<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019fd276-22e0-751b-85e7-c5d58d01810d,g:428ccc5b-7c73-4bf2-8d01-310183e508e1-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://pelthos.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="pths-20260331.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019fd276-249e-767a-a939-8dff5be43318" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019fd276-249e-777f-bab3-2f603402694e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd276-249e-767a-a939-8dff5be43318" xlink:to="loc_us-gaap_AccountsPayableCurrent_019fd276-249e-777f-bab3-2f603402694e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019fd276-249e-76f4-80c0-96983e591a76" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd276-249e-767a-a939-8dff5be43318" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_019fd276-249e-76f4-80c0-96983e591a76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionContingentConsiderationLiabilityCurrent_019fd276-249e-75a9-bdba-4066cd283fbb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionContingentConsiderationLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd276-249e-767a-a939-8dff5be43318" xlink:to="loc_us-gaap_AssetAcquisitionContingentConsiderationLiabilityCurrent_019fd276-249e-75a9-bdba-4066cd283fbb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019fd276-249e-7325-8118-15dddd644103" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd276-249e-767a-a939-8dff5be43318" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019fd276-249e-7325-8118-15dddd644103" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019fd276-249e-714e-8a94-8f0a77490caf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd276-249e-767a-a939-8dff5be43318" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019fd276-249e-714e-8a94-8f0a77490caf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019fd276-249e-7f43-b7d3-3024607b8dde" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019fd276-249e-767a-a939-8dff5be43318" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_019fd276-249e-7f43-b7d3-3024607b8dde" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019fd276-249e-7549-b316-2c0891e3f9b2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019fd276-249e-7593-8ff8-3f7a44787892" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fd276-249e-7549-b316-2c0891e3f9b2" xlink:to="loc_us-gaap_LiabilitiesCurrent_019fd276-249e-7593-8ff8-3f7a44787892" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019fd276-249e-7d7c-b91b-e310a31de686" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fd276-249e-7549-b316-2c0891e3f9b2" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019fd276-249e-7d7c-b91b-e310a31de686" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredLongTermDebt_019fd276-249e-7f23-8810-0496ba2ab368" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SecuredLongTermDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fd276-249e-7549-b316-2c0891e3f9b2" xlink:to="loc_us-gaap_SecuredLongTermDebt_019fd276-249e-7f23-8810-0496ba2ab368" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_019fd276-249e-70c6-9ead-59a12965afbd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fd276-249e-7549-b316-2c0891e3f9b2" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_019fd276-249e-70c6-9ead-59a12965afbd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtNoncurrent_019fd276-249e-7918-b45f-031c66204dcc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConvertibleDebtNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fd276-249e-7549-b316-2c0891e3f9b2" xlink:to="loc_us-gaap_ConvertibleDebtNoncurrent_019fd276-249e-7918-b45f-031c66204dcc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019fd276-249e-70be-935e-2a99935fb819" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019fd276-249e-7549-b316-2c0891e3f9b2" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019fd276-249e-70be-935e-2a99935fb819" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019fd276-249e-78a2-9dd3-aabcc3d3d604" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019fd276-249e-7c12-9956-b4f9af1e773b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd276-249e-78a2-9dd3-aabcc3d3d604" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019fd276-249e-7c12-9956-b4f9af1e773b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashCurrent_019fd276-249e-7d3e-a7ae-f7d9bd4f5f6d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd276-249e-78a2-9dd3-aabcc3d3d604" xlink:to="loc_us-gaap_RestrictedCashCurrent_019fd276-249e-7d3e-a7ae-f7d9bd4f5f6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019fd276-249e-7daa-a41b-258168a15795" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd276-249e-78a2-9dd3-aabcc3d3d604" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019fd276-249e-7daa-a41b-258168a15795" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019fd276-249e-720e-acc2-867b0db89a0e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd276-249e-78a2-9dd3-aabcc3d3d604" xlink:to="loc_us-gaap_InventoryNet_019fd276-249e-720e-acc2-867b0db89a0e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd276-249e-7070-b2e6-7d9c5e8c6315" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019fd276-249e-78a2-9dd3-aabcc3d3d604" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd276-249e-7070-b2e6-7d9c5e8c6315" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019fd276-249e-73d2-b97e-d79b26b90428" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019fd276-249e-763b-b1af-8ce5c8353cac" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd276-249e-73d2-b97e-d79b26b90428" xlink:to="loc_us-gaap_PreferredStockValue_019fd276-249e-763b-b1af-8ce5c8353cac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019fd276-249e-7f61-a757-b02d9031e6d8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd276-249e-73d2-b97e-d79b26b90428" xlink:to="loc_us-gaap_CommonStockValue_019fd276-249e-7f61-a757-b02d9031e6d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_019fd276-249e-7c8a-94e7-c5cc0832f19c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd276-249e-73d2-b97e-d79b26b90428" xlink:to="loc_us-gaap_AdditionalPaidInCapital_019fd276-249e-7c8a-94e7-c5cc0832f19c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019fd276-249e-7113-93db-7a9b4d98a24c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd276-249e-73d2-b97e-d79b26b90428" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019fd276-249e-7113-93db-7a9b4d98a24c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019fd276-249e-7bd2-a5ad-cf096fc0b4db" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019fd276-249e-73d2-b97e-d79b26b90428" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019fd276-249e-7bd2-a5ad-cf096fc0b4db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019fd276-249e-79a0-b198-d2ee88abfc79" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019fd276-249e-7154-87fa-3b686c37e8e4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd276-249e-79a0-b198-d2ee88abfc79" xlink:to="loc_us-gaap_AssetsCurrent_019fd276-249e-7154-87fa-3b686c37e8e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019fd276-249e-7022-9938-27d5d71c76e6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd276-249e-79a0-b198-d2ee88abfc79" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019fd276-249e-7022-9938-27d5d71c76e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019fd276-249e-7c49-932c-88dcd26372db" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd276-249e-79a0-b198-d2ee88abfc79" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