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  <xs:element id="vyne_ShareOptionsRSUsAndSharesUnderESPPMember" abstract="true" name="ShareOptionsRSUsAndSharesUnderESPPMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vyne_MSTFranchiseMember" abstract="true" name="MSTFranchiseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vyne_DiscontinuedOperationsNonCashItemsAmount" abstract="false" name="DiscontinuedOperationsNonCashItemsAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vyne_CowenSalesAgreementMember" abstract="true" name="CowenSalesAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vyne_PreFundedWarrantsMember" abstract="true" name="PreFundedWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vyne_CommonStockVotingRightsNumberPerShare" abstract="false" name="CommonStockVotingRightsNumberPerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="vyne_CommissionFromGrossProceedsFromIssuanceOfCommonStock" abstract="false" name="CommissionFromGrossProceedsFromIssuanceOfCommonStock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="vyne_PeriodForNoticeOfIncreaseDecreaseToBeneficialOwnershipLimitation" abstract="false" name="PeriodForNoticeOfIncreaseDecreaseToBeneficialOwnershipLimitation" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="vyne_CommonStockMaximumBeneficialOwnershipByHolderPercent" abstract="false" name="CommonStockMaximumBeneficialOwnershipByHolderPercent" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="vyne_WarrantsExercised" abstract="false" name="WarrantsExercised" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="vyne_A2023PlanMember" abstract="true" name="A2023PlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vyne_A2024InducementPlanMember" abstract="true" name="A2024InducementPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vyne_EmployeeStockPurchasePlanMember" abstract="true" name="EmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vyne_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAvailableForGrant" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAvailableForGrant" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="vyne_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesForfeited" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesForfeited" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="vyne_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAndEquityInstrumentsOtherThanOptionsGrantsInPeriodTotalGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAndEquityInstrumentsOtherThanOptionsGrantsInPeriodTotalGrantDateFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vyne_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vyne_RepibresibVYN201Member" abstract="true" name="RepibresibVYN201Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vyne_ResearchAndDevelopmentOfVYN202Member" abstract="true" name="ResearchAndDevelopmentOfVYN202Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vyne_A2026PlanMember" abstract="true" name="A2026PlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="vyne_ClassOfRightOrWarrantNumberTerminated" abstract="false" name="ClassOfRightOrWarrantNumberTerminated" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="vyne_CashPaymentsOnWarrants" abstract="false" name="CashPaymentsOnWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="vyne_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIncreasePercentage" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIncreasePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
</xs:schema>
