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  <xs:element id="ovid_ClassOfWarrantOrRightPurchasedDuringPeriod" abstract="false" name="ClassOfWarrantOrRightPurchasedDuringPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="ovid_ClassOfWarrantsOrRightsWarrantsReclassified" abstract="false" name="ClassOfWarrantsOrRightsWarrantsReclassified" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="ovid_ClassOfWarrantOrRightAggregateIntrinsicValue" abstract="false" name="ClassOfWarrantOrRightAggregateIntrinsicValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ovid_TwoThousandSeventeenEquityIncentivePlanMember" abstract="true" name="TwoThousandSeventeenEquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_TwoThousandSeventeenEmployeeStockPurchasePlanMember" abstract="true" name="TwoThousandSeventeenEmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_TwoThousandFourteenEquityIncentivePlanMember" abstract="true" name="TwoThousandFourteenEquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfOutstandingStockMaximumIncrease" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfOutstandingStockMaximumIncrease" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="ovid_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorizedMaximum" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorizedMaximum" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="ovid_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExtensionOfExercisableTermDueToDeath" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExtensionOfExercisableTermDueToDeath" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="ovid_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExtensionOfExercisableTermDueToDisability" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExtensionOfExercisableTermDueToDisability" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="ovid_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExtensionOfExercisableTermDueToDeathOrDisability" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExtensionOfExercisableTermDueToDeathOrDisability" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="ovid_ShareBasedPaymentArrangementOptionAndRSUMember" abstract="true" name="ShareBasedPaymentArrangementOptionAndRSUMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_EmployeeStockPurchasePlanMember" abstract="true" name="EmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_NorthwesternUniversityMember" abstract="true" name="NorthwesternUniversityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_AstrazenecaMember" abstract="true" name="AstrazenecaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_GensaicIncMember" abstract="true" name="GensaicIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_LicenseAgreementMember" abstract="true" name="LicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_UpfrontNonCreditableOneTimeLicenseIssuanceFeePayment" abstract="false" name="UpfrontNonCreditableOneTimeLicenseIssuanceFeePayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ovid_AnnualLicenseMaintenanceFeePayable" abstract="false" name="AnnualLicenseMaintenanceFeePayable" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ovid_ConsiderationPayableForRightsGrant" abstract="false" name="ConsiderationPayableForRightsGrant" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ovid_RoyaltyObligationTerm" abstract="false" name="RoyaltyObligationTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="ovid_MinimumNumberOfProductCoveredUnderLicenseAgreement" abstract="false" name="MinimumNumberOfProductCoveredUnderLicenseAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="ovid_UpfrontCashPayment" abstract="false" name="UpfrontCashPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ovid_CommonStockIssuancePeriodImmediatelyPrecedingExecutionDate" abstract="false" name="CommonStockIssuancePeriodImmediatelyPrecedingExecutionDate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="ovid_LicenseAgreementMilestonePayments" abstract="false" name="LicenseAgreementMilestonePayments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ovid_FirstPaymentDueUponCompletionOfFirstPhase" abstract="false" name="FirstPaymentDueUponCompletionOfFirstPhase" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ovid_CollaborationAndOptionAgreementResearchPlanAndBudgetExpectedCosts" abstract="false" name="CollaborationAndOptionAgreementResearchPlanAndBudgetExpectedCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ovid_LicenseAgreementDevelopmentMilestoneApprovalsProductThreshold" abstract="false" name="LicenseAgreementDevelopmentMilestoneApprovalsProductThreshold" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="ovid_LicenseAgreementTerminationAdvanceNoticePeriod" abstract="false" name="LicenseAgreementTerminationAdvanceNoticePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="ovid_CollaborationAndOptionAgreementResearchPlanAndBudgetAmountRemaining" abstract="false" name="CollaborationAndOptionAgreementResearchPlanAndBudgetAmountRemaining" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ovid_TakedaPharmaceuticalCompanyLimitedMember" abstract="true" name="TakedaPharmaceuticalCompanyLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_MarinusPharmaceuticalsIncMember" abstract="true" name="MarinusPharmaceuticalsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_GravitonBioscienceCorporationMember" abstract="true" name="GravitonBioscienceCorporationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_SeriesSeedConvertiblePreferredStockMember" abstract="true" name="SeriesSeedConvertiblePreferredStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_RoyaltyLicensingAndTerminationAgreementRightsSoldOrLicensedToCounterpartyPercentageOfGlobalRights" abstract="false" name="RoyaltyLicensingAndTerminationAgreementRightsSoldOrLicensedToCounterpartyPercentageOfGlobalRights" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="ovid_RevenueRemainingPerformanceObligationVariableConsiderationAmount" abstract="false" name="RevenueRemainingPerformanceObligationVariableConsiderationAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ovid_RoyaltyRevenueUponRegulatoryApprovalPercentageOfSalesMaximum" abstract="false" name="RoyaltyRevenueUponRegulatoryApprovalPercentageOfSalesMaximum" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="ovid_PercentageOfPotentialRoyalties" abstract="false" name="PercentageOfPotentialRoyalties" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="ovid_UpfrontPaymentNumberOfSharesReceivedAsPaymentIntellectualPropertyAssignmentAgreement" abstract="false" name="UpfrontPaymentNumberOfSharesReceivedAsPaymentIntellectualPropertyAssignmentAgreement" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="ovid_IntellectualPropertyRightsAssignmentAgreementMinimumBeneficialOwnershipPercentage" abstract="false" name="IntellectualPropertyRightsAssignmentAgreementMinimumBeneficialOwnershipPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="ovid_IntellectualPropertyRightsAssignmentAgreementMinimumBeneficialOwnershipPercentageExpirationThresholdAntidilutionRight" abstract="false" name="IntellectualPropertyRightsAssignmentAgreementMinimumBeneficialOwnershipPercentageExpirationThresholdAntidilutionRight" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="ovid_IntellectualPropertyRightsAssignmentAgreementMinimumEquitySalesByInvesteeExpirationThresholdAntidilutionRight" abstract="false" name="IntellectualPropertyRightsAssignmentAgreementMinimumEquitySalesByInvesteeExpirationThresholdAntidilutionRight" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ovid_ContractWithCustomerAssetPotentialDevelopmentMilestonePaymentsMaximum" abstract="false" name="ContractWithCustomerAssetPotentialDevelopmentMilestonePaymentsMaximum" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ovid_ContractWithCustomerAssetPotentialSalesMilestonePaymentsMaximum" abstract="false" name="ContractWithCustomerAssetPotentialSalesMilestonePaymentsMaximum" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ovid_ExecutiveChairMember" abstract="true" name="ExecutiveChairMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_OV329Member" abstract="true" name="OV329Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_OV4071Member" abstract="true" name="OV4071Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_KCC2LibraryMember" abstract="true" name="KCC2LibraryMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_OV888GV101Member" abstract="true" name="OV888GV101Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_OtherProgramsMember" abstract="true" name="OtherProgramsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ovid_GeneralOfficeExpenses" abstract="false" name="GeneralOfficeExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ovid_GainOnRecoveryOfFraudulentFundsTransfer" abstract="false" name="GainOnRecoveryOfFraudulentFundsTransfer" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
