<?xml version="1.0" encoding="US-ASCII" ?>
    <!-- Field: Doc-Info; Name: Generator; Value: GoFiler Complete; Version: 6.5a -->
    <!-- Field: Doc-Info; Name: VendorURI; Value: https://www.novaworks.com -->
    <!-- Field: Doc-Info; Name: Status; Value: 0x00000000 -->
    <!-- Field: Doc-Info; Name: Misc; Value: 96Mps7xRiXgen8uDanwsWa+F+bP9z5Z8+ekhvWB7bVl6jyMsBDb+6S3qerSW4VsJ -->
<schema xmlns="http://www.w3.org/2001/XMLSchema" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:dei="http://xbrl.sec.gov/dei/2026" xmlns:us-gaap="http://fasb.org/us-gaap/2026" xmlns:srt="http://fasb.org/srt/2026" xmlns:srt-types="http://fasb.org/srt-types/2026" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:OTLC="http://oncotelic.com/20260630" elementFormDefault="qualified" targetNamespace="http://oncotelic.com/20260630">
    <annotation>
      <appinfo>
        <link:roleType roleURI="http://oncotelic.com/role/Cover" id="Cover">
          <link:definition>00000001 - Document - Cover</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/BalanceSheets" id="BalanceSheets">
          <link:definition>00000002 - Statement - Condensed Consolidated Balance Sheets (Unaudited)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/BalanceSheetsParenthetical" id="BalanceSheetsParenthetical">
          <link:definition>00000003 - Statement - Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/StatementsOfOperations" id="StatementsOfOperations">
          <link:definition>00000004 - Statement - Condensed Consolidated Statements of Operations (Unaudited)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/CondensedConsolidatedStatementOfStockholdersEquity" id="CondensedConsolidatedStatementOfStockholdersEquity">
          <link:definition>00000005 - Statement -  Condensed Consolidated Statement of Stockholders' Equity (Unaudited)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/StatementsOfCashFlows" id="StatementsOfCashFlows">
          <link:definition>00000006 - Statement - Condensed Consolidated Statements of Cash Flows (Unaudited)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/DescriptionOfBusinessAndBasisOfPresentation" id="DescriptionOfBusinessAndBasisOfPresentation">
          <link:definition>999007 - Disclosure - DESCRIPTION OF BUSINESS AND BASIS OF PRESENTATION</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/SummaryOfSignificantAccountingPolicies" id="SummaryOfSignificantAccountingPolicies">
          <link:definition>999008 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/AcquisitionsGoodwillAndIntangibleAssets" id="AcquisitionsGoodwillAndIntangibleAssets">
          <link:definition>999009 - Disclosure - ACQUISITIONS, GOODWILL AND INTANGIBLE ASSETS</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/AccountsPayableAndAccruedLiabilities" id="AccountsPayableAndAccruedLiabilities">
          <link:definition>999010 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED LIABILITIES</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ConvertibleDebenturesNotesAndOtherDebt" id="ConvertibleDebenturesNotesAndOtherDebt">
          <link:definition>999011 - Disclosure - CONVERTIBLE DEBENTURES, NOTES AND OTHER DEBT</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/JointVentureWithGmpBioAndAffiliatesEquityMethodInvestment" id="JointVentureWithGmpBioAndAffiliatesEquityMethodInvestment">
          <link:definition>999012 - Disclosure - JOINT VENTURE WITH GMP BIO AND AFFILIATES, EQUITY METHOD INVESTMENT</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/PrivatePlacement-2Ppm-2AndJhDarbieFunding" id="PrivatePlacement-2Ppm-2AndJhDarbieFunding">
          <link:definition>999013 - Disclosure - PRIVATE PLACEMENT -2 (PPM-2) AND JH DARBIE FUNDING</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/PrivatePlacement-3Ppm-3AndJhDarbieFunding" id="PrivatePlacement-3Ppm-3AndJhDarbieFunding">
          <link:definition>999014 - Disclosure - PRIVATE PLACEMENT -3 (&#8220;PPM-3&#8221;) AND JH DARBIE FUNDING</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/LunaiBioworksTransactions" id="LunaiBioworksTransactions">
          <link:definition>999015 - Disclosure - LUNAI BIOWORKS TRANSACTIONS</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/RelatedPartyTransactions" id="RelatedPartyTransactions">
          <link:definition>999016 - Disclosure - RELATED PARTY TRANSACTIONS</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/EquityPurchaseAgreementAndRegistrationRightsAgreementMastHill" id="EquityPurchaseAgreementAndRegistrationRightsAgreementMastHill">
          <link:definition>999017 - Disclosure - EQUITY PURCHASE AGREEMENT AND REGISTRATION RIGHTS AGREEMENT (MAST HILL)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/StockholdersEquity" id="StockholdersEquity">
          <link:definition>999018 - Disclosure - STOCKHOLDERS&#8217; EQUITY</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/PreferredStock" id="PreferredStock">
          <link:definition>999019 - Disclosure - PREFERRED STOCK</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/Stock-basedCompensation" id="Stock-basedCompensation">
          <link:definition>999020 - Disclosure - STOCK-BASED COMPENSATION</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/CommitmentsAndContingencies" id="CommitmentsAndContingencies">
          <link:definition>999021 - Disclosure - COMMITMENTS AND CONTINGENCIES</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/SubsequentEvents" id="SubsequentEvents">
