75000 - Document - Cover Page
link:presentationLink
link:calculationLink
link:definitionLink
75010 - Statement - Condensed Consolidated Balance Sheets (unaudited)
link:presentationLink
link:calculationLink
link:definitionLink
75020 - Statement - Condensed Consolidated Balance Sheets (unaudited) (Parenthetical)
link:presentationLink
link:calculationLink
link:definitionLink
75030 - Statement - Condensed Consolidated Statements of Operations (unaudited)
link:presentationLink
link:calculationLink
link:definitionLink
75040 - Statement - Condensed Consolidated Statements of Comprehensive Income (Loss)
link:presentationLink
link:calculationLink
link:definitionLink
75050 - Statement - Condensed Consolidated Statements of Cash Flows (unaudited)
link:presentationLink
link:calculationLink
link:definitionLink
75060 - Statement - Condensed Consolidated Statements of Cash Flows (unaudited) 2
link:presentationLink
link:calculationLink
link:definitionLink
75070 - Statement - Condensed Consolidated Statement of Cash Flows (unaudited) (Parenthetical)
link:presentationLink
link:calculationLink
link:definitionLink
75080 - Statement - Condensed Consolidated Statements of Stockholders' Deficit (unaudited)
link:presentationLink
link:calculationLink
link:definitionLink
995455 - Disclosure - Nature of Business, Basis of Presentation and Segment Information
link:presentationLink
link:calculationLink
link:definitionLink
995465 - Disclosure - Product Revenue
link:presentationLink
link:calculationLink
link:definitionLink
995475 - Disclosure - Inventory
link:presentationLink
link:calculationLink
link:definitionLink
995485 - Disclosure - License Agreements
link:presentationLink
link:calculationLink
link:definitionLink
995495 - Disclosure - Fair Value Measurements
link:presentationLink
link:calculationLink
link:definitionLink
995505 - Disclosure - Investments
link:presentationLink
link:calculationLink
link:definitionLink
995515 - Disclosure - Net Loss Per Share
link:presentationLink
link:calculationLink
link:definitionLink
995525 - Disclosure - Stock-based Compensation Expense
link:presentationLink
link:calculationLink
link:definitionLink
995535 - Disclosure - Stockholders' Equity
link:presentationLink
link:calculationLink
link:definitionLink
995545 - Disclosure - Long-Term Obligations
link:presentationLink
link:calculationLink
link:definitionLink
995555 - Disclosure - Common Share Warrants
link:presentationLink
link:calculationLink
link:definitionLink
995565 - Disclosure - Subsequent Event
link:presentationLink
link:calculationLink
link:definitionLink
995575 - Disclosure - Nature of Business, Basis of Presentation and Segment Information (Policies)
link:presentationLink
link:calculationLink
link:definitionLink
995585 - Disclosure - Nature of Business, Basis of Presentation and Segment Information (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995595 - Disclosure - Product Revenue (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995605 - Disclosure - Inventory (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995615 - Disclosure - License Agreements (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995625 - Disclosure - Fair Value Measurements (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995635 - Disclosure - Investments (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995645 - Disclosure - Net Loss Per Share (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995655 - Disclosure - Stock-based Compensation Expense (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995665 - Disclosure - Long-Term Obligations (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995675 - Disclosure - Common Share Warrants (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995685 - Disclosure - Nature of Business, Basis of Presentation and Segment Information (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995695 - Disclosure - Nature of Business, Basis of Presentation and Segment Information - Summary of Cash Payment Due Under Financial Instruments (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995705 - Disclosure - Nature of Business, Basis of Presentation and Segment Information - Schedule of Revenue and Expense Categories in Single Operating Segment (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995715 - Disclosure - Product Revenue - Summary of Product Revenue (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995725 - Disclosure - Product Revenue - Additional Information (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995735 - Disclosure - Inventory - Schedule of Inventory Current (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995745 - Disclosure - License Agreements - Schedule of License and Other Revenue (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995755 - Disclosure - License Agreements - Additional Information (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995755 - Disclosure - License Agreements - Additional Information (Detail) [Default]
link:presentationLink
link:calculationLink
link:definitionLink
995765 - Disclosure - Fair Value Measurements - Schedule of Financial Assets That Have Been Measured at Fair Value (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995775 - Disclosure - Fair Value Measurements - Additional Information (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995785 - Disclosure - Fair Value Measurements - Summary of the Changes in the Estimated Fair Value of the Liabilities (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995795 - Disclosure - Investments - Additional Information (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995805 - Disclosure - Investments - Summary of Investments, Classified as Available-for-Sale (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995815 - Disclosure - Net Loss Per Share - Additional Information (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995825 - Disclosure - Net Loss Per Share - Schedule of Reconciliation of the Numerator and Denominator Used to Calculate Diluted Net Loss per Common Share (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995835 - Disclosure - Net Loss Per Share - Schedule of Potentially Dilutive Securities were Excluded from the Calculation of Diluted Net Loss Per Share Due to Their Anti-Dilutive Effect (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995845 - Disclosure - Stock-based Compensation Expense - Schedule of Total Stock-based Compensation Expense Recognized in Connection with All Share-based Payment Awards (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995845 - Disclosure - Stock-based Compensation Expense - Schedule of Total Stock-based Compensation Expense Recognized in Connection with All Share-based Payment Awards (Detail) [Default]
link:presentationLink
link:calculationLink
link:definitionLink
995855 - Disclosure - Stock-based Compensation Expense - Additional Information (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995865 - Disclosure - Stockholders' Equity - Additional Information (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995875 - Disclosure - Long-Term Obligations - Additional Information (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995875 - Disclosure - Long-Term Obligations - Additional Information (Detail) [Default]
link:presentationLink
link:calculationLink
link:definitionLink
995885 - Disclosure - Long-Term Obligations - Schedule of Interest Expense Recognized Related to 2025 Notes (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995895 - Disclosure - Long-Term Obligations - Summary of Outstanding Balances of Amended Term Loan (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995905 - Disclosure - Long-Term Obligations - Schedule of Interest Expense Recognized Related to Term Loan and Amended Term Loan (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995915 - Disclosure - Long-Term Obligations - Summary of Future Minimum Payments on Amended Term Loan (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995925 - Disclosure - Long-Term Obligations - Summary of Outstanding Balances of New 2029 Notes (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995935 - Disclosure - Long-Term Obligations - Summary of Outstanding Balances of 2028 Notes (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995945 - Disclosure - Long-Term Obligations - Schedule of Interest Expense Recognized Related to 2029 Notes (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995955 - Disclosure - Long-Term Obligations - Schedule of Interest Expense Recognized Related to 2029 Notes and New 2029 Notes (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995965 - Disclosure - Long-Term Obligations - Summary of Future Minimum Payments on New 2029 Notes and 2028 Notes (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995975 - Disclosure - Long-Term Obligations - Summary of Future Minimum Payments on New 2029 Notes and 2028 Notes (Detail) 2
