Aggregate net sales achievement.

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- Definition

Annual license maintenance fee.

+ References

No definition available.

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- Definition

Area of office space.

+ References

No definition available.

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- Definition

Contingent liability.

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No definition available.

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- Definition

Fee due for milestones achieved.

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No definition available.

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- Definition

Lessee operating lease remaining term of contract.

+ References

No definition available.

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- Definition

Number of milestones achieved.

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No definition available.

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- Definition

Prior lease expiration date.

+ References

No definition available.

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- Definition

Regulatory milestone payments obligation.

+ References

No definition available.

+ Details

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- Definition

Remaining milestone payments for first licensed product.

+ References

No definition available.

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- Definition

Represents the aggregate of total long-term debt, including current maturities and short-term debt.

+ References

No definition available.

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- Definition

The current carrying amount of the liability for the freestanding or embedded guarantor's obligations under the guarantee or each group of similar guarantees.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 460
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 4
-Subparagraph (c)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482425/460-10-50-4

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- Definition

Date which lease or group of leases is set to expire, in YYYY-MM-DD format.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 842
-SubTopic 30
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Subparagraph (a)(1)
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Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef
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-Section 50
-Paragraph 3
-Subparagraph (a)(1)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147478964/842-20-50-3

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- Definition

Term of lessee's operating lease, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 842
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Subparagraph (a)(3)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147478964/842-20-50-3

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- Definition

Amount of operating lease expense. Excludes sublease income.

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Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 842
-SubTopic 20
-Name Accounting Standards Codification
-Section 45
-Paragraph 4
-Subparagraph (b)
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-URI https://asc.fasb.org/1943274/2147479041/842-20-45-4

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Balance Type:	debit
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- Definition

Present value of lessee's discounted obligation for lease payments from operating lease.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 842
-SubTopic 20
-Name Accounting Standards Codification
-Section 45
-Paragraph 1
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479041/842-20-45-1

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- Definition

Amount of lessee's right to use underlying asset under operating lease.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 842
-SubTopic 20
-Name Accounting Standards Codification
-Section 45
-Paragraph 1
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479041/842-20-45-1

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

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Balance Type:	na
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- Definition

The amount of cash paid for royalties during the current period.

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Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Section 45
-Paragraph 25
-Subparagraph (g)
-SubTopic 10
-Topic 230
-Publisher FASB
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- Definition

Minimum amount of purchase arrangement in which the entity has agreed to expend funds to procure goods or services from a supplier.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 942
-SubTopic 235
-Name Accounting Standards Codification
-Section S99
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-Subparagraph (SX 210.9-06)
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-Subparagraph (SX 210.12-04(a))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480678/235-10-S99-3

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- Definition

The amount the entity has committed to make for future royalty guarantees.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 928
-SubTopic 440
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147477866/928-440-50-1

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Commitments and Contingencies - Additional Information (Detail)				3 Months Ended		6 Months Ended		12 Months Ended
	Sep. 04, 2024 ft²	Apr. 19, 2024 ft²	Aug. 12, 2022	Jun. 30, 2026 USD ($)	Jun. 30, 2025 USD ($)	Jun. 30, 2026 USD ($) Milestone	Jun. 30, 2025 USD ($) Milestone	Dec. 31, 2022 USD ($) ft²	Dec. 31, 2021 USD ($)	Dec. 31, 2025 USD ($)	Nov. 21, 2024 USD ($)	May 31, 2015 USD ($)
Other Commitments [Line Items]
Non-cancelable purchase obligations related to manufacturing				$ 15,300,000		$ 15,300,000
Rental expense				100,000	$ 100,000	200,000	$ 200,000
Lease liabilities				467,000		467,000				$ 641,000
ROU assets				445,000		445,000				613,000
Debt outstanding				0		0
Indemnification obligations amount				0		0
Contingent liabilities				0		$ 0				$ 0
ALS Therapy Development Foundation, Inc. License Agreement [Member]
Other Commitments [Line Items]
Fee due for milestones achieved												$ 1,000,000
Number of Milestones Achieved \| Milestone						0	0
Remaining milestone payments for first licensed product				6,000,000.0		$ 6,000,000.0
Annual License Maintenance Fee								$ 100,000	$ 100,000
ALS Therapy Development Foundation, Inc. License Agreement [Member] \| Achievement of 500 Million Aggregate Sales [Member]
Other Commitments [Line Items]
Reaching of aggregate net sales						500,000,000.0
Amount of one-time milestone payment				15,000,000.0		15,000,000.0
ALS Therapy Development Foundation, Inc. License Agreement [Member] \| Achievement of 1 Billion Aggregate Sales [Member]
Other Commitments [Line Items]
Reaching of aggregate net sales						1,000,000,000.0
Amount of one-time milestone payment				30,000,000.0		30,000,000.0
Lonza Sales AG Inc. License Agreement
Other Commitments [Line Items]
Royalties paid						$ 0	$ 0
Maximum [Member]
Other Commitments [Line Items]
Remaining term of office lease						1 year 3 months 18 days
Maximum [Member] \| ALS Therapy Development Foundation, Inc. License Agreement [Member]
Other Commitments [Line Items]
Development and regulatory milestone payments				$ 2,500,000		$ 2,500,000
Irvine, California [Member]
Other Commitments [Line Items]
Area of office space \| ft²		5,817						5,197
Operating lease, term of contract		38 months
Lease expiration date		Jun. 30, 2027	Dec. 31, 2024
Burlington, Massachusetts [Member]
Other Commitments [Line Items]
Area of office space \| ft²	6,138
Operating lease, term of contract	36 months
Lease expiration date	Nov. 21, 2027
Prior lease expiration date	Nov. 20, 2024
Lease liabilities											$ 500,000
ROU assets											$ 500,000