The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abivax SA SPONSORED ADS 00370M103 76,757,760 576,000 SH DFND 2 576,000 0 0
Absci Corp COM 00091E109 28,682,515 2,474,764 SH DFND 2 2,474,764 0 0
Adagene Inc ADS 005329107 11,199,997 2,666,666 SH DFND 2 2,666,666 0 0
Aeva Technologies Inc COM NEW 00835Q202 4,177,582 145,459 SH DFND 2 145,459 0 0
Agenus Inc COM NEW 00847G804 3,256,605 1,064,250 SH DFND 2 1,064,250 0 0
Agomab Therapeutics NV SPONSORED ADS 00860C102 5,338,025 411,250 SH DFND 2 411,250 0 0
Alibaba Group Holding Ltd SPONSORED ADS 01609W102 4,799,000 50,000 SH DFND 2 50,000 0 0
Alphabet Inc CAP STK CL A 02079K305 32,163,300 90,000 SH DFND 2 90,000 0 0
Amazon.com Inc COM 023135106 7,746,050 32,500 SH DFND 2 32,500 0 0
Amylyx Pharmaceuticals Inc COM 03237H101 26,591,325 1,480,586 SH DFND 2 1,480,586 0 0
Annexon Inc COM 03589W102 25,458,869 4,458,646 SH DFND 2 4,458,646 0 0
Apple Inc COM 037833100 6,655,280 23,000 SH Call DFND 2 23,000 0 0
Arcus Biosciences Inc COM 03969F109 20,823,507 675,430 SH DFND 1 675,430 0 0
Arcus Biosciences Inc COM 03969F109 53,798,350 1,745,000 SH DFND 2 1,745,000 0 0
Arrowhead Pharmaceuticals Inc COM 04280A100 139,828,449 1,715,476 SH DFND 2 1,715,476 0 0
AT&T Inc COM 00206R102 517,500 25,000 SH DFND 2 25,000 0 0
BeOne Medicines AG SPONSORED ADS 07725L102 132,511,050 465,000 SH DFND 2 465,000 0 0
Bicara Therapeutics Inc COM 055477103 166,352,179 5,602,970 SH DFND 2 5,602,970 0 0
Broadcom Inc COM 11135F101 9,443,750 25,000 SH DFND 2 25,000 0 0
Capital One Finl Corp COM 14040H105 34,429,401 171,615 SH DFND 1 171,615 0 0
Cellebrite DI Ltd ORDINARY SHARES M2197Q107 4,548,542 311,544 SH DFND 2 311,544 0 0
Cogent Biosciences Inc COM 19240Q201 71,954,097 1,859,279 SH DFND 2 1,859,279 0 0
Crinetics Pharmaceuticals Inc COM 22663K107 53,165,887 1,420,788 SH DFND 2 1,420,788 0 0
CrowdStrike Holdings Inc CL A 22788C105 7,631,400 10,000 SH DFND 2 10,000 0 0
Cullinan Therapeutics Inc COM 230031106 34,478,996 1,893,410 SH DFND 2 1,893,410 0 0
Cytokinetics Inc COM NEW 23282W605 64,655,121 758,952 SH DFND 2 758,952 0 0
CytomX Therapeutics Inc COM 23284F105 12,966,416 3,457,711 SH DFND 2 3,457,711 0 0
Damora Therapeutics Inc COM NEW 36322Q206 23,409,000 900,000 SH DFND 2 900,000 0 0
Datadog Inc CL A COM 23804L103 10,414,400 40,000 SH DFND 2 40,000 0 0
Dbv Technologies SA SPONSORED ADS 23306J309 30,460,737 1,857,362 SH DFND 2 1,857,362 0 0
Definium Therapeutics Inc COM SHS 24477V105 66,772,951 1,419,493 SH DFND 2 1,419,493 0 0
Denali Therapeutics Inc COM 24823R105 35,918,314 1,396,513 SH DFND 2 1,396,513 0 0
Design Therapeutics Inc COM 25056L103 7,570,878 523,212 SH DFND 2 523,212 0 0
Disc Medicine Inc COM 254604101 64,977,649 888,401 SH DFND 2 888,401 0 0
Dynatrace, Inc COM NEW 268150109 6,806,050 155,000 SH DFND 2 155,000 0 0
Dyne Therapeutics, Inc COM 26818M108 47,287,866 2,129,125 SH DFND 2 2,129,125 0 0
Edgewise Therapeutics Inc COM 28036F105 129,391,476 3,184,629 SH DFND 2 3,184,629 0 0
Eloxx Pharmaceuticals Inc COM NEW 29014R301 5,552,000 400,000 SH DFND 2 400,000 0 0
enGene Therapeutics Inc COM 29286X101 10,824,025 6,256,662 SH DFND 2 6,256,662 0 0
