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        <link:definition>995456 - Disclosure - FAIR VALUE MEASUREMENTS</link:definition>
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        <link:definition>995460 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES (Tables)</link:definition>
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        <link:definition>995464 - Disclosure - NOTES PAYABLE (Tables)</link:definition>
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        <link:definition>995465 - Disclosure - CONVERTIBLE DEBT (Tables)</link:definition>
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        <link:definition>995468 - Disclosure - FAIR VALUE MEASUREMENTS (Tables)</link:definition>
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        <link:definition>995476 - Disclosure - STOCKHOLDERS DEFICIT (Details Narrative)</link:definition>
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        <link:definition>995477 - Disclosure - STOCK OPTIONS (Details)</link:definition>
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        <link:definition>995484 - Disclosure - NOTES PAYABLE (Details 1)</link:definition>
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        <link:definition>995485 - Disclosure - NOTES PAYABLE (Details Narrative)</link:definition>
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        <link:definition>995486 - Disclosure - CONVERTIBLE DEBT (Details)</link:definition>
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        <link:definition>995487 - Disclosure - CONVERTIBLE DEBT (Details Narrative)</link:definition>
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        <link:definition>995488 - Disclosure - RELATED PARTY DEBT (Details)</link:definition>
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        <link:usedOn>link:definitionLink</link:usedOn>
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        <link:definition>995489 - Disclosure - RELATED PARTY DEBT (Details 1)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType roleURI="http://guidedinc.com/role/RelatedPartyDebtDetailsNarrative" id="RelatedPartyDebtDetailsNarrative">
        <link:definition>995490 - Disclosure - RELATED PARTY DEBT (Details Narrative)</link:definition>
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        <link:definition>995491 - Disclosure - INCOME (LOSS) PER SHARE OF COMMON STOCK (Details)</link:definition>
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        <link:definition>995492 - Disclosure - INCOME (LOSS) PER SHARE OF COMMON STOCK (Details Narrative)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
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        <link:definition>995493 - Disclosure - FAIR VALUE MEASUREMENTS (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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  <element id="gthp_DesignatedSharesOfPreferredStockShares" name="DesignatedSharesOfPreferredStockShares" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
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  <element id="gthp_SharePurchasePricePerUnit" name="SharePurchasePricePerUnit" nillable="true" xbrli:periodType="instant" type="num:perShareItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_CommonStocksConvertibleShares" name="CommonStocksConvertibleShares" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_PreferenceShareStatedValue" name="PreferenceShareStatedValue" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_AccuredStockDividendSharesIssuedForPayment" name="AccuredStockDividendSharesIssuedForPayment" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_PreferredStockStatedValuePerShare" name="PreferredStockStatedValuePerShare" nillable="true" xbrli:periodType="instant" type="num:perShareItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_CumulativeDividendsPercentage" name="CumulativeDividendsPercentage" nillable="true" xbrli:periodType="instant" type="num:percentItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_CommonStockSharesIssuedUponConversionOfConvertiblePreferredStock" name="CommonStockSharesIssuedUponConversionOfConvertiblePreferredStock" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_CommonStockSharesIssuedForConversionOfSeriesFConvertiblePreferredStock" name="CommonStockSharesIssuedForConversionOfSeriesFConvertiblePreferredStock" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
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  <element id="gthp_StockOptionExercisePrice" name="StockOptionExercisePrice" nillable="true" xbrli:periodType="duration" type="num:perShareItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_OperatingLeaseWeightedAverageRemainingLeaseTerm" name="OperatingLeaseWeightedAverageRemainingLeaseTerm" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_PurchaseCommitmentMinimumAmountCommitted" name="PurchaseCommitmentMinimumAmountCommitted" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_MonthlyPayments" name="MonthlyPayments" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_WarrantsToPurchaseShares" name="WarrantsToPurchaseShares" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_AdditionalWarrantToPurchaseshares" name="AdditionalWarrantToPurchaseshares" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsConversionPrice" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsConversionPrice" nillable="true" xbrli:periodType="instant" type="num:perShareItemType" substitutionGroup="xbrli:item" />
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  <element id="gthp_OutstandingPrincipalBalanceOfNotePayable" name="OutstandingPrincipalBalanceOfNotePayable" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_IssuedWarrantsToPurchaseSharesOfCommonStock" name="IssuedWarrantsToPurchaseSharesOfCommonStock" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_PercentageOfAccruedInterestRate" name="PercentageOfAccruedInterestRate" nillable="true" xbrli:periodType="duration" type="num:percentItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_ConvertibleNotesPayableBeforeAdjustments" name="ConvertibleNotesPayableBeforeAdjustments" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_DebtDiscount" name="DebtDiscount" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_ConvertibleDebtInDefault" name="ConvertibleDebtInDefault" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_NumberOfCommonStockPurchaseWarrants" name="NumberOfCommonStockPurchaseWarrants" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_PaymentDueDate" name="PaymentDueDate" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_MonthlyPaymentDescription" name="MonthlyPaymentDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_DebtMonthlyPaymentsDueAmount" name="DebtMonthlyPaymentsDueAmount" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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  <element id="gthp_DiscountOnConvertibleNote" name="DiscountOnConvertibleNote" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_ChangeOfControlPremiumPercentage" name="ChangeOfControlPremiumPercentage" nillable="true" xbrli:periodType="duration" type="num:percentItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_DefaultInterestRate" name="DefaultInterestRate" nillable="true" xbrli:periodType="duration" type="num:percentItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_DeemedPrice" name="DeemedPrice" nillable="true" xbrli:periodType="instant" type="num:perShareItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_DebtMaturityDate" name="DebtMaturityDate" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