link:presentationLink
link:calculationLink
link:definitionLink
995985 - Disclosure - Common Share Warrants - Additional Information (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
995995 - Disclosure - Common Share Warrants - Summary of Activity Related to our Common Stock Warrants (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996005 - Disclosure - Subsequent Event - Additional Information (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
996015 - Disclosure - Subsequent Event - 2025 Notes - Additional Information (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
996025 - Disclosure - Subsequent Event - Senior Secured Term Loan - Additional Information (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
996035 - Disclosure - Subsequent Event - 2029 Notes - Additional Information (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
996045 - Disclosure - Subsequent Event - 2028 Notes - Additional Information (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
996055 - Disclosure - Subsequent Event - Deferred Royalty Obligation - Additional Information (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
996065 - Disclosure - Subsequent Event - Common Shares and Common Share Warrants - Additional Information (Detail)
link:presentationLink
link:calculationLink
link:definitionLink
Scenario [Axis]
Scenario [Axis]
Embedded Derivative, Fair Value of Embedded Derivative Liability
Plus: fair value of embedded derivatives
Common Stock, Capital Shares Reserved for Future Issuance
shares of common stock reserved for feature issuance
Preferred stock, shares issued
Preferred Stock, Shares Issued
Preferred Stock, Shares Issued, Total
Long-Term Obligations
Debt Disclosure [Text Block]
Interest Expense, Operating and Nonoperating
Interest Expense, Operating and Nonoperating, Total
Add back interest expense
Deferred royalty obligation
Deferred Royalty Obligation Noncurrent
Deferred Royalty Obligation Noncurrent
Long-Term Debt, Maturity, Year Three
2029
Debt Instrument, Basis Spread on Variable Rate
Rate margin
Weighted-average number of common shares outstanding used to compute diluted net loss per share
Weighted Average Number of Shares Outstanding, Diluted
Denominator for diluted net loss per common share (D)
Denominator for diluted net loss per common share (B)
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Stock-based compensation
Term Loan.
Term Loan [Member]
Term Loan [Member]
Minimum [Member]
Minimum [Member]
Subsequent Event, Date
Subsequent event date
Two Thousand Twenty Nine Convertable Notes [Member]
2029 Convertable notes.
Common shares deliverable upon conversion of 2029 Notes [Member]
Vesting of restricted stock (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total
Long-Term Debt, Maturity, Year Two
2028
Private Placement [Member]
Private Placement [Member]
Line of Credit Facility, Periodic Payment, Principal
First principal payment
Debt Instrument, Interest Rate, Effective Percentage
Debt instrument interest rate
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Debt instrument maximum amount remaining
Debt Instrument Maximum Remaining Amount
Maximum remaining amount
Six percentage secured convertible senior notes due two thousand twenty nine.
Six Percentage Secured Convertible Senior Notes Due Two Thousand Twenty Nine [Member]
6% Convertible Senior Notes Due 2029 [Member]
Issuance Of Common Stock And Warrants In Private Placement Offering Net Of Issuance Costs Value
Issuance of common stock and warrants in private placement offering, net of issuance costs value
Issuance of common stock and warrants in private placement offering, net of issuance costs
Common stock, shares issued
Common Stock, Shares, Issued
Common Stock, Shares, Issued, Total
Segment Reporting [Line Items]
Principal
Aggregate principal amount
Debt Instrument, Face Amount
Income tax provision
Income tax expense
Income Tax Expense (Benefit)
Income Tax Expense (Benefit), Total
Common shares deliverable upon conversion of 2028 Notes [Member]
Two Thousand Twenty Eight Convertible Notes [Member]
2028 Convertible Notes.
Schedule of Financial Assets That Have Been Measured at Fair Value
Fair Value, Assets and Liabilities Measured on Nonrecurring Basis, Valuation Techniques [Table Text Block]
Counterparty Name [Domain]
Counterparty Name [Domain]
Repayments of Debt
Repayment of principal amount
Unvested Restricted Stock Units [Member]
Restricted Stock Units (RSUs) [Member]
Debt Modifications that Occurred in October 2025 [Member]
Debt modifications that occurred in october 2025.
Debt Modifications that Occurred in October 2025 [Member]
Warrants purchased
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Warrants issued
Common stock purchased with warrants
Operating Segments [Member]
Operating Segments [Member]
Line of credit facility
Line of Credit Facility, Maximum Borrowing Capacity
Principal payment due under our senior secured term loan
Investment Maturity Period
Investment maturity period
Maturity period
Debt Securities, Available-for-sale, Amortized Cost, Total
Debt Securities, Available-for-Sale, Amortized Cost
Amortized Cost
Subsequent Event Type [Domain]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Expirations in Period
Weighted average exercise price expiration
Cost of sales
Cost of Product and Service Sold
Cost of Goods and Services Sold, Total
Cost of sales
Estimated fair value of convertible notes
Debt Instrument Estimated Fair Value
Debt Instrument Estimated Fair Value
Effect of Exchange Rate on Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
Effect of exchange rates on cash, cash equivalents and restricted cash
Repayment terms
Debt Instrument, Payment Terms
Nonoperating Income (Expense)
Other segment income
Total other expense, net
Proceeds from the exercise of stock options and shares issued under the employee stock purchase plan
Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised
Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised, Total
Schedule of Long-term Debt Instruments [Table]
Schedule of Long-Term Debt Instruments [Table]
General and Administrative Expense
General and Administrative Expense, Total
General and administrative expenses
Income Statement [Abstract]
Accounts receivable
Receivables, Net, Current
Receivables, Net, Current, Total
Accounts receivable, net
Aggregate Royalties
Royalty Payments Applicable
Royalty payments applicable
Two Thousand Twenty Five Placement Warrants [Member]
Two thousand twenty five placement warrants.
Two Thousand Twenty Five Placement Warrants [Member]
2025 Placement Warrants [Member]
Interest Expense, Long-Term Debt
Interest Expense, Long-Term Debt, Total
Interest expense added to debt principal
Common stock and warrants.
Common Stock and Warrants [Member]
Common Stock and Warrants [Member]
May 2024 Warrants [Member]
MayTwo Thousand Twenty four Warrants [Member]
MayTwo Thousand Twenty four Warrants [Member]
May Two Thousand Twenty four Warrants [Member]
Related and Nonrelated Parties [Domain]
Basic net income (loss) per common share (= A / B)
Earnings Per Share, Basic
Earnings Per Share, Basic, Total
Basic net loss per share
Document Period End Date
Document Period End Date
Raw materials
Inventory, Raw Materials and Supplies, Gross
Inventory, Raw Materials and Supplies, Gross, Total
Proceeds from Debt, Net of Issuance Costs
Received net cash proceeds
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Location, Statement of Financial Position, Activity, Capitalization [Axis]
Common stock, shares authorized
Common Stock, Shares Authorized
Statement of Stockholders' Equity [Abstract]
Provision for product revenue.