Enliven Therapeutics Inc COM 29337E102 90,051,358 1,774,411 SH DFND 2 1,774,411 0 0
Entera Bio Ltd SHS M40527109 1,303,529 736,457 SH DFND 2 736,457 0 0
Erasca Inc COM 29479A108 208,807,348 11,397,781 SH DFND 2 11,397,781 0 0
Figma Inc CLASS A COM STK 316841105 904,500 50,000 SH DFND 2 50,000 0 0
Foghorn Therapeutics Inc COM 344174107 3,517,114 720,720 SH DFND 2 720,720 0 0
Fox Corp CL A COM 35137L105 521,600 10,000 SH DFND 2 10,000 0 0
Generate Biomedicines Inc COM SHS 370920100 12,418,075 736,104 SH DFND 2 736,104 0 0
GitLab Inc CLASS A COM 37637K108 3,816,250 125,000 SH DFND 2 125,000 0 0
Gossamer Bio Inc COM 38341P102 857,396 5,208,968 SH DFND 2 5,208,968 0 0
Hemab Therapeutics Holdings Inc COM SHS 423494103 76,649,413 2,086,834 SH DFND 2 2,086,834 0 0
Inhibikase Therapeutics Inc COM NEW 45719W205 11,875,500 5,850,000 SH DFND 2 5,850,000 0 0
Invivyd Inc COM 00534A102 4,362,000 5,000,000 SH DFND 2 5,000,000 0 0
IONQ Inc COM 46222L108 9,054,200 170,000 SH DFND 1 170,000 0 0
IREN Ltd ORDINARY SHARES Q4982L109 8,002,750 175,000 SH DFND 2 175,000 0 0
Jfrog Ltd ORD SHS M6191J100 8,679,040 95,500 SH DFND 2 95,500 0 0
Kailera Therapeutics Inc COMMON STOCK 482931102 48,780,721 2,214,286 SH DFND 2 2,214,286 0 0
Kalaris Therapeutics Inc COM 482929106 1,773,698 435,798 SH DFND 2 435,798 0 0
KE Holdings Inc SPONSORED ADS 482497104 1,453,000 100,000 SH DFND 2 100,000 0 0
Korro Bio Inc COM 500946108 4,582,923 347,718 SH DFND 2 347,718 0 0
Kymera Therapeutics Inc COM 501575104 336,651,626 2,935,830 SH DFND 2 2,935,830 0 0
Lexicon Pharmaceuticals Inc COM NEW 528872302 106,328,443 44,303,518 SH DFND 2 44,303,518 0 0
Lumentum Holdings Inc COM 55024U109 905,253 1,055 SH DFND 2 1,055 0 0
MapLight Therapeutics Inc COM 56565P103 16,128,000 450,000 SH DFND 2 450,000 0 0
Medline Inc COM CL A 58507V107 986,000 25,000 SH DFND 2 25,000 0 0
Microsoft Corp COM 594918104 13,988,250 37,500 SH DFND 2 37,500 0 0
Microsoft Corp COM 594918104 8,952,480 24,000 SH Call DFND 2 24,000 0 0
monday.com Ltd SHS M7S64H106 3,076,575 42,500 SH DFND 2 42,500 0 0
Monopar Therapeutics Inc COM NEW 61023L207 25,010,226 270,118 SH DFND 2 270,118 0 0
Nebius Group NV SHS CLASS A N97284108 14,360,840 52,000 SH DFND 2 52,000 0 0
Netflix Inc COM 64110L106 1,784,925 25,000 SH DFND 2 25,000 0 0
Neumora Therapeutics Inc COM 640979100 14,446,297 8,497,822 SH DFND 2 8,497,822 0 0
NovaBridge Biosciences SPONSORED ADS 44975P103 3,909,241 2,004,739 SH DFND 2 2,004,739 0 0
Nu Holdings Ltd. ORD SHS CL A G6683N103 334,000 25,000 SH DFND 2 25,000 0 0
NVIDIA Corp COM 67066G104 19,008,550 95,000 SH DFND 2 95,000 0 0
Oculis Holding AG ORDINARY SHARES H5870P102 8,668,750 625,000 SH DFND 2 625,000 0 0
Odyssey Therapeutics Inc COMMON STOCK 67613T104 3,742,000 200,000 SH DFND 2 200,000 0 0
Olema Pharmaceuticals Inc COM 68062P106 60,760,432 4,856,949 SH DFND 2 4,856,949 0 0
Oric Pharmaceuticals Inc COM 68622P109 10,912,037 1,007,575 SH DFND 1 1,007,575 0 0
Oric Pharmaceuticals Inc COM 68622P109 21,558,382 1,990,617 SH DFND 2 1,990,617 0 0
Oruka Therapeutics Inc COM 687604108 23,792,500 250,000 SH DFND 2 250,000 0 0
Ouster Inc COM NEW 68989M202 4,220,100 67,500 SH DFND 2 67,500 0 0