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  <element id="gthp_ContingentlyConvertiblePromissoryNoteNonCurrent" name="ContingentlyConvertiblePromissoryNoteNonCurrent" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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  <element id="gthp_ContingentlyConvertiblePromissoryNoteIssued" name="ContingentlyConvertiblePromissoryNoteIssued" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_PromissoryNoteIssuedForAtLeastHoldsCashOnHands" name="PromissoryNoteIssuedForAtLeastHoldsCashOnHands" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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  <element id="gthp_ChangeInFairValueOfBeneficialConversionFeatures" name="ChangeInFairValueOfBeneficialConversionFeatures" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_RemeasurementGainLossDeferredCompensationConversionLiabilityRecognizedInOperations" name="RemeasurementGainLossDeferredCompensationConversionLiabilityRecognizedInOperations" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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  <element id="gthp_DebtInstrumentOriginalIssueDiscount" name="DebtInstrumentOriginalIssueDiscount" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_DebtInstrumentMonthlyInstallments" name="DebtInstrumentMonthlyInstallments" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_IssuedWarrantToPurchaseSharesOfCommonStock" name="IssuedWarrantToPurchaseSharesOfCommonStock" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_LitigationAndClaimsAbstract" name="LitigationAndClaimsAbstract" nillable="true" abstract="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_CommitmentsAndContingenciesAbstract" name="CommitmentsAndContingenciesAbstract" nillable="true" abstract="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_ConvertibleDebtAbstract" name="ConvertibleDebtAbstract" nillable="true" abstract="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_RelatedPartyDebtAbstract" name="RelatedPartyDebtAbstract" nillable="true" abstract="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
  <element id="gthp_SegmentReportingDisclosureAbstract" name="SegmentReportingDisclosureAbstract" nillable="true" abstract="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
  <element name="SeriesCPreferredSharesMember" id="gthp_SeriesCPreferredSharesMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="SeriesCOnePreferredSharesMember" id="gthp_SeriesCOnePreferredSharesMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="PreferredStockSeriesFMember" id="gthp_PreferredStockSeriesFMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="PreferredStockSeriesFTwoMember" id="gthp_PreferredStockSeriesFTwoMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="PreferredStockSeriesCMember" id="gthp_PreferredStockSeriesCMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="BlackScholesOptionPricingModelMember" id="gthp_BlackScholesOptionPricingModelMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="PreferredStockSeriesCOneMember" id="gthp_PreferredStockSeriesCOneMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="PreferredStockSeriesCTwoMember" id="gthp_PreferredStockSeriesCTwoMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="VanquishFundingGroupIncMember" id="gthp_VanquishFundingGroupIncMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="SeriesCOneConvertiblePreferredStockMember" id="gthp_SeriesCOneConvertiblePreferredStockMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
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  <element name="SeriesCTwoPreferredStockMember" id="gthp_SeriesCTwoPreferredStockMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="ExchangeAndDeferredCompensationAgreementMember" id="gthp_ExchangeAndDeferredCompensationAgreementMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="WarrantsIssuedConnectionWithPromissoryNoteMember" id="gthp_WarrantsIssuedConnectionWithPromissoryNoteMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="SeriesFTwoPreferredStockMember" id="gthp_SeriesFTwoPreferredStockMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="GTHPTurkeyMember" id="gthp_GTHPTurkeyMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="BlackScholesOptionMember" id="gthp_BlackScholesOptionMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="PreferredStockSeriesDMember" id="gthp_PreferredStockSeriesDMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="DrFaupelsMember" id="gthp_DrFaupelsMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="AndrewTHunterMember" id="gthp_AndrewTHunterMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="GSCapitalPartnersLLCMember" id="gthp_GSCapitalPartnersLLCMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="PremiumFinanceAgreementMember" id="gthp_PremiumFinanceAgreementMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="FiftyLuvivaDevicesMember" id="gthp_FiftyLuvivaDevicesMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
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  <element name="TenPercentSeniorUnsecuredConvertibleDebentureMember" id="gthp_TenPercentSeniorUnsecuredConvertibleDebentureMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="SeriesFPreferredSharesMember" id="gthp_SeriesFPreferredSharesMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
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  <element name="MrFowlerMember" id="gthp_MrFowlerMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
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  <element name="MarchPurchaseAgreementMember" id="gthp_MarchPurchaseAgreementMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
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  <element name="GSCapitalPartnersLLCConvertibleNoteMember" id="gthp_GSCapitalPartnersLLCConvertibleNoteMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
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  <element name="DrJohnImhoffMember" id="gthp_DrJohnImhoffMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <element name="ASU718Member" id="gthp_ASU718Member" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
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  <element name="IronstoneCapitalCorpAndAlanGrujicMember" id="gthp_IronstoneCapitalCorpAndAlanGrujicMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
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</schema>
