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Stock-Based Compensation - Orphai Equity Incentive Plans (Details) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2026	Jun. 30, 2025	Jun. 30, 2026	Jun. 30, 2025
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock-based compensation	$ 12,093,000	$ 1,273,000	$ 13,379,000	$ 2,659,000
2013 Orphai Plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock-based compensation	500,000		500,000
Income tax benefits recognized			0
Options, stock-based compensation not yet recognized	$ 100,000		$ 100,000
Unamortized employee stock-based compensation expected to recognized over remaining estimated vesting period			1 month 17 days
Weighted average grant date fair value per share of stock options			$ 19.59
2013 Orphai Plan \| Employee Stock Option
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Warrants to purchase common stock (in USD per share)	$ 0.6935		$ 0.6935
2026 Orphai Plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock-based compensation	$ 10,700,000		$ 10,700,000
Income tax benefits recognized			0
Options, stock-based compensation not yet recognized	$ 10,500,000		$ 10,500,000
Unamortized employee stock-based compensation expected to recognized over remaining estimated vesting period			1 year 4 months 17 days
Weighted average grant date fair value per share of stock options			$ 19.8