Provision for Product Revenue
Provisions for product revenue
Provisions for product revenue
March 2026 Warrants [Member]
March Two Thousand Twenty Six Warrants [Member]
March two thousand twenty six warrants.
March Two Thousand Twenty Six Warrants [Member]
Pre Funded Warrants [Member]
Pre Funded Warrants [Member]
Pre Funded Warrants Member
Pre-Funded Warrants [Member]
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Line of Credit Facility, Date of First Required Payment
Date of first required payment
Investments [Domain]
Investments [Domain]
Notes, repurchase price
Debt Instrument Repurchase Price Percentage
Debt instrument repurchase price percentage.
2029 Notes.
Two Thousand Twenty Nine Notes [Member]
2029 Notes [Member]
Two Thousand Twenty Nine Notes [Member]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Disaggregation of Revenue [Table]
Long-term [Member]
Long Term Investments [Member]
Long Term Investments [Member]
Total assets
Assets
Title of 12(b) Security
Title of 12(b) Security
Preferred stock, $0.0001 par value; 5,000 shares authorized; none issued and outstanding
Preferred Stock, Value, Issued
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Ending Balance
Stock Issued During Period, Value, Stock Options Exercised
Shares issued under the employee stock purchase plan
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Schedule of Total Stock-based Compensation Expense Recognized in Connection with All Share-based Payment Awards
Antengene [Member]
Antengene Therapeutics Limited [Member]
Antengene Therapeutics Limited.
Senior secured term loan isuued
Senior Secured Term Loan Issued in Exchange of Reduction of Deferred Royalty Obligation
Senior secured term loan issued in exchange of reduction of deferred royalty obligation.
Common stock warrants
Common Stock Warrants
Common stock warrants.
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized
ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized
Number of additional shares available under the 2022 plan
Other [Member]
Health Care, Other [Member]
Variable Rate [Axis]
Proceeds from Issuance of Private Placement
Proceeds from Issuance of Private Placement
Quarter One [Member]
Quarter one.
Quarter One [Member]
Interest Paid, Excluding Capitalized Interest, Operating Activity
Cash paid for interest on convertible debt and term loan
Product [Member]
Product Revenue [Member]
Product [Member]
Cash paid for interest on deferred royalty obligation
Payments for Royalties
Percentage of commission of gross proceeds from the sale of Shares
Commission Percentage On Gross Proceeds From Sale Of Shares
Commission percentage on gross proceeds from sale of shares.
Securities Purchase Agreement [Member]
Securities Purchase Agreement.
Securities Purchase Agreement [Member]
Menarini [Member]
Menarini License Agreement [Member]
Menarini license agreement member.
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award Options [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award Options [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award Options [Table]
Location, Statement of Financial Position, Balance [Axis]
Cash and Cash Equivalents [Domain]
Cash and Cash Equivalents [Domain]
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Other comprehensive (loss) income
Other Milestone Method Revenue Recognized
Other milestone method revenue recognized.
Other milestone method revenue recognized
Schedule of License and Other Revenue
Disaggregation of Revenue [Table Text Block]
Segment Reporting [Table Text Block]
Schedule of Revenue and Expense Categories in Single Operating Segment
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Short-Term Investments, Corporate debt securities.
Short-Term Investments, Corporate debt securities [Member]
Issuance of common stock under Open Market Sale Agreement, net of issuance costs (in shares)
Issuance Of Common Stock Under Open Market Sale Agreement, Net Of Issuance Costs, Shares
Common stock issued under Open Market Sale Agreement, net of issuance costs.
Two Thousand Twenty Two Warrants [Member]
Two Thousand Twenty Two Warrants [Member]
Two thousand twenty two warrants.
2022 Warrants [Member]
KKR & Co. Inc. [Member]
KKR & Co. Inc.
KKR & Co. Inc. [Member]
Annually.
Annually [Member]
Annually [Member]
Purchases of investments
Payments to Acquire Debt Securities, Available-for-Sale
Beginning balance
Ending balance
Equity, Attributable to Parent
Total stockholders' deficit
3% Convertible Senior Notes Due 2025 [Member]
Three Percentage Convertible Senior Notes Due Two Thousand Twenty Five [Member]
3% Convertible senior notes due two thousand twenty five.
Arrangements and Non-arrangement Transactions [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Equity Issuance Costs Included in Accounts Payable and Accrued Expenses
Equity issuance costs included in accounts payable and accrued expenses.
Equity issuance costs included in accounts payable and accrued expenses
Earnings Per Share [Text Block]
Net Loss Per Share
Bifurcation of embedded derivatives
Long-Term Debt, Fair Value
Two Thousand Twenty Five Convertible Notes [Member]
2025 convertible notes.
Common shares deliverable upon conversion of 2025 Notes [Member]
Number of Reportable Segments
Number of reportable segments
Basis of Presentation
Basis of Accounting, Policy [Policy Text Block]
Ending Balance
Beginning Balance
Fair Value, Net Derivative Asset (Liability) Measured on Recurring Basis with Unobservable Inputs
Secured overnight financing rate.
Secured Overnight Financing Rate [Member]
Secured Overnight Financing Rate [Member]
Term Loan
Long-Term Debt
Term Loan
Total estimated cash payments due
Credit Facility [Axis]
New Two Thousand Twenty Nine Notes and Two Thousand Twenty Eight Notes [Member]
New two thousand twenty nine notes and two thousand twenty eight notes.
2029 and 2028 Notes [Member]
Quarter Four [Member]
Quarter Four [Member]
Quarter four.
Commercial Paper [Member]
Commercial Paper, Not Included with Cash and Cash Equivalents [Member]
Warrants and Rights Outstanding, Maturity Date
Expiration date
Two Thousand and Twenty Two Equity Incentive Plan,Two Thousand And Twenty Two Inducement Stock Incentive Plan and Two Thousand Thirteen Employee Stock Purchase Plan [Member]
Two thousand and twenty two equity incentive plan,two thousand and twenty two inducement stock incentive plan and two thousand thirteen employee stock purchase plan.
2022 Equity Incentive Plan, 2022 Inducement Stock Incentive Plan and 2013 Employee Stock Purchase Plan
Minimum Liquidity Covenant Percentage Of Net Cash Proceeds Received From Certain Debt And Equity Issuances
Minimum liquidity covenant percentage of net cash proceeds received from certain debt and equity issuances.
Minimum liquidity covenant percentage
Remaining Payments Payable
Remaining payments payable.
