The Securities and Exchange Commission has not necessarily
reviewed the information in this filing and has not determined
if it is accurate and complete.
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACHIEVE LIFE SCIENCES INC | COMM | 004468500 | 26,342,138 | 4,034,018 | SH | DFND | 1 | 2,601,913 | 1,432,105 | 0 | |
| CORCEPT THERAPEUTICS INC | COMM | 218352102 | 11,868,588 | 136,499 | SH | DFND | 1 | 110,065 | 26,434 | 0 | |
| CORVUS PHARMACEUTICALS INC | COMM | 221015100 | 1,051,477 | 70,380 | SH | DFND | 1 | 70,380 | 0 | 0 | |
| ZEVRA THERAPEUTICS INC | COMM | 488445206 | 3,635,821 | 253,544 | SH | DFND | 1 | 186,172 | 67,372 | 0 | |
| KYVERNA THERAPEUTICS INC | COMM | 501976104 | 7,869,294 | 883,198 | SH | DFND | 1 | 700,595 | 182,603 | 0 | |
| MAZE THERAPEUTICS INC | COMM | 578784100 | 1,306,932 | 43,798 | SH | DFND | 1 | 43,798 | 0 | 0 | |
| OVID THERAPEUTICS INC | COMM | 690469101 | 3,000,797 | 1,115,538 | SH | DFND | 1 | 1,018,721 | 96,817 | 0 | |
| PALISADE BIO INC | COMM | 696389402 | 5,397,191 | 2,582,388 | SH | DFND | 1 | 2,131,845 | 450,543 | 0 | |
| SAGIMET BIOSCIENCES INC-A | COMM | 786700104 | 973,037 | 125,878 | SH | DFND | 1 | 125,878 | 0 | 0 | |
| SCYNEXIS INC | COMM | 811292309 | 2,211,955 | 543,478 | SH | DFND | 1 | 543,478 | 0 | 0 | |
| 4D MOLECULAR THERAPEUTICS IN | COMM | 35104E100 | 3,360,298 | 252,654 | SH | DFND | 1 | 252,654 | 0 | 0 | |
| AQUESTIVE THERAPEUTICS IN | COMM | 03843E104 | 6,000,372 | 1,442,397 | SH | DFND | 1 | 1,163,674 | 278,723 | 0 | |
| ABEONA THERAPEUTICS INC | COMM | 00289Y206 | 6,075,373 | 983,070 | SH | DFND | 1 | 637,654 | 345,416 | 0 | |
| ARTIVA BIOTHERAPEUTICS IN | COMM | 04317A107 | 6,755,429 | 696,436 | SH | DFND | 1 | 595,081 | 101,355 | 0 | |
| LEONABIO INC | COMM | 04746L203 | 1,371,874 | 149,279 | SH | DFND | 1 | 0 | 149,279 | 0 | |
| CELLDEX THERAPEUTICS INC | COMM | 15117B202 | 3,858,491 | 103,695 | SH | DFND | 1 | 50,561 | 53,134 | 0 | |
| COMPASS PATHWAYS PLC | ADRS | 20451W101 | 8,109,167 | 573,086 | SH | DFND | 1 | 458,805 | 114,281 | 0 | |
| DELCATH SYSTEMS INC | COMM | 24661P807 | 10,971,681 | 871,460 | SH | DFND | 1 | 610,334 | 261,126 | 0 | |
| EYEPOINT INC | COMM | 30233G209 | 2,741,954 | 191,745 | SH | DFND | 1 | 146,336 | 45,409 | 0 | |
| IMMUNIC INC | COMM | 4525EP200 | 4,995,588 | 325,022 | SH | DFND | 1 | 294,297 | 30,725 | 0 | |
| INVENTIVA SA - ADR | COMM | 46124U107 | 4,842,981 | 1,281,212 | SH | DFND | 1 | 967,729 | 313,483 | 0 | |
| MILESTONE PHARMACEUTICALS | COMM | 59935V107 | 9,955,651 | 7,429,590 | SH | DFND | 1 | 4,080,211 | 3,349,379 | 0 | |
| OCULAR THERAPEUTIX INC | COMM | 67576A100 | 3,515,226 | 357,966 | SH | DFND | 1 | 276,915 | 81,051 | 0 | |
| ORCHESTRA BIOMED HOLDINGS | COMM | 68572M106 | 3,869,265 | 896,701 | SH | DFND | 1 | 677,314 | 219,387 | 0 | |
| PHATHOM PHARMACEUTICALS I | COMM | 71722W107 | 11,396,384 | 1,050,358 | SH | DFND | 1 | 801,091 | 249,267 | 0 | |
| PLAINS GP HOLDINGS LP-CL | COMM | 72651A207 | 30,880,177 | 1,272,360 | SH | DFND | 1 | 0 | 1,272,360 | 0 | |
| SAB BIOTHERAPEUTICS INC | COMM | 78397T202 | 4,198,654 | 1,076,578 | SH | DFND | 1 | 971,729 | 104,849 | 0 | |
| SILENCE THERAPEUTICS PLC | ADRS | 82686Q101 | 2,105,228 | 191,733 | SH | DFND | 1 | 191,733 | 0 | 0 | |
| UPSTREAM BIO INC | COMM | 91678A107 | 2,424,692 | 350,389 | SH | DFND | 1 | 288,276 | 62,113 | 0 | |