          <link:definition>999022 - Disclosure - SUBSEQUENT EVENTS</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/SummaryOfSignificantAccountingPoliciesPolicies" id="SummaryOfSignificantAccountingPoliciesPolicies">
          <link:definition>999023 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/SummaryOfSignificantAccountingPoliciesTables" id="SummaryOfSignificantAccountingPoliciesTables">
          <link:definition>999024 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Tables)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/AcquisitionsGoodwillAndIntangibleAssetsTables" id="AcquisitionsGoodwillAndIntangibleAssetsTables">
          <link:definition>999025 - Disclosure - ACQUISITIONS, GOODWILL AND INTANGIBLE ASSETS (Tables)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/AccountsPayableAndAccruedLiabilitiesTables" id="AccountsPayableAndAccruedLiabilitiesTables">
          <link:definition>999026 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED LIABILITIES (Tables)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ConvertibleDebenturesNotesAndOtherDebtTables" id="ConvertibleDebenturesNotesAndOtherDebtTables">
          <link:definition>999027 - Disclosure - CONVERTIBLE DEBENTURES, NOTES AND OTHER DEBT (Tables)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/JointVentureWithGmpBioAndAffiliatesEquityMethodInvestmentTables" id="JointVentureWithGmpBioAndAffiliatesEquityMethodInvestmentTables">
          <link:definition>999028 - Disclosure - JOINT VENTURE WITH GMP BIO AND AFFILIATES, EQUITY METHOD INVESTMENT (Tables)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/PrivatePlacement-2Ppm-2AndJhDarbieFundingTables" id="PrivatePlacement-2Ppm-2AndJhDarbieFundingTables">
          <link:definition>999029 - Disclosure - PRIVATE PLACEMENT -2 (PPM-2) AND JH DARBIE FUNDING (Tables)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/PrivatePlacement-3Ppm-3AndJhDarbieFundingTables" id="PrivatePlacement-3Ppm-3AndJhDarbieFundingTables">
          <link:definition>999030 - Disclosure - PRIVATE PLACEMENT -3 (&#8220;PPM-3&#8221;) AND JH DARBIE FUNDING (Tables)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/PreferredStockTables" id="PreferredStockTables">
          <link:definition>999031 - Disclosure - PREFERRED STOCK (Tables)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/Stock-basedCompensationTables" id="Stock-basedCompensationTables">
          <link:definition>999032 - Disclosure - STOCK-BASED COMPENSATION (Tables)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/SubsequentEventsTables" id="SubsequentEventsTables">
          <link:definition>999033 - Disclosure - SUBSEQUENT EVENTS (Tables)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/DescriptionOfBusinessAndBasisOfPresentationDetailsNarrative" id="DescriptionOfBusinessAndBasisOfPresentationDetailsNarrative">
          <link:definition>999034 - Disclosure - DESCRIPTION OF BUSINESS AND BASIS OF PRESENTATION (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/SummaryOfSignificantAccountingPoliciesDetailsNarrative" id="SummaryOfSignificantAccountingPoliciesDetailsNarrative">
          <link:definition>999035 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfUnrealizedGainsAndLossesDetails" id="ScheduleOfUnrealizedGainsAndLossesDetails">
          <link:definition>999036 - Disclosure - SCHEDULE OF UNREALIZED GAINS AND LOSSES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfFairValueOfInvestmentHierarchyDetails" id="ScheduleOfFairValueOfInvestmentHierarchyDetails">
          <link:definition>999037 - Disclosure - SCHEDULE OF FAIR VALUE OF INVESTMENT HIERARCHY (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfQuantitativeInformationAboutSignificantUnobservableInputsDetails" id="ScheduleOfQuantitativeInformationAboutSignificantUnobservableInputsDetails">
          <link:definition>999038 - Disclosure - SCHEDULE OF QUANTITATIVE INFORMATION ABOUT SIGNIFICANT UNOBSERVABLE INPUTS (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/SummaryOfChangesInFairValueOfDerivativeLiabilitiesDetails" id="SummaryOfChangesInFairValueOfDerivativeLiabilitiesDetails">
          <link:definition>999039 - Disclosure - SUMMARY OF CHANGES IN FAIR VALUE OF DERIVATIVE LIABILITIES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/SummaryOfEstimateFairValueOfDerivativeLiabilitiesDetails" id="SummaryOfEstimateFairValueOfDerivativeLiabilitiesDetails">
          <link:definition>999040 - Disclosure - SUMMARY OF ESTIMATE FAIR VALUE OF DERIVATIVE LIABILITIES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfGoodwillDetails" id="ScheduleOfGoodwillDetails">
          <link:definition>999041 - Disclosure - SCHEDULE OF GOODWILL (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/AcquisitionsGoodwillAndIntangibleAssetsDetailsNarrative" id="AcquisitionsGoodwillAndIntangibleAssetsDetailsNarrative">
          <link:definition>999042 - Disclosure - ACQUISITIONS, GOODWILL AND INTANGIBLE ASSETS (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfAccountsPayableAndAccruedExpensesDetails" id="ScheduleOfAccountsPayableAndAccruedExpensesDetails">
          <link:definition>999043 - Disclosure - SCHEDULE OF ACCOUNTS PAYABLE AND ACCRUED EXPENSES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfConvertibleDebenturesAndNotesNetOfDiscountDetails" id="ScheduleOfConvertibleDebenturesAndNotesNetOfDiscountDetails">
          <link:definition>999044 - Disclosure - SCHEDULE OF CONVERTIBLE DEBENTURES AND NOTES, NET OF DISCOUNT (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfConvertibleNotesNetOfDiscountDetails" id="ScheduleOfConvertibleNotesNetOfDiscountDetails">