Remaining payments payable
Schedule of Maturities of Long-Term Debt [Table Text Block]
Summary of Cash Payment Due Under Financial Instruments
Summary of Future Minimum Payments on Convertible Notes
Range [Axis]
Statistical Measurement [Axis]
Money Market Funds [Member]
Money Market Funds [Member]
Entity Interactive Data Current
Entity Interactive Data Current
Add back gain on extinguishment of debt
Add back gain on extinguishment of debt
Gain on extinguishment of debt
Gain (Loss) on Extinguishment of Debt
Gain (Loss) on Extinguishment of Debt, Total
Gain on extinguishment of debt
Minimum Liquidity Covenant Amount
Minimum liquidity covenant amount.
Minimum liquidity covenant amount
Fair Value, Assets and Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Common Stock, Value, Issued
Common Stock, Value, Issued, Total
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Ending Balance
Common stock, $0.0001 par value; 106,000 shares authorized; 22,680 and 18,311 shares issued and outstanding as of June 30, 2026 and December 31, 2025, respectively
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Schedule of Reconciliation of the Numerator and Denominator Used to Calculate Diluted Net Loss per Common Share
US Government Agencies Debt Securities [Member]
US Government and Agency Securities [Member]
Business Description and Basis of Presentation [Text Block]
Nature of Business and Basis of Presentation
Principal amount of notes used in conversion rate
Principal Amount Per Note Used In Conversion Rate
Principal Amount Per Note Used In Conversion Rate
Total liabilities
Liabilities
Three Percentage Unsecured Convertible Senior Notes Due Two Thousand Twenty Five [Member]
3% Unsecured convertible senior notes due two thousand twenty five.
3% Unsecured Convertible Senior Notes Due 2025 [Member]
Reduction of convertible senior notes
Reduction of Convertible Senior Notes
Reduction of Convertible Senior Notes
Neumedicines Inc
Neumedicines Inc [Member]
Neumedicines inc.
Less: unamortized debt issuance costs
Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net
Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net, Total
Less: unamortized debt issuance costs and discounts
Outstanding Stock Options [Member]
Equity Option [Member]
Product and Service [Axis]
Product and Service [Axis]
Short-term [Member]
Short-Term Investments [Member]
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Ending Balance
Accumulated deficit
Level 3 [Member]
Fair Value, Inputs, Level 3 [Member]
Equity Contract [Member]
Cash equivalents
Cash and Cash Equivalents, Fair Value Disclosure
New Two Thousand Twenty Nine Notes and Two Thousand Twenty Nine Notes [Member]
New two thousand twenty nine notes and two thousand twenty nine notes.
New 2029 Notes and 2029 Notes [Member]
Accounts payable
Increase (Decrease) in Accounts Payable
Increase (Decrease) in Accounts Payable, Total
Total operating expenses
Operating Expenses
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
New Two Thousand Twenty Nine Notes [Member]
New two thousand twenty nine notes.
New 2029 Notes [Member]
Corporate Debt Securities [Member]
Debt Security, Corporate, US [Member]
Notes instrument, trading days
Debt Instrument, Convertible, Threshold Trading Days
Disaggregation of Revenue [Line Items]
Changes in operating assets and liabilities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Summary of Activity Related to our Common Stock Warrants
Restricted Stock Units And Performance Stock Units [Member]
Restricted stock units and performance stock units.
RSUs and PSUs
Shares issued, price per share
Shares Issued, Price Per Share
Number of shares of common stock issued
Stock Issued During Period, Shares, New Issues
Issuance of common stock for financial advisory fee (in shares)
Amended Credit Agreement [Member]
Amended Credit Agreement [Member]
Amended credit agreement.
Class of Warrant or Right, Outstanding
Warrants issued
Outstanding, Beginning
Outstanding, Beginning
Outstanding, Ending
Variable Rate [Domain]
Term Loan Borrowings [Member]
Term loan borrowings.
Term Loan Borrowings [Member]
Certificates of Deposit [Member]
Certificate of Deposit [Member]
Deferred royalty obligation at fair value
Financial Liabilities Fair Value Disclosure
Financial Liabilities Fair Value Disclosure, Total
Convertible Notes Derivatives [Member]
Convertible notes derivatives.
Convertible Notes Derivatives [Member]
Subsequent Events [Text Block]
Subsequent Event
Other income
Other Income
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV [Axis]
Short-term Debt, Type [Axis]
Short-Term Debt, Type [Axis]
Senior Secured Term Loan Facility [Member]
Senior secured term loan facility.
Senior Secured Term Loan Facility [Member]
Product Information [Line Items]
Debt Securities, Available-for-Sale
Debt Securities, Available-for-sale, Total
Aggregate Fair Value
Investments
Base Rate [Member]
Base Rate [Member]
Operating lease liabilities
Operating Lease, Liability, Current
Two Thousand Twenty Five Warrants [Member]
Two Thousand Twenty Five Warrants [Member]
Two thousand twenty five warrants.
2025 Warrants [Member]
Secured Debt
Total
Customer [Domain]
Customer [Domain]
Liabilities and Equity
Total liabilities and stockholders' deficit
Research and development
Research and Development Expense
Research and Development Expense, Total
Research and development expenses
Document Fiscal Period Focus
Document Fiscal Period Focus
Quarter Three [Member]
Quarter three.
Quarter Three [Member]
Schedule of Inventory, Current
Schedule of Inventory, Current [Table Text Block]
Debt Instrument Prepayment Premium Percentage Thereafter
Debt instrument prepayment premium percentage thereafter.
Prepayment premium thereafter
2022 Equity Incentive Plan
Two Thousand Twenty Two Equity Incentive Plan [Member]
Two thousand twenty two equity incentive plan.
Sale of Stock [Axis]
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Net decrease in cash, cash equivalents and restricted cash
Entity Current Reporting Status
Entity Current Reporting Status
Level 1 [Member]
Fair Value, Inputs, Level 1 [Member]
Accounts payable
Accounts Payable, Current
Accounts Payable, Current, Total
ESPP [Member]
Employee Stock Purchase Plan [Member]
Employee Stock Purchase Plan [Member]
Investment Type [Axis]
Investment Type [Axis]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Potentially Dilutive Securities were Excluded from the Calculation of Diluted Net Loss Per Share Due to Their Anti-Dilutive Effect
Financial Instrument [Axis]
Financial Instrument [Axis]
Unamortized Debt Issuance Costs Amortized to Interest Expense
Unamortized debt issuance costs amortized to interest expense.
Unamortized debt issuance costs amortized
Total
Total
Assets, Fair Value Disclosure
Amended Credit Agreement and Amended Term Loan [Member]
Amended Credit Agreement and Amended Term Loan [Member]
Amended credit agreement and amended term loan.
Document Transition Report
Document Transition Report
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Inventory
Increase (Decrease) in Inventories
Increase (Decrease) in Inventories, Total
Pre-funded warrants to common stock
Debt Conversion, Converted Instrument, of Pre Funded Warrants
Debt conversion, converted instrument, of pre funded warrants.
