember" name="TwoThousandTwentyThreeCommonWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_StockOfferingAggregatePrice" name="StockOfferingAggregatePrice" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_DiscontinuedOperatingGainOnContingentConsideration" name="DiscontinuedOperatingGainOnContingentConsideration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentOtherThanOptionsNonvestedAndExpectedToVestNumber" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentOtherThanOptionsNonvestedAndExpectedToVestNumber" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_PrepaidExpensesOtherCurrentAssetsAccruedExpensesAndOtherCurrentLiabilitiesTextBlock" name="PrepaidExpensesOtherCurrentAssetsAccruedExpensesAndOtherCurrentLiabilitiesTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ClassOfWarrantOrRightExpired" name="ClassOfWarrantOrRightExpired" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ClassOfWarrantOrRightExercisableWeightedAverageExercisePrice" name="ClassOfWarrantOrRightExercisableWeightedAverageExercisePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="apvo_LiabilityRelatedToSaleOfRoyaltiesCurrent" name="LiabilityRelatedToSaleOfRoyaltiesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_PercentageOfEntitlementToReceiveCanadianApprovalMilestonePayment" name="PercentageOfEntitlementToReceiveCanadianApprovalMilestonePayment" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_OtherSignificantAccountingPolicyTextBlock" name="OtherSignificantAccountingPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ExercisePriceOf860Member" name="ExercisePriceOf860Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_DividendDeclaredOfPreferredSharePurchaseRight" name="DividendDeclaredOfPreferredSharePurchaseRight" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ClassOfWarrantOrRightOutstandingWeightedAverageRemainingContractualTerm" name="ClassOfWarrantOrRightOutstandingWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_CreditAgreementMember" name="CreditAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_FirstAndSecondSEPAMember" name="FirstAndSecondSEPAMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_RightToPurchaseAdditionalShares" name="RightToPurchaseAdditionalShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="apvo_NonCashInterestExpense" name="NonCashInterestExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="apvo_AndyHillCancerResearchEndowmentCAREFundMember" name="AndyHillCancerResearchEndowmentCAREFundMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_WarrantInducementAndReloadLettersMember" name="WarrantInducementAndReloadLettersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_OwnershipPercentage" name="OwnershipPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_DeferredPaymentsIncreasePercentage" name="DeferredPaymentsIncreasePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="apvo_BeneficialOwnershipLimitationPercentage" name="BeneficialOwnershipLimitationPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_SeriesAAndSeriesBCommonWarrantsMember" name="SeriesAAndSeriesBCommonWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_MilestonePayment" name="MilestonePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_ClassOfWarrantOrRightExpiredWeightedAverageExercisePrice" name="ClassOfWarrantOrRightExpiredWeightedAverageExercisePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_April2024CommonWarrantsMember" name="April2024CommonWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_ReverseStockSplitTable" name="ReverseStockSplitTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_LiabilityRelatedToSaleOfRoyaltiesNonCurrent" name="LiabilityRelatedToSaleOfRoyaltiesNonCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_SeriesBTwoCommonWarrantsMember" name="SeriesBTwoCommonWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_ProceedsFromSaleOfInvestments" name="ProceedsFromSaleOfInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="apvo_AprilTwoThousandTwentyFourWarrantsMember" name="AprilTwoThousandTwentyFourWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_CommonWarrantsMember" name="CommonWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_AptevoBiotherapeuticsMember" name="AptevoBiotherapeuticsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_SummaryOfRightOfUseAssetsAcquiredUnderOperatingLeasesTableTextBlock" name="SummaryOfRightOfUseAssetsAcquiredUnderOperatingLeasesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ClassOfWarrantOrRightIssuedWeightedAverageExercisePrice" name="ClassOfWarrantOrRightIssuedWeightedAverageExercisePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ClassOfWarrantOrRightExercisedWeightedAverageExercisePrice" name="ClassOfWarrantOrRightExercisedWeightedAverageExercisePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ClassOfWarrantOrRightOutstandingWeightedAverageExercisePrice" name="ClassOfWarrantOrRightOutstandingWeightedAverageExercisePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="apvo_CommonStockIssuanceCosts" name="CommonStockIssuanceCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="apvo_SeriesAJuniorParticipatingPreferredStockMember" name="SeriesAJuniorParticipatingPreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_BasicAndDilutedNetIncomeLossPerShareAbstract" name="BasicAndDilutedNetIncomeLossPerShareAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_WarrantModificationIncrementalValue" name="WarrantModificationIncrementalValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="apvo_PercentageOfEntitlementToReceiveDeferredPayments" name="PercentageOfEntitlementToReceiveDeferredPayments" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ResearchAndDevelopmentCostPercentage" name="ResearchAndDevelopmentCostPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_PercentageOfCommitmentFee" name="PercentageOfCommitmentFee" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ExistingWarrantsMember" name="ExistingWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_SeriesBCommonWarrantsMember" name="SeriesBCommonWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_OfficeSpaceLeaseMember" name="OfficeSpaceLeaseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_SeattleOfficeLeaseIncludingAmendmentMember" name="SeattleOfficeLeaseIncludingAmendmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_AccountingPronouncementsPendingAdoptionPolicyTextBlock" name="AccountingPronouncementsPendingAdoptionPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_TwoThousandTwentyFourCommonWarrantsMember" name="TwoThousandTwentyFourCommonWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_CommonWarrantIssued" name="CommonWarrantIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_AccruedClinicalResearchAndDevelopmentCosts" name="AccruedClinicalResearchAndDevelopmentCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_WarrantInducementAgreementMember" name="WarrantInducementAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="apvo_ClosingPaymentsReceived" name="ClosingPaymentsReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_DividendAttributableToDownRoundFeatureOfWarrants" name="DividendAttributableToDownRoundFeatureOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="apvo_WarrantActivityTableTextBlock" name="WarrantActivityTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="apvo_ModifiedWarrantsMember" name="ModifiedWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
</xsd:schema>