          <link:definition>999045 - Disclosure - SCHEDULE OF CONVERTIBLE NOTES, NET OF DISCOUNT (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfNetOfDebtDiscountDetails" id="ScheduleOfNetOfDebtDiscountDetails">
          <link:definition>999046 - Disclosure - SCHEDULE OF NET OF DEBT DISCOUNT (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfShort-termLoansDetails" id="ScheduleOfShort-termLoansDetails">
          <link:definition>999047 - Disclosure - SCHEDULE OF SHORT-TERM LOANS (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ConvertibleDebenturesNotesAndOtherDebtDetailsNarrative" id="ConvertibleDebenturesNotesAndOtherDebtDetailsNarrative">
          <link:definition>999048 - Disclosure - CONVERTIBLE DEBENTURES, NOTES AND OTHER DEBT (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfChangeInFairValueOfOurInvestmentDetails" id="ScheduleOfChangeInFairValueOfOurInvestmentDetails">
          <link:definition>999049 - Disclosure - SCHEDULE OF CHANGE IN FAIR VALUE OF OUR INVESTMENT (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/JointVentureWithGmpBioAndAffiliatesEquityMethodInvestmentDetailsNarrative" id="JointVentureWithGmpBioAndAffiliatesEquityMethodInvestmentDetailsNarrative">
          <link:definition>999050 - Disclosure - JOINT VENTURE WITH GMP BIO AND AFFILIATES, EQUITY METHOD INVESTMENT (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/PrivatePlacement-2Ppm-2AndJhDarbieFundingDetailsNarrative" id="PrivatePlacement-2Ppm-2AndJhDarbieFundingDetailsNarrative">
          <link:definition>999051 - Disclosure - PRIVATE PLACEMENT -2 (PPM-2) AND JH DARBIE FUNDING (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfFundsReceivedUnderSubscriptionAgreementDetails" id="ScheduleOfFundsReceivedUnderSubscriptionAgreementDetails">
          <link:definition>999052 - Disclosure - SCHEDULE OF FUNDS RECEIVED UNDER THE SUBSCRIPTION AGREEMENT (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfFairValueWarrantsDetails" id="ScheduleOfFairValueWarrantsDetails">
          <link:definition>999053 - Disclosure - SCHEDULE OF FAIR VALUE WARRANTS (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/PrivatePlacement-3Ppm-3AndJhDarbieFundingDetailsNarrative" id="PrivatePlacement-3Ppm-3AndJhDarbieFundingDetailsNarrative">
          <link:definition>999054 - Disclosure - PRIVATE PLACEMENT -3 (&#8220;PPM-3&#8221;) AND JH DARBIE FUNDING (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfDebtRecordedUnderSubscriptionAgreementDetails" id="ScheduleOfDebtRecordedUnderSubscriptionAgreementDetails">
          <link:definition>999055 - Disclosure - SCHEDULE OF DEBT RECORDED UNDER THE SUBSCRIPTION AGREEMENT (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/LunaiBioworksTransactionsDetailsNarrative" id="LunaiBioworksTransactionsDetailsNarrative">
          <link:definition>999056 - Disclosure - LUNAI BIOWORKS TRANSACTIONS (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/RelatedPartyTransactionsDetailsNarrative" id="RelatedPartyTransactionsDetailsNarrative">
          <link:definition>999057 - Disclosure - RELATED PARTY TRANSACTIONS (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/EquityPurchaseAgreementAndRegistrationRightsAgreementMastHillDetailsNarrative" id="EquityPurchaseAgreementAndRegistrationRightsAgreementMastHillDetailsNarrative">
          <link:definition>999058 - Disclosure - EQUITY PURCHASE AGREEMENT AND REGISTRATION RIGHTS AGREEMENT (MAST HILL) (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/StockholdersEquityDetailsNarrative" id="StockholdersEquityDetailsNarrative">
          <link:definition>999059 - Disclosure - STOCKHOLDERS&#8217; EQUITY (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfPreferredStockDetails" id="ScheduleOfPreferredStockDetails">
          <link:definition>999060 - Disclosure - SCHEDULE OF PREFERRED STOCK (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/PreferredStockDetailsNarrative" id="PreferredStockDetailsNarrative">
          <link:definition>999061 - Disclosure - PREFERRED STOCK (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfCompensationBasedStockOptionActivityDetails" id="ScheduleOfCompensationBasedStockOptionActivityDetails">
          <link:definition>999062 - Disclosure - SCHEDULE OF COMPENSATION BASED STOCK OPTION ACTIVITY (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfOptionsToPurchaseSharesOfCommonStockOutstandingAndExercisableDetails" id="ScheduleOfOptionsToPurchaseSharesOfCommonStockOutstandingAndExercisableDetails">
          <link:definition>999063 - Disclosure - SCHEDULE OF OPTIONS TO PURCHASE SHARES OF COMMON STOCK OUTSTANDING AND EXERCISABLE (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfWarrantsActivityDetails" id="ScheduleOfWarrantsActivityDetails">
          <link:definition>999064 - Disclosure - SCHEDULE OF WARRANTS ACTIVITY (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfWarrantsOutstandingAndExercisableDetails" id="ScheduleOfWarrantsOutstandingAndExercisableDetails">
          <link:definition>999065 - Disclosure - SCHEDULE OF WARRANTS OUTSTANDING AND EXERCISABLE (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/Stock-basedCompensationDetailsNarrative" id="Stock-basedCompensationDetailsNarrative">
          <link:definition>999066 - Disclosure - STOCK-BASED COMPENSATION (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/CommitmentsAndContingenciesDetailsNarrative" id="CommitmentsAndContingenciesDetailsNarrative">
          <link:definition>999067 - Disclosure - COMMITMENTS AND CONTINGENCIES (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/SubsequentEventsDetailsNarrative" id="SubsequentEventsDetailsNarrative">