Class of Warrant or Right [Axis]
Current liabilities:
Liabilities, Current [Abstract]
Warrants and Rights Note Disclosure [Abstract]
Share-Based Payment Arrangement [Abstract]
Term Loan
Term Loan
Secured Long-Term Debt, Noncurrent
Senior secured term loan, net of current portion
Percentage of Minority Ownership By Parent
Percentage of minority ownership by parent.
Percentage of ownership
Common Stock [Member]
Common Stock [Member]
License and Other [Member]
License And Other [Member]
License And Other Revenue.
Credit Facility [Domain]
Range [Domain]
Statistical Measurement [Domain]
Other income (expense):
Nonoperating Income (Expense) [Abstract]
Debt Securities, Available-for-sale [Line Items]
Debt Securities, Available-for-Sale [Line Items]
Equity, Attributable to Parent [Abstract]
Stockholders' deficit
Weighted Average Number of Shares Outstanding, Basic
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted-average number of common shares outstanding
Weighted-average number of common shares outstanding used to compute basic net loss per share
Assets [Abstract]
Assets
Entity Central Index Key
Entity Central Index Key
Two Thousand Twenty Six Warrants [Member]
Two thousand twenty six warrants.
Two Thousand Twenty Six Warrants [Member]
2026 Warrants [Member]
Other Liabilities, Current, Total
Other current liabilities
Other Liabilities, Current
Nature of Operation, Product Information, Concentration of Risk [Table]
Consolidation Items [Axis]
Current Fiscal Year End Date
Current Fiscal Year End Date
Class of Warrant or Right [Domain]
Document Quarterly Report
Milestone Method Revenue Recognized
Milestone method revenue recognized
Milestone method revenue recognized
Notes, maturity date
Debt Instrument, Maturity Date
Maturity date
Net Income (Loss) Available to Common Stockholders, Diluted
Numerator for diluted net loss per common share (A)
Debt Securities, Available-for-sale [Table]
Debt Securities, Available-for-Sale [Table]
Less: interest expense and unamortized debt issuance costs
Interest Expense and Unamortized Debt Issuance Costs
Interest expense and unamortized debt issuance costs.
Less: interest expense and unamortized debt issuance costs
Issuance of common stock for financial advisory fee
Stock Issued During Period, Value, Other
Cash and Cash Equivalents [Axis]
Cash and Cash Equivalents [Axis]
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Period Increase (Decrease)
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Period Increase (Decrease), Total
Add back gain from the change in fair value
Change in fair value
Long-Term Debt, Maturity, Remainder of Fiscal Year
2026
Level 2 [Member]
Fair Value, Inputs, Level 2 [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Beginning Balance
Weighted-average exercise price
Business Combination [Abstract]
Two thousand twenty five notes.
Two Thousand Twenty Five Notes [Member]
2025 Notes [Member]
Two Thousand Twenty Five Notes [Member]
Initial fair value adjustment
Fair Value, Debt Instrument, Valuation Techniques, Change in Technique, Quantification of Effect
Net cash used in operating activities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Diluted net loss per common share (= A / B)
Diluted net loss per share
License and other revenue [Member]
License and Service [Member]
License and Other Revenue [Member]
Common Share Warrants
The entire disclosure for common share warrants.
Common Share Warrants [Text Block]
Sale of Stock, Number of Shares Issued in Transaction
Purchase share of common stock
Revenue Interest Financing Agreement [Member]
Revenue Interest Financing Agreement [Member]
Revenue Interest Financing Agreement Member
Preferred stock, par value
Preferred Stock, Par or Stated Value Per Share
Net income (loss)
Net loss
Net loss
Add back change in fair value
Fair Value Adjustment of Warrants
Net proceeds
Warrants and Rights Outstanding
Outstanding warrants
Restricted cash
Long-term restricted cash
Restricted Cash and Cash Equivalent, Noncurrent
Restricted Cash and Cash Equivalents, Noncurrent, Total
Cash, Cash Equivalents, and Short-Term Investments, Total
Cash, Cash Equivalents, and Short-Term Investments
Cash, cash equivalents and investments
Debt Instrument Liability Component [Abstract]
Liability component:
Debt Instrument Liability Component [Abstract]
Notes converted in to common stock, amount
Debt Conversion, Converted Instrument, Shares Issued
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive loss
Line of Credit Facility, Date of Last Required Payment
Line of credit facility, date of last required payment.
Date of last required payment
Scenario, Unspecified [Domain]
Scenario [Domain]
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Total
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax
Foreign currency translation adjustment
Foreign currency cumulative translation adjustment
Initial fair value
Debt Instrument, Fair Value Disclosure
Debt Instrument, Fair Value Disclosure, Total
Plus: fair value of embedded derivatives
Equity Components [Axis]
Equity Components [Axis]
Investing activities
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Statement of Cash Flows [Abstract]
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV [Domain]
Convertible senior notes due 2029
Convertible Senior Notes Due Two Thousand Twenty Nine
Convertible senior notes due two thousand twenty nine.
Schedule of Product Information [Table Text Block]
Summary of Product Revenue
Prepaid expenses and other assets
Increase (Decrease) in Prepaid Expense and Other Assets
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Incremental Common Shares Attributable to Dilutive Effect of Conversion of Debt Securities
Dilutive effect of Notes calculated using the if-converted method
Cumulative Payments Of Debt
Cumulative payments of debt.
Cumulative payments
Fair Value Measurements
Fair Value Disclosures [Text Block]
HealthCare Royalty Partners IV LP [Member]
HealthCare Royalty Partners IV LP [Member]
Healthcare Royalty Partners Iv Lp Member
Temporary reduction in minimum liquidity covenant
Temporary Reduction in Minimum Liquidity Covenant
Temporary reduction in minimum liquidity covenant.
Preferred stock, shares authorized
Preferred Stock, Shares Authorized
Fair Value, Net Derivative Asset (Liability) Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Debt Instruments [Abstract]
Derivative Contract [Domain]
Derivative Contract [Domain]
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Unrealized loss on investments
Unrealized loss on investments
Dilutive securities excluded from the calculation of diluted net loss per share due to anti-dilutive effect (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Counterparty Name [Axis]
Counterparty Name [Axis]
Class of Warrant or Right [Line Items]
Number of operating segments
Number of Operating Segments
Debt Securities, Available-for-Sale, Current
Debt Securities, Available-for-sale, Current, Total
Investments
Accumulated Other Comprehensive (loss) Income [Member]
AOCI Attributable to Parent [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
common stock available for future issuance
Notes conversion price, percentage
Debt Instrument, Redemption Price, Percentage
Total inventory
Inventory
Inventory, Net
Segment Information
Segment Reporting, Policy [Policy Text Block]
Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities
Accrued expenses and other liabilities
Notes, conversion price per share
Debt Instrument, Convertible, Conversion Price
Accrued expenses
Total Accrued Expenses
Accrued Liabilities, Current
Aggregate Intrinsic Value,Granted
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Customer [Axis]
Customer [Axis]
Work in process
Inventory, Work in Process, Gross
Document Type
Document Type
Gross Product Revenue
Gross product revenue
Gross product revenue.