Palisade Bio Inc COM 696389402 4,180,000 2,000,000 SH DFND 2 2,000,000 0 0
Palvella Therapeutics Inc COM 697947109 39,348,858 257,485 SH DFND 2 257,485 0 0
Parabilis Medicines Inc COM 698955101 81,898,129 2,992,259 SH DFND 2 2,992,259 0 0
PDD Holdings Inc SPONSORED ADS 722304102 7,246,600 95,000 SH DFND 2 95,000 0 0
Quantinuum Inc CL A COM 74768A104 1,634,800 20,000 SH DFND 2 20,000 0 0
Rani Therapeutics Holdings Inc COM CL A 753018100 1,520,800 2,000,000 SH DFND 2 2,000,000 0 0
Rapport Therapeutics Inc COM 75383L102 26,730,013 641,469 SH DFND 2 641,469 0 0
Relay Therapeutics Inc COM 75943R102 68,291,500 3,650,000 SH DFND 2 3,650,000 0 0
Remitly Global Inc COM 75960P104 34,584,703 1,543,271 SH DFND 1 1,543,271 0 0
Revolution Medicines Inc COM 76155X100 168,552,000 900,000 SH DFND 2 900,000 0 0
Rezolute Inc COM NEW 76200L309 17,307,092 3,328,287 SH DFND 2 3,328,287 0 0
Rhythm Pharmaceuticals Inc COM 76243J105 126,160,613 1,136,275 SH DFND 2 1,136,275 0 0
Satellos Bioscience Inc COM 80401L803 6,935,875 892,074 SH DFND 2 892,074 0 0
Scholar Rock Holding Corp COM 80706P103 526,625,715 9,575,013 SH DFND 2 9,575,013 0 0
Seaport Therapeutics Inc COMMON STOCK 81221K108 23,790,264 1,095,316 SH DFND 2 1,095,316 0 0
Seer Inc COM CL A 81578P106 4,081,397 2,458,673 SH DFND 2 2,458,673 0 0
Septerna Inc COM 81734D104 63,631,000 1,900,000 SH DFND 2 1,900,000 0 0
ServiceNow Inc COM 81762P102 9,928,000 100,000 SH DFND 2 100,000 0 0
Silence Therapeutics PLC ADS 82686Q101 36,359,589 3,311,438 SH DFND 2 3,311,438 0 0
Sionna Therapeutics Inc COM 829401108 26,856,555 610,515 SH DFND 2 610,515 0 0
Solid Biosciences Inc COM NEW 83422E204 76,827,146 7,690,405 SH DFND 2 7,690,405 0 0
Spyre Therapeutics Inc COM NEW 00773J202 85,992,130 968,598 SH DFND 2 968,598 0 0
Stoke Therapeutics Inc COM 86150R107 65,287,754 1,995,347 SH DFND 2 1,995,347 0 0
Structure Therapeutics Inc SPONSORED ADS 86366E106 46,852,139 872,967 SH DFND 2 872,967 0 0
Taboola.com Ltd ORD SHS M8744T106 42,117,050 8,423,410 SH DFND 1 8,423,410 0 0
Taiwan Semiconductor Manufacturing Co Ltd SPONSORED ADS 874039100 21,347,379 44,700 SH DFND 2 44,700 0 0
Tango Therapeutics Inc COM 87583X109 193,166,919 6,179,364 SH DFND 2 6,179,364 0 0
Taysha Gene Therapies Inc COM SHS 877619106 67,055,203 9,846,579 SH DFND 2 9,846,579 0 0
Tenax Therapeutics Inc COM NEW 88032L605 6,214,902 427,141 SH DFND 2 427,141 0 0
Tesla Inc COM 88160R101 1,472,100 3,500 SH DFND 2 3,500 0 0
Trevi Therapeutics Inc COM 89532M101 33,325,070 1,786,867 SH DFND 2 1,786,867 0 0
Tyra Biosciences Inc COM 90240B106 23,156,500 725,000 SH DFND 2 725,000 0 0
Veradermics Inc COMMON STOCK 922967104 203,511,680 1,655,374 SH DFND 2 1,655,374 0 0
vTv Therapeutics Inc CL A NEW 918385204 6,136,950 163,000 SH DFND 2 163,000 0 0
Whitehawk Therapeutics Inc COM 00032Q104 10,703,927 2,337,102 SH DFND 2 2,337,102 0 0
Workiva Inc COM CL A 98139A105 2,182,950 45,000 SH DFND 2 45,000 0 0
Xenon Pharmaceuticals Inc COM 98420N105 79,588,523 1,318,564 SH DFND 2 1,318,564 0 0
Zoetis Inc CL A 98978V103 2,515,100 35,000 SH DFND 2 35,000 0 0
Zura Bio Ltd CLASS A ORD SHS G9TY5A101 22,035,709 3,734,866 SH DFND 2 3,734,866 0 0