0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS’ EQUITY (DEFICIT) link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Description of Business and Organization link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Fair value measurements link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Inventory link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Accrued expenses and other current liabilities link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Senior secured term loan facility and warrants link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Deferred royalty obligation and warrants link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Pension and post-retirement benefit obligations link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Commitments and contingencies link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Revenue link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Restructuring, impairment, and other related costs link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Other income (expense) link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Share-based compensation link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Loss per share link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Segment reporting link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Inventory (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Accrued expenses and other current liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Senior secured term loan facility and warrants (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Deferred royalty obligation and warrants (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Pension and post-retirement benefit obligations (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Revenue (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Restructuring, impairment, and other related costs (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Other income (expense) (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Share-based compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Loss per share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Segment reporting (Tables) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Description of Business and Organization (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Summary of Significant Accounting Policies (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Fair value measurements (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Inventory - Schedule of Inventory (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Inventory - Schedule of Inventory (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Inventory - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Accrued expenses and other current liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Senior secured term loan facility and warrants - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Senior secured term loan facility and warrants- Schedule of Interest Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Senior secured term loan facility and warrants - Schedule of Maturities (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Deferred royalty obligation and warrants - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Deferred royalty obligation and warrants - Schedule of Fair Value Inputs (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Deferred royalty obligation and warrants - Schedule of Royalty Obligation (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Pension and post-retirement benefit obligations - Schedule of Net Periodic Benefit Cost (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Revenue - Schedule of Disaggregation of Revenues (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Revenue - Schedule of GTN Product Revenue, Net (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Revenue - Schedule of Concentration Risk by Customer (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Restructuring, impairment, and other related costs - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Restructuring, impairment, and other related costs - Restructuring Costs (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Other income (expense) - Schedule of Interest Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Other income (expense) - Schedule of Other, Net (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Share-based compensation - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Share-based compensation - Schedule of Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Share-based compensation - Schedule of Stock Option Valuation Assumptions (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Share-based compensation - Schedule of RSU Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Loss per share - Schedule of Loss per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Loss per share - Schedule of Potentially Dilutive Securities Excluded from Earnings Per Share Calculation (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Loss per share - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Segment reporting - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Segment reporting - Schedule of Segment Reporting Information, by Segment (Details) link:presentationLink link:calculationLink link:definitionLink