Convertible Note Offering [Member]
Convertible Debt [Member]
Convertible Debt [Member]
Financing Warrants [Member]
Financing warrants.
Financing Warrants [Member]
Operating activities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Liabilities and Equity [Abstract]
Liabilities and stockholders' deficit
Two Thousand Twenty Three Warrants [Member]
Two thousand twenty three warrants.
2023 Warrants [Member]
Subsequent Event [Member]
Subsequent Event [Member]
Loss from operations
Operating Income (Loss)
Sale of stock price per share
Sale of Stock, Price Per Share
Fair Value, Net Derivative Asset (Liability) Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Segment Reporting [Table]
Entity File Number
Securities Act File Number
Finished goods
Inventory, Finished Goods, Gross
Inventory, Finished Goods, Gross, Total
License Agreements
Product Revenue
Revenue from Contract with Customer [Text Block]
Location, Statement of Income, Balance [Axis]
Accumulated Deficit [Member]
Retained Earnings [Member]
Investments
Investment in Debt and Equity Securities and Other Trading Assets [Text Block]
Expected life
Debt Instrument, Term
Reconciliation of cash, cash equivalents and restricted cash reported within the condensed consolidated balance sheets
Restricted Cash and Cash Equivalent [Abstract]
Percentage of redemption fee.
Percentage of Redemption Fee
Percentage of redemption fee
Credit agreement and term loan.
Credit Agreement and Term Loan [Member]
Entity Registrant Name
Entity Registrant Name
Beginning balance,Shares
Ending balance,Shares
Shares, Issued
Earnings Per Share, Basic, by Common Class, Including Two-Class Method [Table]
Accounting Policies [Abstract]
Accounting Policies [Abstract]
Royalty Rate
Royalty rate
Royalty Rate
Depreciation
Depreciation
Depreciation, Total
Depreciation
XPOVIO [Member]
Xpovio Member
Revenue Interest Agreement and Amended Revenue Interest Agreement [Member]
Revenue Interest Agreement And Amended Revenue Interest Agreement [Member]
Revenue Interest Agreement And Amended Revenue Interest Agreement [Member]
Two Thousand Thirteen Employee Stock Purchase Plan [Member]
Two Thousand Thirteen Employee Stock Purchase Plan.
2013 Employee Stock Purchase Plan
Warrant, Exercise Price, Decrease
Warrant, exercise price, decrease
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Debt Securities, Available-for-Sale, Unrealized Gain
Gross Unrealized Gains
Selling, general and administrative
Selling, General and Administrative Expense
Selling, General and Administrative Expense, Total
Proceeds from Issuance of Debt
Additional borrowings
Two Thousand And Twenty Eight Notes and Two Thousand And Twenty Nine Notes [Member]
Two thousand and twenty eight notes and two thousand and twenty nine notes
2028 Notes and 2029 Notes
Entity Address, Address Line One
Entity Address, Address Line One
Interest, payment terms
Line of Credit Facility, Frequency of Payment and Payment Terms
Total current assets
Assets, Current
Debt Instrument, Convertible, Carrying Amount of Equity Component
Outstanding amount, settled on cash
Fair Value Measurements, Recurring and Nonrecurring [Table]
Fair Value, Recurring and Nonrecurring [Table]
Cash paid for amounts included in the measurement of operating lease liabilities
Cash Paid For Amounts Included In Measurement Of Operating Lease Liabilities
Cash paid for amounts included in measurement of operating lease liabilities.
Supplemental disclosures:
Supplemental Cash Flow Information [Abstract]
Two Thousand Twenty Four Warrants [Member]
2024 Warrants.
2024 Warrants [Member]
Entity Small Business
Entity Small Business
Research and Development [Abstract]
Incremental Common Shares Attributable to Dilutive Effect of Share-Based Payment Arrangements
Dilutive effect of warrants using treasury stock method
Schedule of Derivative Liabilities at Fair Value [Table Text Block]
Summary of the Changes in the Estimated Fair Value of the Liabilities
Proceeds from Sale and Maturity of Debt Securities, Available-for-Sale, Total
Proceeds from Sale and Maturity of Debt Securities, Available-for-Sale
Proceeds from maturities of investments
Long-Term Debt, Type [Axis]
License Agreements [Member]
License agreements.
License Agreements [Member]
Consolidation Items [Domain]
Aggregate offering price
Aggregate Offering Price
Aggregate offering price.
Line of Credit Facility, Annual Principal Payment
Aggregate interest payments due
Other assets
Other Assets, Total
Other Assets
Debt instrument convertible threshold consecutive trading days
Debt Instrument, Convertible, Threshold Consecutive Trading Days
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
First investment amount
Proceeds From First Investment Amount
First investment amount.
Payment of Financing and Stock Issuance Costs, Total
Payment of Financing and Stock Issuance Costs
Payment of equity issuance costs
Earnings Per Share [Abstract]
Plan Name [Axis]
Plan Name [Axis]
Subsequent Event Type [Axis]
Equity [Abstract]
Product and Service [Domain]
Product and Service [Domain]
Class of Warrant or Right [Table]
Credit losses
Accounts Receivable, Allowance for Credit Loss, Current
Proceeds from Convertible Debt
Proceeds from convertible debt
Equity [Text Block]
Stockholders' Equity
Compensation Items [Abstract]
Two Thousand And Twenty Two Inducement Stock Incentive Plan [Member]
Two thousand and twenty two inducement stock incentive plan.
2022 Inducement Stock Incentive Plan
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Financing activities
2022 Equity Incentive Plan
Two Thousand and Twenty Two Equity Incentive Plan [Member]
Two thousand and twenty two equity incentive plan.
Entity Tax Identification Number
Entity Tax Identification Number
Convertible senior notes issued to purchase common stock
Stock Issued During Period, Shares, Conversion of Convertible Securities
Derivative Instrument [Axis]
Derivative Instrument [Axis]
Equity Component [Domain]
Equity Component [Domain]
Scheduleof Interest Expense Recognized Relatedto Convertible Notes Table [Text Block]
Schedule of interest expense recognized related to convertible notes Table.
Schedule of Interest Expense Recognized Related to Convertible Notes
Outstanding Warrant
Outstanding Warrant [Member]
Outstanding warrant.