          <link:definition>999068 - Disclosure - SUBSEQUENT EVENTS (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://oncotelic.com/role/ScheduleOfRsuAwardsDetails" id="ScheduleOfRsuAwardsDetails">
          <link:definition>999069 - Disclosure - SCHEDULE OF RSU AWARDS (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:linkbaseRef xlink:type="simple" xlink:href="otlc-20260630_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Presentation Links" />
        <link:linkbaseRef xlink:type="simple" xlink:href="otlc-20260630_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Label Links" />
        <link:linkbaseRef xlink:type="simple" xlink:href="otlc-20260630_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Calculation Links" />
        <link:linkbaseRef xlink:type="simple" xlink:href="otlc-20260630_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Definition Links" />
      </appinfo>
    </annotation>
    <import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
    <import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" />
    <import namespace="http://xbrl.sec.gov/dei/2026" schemaLocation="https://xbrl.sec.gov/dei/2026/dei-2026.xsd" />
    <import namespace="http://fasb.org/us-gaap/2026" schemaLocation="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd" />
    <import namespace="http://fasb.org/us-types/2026" schemaLocation="https://xbrl.fasb.org/us-gaap/2026/elts/us-types-2026.xsd" />
    <import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd" />
    <import namespace="http://xbrl.sec.gov/country/2026" schemaLocation="https://xbrl.sec.gov/country/2026/country-2026.xsd" />
    <import namespace="http://fasb.org/srt/2026" schemaLocation="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd" />
    <import namespace="http://fasb.org/srt-types/2026" schemaLocation="https://xbrl.fasb.org/srt/2026/elts/srt-types-2026.xsd" />
    <element id="OTLC_GMPBiotechnologyLimitedMember" name="GMPBiotechnologyLimitedMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_DragonOverseasCapitalLimitedMember" name="DragonOverseasCapitalLimitedMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_SecuritiesPurchaseAgreementsMember" name="SecuritiesPurchaseAgreementsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_MayTwoThousandAndTwentyTwoAndJulyTwoThousandAndTwentyFiveNoteMember" name="MayTwoThousandAndTwentyTwoAndJulyTwoThousandAndTwentyFiveNoteMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_JVMember" name="JVMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_MayTwoThousandAndTwentyTwoNoteMember" name="MayTwoThousandAndTwentyTwoNoteMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_EquityPurchaseAgreementMember" name="EquityPurchaseAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_IndependentContractorAgreementMember" name="IndependentContractorAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_JHDarbiePlacementAgreementMember" name="JHDarbiePlacementAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_AccreditedInvestorsMember" name="AccreditedInvestorsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_SecuritiesPurchaseAgreementAndPurchaseAgreementMember" name="SecuritiesPurchaseAgreementAndPurchaseAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_GoldenMountainPartnersMember" name="GoldenMountainPartnersMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_SinceInceptionDateMember" name="SinceInceptionDateMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_PointRMergerAgreementMember" name="PointRMergerAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_MastHillMember" name="MastHillMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_LunaiBioworksIncMember" name="LunaiBioworksIncMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_LunaiMember" name="LunaiMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_PointRMergerMember" name="PointRMergerMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_MeasurementInputRevenueGrowthRateMember" name="MeasurementInputRevenueGrowthRateMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_MeasurementInputWeightedAverageCostOfCapitalMember" name="MeasurementInputWeightedAverageCostOfCapitalMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_TerminalGrowthRateMember" name="TerminalGrowthRateMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ProductPenetrationRatesMember" name="ProductPenetrationRatesMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_MergerAgreementMember" name="MergerAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_PointRMember" name="PointRMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_TenPercentageConvertibleNotesPayableDueAprilTwentyThreeTwoThousandTwentyTwoBridgeInvestorMember" name="TenPercentageConvertibleNotesPayableDueAprilTwentyThreeTwoThousandTwentyTwoBridgeInvestorMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ConvertibleDebenturesMember" name="ConvertibleDebenturesMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_TenPercentageConvertibleNotesPayableDueAprilTwentyThreeTwoThousandTwentyTwoRelatedPartyMember" name="TenPercentageConvertibleNotesPayableDueAprilTwentyThreeTwoThousandTwentyTwoRelatedPartyMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_TenPercentageConvertibleNotesPayableDueAugustSixTwoThousandTwentyTwoBridgeInvestorMember" name="TenPercentageConvertibleNotesPayableDueAugustSixTwoThousandTwentyTwoBridgeInvestorMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FivePercentConvertibleNotePayableStephenBoeschMember" name="FivePercentConvertibleNotePayableStephenBoeschMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FallTwoThousandNineteenNotesMember" name="FallTwoThousandNineteenNotesMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FivePercentConvertibleNotePayableRelatedPartyMember" name="FivePercentConvertibleNotePayableRelatedPartyMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FivePercentConvertibleNotePayableDrSanjayJhaMember" name="FivePercentConvertibleNotePayableDrSanjayJhaMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FivePercentConvertibleNotePayableCEOAndCFORelatedPartiesMember" name="FivePercentConvertibleNotePayableCEOAndCFORelatedPartiesMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FivePercentConvertibleNotePayableBridgeInvestorsMember" name="FivePercentConvertibleNotePayableBridgeInvestorsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FivePercentConvertibleNoteAutotelicIncRelatedPartyMember" name="FivePercentConvertibleNoteAutotelicIncRelatedPartyMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_AugustTwentyTwentyOneConvertibleNotesMember" name="AugustTwentyTwentyOneConvertibleNotesMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FivePercentConvertibleNoteBridgeInvestorsMember" name="FivePercentConvertibleNoteBridgeInvestorsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FivePercentConvertibleNoteChiefFinancialOfficerRelatedPartyMember" name="FivePercentConvertibleNoteChiefFinancialOfficerRelatedPartyMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_SixteenPercentConvertibleNoteAccreditedInvestorsMember" name="SixteenPercentConvertibleNoteAccreditedInvestorsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_MarchTwentyTwentyTwoNotesMember" name="MarchTwentyTwentyTwoNotesMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_TwoPercentageConvertibleNotesForeverProsperityMember" name="TwoPercentageConvertibleNotesForeverProsperityMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_DebtClinicalTrialsGMPMember" name="DebtClinicalTrialsGMPMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_SixteenPercentageConvertibleNotesAccreditedInvestorsMember" name="SixteenPercentageConvertibleNotesAccreditedInvestorsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_MayTwoThousandTwentyTwoNoteMember" name="MayTwoThousandTwentyTwoNoteMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_AccruedAndUnpaidInterestMember" name="AccruedAndUnpaidInterestMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_JHDarbiePPMTwoDebtMember" name="JHDarbiePPMTwoDebtMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_TenPercentageConvertibleNotesAccreditedInvestorsMember" name="TenPercentageConvertibleNotesAccreditedInvestorsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_JulyTwoThousandTwentyFiveNoteMember" name="JulyTwoThousandTwentyFiveNoteMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_JanuaryTwoThousandTwentySixNoteMember" name="JanuaryTwoThousandTwentySixNoteMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_TwelvePercentageConvertibleNotesAccreditedInvestorsMember" name="TwelvePercentageConvertibleNotesAccreditedInvestorsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_PacificPierTwoThousandTwentySixNoteMember" name="PacificPierTwoThousandTwentySixNoteMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ShortTermDebtBridgeInvestorsMember" name="ShortTermDebtBridgeInvestorsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_OtherDebtMember" name="OtherDebtMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ShortTermDebtFromCFOMember" name="ShortTermDebtFromCFOMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ShortTermDebtAutotelicIncRelatedPartyMember" name="ShortTermDebtAutotelicIncRelatedPartyMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ShortTermDebtFromCEOMember" name="ShortTermDebtFromCEOMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ShortTermDebtAccreditedInvestorMember" name="ShortTermDebtAccreditedInvestorMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_JHDarbiePPM3DebtMember" name="JHDarbiePPM3DebtMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_BridgeInvestorMember" name="BridgeInvestorMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_SecuritiesPurchaseAgreementMember" name="SecuritiesPurchaseAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FallTwoThousandNineteenDebtFinancingMember" name="FallTwoThousandNineteenDebtFinancingMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_NotePurchaseAgreementsMember" name="NotePurchaseAgreementsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_DrVuongTrieuMember" name="DrVuongTrieuMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_DrSanjayJhaMember" name="DrSanjayJhaMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ChulhoParkMember" name="ChulhoParkMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_AmitShahMember" name="AmitShahMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_TwoAccreditedInvestorsMember" name="TwoAccreditedInvestorsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_GMPNoteMember" name="GMPNoteMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_GMPNoteTwoMember" name="GMPNoteTwoMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_OctoberPurchaseAgreementMember" name="OctoberPurchaseAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ConvertiblePromissoryNoteMember" name="ConvertiblePromissoryNoteMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_JanuaryPurchaseAgreementMember" name="JanuaryPurchaseAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_UnsecuredConvertibleNotePurchaseAgreementsMember" name="UnsecuredConvertibleNotePurchaseAgreementsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_GoldenMountainPartnersLLCMember" name="GoldenMountainPartnersLLCMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_NotePurchaseAgreementMember" name="NotePurchaseAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FourthManLLCMember" name="FourthManLLCMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FiveInstitutionalInvestorsMember" name="FiveInstitutionalInvestorsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_PlacementAgentMember" name="PlacementAgentMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_BlueLakeMember" name="BlueLakeMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FourthManConvertibleNoteMember" name="FourthManConvertibleNoteMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_OneInstitutionalInvestorsMember" name="OneInstitutionalInvestorsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_MayTwoThousandAndTwentyTwoMastNoteMember" name="MayTwoThousandAndTwentyTwoMastNoteMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_MayTwoThousandAndTwentyTwoMember" name="MayTwoThousandAndTwentyTwoMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_JulyTwoThousandAndTwentyFiveMastNoteMember" name="JulyTwoThousandAndTwentyFiveMastNoteMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_JulyTwoThousandAndTwentyFiveMember" name="JulyTwoThousandAndTwentyFiveMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_JanuaryTwoThousandAndTwentySixMastNoteMember" name="JanuaryTwoThousandAndTwentySixMastNoteMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_JuneTwentyTwentySixFinancingtNoteMember" name="JuneTwentyTwentySixFinancingtNoteMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_AutotelicMember" name="AutotelicMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_CFOMember" name="CFOMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FivePercentConvertibleNoteAccreditedInvestorsMember" name="FivePercentConvertibleNoteAccreditedInvestorsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_AugustTwoThousandAndTwentyOneMember" name="AugustTwoThousandAndTwentyOneMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_TenPercentCouponAugustTwoThousandTwentySixMember" name="TenPercentCouponAugustTwoThousandTwentySixMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_TenPercentCouponJanuaryTwoThousandTwentySevenMember" name="TenPercentCouponJanuaryTwoThousandTwentySevenMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_TwelvePercentCouponJuneTwoThousandTwentySixMember" name="TwelvePercentCouponJuneTwoThousandTwentySixMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_OtherShortTermAdvancesMember" name="OtherShortTermAdvancesMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ChiefExecutiveOfficerRelatedPartyMember" name="ChiefExecutiveOfficerRelatedPartyMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_AccreditedInvestorMember" name="AccreditedInvestorMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_GMPBioMember" name="GMPBioMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_DragonOverseasMember" name="DragonOverseasMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_JHDarbiePlacementAgreementTwoMember" name="JHDarbiePlacementAgreementTwoMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_OneConvertiblePromissoryNoteMember" name="OneConvertiblePromissoryNoteMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_NewSubscriptionAgreementsMember" name="NewSubscriptionAgreementsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_JHDarbiePPMThreeDebtMember" name="JHDarbiePPMThreeDebtMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_SubscriptionAgreementsTwoMember" name="SubscriptionAgreementsTwoMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_JHDarbieSubscriptionAgreementMember" name="JHDarbieSubscriptionAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_SubscriptionAgreementsMember" name="SubscriptionAgreementsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ServiceAgreementMember" name="ServiceAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_SeriesBConvertiblePreferredStockMember" name="SeriesBConvertiblePreferredStockMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_AssetTransferAgreementMember" name="AssetTransferAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_MasterServiceAgreementMember" name="MasterServiceAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_AutotelicIncMember" name="AutotelicIncMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_VuongTrieuMember" name="VuongTrieuMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FallTwoThousandAndNineteenNoteMember" name="FallTwoThousandAndNineteenNoteMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_SeriesAConvertiblePreferredStockMember" name="SeriesAConvertiblePreferredStockMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_AugustTwoThousandAndTwentyOneNoteMember" name="AugustTwoThousandAndTwentyOneNoteMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ArtiusConsultingAgreementMember" name="ArtiusConsultingAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_StevenKingMember" name="StevenKingMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_TermSheetAgreementMember" name="TermSheetAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_PacificPierMember" name="PacificPierMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_RestrictedStockAwardsMember" name="RestrictedStockAwardsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_JeffersonCapitalMember" name="JeffersonCapitalMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ValorNationMember" name="ValorNationMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_BoxCapitalIncMember" name="BoxCapitalIncMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_TwoThousandSeventeenEquityIncentivePlanMember" name="TwoThousandSeventeenEquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_TwoThousandFifteenAndTwoThousandFiveEquityIncentivePlanMember" name="TwoThousandFifteenAndTwoThousandFiveEquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ExercisePriceOneMember" name="ExercisePriceOneMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ExercisePriceTwoMember" name="ExercisePriceTwoMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ExercisePriceThreeMember" name="ExercisePriceThreeMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ExercisePriceFourMember" name="ExercisePriceFourMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ExercisePriceFiveMember" name="ExercisePriceFiveMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_SpecialPurchaseAgreementsMember" name="SpecialPurchaseAgreementsMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_VuongTrieuPhDMember" name="VuongTrieuPhDMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_AnthonyEMaidaIIIPhDMAMBAMember" name="AnthonyEMaidaIIIPhDMAMBAMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_StevenWKingMember" name="StevenWKingMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_SeymourFeinMDMember" name="SeymourFeinMDMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_SaranSaundMember" name="SaranSaundMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_GainOnDerecognitionOfNonFinancialAsset" name="GainOnDerecognitionOfNonFinancialAsset" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_SharesIssuedValueInConnectionWithSaleOfEquity" name="SharesIssuedValueInConnectionWithSaleOfEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_SharesIssuedInConnectionWithSaleOfEquity" name="SharesIssuedInConnectionWithSaleOfEquity" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_CommonStockIssuedInConnectionWithDebt" name="CommonStockIssuedInConnectionWithDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_CommonSharesIssuedUponConversionOfDebt" name="CommonSharesIssuedUponConversionOfDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_GainOnDerecognitionOfNonfinancialAssetAndChangeInValueOfEquitySecurities" name="GainOnDerecognitionOfNonfinancialAssetAndChangeInValueOfEquitySecurities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_DisclosureAcquisitionsGoodwillAndIntangibleAssetsAbstract" name="DisclosureAcquisitionsGoodwillAndIntangibleAssetsAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_AcquisitionsGoodwillAndIntangibleAssetsTextBlock" name="AcquisitionsGoodwillAndIntangibleAssetsTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_DisclosurePrivatePlacement2Ppm2AndJhDarbieFundingAbstract" name="DisclosurePrivatePlacement2Ppm2AndJhDarbieFundingAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_PrivatePlacementTwoAndFinancingDisclosureTextBlock" name="PrivatePlacementTwoAndFinancingDisclosureTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_DisclosurePrivatePlacement3Ppm3AndJhDarbieFundingAbstract" name="DisclosurePrivatePlacement3Ppm3AndJhDarbieFundingAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_PrivatePlacementThreeAndFinancingDisclosureTextBlock" name="PrivatePlacementThreeAndFinancingDisclosureTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_DisclosureLunaiBioworksTransactionsAbstract" name="DisclosureLunaiBioworksTransactionsAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_LunaiBioworksDisclosureTextBlock" name="LunaiBioworksDisclosureTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_DisclosureEquityPurchaseAgreementAndRegistrationRightsAgreementMastHillAbstract" name="DisclosureEquityPurchaseAgreementAndRegistrationRightsAgreementMastHillAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_EquityPurchaseAgreementAndRegistrationRightsAgreementMastHillTextBlock" name="EquityPurchaseAgreementAndRegistrationRightsAgreementMastHillTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_DebtIssuanceCostsAndDebtDiscountPolicyTextBlock" name="DebtIssuanceCostsAndDebtDiscountPolicyTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ChangeInFairValueOfEquitySecuritiesPolicyTextBlock" name="ChangeInFairValueOfEquitySecuritiesPolicyTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_DerivativesLiabilityPolicyTextBlock" name="DerivativesLiabilityPolicyTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_JointVentureAgreementPolicyTextBlock" name="JointVentureAgreementPolicyTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ScheduleOfUnrealizedLossOnInvestmentTableTextBlock" name="ScheduleOfUnrealizedLossOnInvestmentTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_SummaryOfChangesInFairValueOfDerivativeLiabilitiesTableTextBlock" name="SummaryOfChangesInFairValueOfDerivativeLiabilitiesTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ScheduleOfConvertibleNotesNetOfDiscountTableTextBlock" name="ScheduleOfConvertibleNotesNetOfDiscountTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ScheduleOfFundsReceivedUnderTheSubscriptionAgreementFromThePrivatePlacementNetOfDebtDiscountTableTextBlock" name="ScheduleOfFundsReceivedUnderTheSubscriptionAgreementFromThePrivatePlacementNetOfDebtDiscountTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ScheduleOfDebtRecordedUnderTheSubscriptionAgreemenDebtDiscountTableTextBlock" name="ScheduleOfDebtRecordedUnderTheSubscriptionAgreemenDebtDiscountTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ScheduleOfWarrantsOutstandingAndExercisableTableTextBlock" name="ScheduleOfWarrantsOutstandingAndExercisableTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_MarketCapitalization" name="MarketCapitalization" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_WorkingCapitalDeficit" name="WorkingCapitalDeficit" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_SignificantAccountingPoliciesAbstract" name="SignificantAccountingPoliciesAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ScheduleOfSignificantAccountingPoliciesTable" name="ScheduleOfSignificantAccountingPoliciesTable" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" />
    <element id="OTLC_JointVentureCombinedEnterpriseValue" name="JointVentureCombinedEnterpriseValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_JointVentureOtherParticipantCapitalContribution" name="JointVentureOtherParticipantCapitalContribution" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FairValueInputsDiscountRate" name="FairValueInputsDiscountRate" nillable="true" xbrli:periodType="instant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FairValueNetInvestment" name="FairValueNetInvestment" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FairValueInputsDiscountRateLimitations" name="FairValueInputsDiscountRateLimitations" nillable="true" xbrli:periodType="instant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_InvestmentFairValue" name="InvestmentFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_WeightedAverageCommonStock" name="WeightedAverageCommonStock" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_FairValueUnobservableInputsPercentageRate" name="FairValueUnobservableInputsPercentageRate" nillable="true" xbrli:periodType="instant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_DerivativeLiabilityMeasurementInputTerm" name="DerivativeLiabilityMeasurementInputTerm" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_StatementsOfIncomeLocationBalanceAxis" name="StatementsOfIncomeLocationBalanceAxis" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" />
    <element id="OTLC_StatementsOfIncomeLocationBalanceDomain" name="StatementsOfIncomeLocationBalanceDomain" abstract="true" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_AmortizationOfDebtDiscount" name="AmortizationOfDebtDiscount" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ConvertibleNotesPayableNet" name="ConvertibleNotesPayableNet" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_DebtFinancing" name="DebtFinancing" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ProceedsFromConvertibleDebtGross" name="ProceedsFromConvertibleDebtGross" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_DebtUnamortizedPrincipalAmount" name="DebtUnamortizedPrincipalAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_DebtDefaultPrincipalAndAccruedInterestPercentage" name="DebtDefaultPrincipalAndAccruedInterestPercentage" nillable="true" xbrli:periodType="instant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_EstimatedDefaultPenalty" name="EstimatedDefaultPenalty" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_PrivatePlacementAndJhDarbieFundingAbstract" name="PrivatePlacementAndJhDarbieFundingAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_PrivatePlacementAndJhDarbieFundingTable" name="PrivatePlacementAndJhDarbieFundingTable" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" />
    <element id="OTLC_StockIssuedDuringPeriodSharesWarrantsGranted" name="StockIssuedDuringPeriodSharesWarrantsGranted" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_LunaiBioworksTransactionsAbstract" name="LunaiBioworksTransactionsAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_LunaiBioworksTransactionsTable" name="LunaiBioworksTransactionsTable" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" />
    <element id="OTLC_ProvisionalPatentsAmount" name="ProvisionalPatentsAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_EquityPurchaseAgreementAndRegistrationRightsAgreementAbstract" name="EquityPurchaseAgreementAndRegistrationRightsAgreementAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_EquityPurchaseAgreementAndRegistrationRightsAgreementTable" name="EquityPurchaseAgreementAndRegistrationRightsAgreementTable" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" />
    <element id="OTLC_EmployeeServiceShareBasedCompensationUnamortizedCompensationCost" name="EmployeeServiceShareBasedCompensationUnamortizedCompensationCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingWeightedAverageExercisePrice" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ShareBasedCompensationArrangementsByShareBasedPaymentAwardNonOptionEquityInstrumentsIssuedInPeriodWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementsByShareBasedPaymentAwardNonOptionEquityInstrumentsIssuedInPeriodWeightedAverageExercisePrice" nillable="true" xbrli:periodType="duration" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice" nillable="true" xbrli:periodType="duration" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ClassOfWarrantWeightedAverageExercisePriceOfWarrants" name="ClassOfWarrantWeightedAverageExercisePriceOfWarrants" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="OTLC_ChangeInFairValueEquityInvestment" name="ChangeInFairValueEquityInvestment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
</schema>