019fd276-249e-7c49-932c-88dcd26372db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd276-249e-79e1-8470-70c0c08de6f7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd276-249e-79a0-b198-d2ee88abfc79" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd276-249e-79e1-8470-70c0c08de6f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019fd276-249e-75fb-9f1b-e2e16bbff433" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019fd276-249e-79a0-b198-d2ee88abfc79" xlink:to="loc_us-gaap_Goodwill_019fd276-249e-75fb-9f1b-e2e16bbff433" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd276-249e-78d8-a76d-24ed9083c108" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019fd276-249e-7a8c-a1d0-3f33ecf45969" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd276-249e-78d8-a76d-24ed9083c108" xlink:to="loc_us-gaap_Liabilities_019fd276-249e-7a8c-a1d0-3f33ecf45969" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019fd276-249e-7473-931a-2ec6afe5347b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd276-249e-78d8-a76d-24ed9083c108" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019fd276-249e-7473-931a-2ec6afe5347b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019fd276-249e-703a-8e39-2712b32e2242" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019fd276-249e-78d8-a76d-24ed9083c108" xlink:to="loc_us-gaap_StockholdersEquity_019fd276-249e-703a-8e39-2712b32e2242" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS" xlink:type="simple" xlink:href="pths-20260331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019fd276-249e-7298-9914-ab994d58b457" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019fd276-249e-717e-a3c0-09bc16a6f69b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019fd276-249e-7298-9914-ab994d58b457" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019fd276-249e-717e-a3c0-09bc16a6f69b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019fd276-249e-7e33-993b-77a3ef6d91d8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019fd276-249e-7298-9914-ab994d58b457" xlink:to="loc_us-gaap_NetIncomeLoss_019fd276-249e-7e33-993b-77a3ef6d91d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd276-249e-7916-aa7f-547641e005d8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019fd276-249e-766e-82fb-0fe21f85f3ed" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd276-249e-7916-aa7f-547641e005d8" xlink:to="loc_us-gaap_OperatingIncomeLoss_019fd276-249e-766e-82fb-0fe21f85f3ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019fd276-249e-7c4a-8d4b-45164cf934e8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd276-249e-7916-aa7f-547641e005d8" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019fd276-249e-7c4a-8d4b-45164cf934e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_019fd276-249e-7bdc-92a8-3af5c6ab7072" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019fd276-249e-7b1d-ab3d-127e70292987" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019fd276-249e-7bdc-92a8-3af5c6ab7072" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019fd276-249e-7b1d-ab3d-127e70292987" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fd276-249e-7f82-8ef3-a33a3476a4a4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019fd276-249e-7bdc-92a8-3af5c6ab7072" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019fd276-249e-7f82-8ef3-a33a3476a4a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019fd276-249e-718d-83c2-11ad45c954bd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019fd276-249e-7bdc-92a8-3af5c6ab7072" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019fd276-249e-718d-83c2-11ad45c954bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019fd276-249e-7b2a-9e48-e5a1fdf6d1a8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019fd276-249e-7bdc-92a8-3af5c6ab7072" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019fd276-249e-7b2a-9e48-e5a1fdf6d1a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019fd276-249e-7886-a249-e06f9a3ce16d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019fd276-249e-7ede-93fc-a17954c1df2c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019fd276-249e-7886-a249-e06f9a3ce16d" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019fd276-249e-7ede-93fc-a17954c1df2c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_ChangeInFairValueOfConvertibleDebt_019fd276-249e-7ba8-8473-2331eae39cf1" xlink:href="pths-20260331.xsd#pths_ChangeInFairValueOfConvertibleDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019fd276-249e-7886-a249-e06f9a3ce16d" xlink:to="loc_pths_ChangeInFairValueOfConvertibleDebt_019fd276-249e-7ba8-8473-2331eae39cf1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019fd276-249e-7075-b771-98d59f91bad2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd276-249e-75be-83ad-4eb25016743e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019fd276-249e-7075-b771-98d59f91bad2" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019fd276-249e-75be-83ad-4eb25016743e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019fd276-249e-75dc-9c7a-f31e75ccc7ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019fd276-249e-7075-b771-98d59f91bad2" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019fd276-249e-75dc-9c7a-f31e75ccc7ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019fd276-249e-7da0-95db-e6f0fa3c4370" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019fd276-249e-70a1-a89d-c735530ed47e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fd276-249e-7da0-95db-e6f0fa3c4370" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019fd276-249e-70a1-a89d-c735530ed47e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_019fd276-249e-77cd-bbf8-17fa6fddd819" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019fd276-249e-7da0-95db-e6f0fa3c4370" xlink:to="loc_us-gaap_CostsAndExpenses_019fd276-249e-77cd-bbf8-17fa6fddd819" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="pths-20260331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_019fd276-249e-79e4-a53d-292b749d2b5a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019fd276-249e-74a0-b272-3d4aea40c4cf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_019fd276-249e-79e4-a53d-292b749d2b5a" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019fd276-249e-74a0-b272-3d4aea40c4cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashCurrent_019fd276-249e-7eba-90f7-f94d8680431d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_019fd276-249e-79e4-a53d-292b749d2b5a" xlink:to="loc_us-gaap_RestrictedCashCurrent_019fd276-249e-7eba-90f7-f94d8680431d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd276-249e-7a96-8fa1-8d8944e9a776" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019fd276-249e-7d5f-b946-52c353c59911" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd276-249e-7a96-8fa1-8d8944e9a776" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019fd276-249e-7d5f-b946-52c353c59911" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_019fd276-249e-7b70-9e9b-d09d40577c60" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-723a-b8d5-8490667ebadc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_019fd276-249e-7b70-9e9b-d09d40577c60" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-723a-b8d5-8490667ebadc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd276-249e-72f3-a212-580b3e215533" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_019fd276-249e-7b70-9e9b-d09d40577c60" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019fd276-249e-72f3-a212-580b3e215533" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd276-249e-7ae0-ba11-e91b605acd84" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_019fd276-249e-7b70-9e9b-d09d40577c60" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd276-249e-7ae0-ba11-e91b605acd84" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019fd276-249e-7d93-8fd2-d52630308d2f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:to="loc_us-gaap_NetIncomeLoss_019fd276-249e-7d93-8fd2-d52630308d2f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionExpense_019fd276-249e-7dd0-9b13-8aba534225fd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccretionExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:to="loc_us-gaap_AccretionExpense_019fd276-249e-7dd0-9b13-8aba534225fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_ChangeInFairValueOfConvertibleDebt_019fd276-249e-7ba5-b518-cf3572fe3820" xlink:href="pths-20260331.xsd#pths_ChangeInFairValueOfConvertibleDebt"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:to="loc_pths_ChangeInFairValueOfConvertibleDebt_019fd276-249e-7ba5-b518-cf3572fe3820" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_019fd276-249e-702e-9ce6-dc38f74f6bb5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:to="loc_us-gaap_Depreciation_019fd276-249e-702e-9ce6-dc38f74f6bb5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019fd276-249e-7f11-abea-64017add01c0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019fd276-249e-7f11-abea-64017add01c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_019fd276-249e-7820-b6fb-eace79f023a2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfDebtDiscountPremium"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_019fd276-249e-7820-b6fb-eace79f023a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019fd276-249e-75b9-9fb8-a5727155a420" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019fd276-249e-75b9-9fb8-a5727155a420" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019fd276-249e-71b5-8f65-f4f061be4692" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:to="loc_us-gaap_ShareBasedCompensation_019fd276-249e-71b5-8f65-f4f061be4692" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019fd276-249e-71c4-a61d-860192027e24" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019fd276-249e-71c4-a61d-860192027e24" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019fd276-249e-70cd-8fe5-7e81155e7acb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019fd276-249e-70cd-8fe5-7e81155e7acb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidExpense_019fd276-249e-75aa-883b-3e47980b5c4f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInPrepaidExpense"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidExpense_019fd276-249e-75aa-883b-3e47980b5c4f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_IncreaseDecreaseInOperatingLeaseRightOfUseAssets_019fd276-249e-7181-886a-4f23549faec8" xlink:href="pths-20260331.xsd#pths_IncreaseDecreaseInOperatingLeaseRightOfUseAssets"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:to="loc_pths_IncreaseDecreaseInOperatingLeaseRightOfUseAssets_019fd276-249e-7181-886a-4f23549faec8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019fd276-249e-79c7-9c9b-fe5349f7bfe7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019fd276-249e-79c7-9c9b-fe5349f7bfe7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_019fd276-249e-75fd-abec-358b1741adce" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_019fd276-249e-75fd-abec-358b1741adce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_AssetAcquisitionContingentConsiderationChangeInContingentConsiderationLiabilityIncreaseDecrease_019fd276-249e-7a0e-980b-f831073f0d22" xlink:href="pths-20260331.xsd#pths_AssetAcquisitionContingentConsiderationChangeInContingentConsiderationLiabilityIncreaseDecrease"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:to="loc_pths_AssetAcquisitionContingentConsiderationChangeInContingentConsiderationLiabilityIncreaseDecrease_019fd276-249e-7a0e-980b-f831073f0d22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019fd276-249e-7d0a-9eb9-e2925056018b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019fd276-249e-7d0a-9eb9-e2925056018b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_019fd276-249e-7626-b7c6-8e099058c9fe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019fd276-249e-70cf-ab9f-e6f470dd8bdb" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_019fd276-249e-7626-b7c6-8e099058c9fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd276-249e-7782-b9d4-3251a82ef88a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSecuredDebt_019fd276-249e-7ac4-b3ec-326300e5be1e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromIssuanceOfSecuredDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd276-249e-7782-b9d4-3251a82ef88a" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSecuredDebt_019fd276-249e-7ac4-b3ec-326300e5be1e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDebtNetOfIssuanceCosts_019fd276-249e-7450-b826-cff496ed8409" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromDebtNetOfIssuanceCosts"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd276-249e-7782-b9d4-3251a82ef88a" xlink:to="loc_us-gaap_ProceedsFromDebtNetOfIssuanceCosts_019fd276-249e-7450-b826-cff496ed8409" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_019fd276-249e-73fa-91f3-a45fe6dbc1eb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019fd276-249e-7782-b9d4-3251a82ef88a" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_019fd276-249e-73fa-91f3-a45fe6dbc1eb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/ACQUISITIONOFLNHCINCScheduleofTangibleandIntangibleAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="simple" xlink:href="pths-20260331.xsd#ACQUISITIONOFLNHCINCScheduleofTangibleandIntangibleAssetsAcquiredandLiabilitiesAssumedDetails"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/ACQUISITIONOFLNHCINCScheduleofTangibleandIntangibleAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_019fd276-253e-7b5c-8624-957689e59dec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_019fd276-253e-7b5c-8624-957689e59dec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_019fd276-253e-7bd7-bb55-48177cb44d8b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_019fd276-253e-7bd7-bb55-48177cb44d8b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_019fd276-253e-77e0-8ef8-e44dc8f5210c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_019fd276-253e-77e0-8ef8-e44dc8f5210c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_019fd276-253e-763f-a784-349fca7190d0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_019fd276-253e-763f-a784-349fca7190d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_019fd276-253e-7391-acf8-83a825ded9e3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_019fd276-253e-7391-acf8-83a825ded9e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_019fd276-253e-7e18-8215-409b8c080345" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_019fd276-253e-7e18-8215-409b8c080345" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_BusinessCombinationRecognizedAssetsAcquiredOperatingLeaseRightOfUseAssets_019fd276-253e-765c-9458-f5ace808312c" xlink:href="pths-20260331.xsd#pths_BusinessCombinationRecognizedAssetsAcquiredOperatingLeaseRightOfUseAssets"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:to="loc_pths_BusinessCombinationRecognizedAssetsAcquiredOperatingLeaseRightOfUseAssets_019fd276-253e-765c-9458-f5ace808312c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_019fd276-253e-7d23-900f-c3a7d2f6c6b4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_019fd276-253e-7d23-900f-c3a7d2f6c6b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_019fd276-253e-7964-82f7-5df4af92618a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_019fd276-253e-7964-82f7-5df4af92618a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_BusinessCombinationRecognizedLiabilityAssumedAccruedLiabilitiesCurrent_019fd276-253e-7a79-a6d6-75d89ec35578" xlink:href="pths-20260331.xsd#pths_BusinessCombinationRecognizedLiabilityAssumedAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:to="loc_pths_BusinessCombinationRecognizedLiabilityAssumedAccruedLiabilitiesCurrent_019fd276-253e-7a79-a6d6-75d89ec35578" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesLongTermDebt_019fd276-253e-7aef-b344-0c9488ecb2b8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesLongTermDebt"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesLongTermDebt_019fd276-253e-7aef-b344-0c9488ecb2b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue_019fd276-253e-7d0e-9bc5-93ebaf483661" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue_019fd276-253e-7d0e-9bc5-93ebaf483661" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_BusinessCombinationRecognizedLiabilityAssumedOperatingLeaseLiabilitiesCurrent_019fd276-253e-76ec-bd9b-c1380923fda0" xlink:href="pths-20260331.xsd#pths_BusinessCombinationRecognizedLiabilityAssumedOperatingLeaseLiabilitiesCurrent"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:to="loc_pths_BusinessCombinationRecognizedLiabilityAssumedOperatingLeaseLiabilitiesCurrent_019fd276-253e-76ec-bd9b-c1380923fda0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_BusinessCombinationRecognizedLiabilityAssumedDeferredRevenueLongTermPortion_019fd276-253e-7c23-83ea-6d5cd03e18f0" xlink:href="pths-20260331.xsd#pths_BusinessCombinationRecognizedLiabilityAssumedDeferredRevenueLongTermPortion"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:to="loc_pths_BusinessCombinationRecognizedLiabilityAssumedDeferredRevenueLongTermPortion_019fd276-253e-7c23-83ea-6d5cd03e18f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_BusinessCombinationRecognizedLiabilityAssumedOperatingLeaseLiabilitiesNoncurrent_019fd276-253e-78fe-ac5d-4e0c97df3eb5" xlink:href="pths-20260331.xsd#pths_BusinessCombinationRecognizedLiabilityAssumedOperatingLeaseLiabilitiesNoncurrent"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:to="loc_pths_BusinessCombinationRecognizedLiabilityAssumedOperatingLeaseLiabilitiesNoncurrent_019fd276-253e-78fe-ac5d-4e0c97df3eb5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_019fd276-253e-7cdb-934b-a4a3179ad482" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities"/>
    <link:calculationArc order="16" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_019fd276-253e-7cdb-934b-a4a3179ad482" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_019fd276-253e-7f19-80a3-f218e8245a6d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther"/>
    <link:calculationArc order="17" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-7d61-9124-b1cdc0dd8f14" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_019fd276-253e-7f19-80a3-f218e8245a6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_019fd276-253e-7d24-a683-519cfc4fb67c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-773f-ba12-66933db17670" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_019fd276-253e-7d24-a683-519cfc4fb67c" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019fd276-253e-773f-ba12-66933db17670" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019fd276-253e-78e8-97b7-40fe3134e130" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_019fd276-253e-7d24-a683-519cfc4fb67c" xlink:to="loc_us-gaap_Goodwill_019fd276-253e-78e8-97b7-40fe3134e130" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/BALANCESHEETACCOUNTDETAILSScheduleofPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="pths-20260331.xsd#BALANCESHEETACCOUNTDETAILSScheduleofPrepaidExpensesandOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/BALANCESHEETACCOUNTDETAILSScheduleofPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd276-253e-77b8-baf4-1df4d5169b97" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_PrepaidPrescriptionDrugUserFeeActFeesCurrent_019fd276-253e-7fb6-b2f9-593c3707a9d0" xlink:href="pths-20260331.xsd#pths_PrepaidPrescriptionDrugUserFeeActFeesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd276-253e-77b8-baf4-1df4d5169b97" xlink:to="loc_pths_PrepaidPrescriptionDrugUserFeeActFeesCurrent_019fd276-253e-7fb6-b2f9-593c3707a9d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidInsurance_019fd276-253e-7913-b6bd-06a12817ddb4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidInsurance"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd276-253e-77b8-baf4-1df4d5169b97" xlink:to="loc_us-gaap_PrepaidInsurance_019fd276-253e-7913-b6bd-06a12817ddb4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsAssetsCurrent_019fd276-253e-7f3a-936c-3015da9fe55a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DepositsAssetsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd276-253e-77b8-baf4-1df4d5169b97" xlink:to="loc_us-gaap_DepositsAssetsCurrent_019fd276-253e-7f3a-936c-3015da9fe55a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_CommercialDataPlatformsCurrent_019fd276-253e-77c1-ba20-24861305726d" xlink:href="pths-20260331.xsd#pths_CommercialDataPlatformsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd276-253e-77b8-baf4-1df4d5169b97" xlink:to="loc_pths_CommercialDataPlatformsCurrent_019fd276-253e-77c1-ba20-24861305726d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_PatientAssistancePlatformsCurrent_019fd276-253e-7219-a976-d0796b1f68b1" xlink:href="pths-20260331.xsd#pths_PatientAssistancePlatformsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd276-253e-77b8-baf4-1df4d5169b97" xlink:to="loc_pths_PatientAssistancePlatformsCurrent_019fd276-253e-7219-a976-d0796b1f68b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_FinancialReportingPlatformsCurrent_019fd276-253e-7110-a367-1f282c7d4955" xlink:href="pths-20260331.xsd#pths_FinancialReportingPlatformsCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd276-253e-77b8-baf4-1df4d5169b97" xlink:to="loc_pths_FinancialReportingPlatformsCurrent_019fd276-253e-7110-a367-1f282c7d4955" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredOfferingCosts_019fd276-253e-7055-8021-c566fa296650" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredOfferingCosts"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd276-253e-77b8-baf4-1df4d5169b97" xlink:to="loc_us-gaap_DeferredOfferingCosts_019fd276-253e-7055-8021-c566fa296650" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_OtherPrepaidExpensesAndOtherCurrentAssetsCurrent_019fd276-253e-7437-8a34-34a4610bf6c3" xlink:href="pths-20260331.xsd#pths_OtherPrepaidExpensesAndOtherCurrentAssetsCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019fd276-253e-77b8-baf4-1df4d5169b97" xlink:to="loc_pths_OtherPrepaidExpensesAndOtherCurrentAssetsCurrent_019fd276-253e-7437-8a34-34a4610bf6c3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/BALANCESHEETACCOUNTDETAILSScheduleofInventoryDetails" xlink:type="simple" xlink:href="pths-20260331.xsd#BALANCESHEETACCOUNTDETAILSScheduleofInventoryDetails"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/BALANCESHEETACCOUNTDETAILSScheduleofInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019fd276-253e-7462-8b16-5db4803c0b47" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019