Entity Address, City or Town
Entity Address, City or Town
Long-Term Debt, Maturity, Year One
2027
Stock Issued During Period, Value, New Issues
Net proceeds from common stock
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Entity [Domain]
Certain holders of the notes
Certain Holders of the Notes [Member]
Certain holders of the notes [Member]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Antidilutive Security, Excluded EPS Calculation [Table]
Issuance Of Common Stock And Warrants In Private Placement Offering Net Of Issuance Costs Shares
Issuance of common stock and warrants in private placement offering, net of issuance costs shares
Issuance of common stock and warrants in private placement offering, net of issuance costs (in shares)
Statement [Table]
Statement [Table]
Royalty [Member]
Royalty [Member]
Royalty Payment [Member]
Operating lease liabilities
Increase Decrease in Operating Lease Liabilities
Increase decrease in operating lease liabilities.
Stock-based compensation expense
Total stock-based compensation expense
Share-Based Payment Arrangement, Expense
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Loss before income taxes
Entity Shell Company
Entity Shell Company
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Net cash (used in) provided by investing activities
Percentage of redeem notes at premium with proceeds.
Percentage of Redeem Notes at Premium with Proceeds
Percentage of redeem notes at premium with proceeds
Statement [Line Items]
Statement [Line Items]
Conversion price description
Common Stock, Conversion Basis
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Other Royalty [Member]
Other Royalty [Member]
Other Royalty.
Maximum [Member]
Maximum [Member]
Debt Disclosure [Abstract]
Sale of Stock [Domain]
Secured Debt, Current
Senior secured term loan
Percentage of Issuance of Indebtedness For Borrowed Money or Capital Stock
Percentage of issuance of indebtedness for borrowed money or capital stock.
Percentage of net cash proceeds from issuance of indebtedness
Near Term Deferrals of Interest [Member]
Near term deferrals of interest.
Near Term Deferrals of Interest [Member]
Jefferies LLC [Member]
Jefferies LLC [Member]
Jefferies LLC.
Interest income
Investment Income, Interest
Amended Term Loan [Member]
Amended term loan.
Amended Term Loan [Member]
Convertible senior notes due 2029 issued with warrants to purchase 45,776,213 shares of common stock in exchange for a $148.0 million reduction of convertible senior notes due 2025
Notes converted in to common stock, shares
Debt Conversion, Converted Instrument, Amount
Operating lease right-of-use assets
Increase Decrease In Operating Lease Right Of Use Asset
Increase decrease in operating lease right of use asset.
Reimbursement of development related expenses
Reimbursement of Development Related Expenses
Reimbursement of development related expenses
Debt Instrument, Redemption, Period [Domain]
Principles of Consolidation
Consolidation, Policy [Policy Text Block]
Basis of Consolidation
Subsequent Events [Abstract]
Investments Debt And Equity Securities [Abstract]
Investments, Debt and Equity Securities [Abstract]
Amortization of Debt Issuance Costs
Amortization of debt issuance costs
Amortization of debt issuance costs and discounts
Change in fair value of embedded derivatives and common stock warrants
Embedded Derivative, Gain (Loss) on Embedded Derivative, Net
Embedded Derivative, Gain (Loss) on Embedded Derivative, Net, Total
Common Stock Unissued And Unreserved
Common stock unissued and unreserved.
Common stock unissued and unreserved
Current assets:
Assets, Current [Abstract]
Debt issuance costs
Debt Issuance Costs, Net
Debt Issuance Costs, Net, Total
Less: debt issuance costs
Sale of Stock, Consideration Received on Transaction
Gross proceeds
Aggregate net proceeds
Line of Credit [Member]
Line of Credit [Member]
Document Fiscal Year Focus
Document Fiscal Year Focus
Net amortization of premiums and discounts on investments
Accretion (Amortization) of Discounts and Premiums, Investments
Common stock, shares outstanding
Common Stock, Shares, Outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Bad debt write-offs
Accounts Receivable, Allowance for Credit Loss, Writeoff
Financial Instruments [Domain]
Financial Instruments [Domain]
Statement Of Income And Comprehensive Income [Abstract]
Statement of Comprehensive Income [Abstract]
First Investment Amount and Second Investment
Revenue Interest Agreement And Amended Revenue Interest Agreement 1 [Member]
Revenue interest agreement and amended revenue interest agreement 1.
Summary of Outstanding Balances of Convertible Notes
Convertible Debt [Table Text Block]
Unvested restricted stock units and performance-based restricted stock units [Member]
Unvested Restricted Stock Units and Performance Based Restricted Stock Units [Member]
Unvested restricted stock units and performance based restricted stock units.
Scenario, Forecast [Member]
Forecast [Member]
Summary of Gain on Extinguishment of Debt
Schedule of Extinguishment of Debt [Table Text Block]
Operating lease liabilities, net of current portion
Operating Lease, Liability, Noncurrent
Debt instrument exchange amount.
Debt Instrument Exchange Amount
Debt instrument exchange amount
Additional paid-in capital
Additional Paid in Capital, Common Stock
Additional Paid in Capital, Common Stock, Beginning Balance
Additional Paid in Capital, Common Stock, Ending Balance
Security Exchange Name
Security Exchange Name
Embedded Derivatives on Two Thousand Twenty Eight Notes [Member]
Embedded derivatives on 2028 Notes [Member]
Embedded derivatives on 2028 Notes [Member]
Commercial expenses
Commercial Segment Operating Expense
Commercial segment operating expense.
Related and Nonrelated Parties [Axis]
Warrant [Member]
Warrant [Member]
Outstanding common stock warrants, except pre-funded warrants [Member]
Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items]
Earnings Per Share Basic [Line Items]
Quarter Two [Member]
Quarter two.
Quarter Two [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights
Exercise price
Entity Address, State or Province
Entity Address, State or Province
Operating lease right-of-use asset
Operating Lease, Right-of-Use Asset
Operating lease right-of-use assets
Amendment Flag
Amendment Flag
Schedule of Research and Development Arrangement, Contract to Perform for Others [Table]
Research and Development, Contract to Perform for Others [Table]
Stock-based Compensation
Share-Based Payment Arrangement [Text Block]
Stock-based Compensation Expense
Total license and other revenue
Contract with Customer License and Other Revenue
Contract with customer license and other revenue.
HCRx Derivative [Member]
HCRx Derivative [Member]
HCRx derivative.
Interest expense on debt
Total interest expense
Interest Expense, Debt
Debt Instrument [Axis]
Debt Instrument [Axis]
Other Nonoperating Income (Expense)
Other Nonoperating Income (Expense), Total
Other (expense) income, net
Interest expense
Contractual interest expense
Interest Expense, Debt, Excluding Amortization
Total cash, cash equivalents and restricted cash
Cash, cash equivalents and restricted cash at beginning of period
Cash, cash equivalents and restricted cash at end of period
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
City Area Code
City Area Code
Interest expense
Interest Expense, Nonoperating, Total
Interest Expense, Nonoperating
Interest expense
Amended & Restated 2013 Employee Stock Purchase Plan
Amended and Restated Two Thousand Thirteen Employee Stock Purchase Plan [Member]
Amended and restated Two thousand thirteen employee stock purchase plan.