fd276-253e-7303-95d1-c051dd84719b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019fd276-253e-7462-8b16-5db4803c0b47" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019fd276-253e-7303-95d1-c051dd84719b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019fd276-253e-7d4d-ab9a-84400307e4ad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019fd276-253e-7462-8b16-5db4803c0b47" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019fd276-253e-7d4d-ab9a-84400307e4ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019fd276-253e-7e07-8b53-74a7b5cecb55" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019fd276-253e-7462-8b16-5db4803c0b47" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019fd276-253e-7e07-8b53-74a7b5cecb55" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/BALANCESHEETACCOUNTDETAILSScheduleofPropertyPlantandEquipmentDetails" xlink:type="simple" xlink:href="pths-20260331.xsd#BALANCESHEETACCOUNTDETAILSScheduleofPropertyPlantandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/BALANCESHEETACCOUNTDETAILSScheduleofPropertyPlantandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019fd276-253e-70b9-8d2a-cd117e2101b6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_019fd276-253e-7299-ae5c-353d583b59e1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019fd276-253e-70b9-8d2a-cd117e2101b6" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_019fd276-253e-7299-ae5c-353d583b59e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019fd276-253e-7f12-ae02-5a3040e7567a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019fd276-253e-70b9-8d2a-cd117e2101b6" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019fd276-253e-7f12-ae02-5a3040e7567a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/BALANCESHEETACCOUNTDETAILSScheduleofIntangibleAssetsandGoodwillDetails" xlink:type="simple" xlink:href="pths-20260331.xsd#BALANCESHEETACCOUNTDETAILSScheduleofIntangibleAssetsandGoodwillDetails"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/BALANCESHEETACCOUNTDETAILSScheduleofIntangibleAssetsandGoodwillDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_019fd276-253e-76eb-8e7d-8ed7e3dcbfc5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd276-253e-7893-ba87-52a0bee1d730" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_019fd276-253e-76eb-8e7d-8ed7e3dcbfc5" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd276-253e-7893-ba87-52a0bee1d730" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019fd276-253e-788c-87e4-2924ffddd3fa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_019fd276-253e-76eb-8e7d-8ed7e3dcbfc5" xlink:to="loc_us-gaap_Goodwill_019fd276-253e-788c-87e4-2924ffddd3fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd276-253e-7038-94c9-34d99c884cf3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019fd276-253e-7a11-8c3b-069c3a1ac549" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd276-253e-7038-94c9-34d99c884cf3" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019fd276-253e-7a11-8c3b-069c3a1ac549" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019fd276-253e-7464-8370-1716d0598894" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd276-253e-7038-94c9-34d99c884cf3" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019fd276-253e-7464-8370-1716d0598894" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/BALANCESHEETACCOUNTDETAILSScheduleofAccruedLiabilitiesDetails" xlink:type="simple" xlink:href="pths-20260331.xsd#BALANCESHEETACCOUNTDETAILSScheduleofAccruedLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/BALANCESHEETACCOUNTDETAILSScheduleofAccruedLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019fd276-253e-7a6d-8705-850643107d07" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019fd276-253e-7a72-94d1-23ab76c97cc5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019fd276-253e-7a6d-8705-850643107d07" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019fd276-253e-7a72-94d1-23ab76c97cc5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_DrugProductManufacturingSubcontractorCurrent_019fd276-253e-72fe-9afe-09a2029c29d7" xlink:href="pths-20260331.xsd#pths_DrugProductManufacturingSubcontractorCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019fd276-253e-7a6d-8705-850643107d07" xlink:to="loc_pths_DrugProductManufacturingSubcontractorCurrent_019fd276-253e-72fe-9afe-09a2029c29d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_PDUFAFeeCurrent_019fd276-253e-7195-89e2-d15bae8fd986" xlink:href="pths-20260331.xsd#pths_PDUFAFeeCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019fd276-253e-7a6d-8705-850643107d07" xlink:to="loc_pths_PDUFAFeeCurrent_019fd276-253e-7195-89e2-d15bae8fd986" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedInsuranceCurrent_019fd276-253e-77ce-a1f2-752b96bcd9f0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedInsuranceCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019fd276-253e-7a6d-8705-850643107d07" xlink:to="loc_us-gaap_AccruedInsuranceCurrent_019fd276-253e-77ce-a1f2-752b96bcd9f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrent_019fd276-253e-7108-9a7f-22868ee516b4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestPayableCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019fd276-253e-7a6d-8705-850643107d07" xlink:to="loc_us-gaap_InterestPayableCurrent_019fd276-253e-7108-9a7f-22868ee516b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrent_019fd276-253e-7111-997b-c7dda747cfb2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedRoyaltiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019fd276-253e-7a6d-8705-850643107d07" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrent_019fd276-253e-7111-997b-c7dda747cfb2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_AccruedGrossToNetAdjustmentsCurrent_019fd276-253e-752f-a9af-5647603c202d" xlink:href="pths-20260331.xsd#pths_AccruedGrossToNetAdjustmentsCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019fd276-253e-7a6d-8705-850643107d07" xlink:to="loc_pths_AccruedGrossToNetAdjustmentsCurrent_019fd276-253e-752f-a9af-5647603c202d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019fd276-253e-7d13-8305-65b76d5aeebb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019fd276-253e-7a6d-8705-850643107d07" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019fd276-253e-7d13-8305-65b76d5aeebb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/BALANCESHEETACCOUNTDETAILSScheduleofOtherLiabilitiesandOtherLongtermLiabilitiesDetails" xlink:type="simple" xlink:href="pths-20260331.xsd#BALANCESHEETACCOUNTDETAILSScheduleofOtherLiabilitiesandOtherLongtermLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/BALANCESHEETACCOUNTDETAILSScheduleofOtherLiabilitiesandOtherLongtermLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019fd276-253e-7165-b4cb-14809574ad52" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_ContractualObligationNoncurrent_019fd276-253e-7c8d-a54d-fd330394810e" xlink:href="pths-20260331.xsd#pths_ContractualObligationNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019fd276-253e-7165-b4cb-14809574ad52" xlink:to="loc_pths_ContractualObligationNoncurrent_019fd276-253e-7c8d-a54d-fd330394810e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_InterestPayableNoncurrent_019fd276-253e-7d0c-821e-7a4f1baaa662" xlink:href="pths-20260331.xsd#pths_InterestPayableNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019fd276-253e-7165-b4cb-14809574ad52" xlink:to="loc_pths_InterestPayableNoncurrent_019fd276-253e-7d0c-821e-7a4f1baaa662" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019fd276-253e-7a87-8b01-669e9b8454d4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_ContractualObligationCurrent_019fd276-253e-7741-a647-2fd97d275caa" xlink:href="pths-20260331.xsd#pths_ContractualObligationCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019fd276-253e-7a87-8b01-669e9b8454d4" xlink:to="loc_pths_ContractualObligationCurrent_019fd276-253e-7741-a647-2fd97d275caa" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/GOODWILLANDINTANGIBLEASSETSScheduleofConsiderationForAssetAcquisitionDetails" xlink:type="simple" xlink:href="pths-20260331.xsd#GOODWILLANDINTANGIBLEASSETSScheduleofConsiderationForAssetAcquisitionDetails"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/GOODWILLANDINTANGIBLEASSETSScheduleofConsiderationForAssetAcquisitionDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionConsiderationTransferred_019fd276-253e-76ef-bb78-eb2730892908" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionConsiderationTransferred"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_019fd276-253e-74b5-addf-1fac5c0a9be2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireProductiveAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetAcquisitionConsiderationTransferred_019fd276-253e-76ef-bb78-eb2730892908" xlink:to="loc_us-gaap_PaymentsToAcquireProductiveAssets_019fd276-253e-74b5-addf-1fac5c0a9be2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionConsiderationTransferredContingentConsideration_019fd276-253e-71e1-bc9b-b53f9e730a4c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionConsiderationTransferredContingentConsideration"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetAcquisitionConsiderationTransferred_019fd276-253e-76ef-bb78-eb2730892908" xlink:to="loc_us-gaap_AssetAcquisitionConsiderationTransferredContingentConsideration_019fd276-253e-71e1-bc9b-b53f9e730a4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionConsiderationTransferredTransactionCost_019fd276-253e-71bb-97c6-be2819b59a41" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionConsiderationTransferredTransactionCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetAcquisitionConsiderationTransferred_019fd276-253e-76ef-bb78-eb2730892908" xlink:to="loc_us-gaap_AssetAcquisitionConsiderationTransferredTransactionCost_019fd276-253e-71bb-97c6-be2819b59a41" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/GOODWILLANDINTANGIBLEASSETSScheduleofDefiniteandIndefiniteLivedIntangibleAssetsDetails" xlink:type="simple" xlink:href="pths-20260331.xsd#GOODWILLANDINTANGIBLEASSETSScheduleofDefiniteandIndefiniteLivedIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/GOODWILLANDINTANGIBLEASSETSScheduleofDefiniteandIndefiniteLivedIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_pths_IntangibleAssetsGrossIncludingGoodwill_019fd276-253e-7acf-a70f-c3b38997dc75" xlink:href="pths-20260331.xsd#pths_IntangibleAssetsGrossIncludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019fd276-253e-7307-b884-48f67e0a0762" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_IntangibleAssetsGrossIncludingGoodwill_019fd276-253e-7acf-a70f-c3b38997dc75" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019fd276-253e-7307-b884-48f67e0a0762" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillGross_019fd276-253e-7e3d-97cd-858bdd4ad120" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GoodwillGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_IntangibleAssetsGrossIncludingGoodwill_019fd276-253e-7acf-a70f-c3b38997dc75" xlink:to="loc_us-gaap_GoodwillGross_019fd276-253e-7e3d-97cd-858bdd4ad120" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019fd276-253e-7ba9-bdef-c27610c001d2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Goodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillGross_019fd276-253e-7cee-a96e-43ae72b943bb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GoodwillGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Goodwill_019fd276-253e-7ba9-bdef-c27610c001d2" xlink:to="loc_us-gaap_GoodwillGross_019fd276-253e-7cee-a96e-43ae72b943bb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/GOODWILLANDINTANGIBLEASSETSScheduleofAmortizationExpenseExpectedtobeRecognizedDetails" xlink:type="simple" xlink:href="pths-20260331.xsd#GOODWILLANDINTANGIBLEASSETSScheduleofAmortizationExpenseExpectedtobeRecognizedDetails"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/GOODWILLANDINTANGIBLEASSETSScheduleofAmortizationExpenseExpectedtobeRecognizedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd276-253e-7920-beb8-70fff01bba06" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_019fd276-253e-7b7e-9010-6d7fabade284" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd276-253e-7920-beb8-70fff01bba06" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_019fd276-253e-7b7e-9010-6d7fabade284" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019fd276-253e-7fcf-ac46-8432bccbe03f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd276-253e-7920-beb8-70fff01bba06" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019fd276-253e-7fcf-ac46-8432bccbe03f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019fd276-253e-7ad9-99b8-9659b7a4533f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd276-253e-7920-beb8-70fff01bba06" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019fd276-253e-7ad9-99b8-9659b7a4533f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_019fd276-253e-7d50-bb96-7f52815b8251" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd276-253e-7920-beb8-70fff01bba06" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_019fd276-253e-7d50-bb96-7f52815b8251" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_019fd276-253e-762f-8df4-bffe0fd736a2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd276-253e-7920-beb8-70fff01bba06" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_019fd276-253e-762f-8df4-bffe0fd736a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_019fd276-253e-70e8-8beb-2cd919524b97" xlink:href="pths-20260331.xsd#pths_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019fd276-253e-7920-beb8-70fff01bba06" xlink:to="loc_pths_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_019fd276-253e-70e8-8beb-2cd919524b97" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/NOTESPAYABLEScheduleofAllocationofFairValueDetails" xlink:type="simple" xlink:href="pths-20260331.xsd#NOTESPAYABLEScheduleofAllocationofFairValueDetails"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/NOTESPAYABLEScheduleofAllocationofFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_pths_DebtInstrumentsAndWarrantsFairValueDisclosure_019fd276-253e-7b71-9d9a-f1697b28ab35" xlink:href="pths-20260331.xsd#pths_DebtInstrumentsAndWarrantsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtFairValue_019fd276-253e-7e89-95b5-2fd7e0d8f661" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_DebtInstrumentsAndWarrantsFairValueDisclosure_019fd276-253e-7b71-9d9a-f1697b28ab35" xlink:to="loc_us-gaap_LongTermDebtFairValue_019fd276-253e-7e89-95b5-2fd7e0d8f661" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_WarrantLiability_019fd276-253e-71c0-b1e5-6ae765e28e57" xlink:href="pths-20260331.xsd#pths_WarrantLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_DebtInstrumentsAndWarrantsFairValueDisclosure_019fd276-253e-7b71-9d9a-f1697b28ab35" xlink:to="loc_pths_WarrantLiability_019fd276-253e-71c0-b1e5-6ae765e28e57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_DebtInstrumentsAndWarrantsFairValueAllocationPercent_019fd276-253e-7220-9705-9c8f7d94cef5" xlink:href="pths-20260331.xsd#pths_DebtInstrumentsAndWarrantsFairValueAllocationPercent"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_LongTermDebtFairValueAllocationPercent_019fd276-253e-7bb4-be9a-b2e542434991" xlink:href="pths-20260331.xsd#pths_LongTermDebtFairValueAllocationPercent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_DebtInstrumentsAndWarrantsFairValueAllocationPercent_019fd276-253e-7220-9705-9c8f7d94cef5" xlink:to="loc_pths_LongTermDebtFairValueAllocationPercent_019fd276-253e-7bb4-be9a-b2e542434991" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_WarrantLiabilityFairValueAllocationPercent_019fd276-253e-7fcb-921a-17addec4999a" xlink:href="pths-20260331.xsd#pths_WarrantLiabilityFairValueAllocationPercent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_DebtInstrumentsAndWarrantsFairValueAllocationPercent_019fd276-253e-7220-9705-9c8f7d94cef5" xlink:to="loc_pths_WarrantLiabilityFairValueAllocationPercent_019fd276-253e-7fcb-921a-17addec4999a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_DebtInstrumentsAndWarrantsFairValueAllocationNet_019fd276-253e-753f-a158-4fc9de8add5a" xlink:href="pths-20260331.xsd#pths_DebtInstrumentsAndWarrantsFairValueAllocationNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_LongTermDebtFairValueAllocationNet_019fd276-253e-793a-9053-4d933eebb4fd" xlink:href="pths-20260331.xsd#pths_LongTermDebtFairValueAllocationNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_DebtInstrumentsAndWarrantsFairValueAllocationNet_019fd276-253e-753f-a158-4fc9de8add5a" xlink:to="loc_pths_LongTermDebtFairValueAllocationNet_019fd276-253e-793a-9053-4d933eebb4fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_WarrantLiabilityFairValueAllocationNet_019fd276-253e-7740-905d-3d070566da35" xlink:href="pths-20260331.xsd#pths_WarrantLiabilityFairValueAllocationNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_DebtInstrumentsAndWarrantsFairValueAllocationNet_019fd276-253e-753f-a158-4fc9de8add5a" xlink:to="loc_pths_WarrantLiabilityFairValueAllocationNet_019fd276-253e-7740-905d-3d070566da35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_LongTermDebtFairValueAllocationNet_019fd276-253e-7b72-b573-d9f432fe2fbc" xlink:href="pths-20260331.xsd#pths_LongTermDebtFairValueAllocationNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_LongTermDebtFairValueAllocationAmount_019fd276-253e-7f19-acc3-fb2624b1e006" xlink:href="pths-20260331.xsd#pths_LongTermDebtFairValueAllocationAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_LongTermDebtFairValueAllocationNet_019fd276-253e-7b72-b573-d9f432fe2fbc" xlink:to="loc_pths_LongTermDebtFairValueAllocationAmount_019fd276-253e-7f19-acc3-fb2624b1e006" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFeeAmount_019fd276-253e-7826-957c-f2de6d053842" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentFeeAmount"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_LongTermDebtFairValueAllocationNet_019fd276-253e-7b72-b573-d9f432fe2fbc" xlink:to="loc_us-gaap_DebtInstrumentFeeAmount_019fd276-253e-7826-957c-f2de6d053842" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_DebtInstrumentThirdPartyFeeAmount_019fd276-253e-7799-b86e-d9662ef74863" xlink:href="pths-20260331.xsd#pths_DebtInstrumentThirdPartyFeeAmount"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_LongTermDebtFairValueAllocationNet_019fd276-253e-7b72-b573-d9f432fe2fbc" xlink:to="loc_pths_DebtInstrumentThirdPartyFeeAmount_019fd276-253e-7799-b86e-d9662ef74863" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_DebtInstrumentsAndWarrantsFairValueAllocationAmount_019fd276-253e-7b7d-9fb7-f672ce86b162" xlink:href="pths-20260331.xsd#pths_DebtInstrumentsAndWarrantsFairValueAllocationAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_LongTermDebtFairValueAllocationAmount_019fd276-253e-7d22-989e-257108a68699" xlink:href="pths-20260331.xsd#pths_LongTermDebtFairValueAllocationAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_DebtInstrumentsAndWarrantsFairValueAllocationAmount_019fd276-253e-7b7d-9fb7-f672ce86b162" xlink:to="loc_pths_LongTermDebtFairValueAllocationAmount_019fd276-253e-7d22-989e-257108a68699" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_WarrantLiabilityFairValueAllocationAmount_019fd276-253e-74ac-a638-b425e1756526" xlink:href="pths-20260331.xsd#pths_WarrantLiabilityFairValueAllocationAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_DebtInstrumentsAndWarrantsFairValueAllocationAmount_019fd276-253e-7b7d-9fb7-f672ce86b162" xlink:to="loc_pths_WarrantLiabilityFairValueAllocationAmount_019fd276-253e-74ac-a638-b425e1756526" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_WarrantLiabilityFairValueAllocationNet_019fd276-253e-7c43-94d0-c0fedd1ef79d" xlink:href="pths-20260331.xsd#pths_WarrantLiabilityFairValueAllocationNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_WarrantLiabilityFairValueAllocationAmount_019fd276-253e-7a0f-9c04-aaf7fe82b6b5" xlink:href="pths-20260331.xsd#pths_WarrantLiabilityFairValueAllocationAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_WarrantLiabilityFairValueAllocationNet_019fd276-253e-7c43-94d0-c0fedd1ef79d" xlink:to="loc_pths_WarrantLiabilityFairValueAllocationAmount_019fd276-253e-7a0f-9c04-aaf7fe82b6b5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/NOTESPAYABLEScheduleofAllocationofFairValueDetails_1" xlink:type="simple" xlink:href="pths-20260331.xsd#NOTESPAYABLEScheduleofAllocationofFairValueDetails_1"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/NOTESPAYABLEScheduleofAllocationofFairValueDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_pths_DebtInstrumentsAndWarrantsFairValueAllocationNet_019fd276-253e-79a4-823d-8274b2b316d2" xlink:href="pths-20260331.xsd#pths_DebtInstrumentsAndWarrantsFairValueAllocationNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_DebtInstrumentsAndWarrantsFairValueAllocationAmount_019fd276-253e-70fd-b58c-cac682dc15e2" xlink:href="pths-20260331.xsd#pths_DebtInstrumentsAndWarrantsFairValueAllocationAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_DebtInstrumentsAndWarrantsFairValueAllocationNet_019fd276-253e-79a4-823d-8274b2b316d2" xlink:to="loc_pths_DebtInstrumentsAndWarrantsFairValueAllocationAmount_019fd276-253e-70fd-b58c-cac682dc15e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFeeAmount_019fd276-253e-7aec-b646-ca653682212d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentFeeAmount"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_DebtInstrumentsAndWarrantsFairValueAllocationNet_019fd276-253e-79a4-823d-8274b2b316d2" xlink:to="loc_us-gaap_DebtInstrumentFeeAmount_019fd276-253e-7aec-b646-ca653682212d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_DebtInstrumentThirdPartyFeeAmount_019fd276-253e-7336-81a1-ab6ced41e43d" xlink:href="pths-20260331.xsd#pths_DebtInstrumentThirdPartyFeeAmount"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_DebtInstrumentsAndWarrantsFairValueAllocationNet_019fd276-253e-79a4-823d-8274b2b316d2" xlink:to="loc_pths_DebtInstrumentThirdPartyFeeAmount_019fd276-253e-7336-81a1-ab6ced41e43d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/NOTESPAYABLEScheduleofDebtDiscountRateDetails" xlink:type="simple" xlink:href="pths-20260331.xsd#NOTESPAYABLEScheduleofDebtDiscountRateDetails"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/NOTESPAYABLEScheduleofDebtDiscountRateDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_pths_DebtInstrumentDiscountRatePercent_019ff64e-788f-76da-9f29-5f65bc66b9e3" xlink:href="pths-20260331.xsd#pths_DebtInstrumentDiscountRatePercent"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_DebtInstrumentSubordinationPremiumPercent_019ff64e-788f-7339-99e5-e36856aec8ad" xlink:href="pths-20260331.xsd#pths_DebtInstrumentSubordinationPremiumPercent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_DebtInstrumentDiscountRatePercent_019ff64e-788f-76da-9f29-5f65bc66b9e3" xlink:to="loc_pths_DebtInstrumentSubordinationPremiumPercent_019ff64e-788f-7339-99e5-e36856aec8ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_DebtInstrumentCompanySpecificRiskPremiumPercent_019ff64e-788f-7c3b-bfd0-30faef7da1e4" xlink:href="pths-20260331.xsd#pths_DebtInstrumentCompanySpecificRiskPremiumPercent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_DebtInstrumentDiscountRatePercent_019ff64e-788f-76da-9f29-5f65bc66b9e3" xlink:to="loc_pths_DebtInstrumentCompanySpecificRiskPremiumPercent_019ff64e-788f-7c3b-bfd0-30faef7da1e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_DebtInstrumentBloombergBYieldCurvePercent_019ff64e-788f-7481-a4bc-53675d6695df" xlink:href="pths-20260331.xsd#pths_DebtInstrumentBloombergBYieldCurvePercent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_pths_DebtInstrumentDiscountRatePercent_019ff64e-788f-76da-9f29-5f65bc66b9e3" xlink:to="loc_pths_DebtInstrumentBloombergBYieldCurvePercent_019ff64e-788f-7481-a4bc-53675d6695df" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/NOTESPAYABLEScheduleofCarryingValueofLoanDetails" xlink:type="simple" xlink:href="pths-20260331.xsd#NOTESPAYABLEScheduleofCarryingValueofLoanDetails"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/NOTESPAYABLEScheduleofCarryingValueofLoanDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019fd276-253e-7f7c-83fc-2f442d7409c8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019fd276-253e-72a9-9cc9-3a86e309efa5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019fd276-253e-7f7c-83fc-2f442d7409c8" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019fd276-253e-72a9-9cc9-3a86e309efa5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_019fd276-253e-77bd-97af-74f421a4f07b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019fd276-253e-7f7c-83fc-2f442d7409c8" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_019fd276-253e-77bd-97af-74f421a4f07b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/NOTESPAYABLEScheduleofMaturitiesofLongTermDebtDetails" xlink:type="simple" xlink:href="pths-20260331.xsd#NOTESPAYABLEScheduleofMaturitiesofLongTermDebtDetails"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/NOTESPAYABLEScheduleofMaturitiesofLongTermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019fd276-253e-7567-93dc-0de6288e7112" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_019fd276-253e-7a53-8964-effc6ad1844d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019fd276-253e-7567-93dc-0de6288e7112" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_019fd276-253e-7a53-8964-effc6ad1844d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_019fd276-253e-73ed-9e5a-39e7d8fab1ee" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019fd276-253e-7567-93dc-0de6288e7112" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_019fd276-253e-73ed-9e5a-39e7d8fab1ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_019fd276-253e-7abc-882e-d85b5a7aa88c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019fd276-253e-7567-93dc-0de6288e7112" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_019fd276-253e-7abc-882e-d85b5a7aa88c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_019fd276-253e-780a-bcf9-a00c5fe1fab7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019fd276-253e-7567-93dc-0de6288e7112" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_019fd276-253e-780a-bcf9-a00c5fe1fab7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_019fd276-253e-7e57-822f-93d2de179eab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019fd276-253e-7567-93dc-0de6288e7112" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_019fd276-253e-7e57-822f-93d2de179eab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_LongTermDebtMaturityYearFiveAndThereafter_019fd276-253e-7bda-a054-adaf2ec81ae0" xlink:href="pths-20260331.xsd#pths_LongTermDebtMaturityYearFiveAndThereafter"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019fd276-253e-7567-93dc-0de6288e7112" xlink:to="loc_pths_LongTermDebtMaturityYearFiveAndThereafter_019fd276-253e-7bda-a054-adaf2ec81ae0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/LEASESScheduleofFutureMinimumLeasePaymentsDetails" xlink:type="simple" xlink:href="pths-20260331.xsd#LEASESScheduleofFutureMinimumLeasePaymentsDetails"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/LEASESScheduleofFutureMinimumLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019fd276-25e9-76db-8ec8-048acfd16504" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019fd276-25e9-7f5e-939f-2b47bc561abc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019fd276-25e9-76db-8ec8-048acfd16504" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019fd276-25e9-7f5e-939f-2b47bc561abc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019fd276-25e9-7a86-8427-eef069001769" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019fd276-25e9-76db-8ec8-048acfd16504" xlink:to="loc_us-gaap_OperatingLeaseLiability_019fd276-25e9-7a86-8427-eef069001769" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://pelthos.com/role/LEASESScheduleofFutureMinimumLeasePaymentsDetails_1" xlink:type="simple" xlink:href="pths-20260331.xsd#LEASESScheduleofFutureMinimumLeasePaymentsDetails_1"/>
  <link:calculationLink xlink:role="http://pelthos.com/role/LEASESScheduleofFutureMinimumLeasePaymentsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019fd276-25e9-739f-861e-28a34bd2c23d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019fd276-25e9-75fc-be8e-21837266134d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019fd276-25e9-739f-861e-28a34bd2c23d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019fd276-25e9-75fc-be8e-21837266134d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019fd276-25e9-71ff-a24d-f211b7657992" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019fd276-25e9-739f-861e-28a34bd2c23d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019fd276-25e9-71ff-a24d-f211b7657992" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019fd276-25e9-7369-a844-9c1e8a594106" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019fd276-25e9-739f-861e-28a34bd2c23d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019fd276-25e9-7369-a844-9c1e8a594106" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019fd276-25e9-71e4-8457-eef97ecbd28d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019fd276-25e9-739f-861e-28a34bd2c23d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019fd276-25e9-71e4-8457-eef97ecbd28d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019fd276-25e9-7ae1-8561-f4526172733a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019fd276-25e9-739f-861e-28a34bd2c23d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019fd276-25e9-7ae1-8561-f4526172733a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_pths_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_019fd276-25e9-7423-bdee-e7b6ec06cc5b" xlink:href="pths-20260331.xsd#pths_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019fd276-25e9-739f-861e-28a34bd2c23d" xlink:to="loc_pths_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_019fd276-25e9-7423-bdee-e7b6ec06cc5b" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