Summary of the Debt Issuance Cost and Discounts
Summary of the Debt Issuance Cost and Discounts Table Text Block
Summary of the debt issuance Cost and discounts table text block.
Net proceeds from sale of common stock
Proceeds from Issuance of Common Stock
Proceeds from issuance of common stock under Open Market Sale Agreement
License [Member]
License [Member]
Open Market Sale Agreement [Member]
Open Market Sale Agreement [Member]
Open market sale agreement.
Operating expenses:
Operating Expenses [Abstract]
Inventory
Inventory Disclosure [Text Block]
Amended Revenue Interest Agreement [Member]
Amended Revenue Interest Agreement [Member]
Amended Revenue Interest Agreement [Member]
Debt discount and issuance costs amortized to interest expense, amortization period
Debt Issuance Costs Allocated To Liability Component Amortized To Interest Expense Amortization Period
Debt issuance costs allocated to liability component amortized to interest expense amortization period.
Debt Instrument, Redemption, Period [Axis]
Term Loan and Amended Term Loan [Member]
Term loan and amended term Loan.
Term Loan and Amended Term Loan [Member]
Transaction [Domain]
Common Stock Outstanding Percentage
Common stock outstanding percentage.
Percentage common stock outstanding
Common stock, par value
Common Stock, Par or Stated Value Per Share
Legal Entity [Axis]
Debt instrument prepayment premium percentage.
Debt Instrument Prepayment Premium Percentage
Prepayment premium
Proceeds from issuance of common stock and warrants in private placement offering
Proceeds from Issuance of Common Stock and Warrants in Private Placement Offering
Proceeds from issuance of common stock and warrants in private placement offering.
9.00% senior secured convertible notes due 2029 [Member]
Nine Percentage Secured Convertible Senior Notes Due Two Thousand Twenty Nine [Member]
Nine percentage secured convertible senior notes due two thousand twenty nine.
Short-term Debt, Type [Domain]
Short-Term Debt, Type [Domain]
Total current liabilities
Liabilities, Current
Summary of Investments, Classified as Available-for-Sale
Debt Securities, Available-for-Sale [Table Text Block]
Convertible Senior Notes Due Two Thousand Twenty Eight
Convertible senior notes due two thousand twenty eight.
Convertible senior notes due 2028
Type of Arrangement and Non-arrangement Transactions [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Trading Symbol
Trading Symbol
Amortization of debt issuance costs and discounts
Amortization of Debt Issuance Costs and Discounts
Amortization of Debt Issuance Costs and Discounts, Total
Subsequent Event [Table]
Subsequent Event [Table]
Notes, interest rate
Debt Instrument, Interest Rate During Period
Entity Emerging Growth Company
Entity Emerging Growth Company
Additional Paid-In Capital [Member]
Additional Paid-in Capital [Member]
Two Thousand Twenty Six Leadership Cash Retention Program [Member]
Two thousand twenty six leadership cash retention program.
2026 Leadership Cash Retention Program [Member]
Debt instrument, convertible latest date
Debt Instrument, Convertible, Latest Date
Total minimum payments
Long-Term Debt, Gross
Long-term debt gross
Minimum payments due in 2025
Plan Name [Domain]
Plan Name [Domain]
Liability Classified Warrants [Member]
Liability classified warrants.
Liability Classified Warrants [Member]
Other liabilities
Other Liabilities, Noncurrent
Two Thousand Twenty Eight Notes [Member]
Two thousand twenty eight notes.
2028 Notes [Member]
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Shares issued under the employee stock purchase plan, (in shares)
Business Combination [Table]
Nine Percentage Secured Convertible Senior Notes Due Two Thousand Twenty Eight [Member]
9.00% senior secured convertible notes due 2028
9.00% senior secured convertible notes due 2028 [Member]
2029 Notes and New 2029 Notes [Member]
Two Thousand Twenty Nine and New Two Thousand Twenty Nine Notes [Member]
Two thousand twenty nine and new two thousand twenty nine notes.
Cover [Abstract]
Convertible senior notes issued
Convertible Senior Notes Issued in Exchange of Reduction of Deferred Royalty Obligation
Convertible senior notes issued in exchange of reduction of deferred royalty obligation.
Revenue from Contract with Customer [Abstract]
Revenues:
Revenue from Contract with Customer [Abstract]
Long-Term Debt, Type [Domain]
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated other comprehensive income
Share-Based Compensation Arrangement by Share-Based Payment Award, Description
Share Based Compensation Arrangement by Share-Based Payment Award, Description
Issuance Of Common Stock Under Open Market Sale Agreement, Net Of Issuance Costs
Amount of issuance of common stock under Open Market Sale Agreement, net of issuance costs.
Issuance of common stock under Open Market Sale Agreement, net of issuance costs
Stock-based compensation expense
Share-Based Payment Arrangement, Noncash Expense
Share-based Payment Arrangement, Noncash Expense, Total
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Fair Value Disclosures [Abstract]
Cash and cash equivalents
Cash and Cash Equivalent
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Class Of Warrant Or Right Number Of Warrants Or Rights Issued
Class of warrant or right number of warrants or rights issued.
Issued
Capital Units, Authorized
Capital stock, shares authorized
Debt Securities, Available-for-Sale, Unrealized Loss
Total Unrealized Loss
Total Unrealized Loss
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Net cash provided by financing activities
Percentage of line of credit facility periodic payment.
Percentage of Line of Credit Facility Periodic Payment
Quarterly cash payments
Equity Offering [Line Items]
Equity Offering [Line Items]
Equity offering.
Entity Filer Category
Entity Filer Category
Debt Instrument, Name [Domain]
Debt Instrument, Name [Domain]
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description
Accounts receivable, net
Increase (Decrease) in Accounts Receivable
Debt Issued for Interest Payments
Debt issued for interest payments.
Debt issued for interest payments
Property and equipment, net
Property and equipment, net
Property, Plant, and Equipment, after Accumulated Depreciation, Depletion, and Amortization
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net, Ending Balance
Revenue from contract with customer, license and other revenue
Royalty revenue recognized
Revenue from Contract with Customer, Excluding Assessed Tax
Total product revenue, net
Revenue from external customers
Financing Transactions [Member]
Financing transactions.
Financing Transactions [Member]
Inventory Disclosure [Abstract]
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Issuances
Initial recognition
Transaction Type [Axis]
Segment Reporting [Abstract]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Statement of Financial Position [Abstract]
Local Phone Number
Local Phone Number